{"id":254426,"date":"2025-01-23T23:24:58","date_gmt":"2025-01-23T22:24:58","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%82%b9%e3%83%88%e3%83%ac%e3%83%b3%e3%82%b0%e3%82%b9%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%81%b8\/"},"modified":"2025-02-16T22:45:37","modified_gmt":"2025-02-16T21:45:37","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%82%b9%e3%83%88%e3%83%ac%e3%83%b3%e3%82%b0%e3%82%b9%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%81%b8","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%82%b9%e3%83%88%e3%83%ac%e3%83%b3%e3%82%b0%e3%82%b9%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%81%b8\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – \u30b9\u30c8\u30ec\u30f3\u30b0\u30b9\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u7cfb\u3078\u306e\u6709\u76ca\u6027\u6b20\u5982\u306e\u7406\u7531\u3092\u63a2\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30b9\u30c8\u30ec\u30f3\u30b0\u30b9\u3067\u5fc3\u8840\u7ba1\u7cfb\u306b\u52b9\u679c\u304c\u306a\u3044\u7406\u7531\u3092\u63a2\u308b<\/span><\/h2>\n
2021\u5e749\u67087\u65e5<\/span><\/h5>\n
\n
\n
\n
\n
\n
\n
STRENGTH\u306e\u65b0\u3057\u3044\u89e3\u6790\u3067\u306f\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u304a\u3088\u3073\u30c9\u30b3\u30b5\u30d8\u30ad\u30b5\u30a8\u30f3\u9178\uff08DHA\uff09\u306e\u9054\u6210\u30ec\u30d9\u30eb\u3068\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u3068\u306e\u9593\u306b\u95a2\u9023\u306f\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/div>\n
Nissen SE, Lincoff AM, Wolski K, et al. \u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u9054\u6210\u03c9-3\u8102\u80aa\u9178\u30ec\u30d9\u30eb\u3068\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u306e\u95a2\u9023\u3002STRENGTH Trial\u306e\u4e8c\u6b21\u89e3\u6790\u3002JAMA Cardiol 2021; doi:10.1001\/jamacardio.2021.1157 <\/em><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nSTRENGTH\uff08Long-Term Outcomes Study to Assessess Statin Residual Risk with Epanova in High Cardiovascular Risk Patients with Hypertriglyceridemia\uff1a\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3059\u308b\u9ad8\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308bEPA\u304a\u3088\u3073DHA\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u3068\u5fc3\u8840\u7ba1\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3059\u308b\u8a66\u9a13\uff09\u306b\u304a\u3044\u3066\u3001EPA\u304a\u3088\u3073DHA\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u3068\u5fc3\u8840\u7ba1\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3059\u308b\u3002ClinicalTrials.gov Identifier\uff1aNCT02104817 <\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\nSTRENGTH\u8a66\u9a13\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u304c\u9ad8\u304f\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u5024\u304c\u4f4e\u3044\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4e8c\u91cd\u76f2\u691c\u591a\u65bd\u8a2d\u5171\u540c\u8a66\u9a13\u3067\u3042\u308b\u3002\u60a3\u8005\u306f\u30011\u65e54g\u306eEPA\/DHA\u30ab\u30eb\u30dc\u30f3\u9178\u88fd\u5264\u3092\u6295\u4e0e\u3059\u308b\u7fa4\u3068\u3001\u4e0d\u6d3b\u6027\u306a\u6bd4\u8f03\u5bfe\u8c61\u3067\u3042\u308b\u30b3\u30fc\u30f3\u6cb9\u3092\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u672c\u8a66\u9a13\u306f\u3001\u81e8\u5e8a\u7684\u6709\u7528\u6027\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u4f4e\u304b\u3063\u305f\u305f\u3081\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u52e7\u544a\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n13,078\u4eba\u306e\u60a3\u8005\u304c\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u30016539\u4eba\uff0850\uff05\uff09\u304cEPA\/DHA\u88fd\u5264\u307e\u305f\u306f\u30b3\u30fc\u30f3\u6cb9\u306b\u3088\u308b\u6cbb\u7642\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u300210382\u4f8b\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u3068\u7121\u4f5c\u70ba\u5316\u5f8c12\u30f5\u6708\u306e\u4e21\u65b9\u3067EPA\u3068DHA\u306e\u6fc3\u5ea6\u304c\u5f97\u3089\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u8a66\u9a13\u7d50\u679c<\/strong><\/td>\n– \u6709\u52b9\u6027\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u3002
– \u8840\u6f3f\u4e2dEPA\u304a\u3088\u3073DHA\u6fc3\u5ea6\u306e\u9054\u6210\u30ec\u30d9\u30eb\u3068\u5909\u5316<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u3053\u308c\u306f\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u3068EPA\u3001DHA\u306e\u9054\u6210\u30ec\u30d9\u30eb\u3001\u307e\u305f\u306f\u3053\u308c\u3089\u306e\u8102\u80aa\u9178\u306e\u30ec\u30d9\u30eb\u306e\u5909\u5316\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u4e8b\u5f8c\u89e3\u6790\u3067\u3042\u3063\u305f\u3002\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u306f\u3001EPA\/DHA\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u60a3\u8005\u306b\u3064\u3044\u3066\u3001\u9054\u6210\u8840\u6f3fEPA\u304a\u3088\u3073DHA\u306e\u4e09\u5206\u4f4d\u6570\u3067\u6bd4\u8f03\u3057\u305f\u3002\u591a\u5909\u91cf\u30e2\u30c7\u30ea\u30f3\u30b0\u306b\u3088\u308a\u540c\u5b9a\u3055\u308c\u305f\u5171\u5909\u91cf\u3092\u7528\u3044\u3066\u3001Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u5404\u7fa4\u306e\u5404\u30bf\u30fc\u30c1\u30eb\u306e\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u304a\u3088\u307395\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u306e\u63a8\u5b9a\u5024\u3092\u7b97\u51fa\u3057\u305f\u3002\u8102\u80aa\u9178\u306e\u5404\u30bf\u30fc\u30c1\u30eb\u306f\u3001Wald \u03c72\u7d71\u8a08\u91cf\u3092\u7528\u3044\u3066\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

EPA\u307e\u305f\u306fDHA\u306e\u9054\u6210\u30ec\u30d9\u30eb\u3068\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u306e\u9593\u306b\u95a2\u9023\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u88681\uff09<\/strong>\u3002EPA\u304a\u3088\u3073DHA\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u306e\u5909\u5316\u306b\u57fa\u3065\u304f\u611f\u5ea6\u5206\u6790\u3067\u3082\u540c\u69d8\u306e\u7d50\u679c\u304c\u793a\u3055\u308c\u305f\u3002 <\/p>\n

 <\/p>\n

\u8868\u8840\u6f3f\u4e2dEPA\u304a\u3088\u3073DHA\u6fc3\u5ea6\u306e\u9054\u6210\u5ea6\u4e09\u5206\u4f4d\u5024\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8*\u3068\u306e\u95a2\u9023 <\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u8840\u6f3f\u8102\u80aa\u9178<\/strong> <\/span>(mg\/mL)<\/p>\n<\/td>\n

\n

HR\uff0895\uff05\u4fe1\u983c\u533a\u9593<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

EPA\u9054\u6210<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30b3\u30fc\u30f3\u6cb9<\/p>\n<\/td>\n

\n

NA<\/p>\n<\/td>\n

\n

1\uff08\u53c2\u8003\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

EPA\u4e09\u5206\u4f4d\u6570<\/p>\n<\/td>\n

\n

<62.4<\/p>\n

62.5-116.3<\/p>\n

>116.4<\/p>\n<\/td>\n

\n

0.99 (0.84-1.18)<\/p>\n

1.10 (0.93-1.28)<\/p>\n

0.98 (0.83-1.16)<\/p>\n<\/td>\n<\/tr>\n

\n

DHA\u9054\u6210<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30b3\u30fc\u30f3\u6cb9<\/p>\n<\/td>\n

\n

NA<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

DHA\u4e09\u5206\u4f4d\u6570<\/p>\n<\/td>\n

\n

<78.2<\/p>\n<\/td>\n

\n

1.03 (0.87-1.22)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

78.3-105.1<\/p>\n<\/td>\n

\n

1.03 (0.87-1.21)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

>105.2<\/p>\n<\/td>\n

\n

1.02 (0.86-1.20)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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<\/div>\n
\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\n

* \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u8102\u80aa\u9178\u5024\u3001\u5730\u57df\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u7cd6\u5c3f\u75c5\u3001\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u3001\u975eHDL-C\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\u3001\u6297\u8840\u5c0f\u677f\u85ac\u3001\u03b2\u906e\u65ad\u85ac\u3001\u30ec\u30cb\u30f3\u30fb\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u963b\u5bb3\u85ac\u3067\u8abf\u6574\u3002<\/p>\n

 <\/p>\n

STRENGTH\u8a66\u9a13\u306b\u304a\u3044\u3066EPA\/DHA\u30ab\u30eb\u30dc\u30f3\u9178\u88fd\u5264\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u3046\u3061\u3001EPA\u304a\u3088\u3073DHA\u306e\u6700\u9ad8\u5230\u9054\u4e09\u5206\u4f4d\u5024\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u6709\u76ca\u6027\u3068\u3082\u6709\u5bb3\u6027\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

STRENGTH\uff08\u4e2d\u7acb\u7684\u306a\u8a66\u9a13\uff09\u3068REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial\u3001\u80af\u5b9a\u7684\u306a\u8a66\u9a13\uff09\u306e\u5bfe\u7167\u7684\u306a\u7d50\u679c\u306f\u3001\u591a\u304f\u306e\u8b70\u8ad6\u3092\u5dfb\u304d\u8d77\u3053\u3057\u305f\uff081-3\uff09\u3002REDUCE-IT\u3067\u306fEPA\u306e\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u304c\u9ad8\u3044\u3053\u3068\u304c\u6709\u76ca\u6027\u306e\u539f\u56e0\u3067\u3042\u308b\u3068\u304b\u3001STRENGTH\u3067\u306fDHA\u6210\u5206\u306b\u3088\u308b\u6709\u5bb3\u4f5c\u7528\u304cEPA\u306e\u6f5c\u5728\u7684\u6709\u76ca\u6027\u3092\u6253\u3061\u6d88\u3057\u305f\u3068\u3044\u3046\u4eee\u8aac\u304c\u63d0\u5531\u3055\u308c\u305f(3)\u3002 <\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22.
2.Nicholls SJ, Lincoff AM, Garcia M, et al. \u9ad8\u7528\u91cf\u30aa\u30e1\u30ac3\u8102\u80aa\u9178vs\u30b3\u30fc\u30f3\u6cb9\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u52b9\u679c\uff1aSTRENGTH\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002jama 2020;324:2268-80.
3.Sharma G, Martin SS, Blumenthal RS.\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u52b9\u679c\uff1a\u4f55\u304c\u6700\u3082\u91cd\u8981\u304b\uff1a\u85ac\u7269\u3001\u7528\u91cf\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\uff1f\u30b8\u30e3\u30de2020;324:2262-4\u3002 <\/td>\n<\/tr>\n
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