{"id":254421,"date":"2025-01-21T13:17:42","date_gmt":"2025-01-21T12:17:42","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%83%97%e3%83%ad%e3%83%9f%e3%83%8d%e3%83%b3%e3%83%88%e3%81%ae%e7%b5%90%e6%9e%9c%e3%81%8c%e5%87%ba%e3%81%9f\/"},"modified":"2025-02-16T22:44:32","modified_gmt":"2025-02-16T21:44:32","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%83%97%e3%83%ad%e3%83%9f%e3%83%8d%e3%83%b3%e3%83%88%e3%81%ae%e7%b5%90%e6%9e%9c%e3%81%8c%e5%87%ba%e3%81%9f","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%83%97%e3%83%ad%e3%83%9f%e3%83%8d%e3%83%b3%e3%83%88%e3%81%ae%e7%b5%90%e6%9e%9c%e3%81%8c%e5%87%ba%e3%81%9f\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af &#8211; \u30d7\u30ed\u30df\u30cd\u30f3\u30c8\u306e\u7d50\u679c\u304c\u51fa\u305f"},"content":{"rendered":"\n[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;1px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; header_2_text_color=&#8221;gcid-primary-color&#8221; header_5_text_color=&#8221;gcid-secondary-color&#8221; text_orientation=&#8221;center&#8221; width=&#8221;99%&#8221; custom_margin=&#8221;|-147px||||&#8221; custom_padding=&#8221;|0px||||&#8221; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}&#8221;]<h2><span>\u30d7\u30ed\u30df\u30cd\u30f3\u30c8\u306e\u7d50\u679c\u304c\u51fa\u305f<\/span><\/h2>\n<h5><span>6 2022\u5e7412\u6708<\/span><\/h5>\n<div class=\"summary\">\n<div class=\"summary\">\n<div class=\"summary\">\n<div class=\"summary\">\n<div class=\"summary\">\n<div class=\"summary\">\n<div class=\"summary\">PROMINENT\uff08Pemafibrate to Reduce Cardiovascular OutcoMes by Reducing Triglycerides IN patiENts With diabetes\uff1a\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6291\u5236\uff09\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u3068\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u5f37\u529b\u306a\u6cbb\u7642\u306b\u52a0\u3048\u3066\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3067\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u309226\uff05\u4f4e\u4e0b\u3055\u305b\u3066\u3082\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306f\u6709\u610f\u306b\u6e1b\u5c11\u3057\u306a\u304b\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u63a2\u7d22\u7684\u30c7\u30fc\u30bf\u304b\u3089\u3001\u3053\u306e\u6cbb\u7642\u6cd5\u306f\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u306b\u304a\u3044\u3066\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002 <\/div>\n<div class=\"authors\"><em>\u30d7\u30e9\u30c0\u30f3AD\u3001\u30b0\u30ea\u30f3RJ\u3001\u30d5\u30eb\u30c1\u30e3\u30fc\u30c8JC\u3001\u4ed6\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u8efd\u6e1b\u306e\u305f\u3081\u306e\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3002New Engl J Med 2022; DOI: 10.1056\/NEJMoa2210645  <\/em><\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"authors\">\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"authors\">\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"3\" bgcolor=\"#CCCCCC\">\n<tbody>\n<tr valign=\"middle\">\n<td colspan=\"2\" bgcolor=\"#FFFFFF\"><strong>\u7814\u7a76\u6982\u8981<\/strong><\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\" width=\"17%\"><strong>\u76ee\u7684<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\" width=\"83%\">TG\u5024\u304c\u9ad8\u304f\uff0c\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL C\uff09\u5024\u304c\u4f4e\u30442\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\uff0c\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u306b\uff0c\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u7528\u3044\u3066\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\uff0c\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u304c\u6e1b\u5c11\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3059\u308b\u3002<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">PROMINENT\u8a66\u9a13\u306f\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002\u60a3\u8005\u306f\u307e\u305a21\u65e5\u9593\u306e\u30d7\u30e9\u30bb\u30dc\u30e9\u30f3\u30a4\u30f3\u671f\u9593\u306b\u5165\u308a\u3001\u305d\u306e\u5f8c\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u306e\u9ad8\u3044\u9069\u683c\u306a\u60a3\u8005\u304c\u3001\u6027\u5225\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u306b\u3088\u308a\u5c64\u5225\u5316\u3055\u308c\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff080.2mg\u93201\u65e52\u56de\uff09\u307e\u305f\u306f\u30de\u30c3\u30c1\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u306b\u3088\u308b\u6cbb\u7642\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u60a3\u8005\u306f2\u30f5\u6708\u30014\u30f5\u6708\u30016\u30f5\u6708\u30018\u30f5\u6708\u300112\u30f5\u6708\u3068\u305d\u306e\u5f8c4\u30f5\u6708\u3054\u3068\u306b\u6765\u9662\u3057\u305f\u3002  <\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td valign=\"top\" bgcolor=\"#E9E9E9\"><strong>\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">T2DM\u3092\u6709\u3057\u3001TG\u304c200\uff5e499mg\/dL\uff082.23\uff5e5.6mmol\/L\uff09\u3001HDL-C\u304c40mg\/dL\uff081.03mmol\/L\uff09\u4ee5\u4e0b\u306e\u60a3\u8005\u3002\u5bfe\u8c61\u306f18\u6b73\u4ee5\u4e0a\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u60a3\u8005\u306850\u6b73\u4ee5\u4e0a\uff08\u7537\u6027\uff09\u307e\u305f\u306f55\u6b73\u4ee5\u4e0a\uff08\u5973\u6027\uff09\u306eASCVD\u975e\u767a\u75c7\u60a3\u8005\u3002\u60a3\u8005\u306f\u4e2d\u5f37\u5ea6\u307e\u305f\u306f\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u3092\u5b89\u5b9a\u91cf\uff0812\u9031\u9593\u4ee5\u4e0a\uff09\u670d\u7528\u3057\u3066\u3044\u308b\u304b\u3001\u672a\u6cbb\u7642\u3067\u3042\u308b\u304b\u3001\u307e\u305f\u306f\u4ed6\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u904e\u53bb12\u30f5\u6708\u9593\u306bLDL-C\u304c70mg\/dL\uff081.8mmol\/L\uff09\u4ee5\u4e0b\u3067\u3042\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u3063\u305f\u3002\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u6027\u306e\u60a3\u8005\u306f\u3001\u904e\u53bb12\u30f5\u6708\u4ee5\u5185\u306bLDL-C\u304c\u2266100mg\/dL\uff08\u22662.6mmol\/L\uff09\u3067\u3042\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u3063\u305f\u3002\u4e3b\u306a\u9664\u5916\u9805\u76ee\u306f\u3001T1DM\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u306a\u3044\u7cd6\u5c3f\u75c5\u3001\u672a\u6cbb\u7642\u307e\u305f\u306f\u6cbb\u7642\u4e0d\u5341\u5206\u306a\u7532\u72b6\u817a\u6a5f\u80fd\u4f4e\u4e0b\u75c7\u307e\u305f\u306f\u7532\u72b6\u817a\u6a5f\u80fd\u4ea2\u9032\u75c7\u3001\u91cd\u75c7\u5fc3\u4e0d\u5168\u3001\u91cd\u75c7\u814e\u75be\u60a3\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u809d\u75be\u60a3\u3067\u3042\u3063\u305f\u3002    <\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\n<p>\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u521d\u56deMACE\u3067\u3001\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u8a08\u753b\u5916\u306e\u51a0\u8840\u884c\u518d\u5efa\u8853\u3092\u5fc5\u8981\u3068\u3059\u308b\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u8907\u5408\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u30022020\u5e743\u670818\u65e5\u3001\u76f2\u691c\u4e0b\u3067\u306e\u691c\u8a0e\u306e\u7d50\u679c\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3092\u542b\u3080\u3088\u3046\u306b\u4fee\u6b63\u3055\u308c\u305f\u3002 <\/p>\n<p>\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f\u526f\u6b21\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\uff1a<br>&#8211; \u5f53\u521d\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff08\u4e0a\u8a18\u53c2\u7167\uff09<br>&#8211; \u5fc3\u7b4b\u6897\u585e\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u8907\u5408<br>&#8211; \u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408<br>&#8211; \u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u307e\u305f\u306f\u3042\u3089\u3086\u308b\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u8907\u5408<br>&#8211; \u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u500b\u3005\u306e\u69cb\u6210\u8981\u7d20<br>&#8211; \u65b0\u898f\u307e\u305f\u306f\u60aa\u5316\u3057\u305f\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3002<br>\u305d\u306e\u4ed6\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u3066\u306f\u3001\u8102\u8cea\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3001\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u5b9a\u7fa9\u3055\u308c\u305f\u7db2\u819c\u75c7\u304a\u3088\u3073\u814e\u75c7\u304c\u3042\u3089\u304b\u3058\u3081\u6307\u5b9a\u3055\u308c\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u65b9\u6cd5<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\n<p>\u672c\u8a66\u9a13\u306f\u30a4\u30d9\u30f3\u30c8\u30fb\u30c9\u30ea\u30d6\u30f3\u3067\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u6bd4\u8f03\u3057\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u76f8\u5bfe\u7684\u30ea\u30b9\u30af\u309218\uff05\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u691c\u51fa\u3059\u308b\u691c\u51fa\u529b\u304c90\uff05\u306b\u306a\u308b\u3088\u3046\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u3002\u7121\u4f5c\u70ba\u5316\u306f\u7d0410,000\u4eba\u306e\u60a3\u8005\u3092\u7d44\u307f\u5165\u308c\u308b\u3053\u3068\u3092\u76ee\u6a19\u3068\u3057\u3001\u5c11\u306a\u304f\u3068\u3082300\u4eba\u304c\u65e5\u672c\u3067\u767b\u9332\u3055\u308c\u3001\u5c11\u306a\u304f\u3068\u308220\uff05\u304c\u5973\u6027\u3067\u3001\u4e00\u6b21\u4e88\u9632\u30b3\u30db\u30fc\u30c8\u306f3\u5206\u306e1\u4ee5\u4e0b\u3067\u3042\u3063\u305f\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u5909\u66f4\u306b\u3088\u308a\u3001\u76ee\u6a19\u30a4\u30d9\u30f3\u30c8\u6570\u306f1092\u304b\u30891304\u306b\u5897\u52a0\u3057\u3001\u3053\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u304a\u3051\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u76f8\u5bfe\u5dee16.6\uff05\u3092\u691c\u51fa\u3059\u308b90\uff05\u306e\u691c\u51fa\u529b\u304c\u5f97\u3089\u308c\u305f\u3002  <\/p>\n<p>\u30c7\u30fc\u30bf\u306f\u3001\u72ec\u7acb\u3057\u305f\u30c7\u30fc\u30bf\u30fb\u5b89\u5168\u6027\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\uff08DSMB\uff09\u306b\u3088\u308a\u3001\u8a66\u9a13\u671f\u9593\u4e2d\u306e\u5b89\u5168\u6027\u3068\u3001\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f3\u3064\u306e\u4e2d\u9593\u6642\u70b9\u306b\u304a\u3051\u308b\u7121\u76ca\u6027\u3068\u6709\u52b9\u6027\u304c\u691c\u8a0e\u3055\u308c\u305f\u30022022\u5e743\u670818\u65e5\u3001\u4e2d\u9593\u30c7\u30fc\u30bf\u306e\u30ec\u30d3\u30e5\u30fc\uff08\u76ee\u6a19\u30a4\u30d9\u30f3\u30c8\u6570\u306e75\uff05\u304c\u767a\u751f\u3057\u305f\u5f8c\uff09\u306b\u304a\u3044\u3066\u3001DSMB\u306f\u5168\u4f1a\u4e00\u81f4\u3067\u3001\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f\u7121\u76ca\u6027\u306e\u5883\u754c\u3092\u8d8a\u3048\u305f\u3068\u3057\u3066\u3001\u8a66\u9a13\u306e\u65e9\u671f\u7d42\u4e86\u3092\u52e7\u544a\u3057\u305f\u3002 <\/p>\n<p>\u89e3\u6790\u3067\u306f\u3001\u60a3\u8005\u306f\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u306b\u95a2\u4fc2\u306a\u304f\u7121\u4f5c\u70ba\u5316\u7fa4\u306b\u5f93\u3063\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u30a4\u30d9\u30f3\u30c8\u307e\u3067\u306e\u671f\u9593\u306e\u89e3\u6790\u306f\u3001\u6027\u5225\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3057\u305f\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u306b\u57fa\u3065\u304f\u5c24\u5ea6\u6bd4\u691c\u5b9a\u3092\u7528\u3044\u3066\u884c\u3063\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"authors\"><em><\/em><\/div>\n<div class=\"authors\"><em><\/em><\/div>\n<div class=\"authors\"><em><\/em><\/div>\n<div class=\"authors\"><em><\/em><\/div>\n<\/div>\n<\/div>\n<div class=\"authors\"><\/div>\n<div class=\"authors\"><\/div>\n<\/div>\n<div><\/div>\n<div><strong>\u7d50\u679c<\/strong><\/div>\n<div>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"3\" bgcolor=\"#CCCCCC\">\n<tbody>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\n<p>\u672c\u8a66\u9a13\u3067\u306f10,538\u4f8b\u306e\u60a3\u8005\u304c\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u3001\u305d\u306e\u3046\u306110,497\u4f8b\uff08\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa45240\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa45257\u4f8b\uff09\u304cintention-to-treat\uff08ITT\uff09\u6709\u52b9\u6027\u96c6\u56e3\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002\u5168\u4f53\u306e\u5e74\u9f62\u4e2d\u592e\u5024\u306f64\u6b73\u300127.5\uff05\u304c\u5973\u6027\u300119.4\uff05\u304c\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u307e\u305f\u306f\u30e9\u30c6\u30f3\u7cfb\u300133.1\uff05\u304c\u4e00\u6b21\u4e88\u9632\u3001\u307b\u307c\u5168\u54e1\uff0895.7\uff05\uff09\u304c\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u3092\u53d7\u3051\u3066\u3044\u305f\u3002\u4e21\u7fa4\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7279\u5fb4\u306f\u5747\u8861\u3057\u3066\u3044\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u7a7a\u8179\u6642TG\u4e2d\u592e\u5024\u306f271mg\/dL\uff083.1mmol\/L\uff09\u3001HDL-C\u4e2d\u592e\u5024\u306f33mg\/dL\uff080.9mmol\/L\uff09\u3001LDL-C\u4e2d\u592e\u5024\u306f78mg\/dL\uff082.0mmol\/L\uff09\u3067\u3042\u3063\u305f\u3002   <\/p>\n<p><strong>\u88681. 4\u30f5\u6708\u5f8c\u306e\u4e3b\u8981\u8102\u8cea\u306e\u5909\u5316\u3068\u6cbb\u7642\u52b9\u679c<\/strong><\/p>\n<table class=\"study-table\" width=\"549\">\n<tbody>\n<tr>\n<td width=\"135\">\n<p><strong>\u30d1\u30e9\u30e1\u30fc\u30bf<\/strong><\/p>\n<\/td>\n<td width=\"135\">\n<p><strong>\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8<\/strong><\/p>\n<p><strong>(N=5240)<\/strong><\/p>\n<\/td>\n<td width=\"135\">\n<p><strong>\u30d7\u30e9\u30bb\u30dc<\/strong><\/p>\n<p><strong>(N=5257)<\/strong><\/p>\n<\/td>\n<td width=\"144\">\n<p><strong>\u5e73\u5747\u6cbb\u7642\u52b9\u679c\u3002 (95% CI) <\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p>TG<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p> \u7d76\u5bfe\u5909\u5316\u91cf\uff08mg\/dL\uff09<\/p>\n<p> \u5909\u5316\u7387<\/p>\n<\/td>\n<td width=\"135\">\n<p>-84<\/p>\n<p>&nbsp;<\/p>\n<p>-31.1%<\/p>\n<\/td>\n<td width=\"135\">\n<p>-15<\/p>\n<p>&nbsp;<\/p>\n<p>-6.9%<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>-26.2 (-28.4 \uff5e -24.10)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p>VLDL-C*<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p> \u7d76\u5bfe\u5909\u5316\u91cf\uff08mg\/dL\uff09<\/p>\n<p> \u5909\u5316\u7387<\/p>\n<\/td>\n<td width=\"135\">\n<p>-18<\/p>\n<p>&nbsp;<\/p>\n<p>-35.0%<\/p>\n<\/td>\n<td width=\"135\">\n<p>-6<\/p>\n<p>&nbsp;<\/p>\n<p>-10.5%<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>-25.8 (-27.8 \uff5e -23.9)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p>\u30ec\u30e0\u30ca\u30f3\u30c8C<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p> \u7d76\u5bfe\u5909\u5316\u91cf\uff08mg\/dL\uff09<\/p>\n<p> \u5909\u5316\u7387<\/p>\n<\/td>\n<td width=\"135\">\n<p>-26<\/p>\n<p>&nbsp;<\/p>\n<p>-43.6%<\/p>\n<\/td>\n<td width=\"135\">\n<p>-12<\/p>\n<p>&nbsp;<\/p>\n<p>-20.2%<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>-25.6 (-27.3 \uff5e -24.0)<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p>\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\u8ceaCIII<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p> \u7d76\u5bfe\u5909\u5316\u91cf\uff08mg\/dL\uff09<\/p>\n<p> \u5909\u5316\u7387<\/p>\n<\/td>\n<td width=\"135\">\n<p>-4<\/p>\n<p>&nbsp;<\/p>\n<p>-27.8%<\/p>\n<\/td>\n<td width=\"135\">\n<p>0<\/p>\n<\/td>\n<td width=\"144\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>-27.6 (-29.1 to -26.1)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>* \u4fe1\u983c\u533a\u9593<\/p>\n<p>\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30894\u30f5\u6708\u5f8c\u307e\u3067\u306e\u7a7a\u8179\u6642TG\u306e\u5909\u5316\u7387\u306e\u4e2d\u592e\u5024\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa4\u3067-31.1\uff05\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067-6.9\uff05\u3067\u3042\u3063\u305f\uff08\u7fa4\u9593\u5dee-26.2\uff05\uff09\u3002\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08VLDL-C\uff09\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08remnant-C\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09CIII\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u52b9\u679c\u304c\u5831\u544a\u3055\u308c\u305f<strong>\uff08\u88681<\/strong>\uff09\u3002\u3053\u308c\u3089\u306e\u6cbb\u7642\u52b9\u679c\u306f\u9577\u671f\u306b\u308f\u305f\u3063\u3066\u6301\u7d9a\u3057\u305f\u3002LDL-C\u5024\u306f\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u3063\u3066\u4e0a\u6607\u3057\uff08\u4e2d\u592e\u502414.0\uff05\u306e\u4e0a\u6607\uff09\u3001\u975eHDL-C\u5024\u304a\u3088\u3073\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u306f\u5909\u5316\u304c\u307f\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3059\u308b\u5e73\u5747\u6cbb\u7642\u52b9\u679c\u306f\u305d\u308c\u305e\u308c-0.2\uff05\u304a\u3088\u30730.8\uff05\uff09\u304c\u3001apoB\u5024\u306b\u306f\u308f\u305a\u304b\u306a\u4e0a\u6607\u304c\u307f\u3089\u308c\u305f\uff08\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u30664.8\uff05\uff09\u3002   <\/p>\n<p>\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50243.4\u5e74\uff08\u6700\u95775.0\u5e74\uff09\u306e\u9593\u306b\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7fa4572\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4560\u4f8b\u304c\u6700\u521d\u306eMACE\u3092\u7d4c\u9a13\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\u30011.03\uff1b95\uff05CI 0.91\u301c1.15\u3001p\uff1d0.67\uff09\u3002\u3059\u3079\u3066\u306e\u8907\u5408\u4e8c\u6b21\u5fc3\u8840\u7ba1\u7cfb\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304a\u3088\u3073\u3053\u308c\u3089\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3092\u69cb\u6210\u3059\u308b\u500b\u3005\u306e\u8981\u7d20\u306b\u304a\u3044\u3066\u3001\u5f71\u97ff\u306f\u4e2d\u7acb\u3067\u3042\u3063\u305f\u3002 <\/p>\n<p>\u5b89\u5168\u6027\u306b\u95a2\u3057\u3066\u306f\u3001\u814e\u6709\u5bb3\u4e8b\u8c61\u3001\u809d\u6709\u5bb3\u4e8b\u8c61\u3001\u8840\u6813\u585e\u6813\u4e8b\u8c61\u3067\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5dee\u304c\u5831\u544a\u3055\u308c\u305f<strong>\uff08\u88682<\/strong>\uff09\u3002\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u3001\u611f\u67d3\u75c7\u3001\u7b4b\u9aa8\u683c\u7cfb\u4e8b\u8c61\u3001\u305d\u306e\u4ed6\u306e\u6709\u5bb3\u4e8b\u8c61\u306b\u3064\u3044\u3066\u306f\u4e21\u7fa4\u9593\u306b\u5dee\u306f\u306a\u304b\u3063\u305f\u3002 <\/p>\n<p><strong>\u88682.\u6709\u5bb3\u4e8b\u8c61\u306b\u304a\u3051\u308b\u7d71\u8a08\u5b66\u7684\u6709\u610f\u5dee\u3002 <\/strong><\/p>\n<table class=\"study-table\" width=\"545\">\n<tbody>\n<tr>\n<td rowspan=\"2\" width=\"189\">\n<p><strong>\u30d1\u30e9\u30e1\u30fc\u30bf<\/strong><\/p>\n<\/td>\n<td colspan=\"2\" width=\"270\">\n<p><strong>100\u4eba\u5e74\u5f53\u305f\u308a\u306e\u7f79\u60a3\u7387<\/strong><\/p>\n<\/td>\n<td width=\"87\">\n<p><strong> <\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"135\">\n<p><strong>\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8<\/strong><\/p>\n<p><strong>(N=5240)<\/strong><\/p>\n<\/td>\n<td width=\"135\">\n<p><strong>\u30d7\u30e9\u30bb\u30dc<\/strong><\/p>\n<p><strong>(N=5257)<\/strong><\/p>\n<\/td>\n<td width=\"87\">\n<p><strong>p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p>\u814e\u81d3\u306b\u95a2\u3059\u308b\u6709\u5bb3\u4e8b\u8c61<\/p>\n<\/td>\n<td width=\"135\">\n<p>10.67<\/p>\n<\/td>\n<td width=\"135\">\n<p>9.55<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.004<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> \u6162\u6027\u814e\u81d3\u75c5<\/p>\n<\/td>\n<td width=\"135\">\n<p>1.11<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.71<\/p>\n<\/td>\n<td width=\"87\">\n<p>&lt;0.001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> \u6025\u6027\u814e\u969c\u5bb3<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.97<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.64<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> \u7cd6\u5c3f\u75c5\u6027\u814e\u75c7<\/p>\n<\/td>\n<td width=\"135\">\n<p>5.73<\/p>\n<\/td>\n<td width=\"135\">\n<p>5.16<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.04<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"87\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p>\u809d\u969c\u5bb3<\/p>\n<\/td>\n<td width=\"135\">\n<p>1.35<\/p>\n<\/td>\n<td width=\"135\">\n<p>1.64<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.04<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> NAFLD<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.95<\/p>\n<\/td>\n<td width=\"135\">\n<p>1.22<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.02<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"87\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p>\u81e8\u5e8a\u7684\u306b\u95a2\u5fc3\u306e\u3042\u308b\u305d\u306e\u4ed6\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u5b9a\u7fa9\u3055\u308c\u305f\u4e8b\u8c61*\u3002<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"135\">\n<p>&nbsp;<\/p>\n<\/td>\n<td width=\"87\">\n<p>&nbsp;<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> \u9759\u8108\u8840\u6813\u585e\u6813\u75c7<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.43<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.21<\/p>\n<\/td>\n<td width=\"87\">\n<p>&lt;0.001<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> \u80ba\u585e\u6813\u75c7<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.24<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.11<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.008<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"189\">\n<p> \u6df1\u90e8\u9759\u8108\u8840\u6813\u75c7<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.27<\/p>\n<\/td>\n<td width=\"135\">\n<p>0.11<\/p>\n<\/td>\n<td width=\"87\">\n<p>0.001<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>* \u4e8b\u524d\u306b\u5b9a\u7fa9\u3055\u308c\u3001\u8a3a\u5bdf\u306e\u305f\u3073\u306b\u7167\u4f1a\u3055\u308c\u308b\u3002<\/p>\n<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">T2DM\uff0c\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff0c\u4f4eHDL-C\uff0c\u4f4eLDL-C\u5024\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\uff0c\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6295\u4e0e\u7fa4\u306f\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u306b\u6bd4\u3057\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u306f\u4f4e\u4e0b\u3057\u306a\u304b\u3063\u305f\u304c\uff0c\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6295\u4e0e\u7fa4\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff0cVLDL-C\uff0c\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0c\u30a2\u30ddC-III\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p style=\"text-align: left;\"><strong>\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n<p style=\"text-align: left;\">\u975eLDL-\u30ea\u30dd\u86cb\u767d\u3001\u7279\u306bTG\u3001VLDL-C\u3001remnant-C\u304a\u3088\u3073apoCIII\u306f\u6709\u610f\u304b\u3064\u81e8\u5e8a\u7684\u306b\u610f\u7fa9\u306e\u3042\u308b\u6e1b\u5c11\u3092\u793a\u3057\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6295\u4e0e\u306f\u3001LDL-C\u5024\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308bT2DM\u60a3\u8005\uff08ASCVD\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\uff09\u306b\u304a\u3044\u3066MACE\u3092\u6e1b\u5c11\u3055\u305b\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001HDL-C\u306e\u4f4e\u5024\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u306bTG\u4f4e\u4e0b\u8a66\u9a13\u3092\u691c\u8a0e\u3057\u305f\u4ed6\u306e\u8a66\u9a13\uff3b\u3059\u306a\u308f\u3061\u3001\u9ad8\u7528\u91cf\u306en-3\u8102\u80aa\u9178\u3092\u7528\u3044\u305fSTRENGTH\u8a66\u9a13\uff081\uff09\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3092\u7528\u3044\u305fAIM-HIGH\u8a66\u9a13\uff082\uff09\u3001\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u7528\u3044\u305fACCORD Lipid\u8a66\u9a13\uff083\uff09\uff3d\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u3067\u3082TG\u5024\u309220\u301c30\uff05\u4f4e\u4e0b\u3055\u305b\u305f\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u6709\u610f\u306a\u81e8\u5e8a\u7684\u6709\u76ca\u6027\u306f\u793a\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001REDUCE-IT\u3067\u306f\u9ad8\u7528\u91cf\u306eicosapent ethyl\u306b\u3088\u308a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6709\u610f\u306a\u6e1b\u5c11\u304c\u793a\u3055\u308c\u305f\u304c\u3001\u81e8\u5e8a\u7684\u5229\u76ca\u306e\u5927\u304d\u3055\u306fTG\u306e\u6e1b\u5c11\u306e\u7a0b\u5ea6\uff0818\uff05\uff09\u3068\u76f8\u95a2\u3057\u306a\u304b\u3063\u305f\uff084\uff09\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u6cbb\u7642\u3082\u307e\u305f\u3001\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u89b3\u5bdf\u3068\u540c\u69d8\u306b\u3001\u814e\u6709\u5bb3\u4e8b\u8c61\u307e\u305f\u306f\u8840\u6813\u585e\u6813\u6027\u4e8b\u8c61\u306e\u60a3\u8005\u6570\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f(5)\u3002\u809d\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u691c\u8a0e\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u73fe\u5728\u9032\u884c\u4e2d\u306e\u8a66\u9a13\uff08NCT05327127\uff09\u3067\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u3002    <\/p>\n<p style=\"text-align: left;\">PROMINENT\u306e\u77e5\u898b\u306f\u3001\u8102\u8cea\u306b\u95a2\u9023\u3057\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u95a2\u3059\u308b\u7814\u7a76\u306b\u3068\u3063\u3066\u3069\u306e\u3088\u3046\u306a\u610f\u5473\u3092\u6301\u3064\u306e\u3067\u3042\u308d\u3046\u304b\uff1f\u89b3\u5bdf\u7814\u7a76\u3001\u524d\u81e8\u5e8a\u8a66\u9a13\u3001\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u3001TG\u3001TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\uff08TRL\uff09\u3001TRL\u6b8b\u6e23\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u652f\u6301\u3059\u308b\u5e83\u7bc4\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u306a\u3044(6,7)\u3002\u3057\u304b\u3057\u3001TRL\u3068\u305d\u306e\u6b8b\u5b58\u7269\u306e\u751f\u6210\u3001\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3001\u4ee3\u8b1d\u51e6\u7406\u306b\u95a2\u4e0e\u3059\u308b\u7d4c\u8def\u304c\u8907\u96d1\u3067\u3042\u308b\u305f\u3081\u3001\u3053\u308c\u3092\u81e8\u5e8a\u8a66\u9a13\u3067\u7acb\u8a3c\u3059\u308b\u306e\u306f\u56f0\u96e3\u3067\u3042\u308b(6)\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u3001TG\u4ee3\u8b1d\u306e\u4e3b\u8981\u306a\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308b\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u306e\u6d3b\u6027\u3092\u9ad8\u3081\u3001\u5faa\u74b0\u4e2d\u306e\u5927\u304d\u306a\u65b0\u751fTRL\u306e\u6570\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u8840\u6f3f\u4e2d\u306eTG\u6fc3\u5ea6\u3092\u4f4e\u4e0b\u3055\u305b\u308b(8)\u3002\u5b9f\u969b\u3001\u30d7\u30ed\u30df\u30cd\u30f3\u30c8\u3067\u89b3\u5bdf\u3055\u308c\u305fLDL-C\u3068\u30a2\u30ddB\u306e\u5897\u52a0\u306f\u3001\u809d\u81d3\u306b\u3088\u308bTRL\u306e\u9664\u53bb\u3084VLDL\u306e\u7523\u751f\u6e1b\u5c11\u3088\u308a\u3082\u3001\u3080\u3057\u308dTRL\u306e\u6b8b\u9ab8\u3092LDL\u306b\u5909\u63db\u3059\u308b\u52b9\u529b\u306e\u5897\u52a0\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002\u5f93\u3063\u3066\u3001\u4e2d\u7acb\u7684\u306a PROMINENT \u8a66\u9a13\u304b\u3089\u63a8\u6e2c\u3055\u308c\u308b\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3084\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u81e8\u5e8a\u52b9\u679c\u3092\u5f97\u308b\u305f\u3081\u306b\u306f\u3001VLDL \u7523\u751f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u5f62\u6210\u3001TRL \u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042\u308d\u3046\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002     <br><br><\/p>\n<\/div>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"3\" bgcolor=\"#CCCCCC\">\n<tbody>\n<tr style=\"text-align: left;\">\n<td valign=\"top\" bgcolor=\"#E9E9E9\" width=\"13%\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/td>\n<td valign=\"top\" bgcolor=\"#FFFFFF\" width=\"87%\">\n<ol>\n<li>Nicholls SJ, Lincoff AM, Garcia M, et al.\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u9ad8\u7528\u91cf\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u5bfe\u30b3\u30fc\u30f3\u6cb9\u306e\u52b9\u679c\uff1aSTRENGTH\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002JAMA 2020;324:2268-80.  <\/li>\n<li>AIM-HIGH\u7814\u7a76\u8005\u3002\u96c6\u4e2d\u7684\u306a\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4f4e\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u3002N Engl J Med 2011;365:2255-67.  <\/li>\n<li>ACCORD\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u30022\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u306e\u52b9\u679c\u3002N Engl J Med 2010;362:1563-74.  <\/li>\n<li>Bhatt DL\u3001Steg PG\u3001Miller M\u3001\u4ed6\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22.  <\/li>\n<li>Keech A, Simes RJ, Barter P, et al. 9795\u4eba\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u9577\u671f\u6295\u4e0e\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u52b9\u679c\uff08FIELD\u8a66\u9a13\uff09\uff1a\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3002Lancet 2005;366:1849-61.  <\/li>\n<li>Ginsberg HN, Packard CJ, Chapman MJ, et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u4f59\u7269\uff1a\u4ee3\u8b1d\u7684\u6d1e\u5bdf\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u5f79\u5272\u3001\u304a\u3088\u3073\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565-\u6b27\u5dde\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002\u6b27\u5dde\u5fc3\u81d3J 2021;42:4791-806\u3002  <\/li>\n<li>Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/li>\n<li>Fruchart J-C.\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff08K-877\uff09\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306e\u65b0\u898f\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\u3002Cardiovasc Diabetol 2017;16:124.  <\/li>\n<\/ol>\n<\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" bgcolor=\"#E9E9E9\" style=\"text-align: left;\"><strong>\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n<td valign=\"top\" bgcolor=\"#FFFFFF\" style=\"text-align: left;\"><em>\u30d7\u30ed\u30df\u30cd\u30f3\u30c8\uff1b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff1b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\uff1b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff1b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: 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