{"id":254433,"date":"2025-01-25T15:32:00","date_gmt":"2025-01-25T14:32:00","guid":{"rendered":"https:\/\/r3i.org\/%e7%94%bb%e6%9c%9f%e7%9a%84%e3%81%aa%e7%a0%94%e7%a9%b6-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%82%92%e7%9b%ae%e6%a8%99%e3%81%ab%e6%b2%bb%e7%99%82%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6%ef%bc%9a%e8%84%b3\/"},"modified":"2025-02-16T22:47:12","modified_gmt":"2025-02-16T21:47:12","slug":"%e7%94%bb%e6%9c%9f%e7%9a%84%e3%81%aa%e7%a0%94%e7%a9%b6-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%82%92%e7%9b%ae%e6%a8%99%e3%81%ab%e6%b2%bb%e7%99%82%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6%ef%bc%9a%e8%84%b3","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e7%94%bb%e6%9c%9f%e7%9a%84%e3%81%aa%e7%a0%94%e7%a9%b6-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%82%92%e7%9b%ae%e6%a8%99%e3%81%ab%e6%b2%bb%e7%99%82%e3%81%99%e3%82%8b%e7%a0%94%e7%a9%b6%ef%bc%9a%e8%84%b3\/","title":{"rendered":"\u753b\u671f\u7684\u306a\u7814\u7a76 – \u8133\u5352\u4e2d\u3092\u76ee\u6a19\u306b\u6cbb\u7642\u3059\u308b\u7814\u7a76\uff1a\u8133\u5352\u4e2d\u5f8c\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u76ee\u6a19\u5024\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u8133\u5352\u4e2d\u3092\u76ee\u6a19\u306b\u6cbb\u7642\u3059\u308b\u7814\u7a76\uff1a\u8133\u5352\u4e2d\u5f8c\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u76ee\u6a19\u5024\u3092\u4e0b\u3052\u308b\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u6e1b\u5c11\u3059\u308b<\/span><\/h2>\n
2019 \u5e74 12 \u6708 19 \u65e5<\/span><\/h5>\n
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< \u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306f\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\uff08TIA\uff09\u3092\u767a\u75c7\u3057\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u304c\u8a8d\u3081\u3089\u308c\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u309270mg\/dL\uff08<1.8mmol\/L\uff09\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u3001\u3088\u308a\u9ad8\u3044\u76ee\u6a19\u5024\uff0890\uff5e110mg\/dL[2 .3 to 2.8 mmol\/L] \uff09\u306b\u6bd4\u3079\u3066\u3001\u305d\u306e\u5f8c\u306e\u5fc3\u8840\u7ba1\uff08CV\uff09\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002<\/span><\/div>\n
Amarenco P, Kim JS, Labreuche J et al. \u865a\u8840\u6027\u8133\u5352\u4e2d\u5f8c\u306e2\u3064\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u76ee\u6a19\u306e\u6bd4\u8f03\u3002N Engl J Med 2019; DOI: 10.1056\/NEJMoa1910355 <\/span><\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u8133\u5352\u4e2d\u5f8c\u306eCV\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u306e\u305f\u3081\u306eLDL-C\u306e\u76ee\u6a19\u5024\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u30d5\u30e9\u30f3\u30b9\uff0861\u65bd\u8a2d\uff09\u304a\u3088\u3073\u97d3\u56fd\uff0816\u65bd\u8a2d\uff09\u3067\u5b9f\u65bd\u3055\u308c\u305f\u591a\u65bd\u8a2d\u5171\u540c\u7121\u4f5c\u70ba\u5316\u4e26\u884c\u7fa4\u9593\u30a4\u30d9\u30f3\u30c8\u30c9\u30ea\u30d6\u30f3\u8a66\u9a13\u3002\u904e\u53bb3\u30f5\u6708\u4ee5\u5185\u306b\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306f\u904e\u53bb15\u65e5\u4ee5\u5185\u306bTIA\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u3092\uff0cLDL-C\u306e\u76ee\u6a19\u5024\u3092<70mg\/dL\uff08\u4f4e\u76ee\u6a19\u5024\u7fa4\uff09\u307e\u305f\u306f90\uff5e110mg\/dL\uff08\u9ad8\u76ee\u6a19\u5024\u7fa4\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\uff081\uff1a1\uff09\u3002\u7121\u4f5c\u70ba\u5316\u304b\u30893\u9031\u9593\u5f8c\u306bLDL-C\u3092\u6e2c\u5b9a\u3057\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u6295\u4e0e\u91cf\u3092\u8abf\u6574\u3057\u3001\u5fc5\u8981\u3067\u3042\u308c\u3070\u4ed6\u306e\u8102\u8cea\u4f4e\u4e0b\u85ac\u3092\u8ffd\u52a0\u3057\u3066\u5fc5\u8981\u306aLDL-C\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u305f\u3002\u60a3\u8005\u306f\u305d\u306e\u5f8c6\u30f5\u6708\u3054\u3068\u306b\u8ffd\u8de1\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n\u5bfe\u8c61\u8005\u306f2860\u4eba\uff08\u5404\u5bfe\u8c61\u7fa4\u306b1430\u4eba\uff09\u3067\u3042\u3063\u305f\u3002\u5927\u591a\u6570\u306f\u7537\u6027\u3067\uff0867\u301c68\uff05\uff09\u3001\u5e73\u5747\u5e74\u9f62\u306f66.4\u301c67.0\u6b73\u3001\u5371\u967a\u56e0\u5b50\u306e\u6709\u75c5\u7387\u306f\u9ad8\u304b\u3063\u305f\uff08\u9ad8\u8840\u572764\u301c67\uff05\u3001\u8102\u8cea\u7570\u5e38\u75c761\u301c62\uff05\u3001\u55ab\u7159\u6b7451\u301c56\uff05\u3001\u7cd6\u5c3f\u75c522\u301c23\uff05\uff09\u3002\u534a\u6570\u4ee5\u4e0a\u306f\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u6cbb\u7642\u6b74\u304c\u306a\u304b\u3063\u305f\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5e73\u5747LDL-C\u306f135\u301c136mg\/dL\uff09\u3002 <\/td>\n<\/tr>\n
\u6709\u52b9\u6027\u306e\u5909\u6570\uff1a<\/strong><\/td>\n\n

– \u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff1a\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u3001\u51a0\u52d5\u8108\u307e\u305f\u306f\u9838\u52d5\u8108\u306e\u7dca\u6025\u8840\u884c\u518d\u5efa\u8853\u306b\u3064\u306a\u304c\u308b\u65b0\u305f\u306a\u75c7\u72b6\u3001\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u3092\u542b\u3080\u4e3b\u8981\u306aCV\u30a4\u30d9\u30f3\u30c8\u306e\u8907\u5408\u3002<\/p>\n

– \u526f\u6b21\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c81\uff09\u65b0\u305f\u306a\u75c7\u72b6\u767a\u73fe\u5f8c\u306e\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u7dca\u6025\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u30012\uff09TIA\u5f8c\u306e\u8133\u6897\u585e\u307e\u305f\u306f\u9838\u52d5\u8108\u3082\u3057\u304f\u306f\u8133\u52d5\u8108\u306e\u7dca\u6025\u8840\u884c\u518d\u5efa\u8853\u30013\uff09\u8133\u6897\u585e\u307e\u305f\u306fTIA\uff1b4\uff09\u51a0\u52d5\u8108\u3001\u8133\u52d5\u8108\u3001\u672b\u68a2\u52d5\u8108\u306e\u8840\u884c\u518d\u5efa\u8853\uff08\u7dca\u6025\u307e\u305f\u306f\u9078\u629e\u7684\uff09\u30014\uff09CV\u6b7b\u30015\uff09\u3042\u3089\u3086\u308b\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u30016\uff09\u8133\u6897\u585e\u307e\u305f\u306f\u982d\u84cb\u5185\u51fa\u8840\uff08ICH\uff09\u30017\uff09ICH\u30018\uff09\u65b0\u305f\u306b\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3082\u306e\u30019\uff09\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u307e\u305f\u306fICH\u306e\u8907\u5408\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u69cb\u6210\u8981\u7d20\u3067\u3042\u308b\u3059\u3079\u3066\u306e\u5076\u767a\u4e8b\u8c61\u306f\u3001\u8a66\u9a13\u7fa4\u306e\u5272\u308a\u4ed8\u3051\u3084LDL-C\u5024\u3092\u77e5\u3089\u306a\u3044\u59d4\u54e1\u4f1a\u306b\u3088\u3063\u3066\u5224\u5b9a\u3055\u308c\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u3053\u306e\u8a66\u9a13\u306f\u30a4\u30d9\u30f3\u30c8\u30c9\u30ea\u30d6\u30f3\u306e\u8a66\u9a13\u3067\u3042\u3063\u305f\u30023786\u4f8b\u306e\u60a3\u8005\u304c\u767b\u9332\u3055\u308c\u305f\u5834\u5408\u3001385\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c\u5f97\u3089\u308c\u30013\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u300120\uff05\u306e\u8131\u843d\u7387\u3067\u3001\u4f4e\u6a19\u7684\u7fa4\u3068\u9ad8\u6a19\u7684\u7fa4\u306e\u4e3b\u8981CV\u30a4\u30d9\u30f3\u30c8\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u304c25\uff05\u4f4e\u3044\u3053\u3068\u3092\u691c\u51fa\u3059\u308b80\uff05\u306e\u691c\u51fa\u529b\u304c\u5f97\u3089\u308c\u308b\u3068\u63a8\u5b9a\u3055\u308c\u305f\u3002\u8a66\u9a13\u306f277\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u30a4\u30d9\u30f3\u30c8\u306e\u5f8c\u306b\u7ba1\u7406\u4e0a\u306e\u7406\u7531\u3067\u4e2d\u6b62\u3055\u308c\u305f\u3002\u4e3b\u8981\u6709\u52b9\u6027\u89e3\u6790\u306f\u5e74\u9f62\u3001\u6027\u5225\u3001\u6307\u6a19\u30a4\u30d9\u30f3\u30c8\uff08\u8133\u5352\u4e2d\u307e\u305f\u306fTIA\uff09\u3001\u6307\u6a19\u30a4\u30d9\u30f3\u30c8\u304b\u3089\u306e\u671f\u9593\u3092\u5171\u5909\u91cf\u3068\u3057\u3066\u542b\u3080Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u884c\u308f\u308c\u305f\u3002\u5171\u5909\u91cf\u306e\u6b20\u6e2c\u5024\u306fmultiple-imputation\u6cd5\u3092\u7528\u3044\u3066\u51e6\u7406\u3057\u305f\u3002\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u89e3\u6790\u306b\u306f\u3001\u591a\u91cd\u6bd4\u8f03\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u305f\u3081\u306e\u968e\u5c64\u7684\u624b\u9806\u306b\u5f93\u3063\u3066\u30ed\u30b0\u30e9\u30f3\u30af\u691c\u5b9a\u3092\u7528\u3044\u305f\u3002 <\/td>\n<\/tr>\n
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\u7d50\u679c<\/strong><\/p>\n<\/div>\n

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\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001\u4f4e\u6a19\u7684\u7fa4\u30673.5\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f2[IQR] \u30012.0\u301c6.7\uff09\u3001\u9ad8\u6a19\u7684\u7fa4\u30673.6\u5e74\uff08IQR 2.0\u301c6.7\uff09\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u9593\u306e\u5e73\u5747LDL-C\u5024\u306f\u3001\u4f4e\u5024\u76ee\u6a19\u7fa4\u306765mg\/dL\uff081.7mmol\/L\uff09\u3001\u9ad8\u5024\u76ee\u6a19\u7fa4\u306796mg\/dL\uff082.5mmol\/L\uff09\u3067\u3042\u3063\u305f\u3002\u4f4e\u7528\u91cf\u76ee\u6a19\u7fa4\u3067\u306f\u3001\u60a3\u8005\u306e47.2\uff05\u304cLDL-C\u5024>70mg\/dL\u300144.7\uff05\u304cLDL-C\u502450mg\/dL\uff5e70mg\/dL\u3001\u6b8b\u308a\u304cLDL-C\u5024<50mg\/dL\u3067\u3042\u3063\u305f\u3002\u9ad8\u5024\u76ee\u6a19\u7fa4\u3067\u306f\u300148.5\uff05\u304cLDL-C\u5024<90mg\/dL\u300116.8\uff05\u304cLDL-C\u5024>110mg\/dL\u3067\u3042\u3063\u305f\u3002 <\/p>\n

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\u5168\u4f53\u3068\u3057\u3066\u3001\u4f4e\u7528\u91cf\u7fa4\u306e65.9\uff05\u3001\u9ad8\u7528\u91cf\u7fa4\u306e94.0\uff05\u304c\u30b9\u30bf\u30c1\u30f3\u3092\u6295\u4e0e\u3055\u308c\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u306f\u305d\u308c\u305e\u308c33.8\uff05\u30015.8\uff05\u3067\u3042\u3063\u305f\u3002\u4e21\u7fa4\u306e\u4e2d\u592e\u50242.7\u5e74\u306b\u304a\u3051\u308b\u4e2d\u6b62\u7387\u306f\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\uff08\u305d\u308c\u305e\u308c30.3\uff05\u306828.5\uff05\uff09\u3002\u6cbb\u7642\u57df\u306b\u3042\u3063\u305f\u671f\u9593\u306e\u5272\u5408\u306f\u4f4e\u7528\u91cf\u7fa4\u306752.8\uff05\u3001\u9ad8\u7528\u91cf\u7fa4\u306732.2\uff05\u3067\u3042\u3063\u305f\u3002 <\/p>\n

 <\/p>\n

\u4e00\u6b21\u304a\u3088\u3073\u4e8c\u6b21\u6709\u52b9\u6027\u89e3\u6790\u306e\u7d50\u679c\u3092\u4ee5\u4e0b\u306b\u8981\u7d04\u3059\u308b\u3002 LDL-C\u76ee\u6a19\u5024\u304c\u4f4e\u3044\u7fa4\u3067\u306f\u9ad8\u3044\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u60a3\u8005\u3088\u308a\u3082\u305d\u306e\u5f8c\u306e\u4e3b\u8981\u306aCV\u30a4\u30d9\u30f3\u30c8\uff08\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff09\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u30a4\u30d9\u30f3\u30c8\u306e\u307b\u3068\u3093\u3069\u306f\u8133\u6897\u585e\u307e\u305f\u306f\u8133\u5352\u4e2d\u3067\u3042\u3063\u305f\u3002\u3059\u3079\u3066\u306e\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u3068\u6982\u306d\u540c\u3058\u65b9\u5411\u3067\u3042\u3063\u305f\u3002ICH\u30a4\u30d9\u30f3\u30c8\u306e\u6570\u306f\u4f4e\u6a19\u7684\u7fa4\u306e\u65b9\u304c\u9ad8\u6a19\u7684\u7fa4\u3088\u308a\u3082\u591a\u304b\u3063\u305f\u304c\u300195\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u304b\u3089\u7fa4\u9593\u5dee\u306f\u6709\u610f\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n

\u88681. \u4e3b\u8981\u304a\u3088\u3073\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/strong><\/td>\n\n

\u76ee\u6a19\u5024\u306e\u4f4e\u3044\u7fa4\uff08\u226670mg\/dL\uff09<\/strong><\/p>\n

(N=1430)<\/strong><\/p>\n<\/td>\n

\u9ad8\u5024\u76ee\u6a19\u7fa4\uff0890\uff5e110mg\/dL\uff09\uff08N=1430\uff09<\/strong><\/td>\n\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/strong><\/td>\np\u5024<\/strong><\/td>\n<\/tr>\n
<\/td>\n\u30a4\u30d9\u30f3\u30c8\u306e\u6570(%)<\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/td>\n121 (8.5)<\/td>\n156 (10.9)<\/td>\n0.78 (0.61-0.98)*<\/td>\n0.04<\/td>\n<\/tr>\n
\u526f\u6b21\u7684\u8a55\u4fa1\u9805\u76ee<\/td>\n <\/td>\n <\/td>\n <\/td>\n <\/td>\n<\/tr>\n
MI\/\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853<\/td>\n20 (1.4)<\/td>\n31 (2.2)<\/td>\n0.64 (0.37-1.13)<\/td>\n0.12**<\/td>\n<\/tr>\n
\u8133\u6897\u585e\/\u8840\u884c\u518d\u5efa\u8853<\/td>\n88 (6.2)<\/td>\n109 (7.6)<\/td>\n0.81 (0.61-1.07)<\/td>\n <\/td>\n<\/tr>\n
\u8133\u6897\u585e\/TIA<\/td>\n120 (8.4)<\/td>\n139 (9.7)<\/td>\n0.87 (0.68-1.11)<\/td>\n <\/td>\n<\/tr>\n
\u4f55\u3089\u304b\u306e\u8840\u884c\u518d\u5efa\u8853<\/td>\n94 (6.6)<\/td>\n99 (6.9)<\/td>\n0.93 (0.70-1.24)<\/td>\n <\/td>\n<\/tr>\n
CV\u6b7b\u4ea1<\/td>\n22 (1.5)<\/td>\n22 (1.5)<\/td>\n0.69 (0.40-1.18)<\/td>\n <\/td>\n<\/tr>\n
\u5168\u6b7b\u56e0\u6b7b\u4ea1<\/td>\n88 (6.2)<\/td>\n93 (6.5)<\/td>\n0.97 (0.73-1.30)<\/td>\n <\/td>\n<\/tr>\n
\u8133\u6897\u585e\/ICH<\/td>\n103 (7.2)<\/td>\n126 (8.8)<\/td>\n0.82 (0.63-1.07)<\/td>\n <\/td>\n<\/tr>\n
ICH<\/td>\n18 (1.3)<\/td>\n13 (0.9)<\/td>\n1.38 (0.68-2.82)<\/td>\n <\/td>\n<\/tr>\n
\u65b0\u898f\u767a\u75c7\u7cd6\u5c3f\u75c5<\/td>\n103 (7.2)<\/td>\n82 (5.7)<\/td>\n1.27 (0.95-1.70)<\/td>\n <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u5171\u5909\u91cf\u3067\u8abf\u6574\uff1b<\/p>\n

** \u8ffd\u52a0\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306ep\u5024\u306f\u3001\u6700\u521d\u306e\u8a55\u4fa1\u9805\u76ee\u3067\u6709\u610f\u306a\u7fa4\u9593\u5dee\u304c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u968e\u5c64\u7684\u691c\u5b9a\u3067\u306f\u7b97\u51fa\u3057\u306a\u304b\u3063\u305f\uff1b<\/p>\n

*** \u7cd6\u5c3f\u75c5\u306e\u65b0\u898f\u767a\u75c7\u306f\u3001\u8ffd\u8de1\u8abf\u67fb\u6642\u306b\u7a7a\u8179\u6642\u30b0\u30eb\u30b3\u30fc\u30b9\u2267126mg\/dL\uff087.0mmol\/L\uff09\u307e\u305f\u306fHbA1c\u22676.5\uff05\u3092\u5c11\u306a\u304f\u3068\u30822\u56de\u6e2c\u5b9a\u3057\u305f\u3053\u3068\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u3053\u306e\u5206\u985e\u306f\u5224\u5b9a\u3055\u308c\u306a\u304b\u3063\u305f\u3002 <\/span><\/strong><\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306fTIA\u3067\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u304c\u8a8d\u3081\u3089\u308c\u305f\u5f8c\u3001LDL-C\u306e\u76ee\u6a19\u5024\u3092<70mg\/dL\u3068\u3057\u305f\u60a3\u8005\u306f\u3001\u305d\u308c\u4ee5\u4e0a\u306e\u76ee\u6a19\u5024\uff0890\uff5e110mg\/dL\uff09\u3092\u8a2d\u5b9a\u3057\u305f\u60a3\u8005\u3088\u308a\u3082\u305d\u306e\u5f8c\u306eCV\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u4f4e\u304b\u3063\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u73fe\u5728\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306fTIA\u5f8c\u306eCV\u30a4\u30d9\u30f3\u30c8\u4e88\u9632\u306e\u305f\u3081\u306b\u96c6\u4e2d\u7684\u306a\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u63a8\u5968\u3057\u3066\u304a\u308a1\u3001SPARCL\uff08Stroke Prevention by Aggressive Reduction in Cholesterol Level\uff09\u8a66\u9a13\u306e\u7d50\u679c2-4\u3084\u6700\u8fd1\u306e\u30e1\u30bf\u56de\u5e30\u5206\u67905\u306b\u3088\u3063\u3066\u652f\u6301\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

PCSK9 (proprotein convertase subtilisin\/kexin type 9)\u963b\u5bb3\u85ac\u306e\u3088\u3046\u306a\u975e\u5e38\u306b\u6709\u52b9\u306aLDL-C\u4f4e\u4e0b\u85ac\u306e\u51fa\u73fe\u306b\u3088\u308a\u3001LDL-C\u5024\u306f\uff08\u901a\u5e38\u3001\u96c6\u4e2d\u7684\u306a\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u80cc\u666f\u306b\uff09\u975e\u5e38\u306b\u4f4e\u304f\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u85ac\u5264\u3092\u7528\u3044\u305f\u4e3b\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u30b9\u30bf\u30c7\u30a3\u306e\u7d50\u679c\u304b\u3089\u306f\u3001\u6b8b\u5b58\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3044\u3046\u3055\u3089\u306a\u308b\u6709\u76ca\u6027\u304c\u793a\u3055\u308c\u3066\u3044\u308b7,8\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u7570\u306a\u308b\u76ee\u6a19LDL-C\u5024\u306e\u9054\u6210\u306e\u52b9\u679c\u3092\u3001\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3068\u975e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306e\u4e21\u65b9\u3092\u4f75\u7528\u3057\u3066\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002 <\/p>\n

\u6700\u8fd1\u306e\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306fTIA\u3067\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u304c\u8a8d\u3081\u3089\u308c\u305f\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4eca\u56de\u306eTreat Stroke to Target\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001LDL-C\u306e\u76ee\u6a19\u5024\uff08<70mg\/dL\u5bfe90-110mg\/dL\uff09\u3092\u4f4e\u304f\u8a2d\u5b9a\u3059\u308b\u3053\u3068\u304c\u3001\u305d\u306e\u5f8c\u306eCV\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u660e\u78ba\u306b\u793a\u3057\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u30d5\u30e9\u30f3\u30b9\u4eba\u60a3\u8005\u3068\u97d3\u56fd\u4eba\u60a3\u8005\u3067\u306f\u3001\u7d50\u679c\u306b\u7570\u8cea\u6027\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u305f\u3060\u3057\u3001\u8ffd\u8de1\u671f\u9593\u306f\u4e2d\u592e\u5024\u30672.0\u5e74\u3001\u30d5\u30e9\u30f3\u30b9\u4eba\u60a3\u8005\u3067\u306f5.3\u5e74\u3067\u3042\u3063\u305f\uff09\u3002\u8d85\u4f4eLDL-C\u5024\u306b\u95a2\u3059\u308b\u3082\u30461\u3064\u306e\u7591\u554f\u306f\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002SPARCL\u8a66\u9a13\u3068Heart Protection\u8a66\u9a132,9\u3001\u304a\u3088\u3073\u30b9\u30bf\u30c1\u30f3\u8a66\u9a13\u306e\u30e1\u30bf\u89e3\u679010\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u96c6\u4e2d\u7684\u306a\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066ICH\u30a4\u30d9\u30f3\u30c8\u306e\u6570\u304c\u6570\u5024\u7684\u306b\u591a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306fLDL-C\u76ee\u6a19\u5024\u304c\u4f4e\u3044\u7fa4\u3067ICH\u30a4\u30d9\u30f3\u30c8\u304c\u6570\u5024\u7684\u306b\u306f\u591a\u304b\u3063\u305f\u3082\u306e\u306e\u300195\uff05\u4fe1\u983c\u533a\u9593\u3067\u306f\u4e21\u7fa4\u9593\u306b\u6709\u610f\u306a\u30ea\u30b9\u30af\u306e\u5dee\u306f\u306a\u304b\u3063\u305f\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002 <\/p>\n

Treat Stroke to Target\u8a66\u9a13\u306f\u3001\u3057\u3063\u304b\u308a\u3068\u3057\u305f\u30c7\u30b6\u30a4\u30f3\u3068\u65b9\u6cd5\u8ad6\u3092\u6301\u3063\u3066\u3044\u305f\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u8a66\u9a13\u7d50\u679c\u306b\u306f\u6ce8\u610f\u3059\u3079\u304d\u9650\u754c\u304c\u3042\u308b\u3002\u305d\u306e\u6700\u305f\u308b\u3082\u306e\u306f\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50243.5\u5e74\u3067\u8a66\u9a13\u304c\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f\u3053\u3068\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u6570\u304c\u691c\u51fa\u529b\u8a08\u7b97\u3067\u4e88\u5b9a\u3055\u308c\u3066\u3044\u305f\u6570\u3088\u308a\u5c11\u306a\u304b\u3063\u305f\u3053\u3068\u3067\u3042\u308b\uff08\u8a08\u753b\u5024385\u306b\u5bfe\u3057\u3066277\uff09\u3002\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u306e\u8a66\u9a13\u3067\u306f\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u3001LDL-C\u76ee\u6a19\u5024\u304c\u9ad8\u3044\u3088\u308a\u3082\u4f4e\u3044\u65b9\u304c\u3053\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u304c22\uff05\u6e1b\u5c11\u3057\u305f\u3002 <\/p>\n

\u30b9\u30bf\u30c1\u30f3\u3092\u542b\u3080\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u52d5\u8108\u786c\u5316\u3092\u539f\u56e0\u3068\u3059\u308b\u865a\u8840\u6027\u8133\u5352\u4e2d\u3084TIA\u3092\u542b\u3080\u975e\u5e38\u306b\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u9ad8\u3044CV\u30ea\u30b9\u30af\u304c\u6b8b\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b6\u3002\u3053\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u6cbb\u7642\u6226\u7565\u306e1\u3064\u306f\u3001LDL-C\u5024\u3092\u3055\u3089\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3067\u3042\u308a\u3001\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001LDL-C\u306e\u76ee\u6a19\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u3044\u3046\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u63a8\u5968\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001LDL-C\u306e\u76ee\u6a19\u5024\u3092\u4e0b\u3052\u305f\u3068\u3057\u3066\u3082\uff08\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6cbb\u7642\u3092\u884c\u3063\u305f\u3068\u3057\u3066\u3082\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3084TIA\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u306f\u91cd\u5927\u306aCV\u30a4\u30d9\u30f3\u30c8\u3092\u7d4c\u9a13\u3057\u7d9a\u3051\u308b\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308a\u3001\u4ed6\u306e\u6cbb\u7642\u76ee\u6a19\u3092\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u3067\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u4eba\uff081.5mmol\/l\uff0858mg\/dl\uff09\u4ee5\u4e0a\uff09\u306b\u304a\u3044\u3066\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u3001\u4ed8\u52a0\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u793a\u5506\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u3066\u3044\u308b11\u3002 <\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001Treat Stroke to Target\u8a66\u9a13\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u7531\u6765\u306e\u865a\u8840\u6027\u8133\u5352\u4e2d\u307e\u305f\u306fTIA\u306e\u65e2\u5f80\u306e\u3042\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u305d\u306e\u5f8c\u306e\u4e3b\u8981\u306aCV\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u3001LDL-C\u306e\u76ee\u6a19\u5024\u3092\u226670mg\/dL\u3068\u3059\u308b\u3053\u3068\u3092\u652f\u6301\u3057\u3066\u3044\u308b\u3002\u73fe\u5728\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u30ac\u30a4\u30c9\u30e9\u30a4\u30f312\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308bLDL-C\u306e\u76ee\u6a19\u5024<50 mg\/dL (<1.4 mmol\/L)\u304c\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3092\u3055\u3089\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u306f\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Kernan WN, Ovbiagele B, Black HR, et al. \u8133\u5352\u4e2d\u304a\u3088\u3073\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\u60a3\u8005\u306b\u304a\u3051\u308b\u8133\u5352\u4e2d\u4e88\u9632\u306e\u305f\u3081\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u7c73\u56fd\u5fc3\u81d3\u5354\u4f1a\uff0f\u7c73\u56fd\u8133\u5352\u4e2d\u5354\u4f1a\u306b\u3088\u308b\u533b\u7642\u5f93\u4e8b\u8005\u5411\u3051\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3002Stroke 2014; 45: 2160-23. <\/p>\n

2.\u8133\u5352\u4e2d\u307e\u305f\u306f\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\u5f8c\u306e\u9ad8\u7528\u91cf\u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\u3002N Engl J Med 2006;355:549-59. <\/p>\n

3.Sillesen H, Amarenco P, Hennerici MG, et al. \u30a2\u30c8\u30eb\u30d0\u30b9\u30bf\u30c1\u30f3\u306f\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\uff1a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u7a4d\u6975\u7684\u4f4e\u4e0b\u306b\u3088\u308b\u8133\u5352\u4e2d\u4e88\u9632\uff08SPARCL\uff09\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002Stroke 2008; 39: 3297-302. <\/p>\n

4.Amarenco P, Goldstein LB, Szarek M, et al. \u8133\u5352\u4e2d\u307e\u305f\u306f\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\u60a3\u8005\u306b\u304a\u3051\u308b\u5f37\u529b\u306a\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6e1b\u5c11\u306e\u52b9\u679c\uff1a\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u7a4d\u6975\u7684\u6e1b\u5c11\u306b\u3088\u308b\u8133\u5352\u4e2d\u4e88\u9632\uff08SPARCL\uff09\u8a66\u9a13\u3002Stroke 2007; 38: 3198-204. <\/p>\n

5.\u9054\u6210\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068\u8133\u5352\u4e2d\u30ea\u30b9\u30af\uff1a23\u306e\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002Eur J Prev Cardiol 2019: doi: 10.1177\/2047487319830503.[Epub ahead of print]. <\/p>\n

6.Amarenco P, Lavall\u00e9e PC, Monteiro Tavares L, et al. TIA\u307e\u305f\u306f\u8efd\u75c7\u865a\u8840\u6027\u8133\u5352\u4e2d\u5f8c\u306e\u8133\u5352\u4e2d\u306e5\u5e74\u30ea\u30b9\u30af\u3002N Engl J Med 2018; 378: 2182-90. <\/p>\n

7.\u30b9\u30df\u30b9 DA.\u7dcf\u8aac\uff1a\u8102\u8cea\u7570\u5e38\u75c7\u307e\u305f\u306f\u52d5\u8108\u786c\u5316\u6027CVD\u306b\u304a\u3044\u3066\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u3068\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u5bfe\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306f\u305d\u308c\u305e\u308cMI\u3068\u8133\u5352\u4e2d\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3002Ann Intern Med 2019;171:JC56. doi: 10.7326\/ACPJ201911190-056. <\/p>\n

8.Salvatore T, Morganti R, Marchioli R, De Caterina R. Cholesterol lowering and stroke: no longer room for pleiotropic effects of statins – confirmation from PCSK9 inhibitor studies.Am J Med 2019; doi: 10.1016\/j.amjmed.2019.06.029. <\/p>\n

9.\u5fc3\u81d3\u4fdd\u8b77\u7814\u7a76\u5171\u540c\u30b0\u30eb\u30fc\u30d7\u3002MRC\/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial.Lancet 2002; 360: 7-22. <\/p>\n

10.Collins R, Reith C, Emberson J, et al. \u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u89e3\u91c8\u3002Lancet 2016; 388: 2532-61. <\/p>\n

11.Varbo A, Nordestgaard BG.\u4e00\u822c\u96c6\u56e3112,512\u4eba\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3002Ann Neurol 2019;85:550-9. <\/p>\n

12.Mach F, Baigent C, Catapano AL et al. 2019 ESC\/EAS Guidelines for the Management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Eur Heart J 2019. doi: 10.1093\/eurheartj\/ehz455. [Epub ahead of print]<\/p>\n<\/td>\n<\/tr>\n

\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\nTreat Stroke to Target Study\uff1b\u865a\u8840\u6027\u8133\u5352\u4e2d\uff1b\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1b\u8102\u8cea\u76ee\u6a19\u5024\uff1b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n

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