{"id":254431,"date":"2025-01-23T23:48:50","date_gmt":"2025-01-23T22:48:50","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%ab%e3%82%88%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4\/"},"modified":"2025-02-16T22:46:36","modified_gmt":"2025-02-16T21:46:36","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%ab%e3%82%88%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%ab%e3%82%88%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u8a66\u9a13\uff08REDUCE-IT\uff09REVASC"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u8a66\u9a13\uff08REDUCE-IT\uff09 REVASC<\/span><\/h2>\n
2021\u5e742\u670816\u65e5<\/span><\/h5>\n
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REDUCE-IT\u306e\u6700\u65b0\u30c7\u30fc\u30bf\u306f\u3001\u9ad8\u7528\u91cf\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u304c\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u304c\u9ad8\u3044\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306e\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/span><\/div>\n
\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u8840\u884c\u518d\u5efa\u8853\u306e\u6e1b\u5c11\uff1aREDUCE-IT REVASC\u304b\u3089\u306e\u77e5\u898b\u3002Circulation 2020; doi 10.1161\/CIRCULATIONAHA.120.050276. <\/em><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u9ad8\u5ea6\u306b\u7cbe\u88fd\u3055\u308c\u305f\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u578b\u3067\u3042\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3068\u30d7\u30e9\u30bb\u30dc\uff08\u9271\u6cb9\uff09\u306e\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306e\u521d\u56de\u30a4\u30d9\u30f3\u30c8\u3068\u5168\u30a4\u30d9\u30f3\u30c8\uff08\u521d\u56de\u3068\u305d\u306e\u5f8c\u306e\u30a4\u30d9\u30f3\u30c8\uff09\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u3002<\/td>\n<\/tr>\n
\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\nREDUCE-IT\u8a66\u9a13\uff081\uff09\u306f\u3001\u7b2c3b\u76f8\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305aTG\u304c\u4e0a\u6607\u3057\u305f\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3092\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb4g\/\u65e5\uff082g\/\u65e52\u56de\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\uff081\uff1a1\uff09\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3<\/strong><\/td>\nREDUCE-IT\u96c6\u56e3\u306f\u3001TG\u9ad8\u5024\uff08135-499mg\/dL\uff09\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u305f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\u300141-100mg\/dL\uff09\u3001\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3068\u4ed6\u306e\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b\u4e00\u6b21\u4e88\u9632\u60a3\u80058,179\u4eba\u3067\u69cb\u6210\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u6210\u679c\uff1a<\/strong><\/td>\n\n

– REDUCE-IT\u8a66\u9a13\u306e\u4e3b\u8981\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3067\u3042\u308a\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002<\/p>\n

– REDUCE-IT REVASC\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3067\u3042\u3063\u305f\u3002\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306f\u3001\u521d\u56de\u307e\u305f\u306f2\u56de\u76ee\u4ee5\u964d\u306e\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u30a4\u30d9\u30f3\u30c8\u3001\u30b5\u30d6\u30bf\u30a4\u30d7\u5225\uff08\u5f85\u6a5f\u7684\u3001\u7dca\u6025\u3001\u7dca\u6025\u3001\u6551\u6e08\u7684\u8840\u884c\u518d\u5efa\u8853\uff09\u3001\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\u3001\u51a0\u52d5\u8108\u30d0\u30a4\u30d1\u30b9\u8853\uff08CABG\uff09\u306b\u5206\u985e\u3055\u308c\u305f\u3002\u8840\u884c\u518d\u5efa\u8853\u306e\u5404\u30b5\u30d6\u30bf\u30a4\u30d7\u3001\u304a\u3088\u307330\u65e5\u5f8c\u306e\u9078\u629e\u7684\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306f\u3001\u500b\u3005\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u3066\u89e3\u6790\u3059\u308b\u3088\u3046\u4e8b\u524d\u306b\u6307\u5b9a\u3055\u308c\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u8840\u884c\u518d\u5efa\u30a4\u30d9\u30f3\u30c8\u306e\u89e3\u6790\u306f\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f\u3002\u4e3b\u8981\u306aREDUCE-IT\u8a66\u9a13\u3068\u540c\u69d8\u306b\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\u306895\uff05\u4fe1\u983c\u533a\u9593\u306f\u3001\u6cbb\u7642\u7fa4\u3092\u5171\u5909\u91cf\u3068\u3057\u3001\u5730\u7406\u7684\u5730\u57df\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u306e\u4f7f\u7528\u3067\u5c64\u5225\u5316\u3057\u305fCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u4f5c\u6210\u3057\u305f\u3002\u5bfe\u6570\u9806\u4f4d\u691c\u5b9a\u306e\u7d71\u8a08\u91cf\u3068p\u5024\u306f\u3001\u5730\u7406\u7684\u5730\u57df\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u306e\u4f7f\u7528\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3055\u308c\u305f\u500b\u3005\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306eKaplan-Meier\u89e3\u6790\u304b\u3089\u4f5c\u6210\u3055\u308c\u305f\u30022\u3064\u306e\u6cbb\u7642\u7fa4\u306b\u304a\u3051\u308b\u8840\u884c\u518d\u5efa\u8853\u306e\u518d\u767a\u7387\u3092\u6bd4\u8f03\u3059\u308b\u305f\u3081\u306b\uff0c\u3055\u307e\u3056\u307e\u306a\u7d71\u8a08\u7684\u30e2\u30c7\u30ea\u30f3\u30b0\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u7528\u3044\u3089\u308c\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u4e2d\u592e\u50244.9\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u3001\u521d\u56de\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u7fa4\u3067376\u4f8b\uff089.2\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067544\u4f8b\uff0813.3\uff05\uff09\u3067\u3042\u308a\u3001\u305d\u306e\u7d50\u679c\u3001\u76f8\u5bfe\u30ea\u30b9\u30af\u306f34\uff05\u6e1b\u5c11\u3057\uff08p<0.0001\uff09\u3001\u30a4\u30d9\u30f3\u30c8\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u306f4.1\uff05\u6e1b\u5c11\u3057\u305f\uff08\u6cbb\u7642\u5fc5\u8981\u6570[NNT] of 24\uff09\uff08\u88681\uff09\u3002\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u65e9\u671f\u306b\u8a8d\u3081\u3089\u308c\u3001\u6cbb\u7642\u958b\u59cb11\u30f5\u6708\u76ee\u304b\u3089\u6cbb\u7642\u7fa4\u9593\u3067\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5dee\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002 <\/p>\n

2\u56de\u76ee\u306e\u8840\u884c\u518d\u5efa\u8853\uff0851\uff05\u6e1b\u3001p<0.0001\uff09\u304a\u3088\u30733\u56de\u76ee\u4ee5\u964d\u306e\u8840\u884c\u518d\u5efa\u8853\uff0850\uff05\u6e1b\u3001p=0.04\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3059\u308b\u76f8\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u7387\u306f\u3055\u3089\u306b\u5927\u304d\u304b\u3063\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u306636\uff05\u306e\u8840\u884c\u518d\u5efa\u3092\u6e1b\u5c11\u3055\u305b\u305f\uff08\u8ca0\u306e\u4e8c\u9805\u78ba\u7387\u6bd40.64\uff1b95\uff05\u4fe1\u983c\u533a\u9593[CI] \u30010.56-0.74\uff1bp<\u30010.0001\uff09\u3002 <\/p>\n

\u305d\u306e\u4ed6\u306e\u521d\u56de\u8840\u884c\u518d\u5efa\u8853\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u304a\u3051\u308b\u76f8\u5bfe\u7684\u30ea\u30b9\u30af\u6e1b\u5c11\u306b\u3064\u3044\u3066\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3068\u30d7\u30e9\u30bb\u30dc\u3067\u540c\u69d8\u306e\u5dee\u304c\u8a8d\u3081\u3089\u308c\u3001\u305d\u306e\u7bc4\u56f2\u306f\u7dca\u6025\u8840\u884c\u518d\u5efa\u8853\u306e38\uff05\u304b\u3089\u5f85\u6a5f\u7684\u8840\u884c\u518d\u5efa\u8853\u306e32\uff05\u3067\u3042\u3063\u305f\uff08\u88681<\/strong>\uff09\u3002\u6551\u547d\u7684\u8840\u884c\u518d\u5efa\u8853\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u306e\u89e3\u6790\u306b\u306f\u5341\u5206\u306a\u30a4\u30d9\u30f3\u30c8\u304c\u306a\u304b\u3063\u305f\uff08\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f2\u4f8b\u306e\u307f\uff09\u3002 <\/p>\n

 <\/p>\n

\u88681. \u521d\u56de\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u89e3\u6790<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
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\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb<\/p>\n

N=4089<\/p>\n<\/td>\n

\n

\u30d7\u30e9\u30bb\u30dc<\/p>\n

N=4090<\/p>\n<\/td>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4 <\/p>\n

(95% CI)<\/p>\n<\/td>\n

\n

p\u5024<\/p>\n<\/td>\n

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\u7d76\u5bfeRR(%)<\/p>\n<\/td>\n<\/tr>\n

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 <\/p>\n<\/td>\n

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n (%)<\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

\n

\u3059\u3079\u3066\u306e\u8840\u884c\u518d\u5efa\u8853<\/p>\n<\/td>\n

\n

376 (9.2)<\/p>\n<\/td>\n

\n

544 (13.3)<\/p>\n<\/td>\n

\n

0.66<\/p>\n

(0.58-0.76)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n

\n

4.1<\/p>\n<\/td>\n<\/tr>\n

\n

\u7dca\u6025\u307e\u305f\u306f\u7dca\u6025<\/p>\n

\u8840\u884c\u518d\u5efa\u8853<\/p>\n<\/td>\n

\n

216 (5.3)<\/p>\n<\/td>\n

\n

321 (7.8)<\/p>\n<\/td>\n

\n

0.65<\/p>\n

(0.55-0.78)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n

\n

2.6<\/p>\n<\/td>\n<\/tr>\n

\n

\u7dca\u6025\u8840\u884c\u518d\u5efa\u8853<\/p>\n<\/td>\n

\n

41 (1.0)<\/p>\n<\/td>\n

\n

65 (1.6)<\/p>\n<\/td>\n

\n

0.62<\/p>\n

(0.42-0.92)<\/p>\n<\/td>\n

\n

0.016<\/p>\n<\/td>\n

\n

0.6<\/p>\n<\/td>\n<\/tr>\n

\n

\u7dca\u6025\u8840\u884c\u518d\u5efa\u8853<\/p>\n<\/td>\n

\n

181 (4.4)<\/p>\n<\/td>\n

\n

268 (6.6)<\/p>\n<\/td>\n

\n

0.66<\/p>\n

(0.54-0.79)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n

\n

2.1<\/p>\n<\/td>\n<\/tr>\n

\n

\u9078\u629e\u7684\u8840\u884c\u518d\u5efa\u8853<\/p>\n<\/td>\n

\n

194 (4.7)<\/p>\n<\/td>\n

\n

278 (6.8)<\/p>\n<\/td>\n

\n

0.68<\/p>\n

(0.57-0.82)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n

\n

2.1<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

RR = \u30ea\u30b9\u30af\u4f4e\u6e1b<\/span><\/p>\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u6cbb\u7642\u3082\u307e\u305f\u3001\u6709\u610f\u306a\u76f8\u5bfe\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3057\u305f\uff1a<\/p>\n

    \n
  • PCI\u306f32\uff05\u6e1b\u5c11\u3057\uff087.7\uff05\u5bfe10.9\uff05\uff1b\u30cf\u30b6\u30fc\u30c9\u6bd40.68\uff1b95\uff05CI 0.59-0.79\uff1bp<0.0001\uff09\u3001\u7d76\u5bfe\u30ea\u30b9\u30af\u306f3.2\uff05\u6e1b\u5c11\u3057\u3001NNT\u306f31\u3067\u3042\u3063\u305f\u3002<\/li>\n
  • CABG\u306f39\uff05\u6e1b\u5c11\u3057\uff081.9\uff05\u5bfe3.0\uff05\uff1b\u30cf\u30b6\u30fc\u30c9\u6bd40.61\uff1b95\uff05CI\u30010.45-0.81\uff1bp\uff1d0.0005\uff09\u3001\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u306f1.1\uff05\u3001NNT\u306f91\u3067\u3042\u3063\u305f\u3002<\/li>\n<\/ul>\n\n\n\n
    \u7d50\u8ad6<\/strong><\/td>\n\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u3001\u4e2d\u6027\u8102\u80aa\u304c\u9ad8\u304f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u521d\u56de\u304a\u3088\u3073\u305d\u306e\u5f8c\u306e\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306e\u5fc5\u8981\u6027\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002\u308f\u308c\u308f\u308c\u306e\u77e5\u308b\u9650\u308a\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306b\u304a\u3044\u3066CABG\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u6700\u521d\u306e\u975eLDL\u964d\u4e0b\u85ac\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    \u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

    \u3053\u306eREDUCE-IT REVASC\u8a66\u9a13\u306e\u89e3\u6790\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3088\u308aLDL-C\u5024\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u9ad8\u5024\u3067\u3042\u308b\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9ad8\u7528\u91cf\u306e\u30a4\u30b3\u30b9\u30d1\u30a8\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u6cbb\u7642\u304c\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306e\u521d\u56de\u30a4\u30d9\u30f3\u30c8\uff0834\uff05\uff09\u304a\u3088\u3073\u5168\u30a4\u30d9\u30f3\u30c8\uff0836\uff05\uff09\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306b\u5bfe\u3059\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306e\u5927\u304d\u3055\u306f\u3001Scandinavian Simvastatin Survival Study\uff084S\uff09\uff082\uff09\u3067\u89b3\u5bdf\u3055\u308c\u305f\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3059\u308b37\uff05\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u306b\u5339\u6575\u3059\u308b\u3002\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u7fa4\u3067\u306fCABG\u3092\u53d7\u3051\u305f\u60a3\u8005\u304c\u6709\u610f\u306b\u5c11\u306a\u304b\u3063\u305f\u3053\u3068\u3067\u3042\u308b\u3002 <\/p>\n

    \u3053\u308c\u3089\u306e\u6240\u898b\u306f\uff0c\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u3063\u3066LDL-C\u5024\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff0c\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u9593\u306b\u6b8b\u5b58\u3059\u308b\u30ea\u30b9\u30af\u306e\u4e00\u56e0\u306fTG\u5024\u306e\u4e0a\u6607\u3067\u3042\u308b\u3068\u3044\u3046\u4e3b\u5f35\u3092\u3042\u308b\u7a0b\u5ea6\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u3053\u306e\u89e3\u6790\u3067\u306f\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3044\u3046\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306e\u5927\u304d\u3055\u306f\u3001\u3053\u306e\u6cbb\u7642\u306b\u3088\u308b\u308f\u305a\u304b\u306aTG\u4f4e\u4e0b\u52b9\u679c\u3092\u4e0a\u56de\u308b\u3082\u306e\u3067\u3042\u308a(1)\u3001\u8102\u8cea\u4f4e\u4e0b\u4ee5\u5916\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3053\u306e\u52b9\u679c\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b(3-5)\u3002 <\/p>\n<\/div>\n\n\n\n\n
    \u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

    1.Bhatt DL, Steg PG, Miller M, et al; REDUCE-IT Investigators.\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/p>\n

    2.\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u60a3\u80054444\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u8a66\u9a13\u3002<\/p>\n

    \u30b9\u30ab\u30f3\u30b8\u30ca\u30d3\u30a2\u306e\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u751f\u5b58\u7814\u7a76\uff084S\uff09\u3002Lancet.1994;344:1383-9. <\/p>\n

    3.Bhatt DL\u3001Steg PG\u3001Miller M\u3001Juliano RA\u3001Ballantyne CM\u3002\u8fd4\u4fe1\uff1a\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u6e1b\u5c11\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3002J Am Coll Cardiol 2019;74:1849-50. <\/p>\n

    4.\u30e1\u30a4\u30bd\u30f3RP\u3001\u30ea\u30d3\u30fcP\u3001\u30d0\u30c3\u30c8DL\u3002\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u5fc3\u8840\u7ba1\u4fdd\u8b77\u306e\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3002Arterioscler Thromb Vasc Biol.ATVBAHA119313286. doi:10.1161\/ATVBAHA.119.313286 <\/p>\n

    5.\u30e1\u30a4\u30bd\u30f3RP\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u6027\u5fc3\u8840\u7ba1\u75c5\u306b\u304a\u3051\u308b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u6d1e\u5bdf\u3002Curr Atheroscler Rep 2019;21,2. <\/p>\n<\/td>\n<\/tr>\n

    \u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\nREDUCE-IT\uff1b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff1b\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff1b\u8840\u884c\u518d\u5efa\uff1b\u4e88\u9632<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

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