{"id":254416,"date":"2025-01-25T15:41:07","date_gmt":"2025-01-25T14:41:07","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e4%b8%8a%e6%98%87%e3%81%97%e3%81%9f%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e3%82%92%e6%a8%99\/"},"modified":"2025-02-16T22:42:18","modified_gmt":"2025-02-16T21:42:18","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e4%b8%8a%e6%98%87%e3%81%97%e3%81%9f%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e3%82%92%e6%a8%99","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%ef%bc%9a%e4%b8%8a%e6%98%87%e3%81%97%e3%81%9f%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e3%82%92%e6%a8%99\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – REDUCE-IT\uff1a\u4e0a\u6607\u3057\u305f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

REDUCE-IT\uff1a\u4e0a\u6607\u3057\u305f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3001\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b<\/span><\/h2>\n
2019\u5e747\u670819\u65e5<\/span><\/h5>\n
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REDUCE-IT\uff08Reduction of Cardiovascular Events with EPA-Intervention Trial\uff09\u8a66\u9a13\u3067\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u304c\u6b8b\u5b58\u3057\u3066\u3044\u308b\u9ad8\u30ea\u30b9\u30af\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u306e\u7cbe\u88fd\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u3067\u3042\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c25\uff05\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u307e\u305f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u6cbb\u7642\u306f\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u8ca0\u62c5\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002 <\/span><\/div>\n
Bhatt DL\u3001Steg PG\u3001Miller M\u3089\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22.Bhatt DL\u3001Steg PG\u3001Miller M\u3089\u3001\u7dcf\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u52b9\u679c\uff1aREDUCE-IT\u3088\u308a\u3002J Am Coll Cardiol 2019;73:2791-802. <\/span><\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u9ad8\u5024\u306e\u9ad8\u30ea\u30b9\u30af\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n \u591a\u65bd\u8a2d\u5171\u540c\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3002\u5bfe\u8c61\u60a3\u8005\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb2g\u30921\u65e52\u56de\u6295\u4e0e\u3059\u308b\u7fa4\uff081\u65e5\u7dcf\u6295\u4e0e\u91cf4g\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n REDUCE-IT\u306b\u306f\u3001\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u304b\u3001\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u80058,179\u4f8b\u304c\u767b\u9332\u3055\u308c\u305f\u3002\u5bfe\u8c61\u60a3\u8005\u306fTG\u5024\u304c135\u301c499mg\/dL\uff081.52\u301c5.63mmol\/L\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c41\u301c100mg\/dL\uff081.06\u301c2.59mmol\/L\uff09\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u6709\u52b9\u6027\u306e\u5909\u6570\uff1a<\/strong><\/td>\n\n

– \u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306e\u8907\u5408\u3067\u3042\u3063\u305f\u3002<\/p>\n

.\u4e3b\u8981\u306a\u526f\u6b21\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u306e\u8907\u5408\u3067\u3042\u3063\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\n

REDUCE-IT\u306f\u30a4\u30d9\u30f3\u30c8\u30c9\u30ea\u30d6\u30f3\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002\u4e00\u6b21\u89e3\u6790\u3067\u306f\u3001icosapent ethyl\u306e\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u307e\u305f\u306f\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u767a\u73fe\u307e\u3067\u306e\u671f\u9593\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u3002\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f\u5f8c\u7d9a\u89e3\u6790\u3067\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u304c\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u8907\u5408\u30a4\u30d9\u30f3\u30c8\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8a55\u4fa1\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u89e3\u6790\u306fintention-to-treat\u3067\u3042\u3063\u305f\u3002 <\/p>\n

Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u3001\u5730\u57df\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u306e\u4f7f\u7528\u306b\u3088\u308a\u5c64\u5225\u5316\u3057\u305f\u8a66\u9a13\u7fa4\u5272\u4ed8\u3051\u3092\u5171\u5909\u91cf\u3068\u3057\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u305f\u7b2c\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u7b2c\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u76f8\u5bfe\u30cf\u30b6\u30fc\u30c9\u3092\u63a8\u5b9a\u3057\u305f\u3002\u4e21\u7fa4\u9593\u306e\u7dcf\u30a4\u30d9\u30f3\u30c8\u306e\u5dee\u306f\u8ca0\u306e\u4e8c\u9805\u56de\u5e30\u3092\u7528\u3044\u3066\u691c\u8a0e\u3055\u308c\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n

<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u4e21\u7fa4\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7279\u5fb4\u306f\u985e\u4f3c\u3057\u3066\u3044\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u300170.7\uff05\u306e\u60a3\u8005\u306f\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3066\u304a\u308a\u300129.3\uff05\u306f\u7cd6\u5c3f\u75c5\u3068\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u4ed8\u52a0\u7684\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b\u4e00\u6b21\u4e88\u9632\u60a3\u8005\u3067\u3042\u3063\u305f\u3002\u5e74\u9f62\u4e2d\u592e\u5024\u306f64\u6b73\u3067\u300128.8\uff05\u304c\u5973\u6027\u3067\u3042\u3063\u305f\u3002LDL-C\u5024\u306e\u4e2d\u592e\u5024\u306f75mg\/dL\uff081.94mmol\/L\uff09\u3001TG\u5024\u306e\u4e2d\u592e\u5024\u306f216mg\/dL\uff082.44mmol\/L\uff09\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f4.9\u5e74\u3067\u3042\u3063\u305f\u30021\u5e74\u5f8c\u3001TG\u5024\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u7fa4\u306718.3\uff05\uff0839mg\/dL\uff09\u6e1b\u5c11\u3057\u305f\u3002LDL-C\u5024\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u7fa4\u30673.1\uff05\uff082.0mg\/dL\uff09\u5897\u52a0\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u3067\u306f10.2\uff05\uff087.0mg\/dL\uff09\u5897\u52a0\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u30676.6\uff05\uff085mg\/dL\uff09\u5897\u52a0\u3057\u305f\u3002 <\/p>\n

\u4e00\u6b21\u304a\u3088\u3073\u4e8c\u6b21\u6709\u52b9\u6027\u89e3\u6790\u306e\u7d50\u679c\u3092\u4ee5\u4e0b\u306b\u8981\u7d04\u3059\u308b\u3002<\/p>\n

\u88681. REDUCE-IT\u306b\u304a\u3051\u308b\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3068\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09\uff08\u968e\u5c64\u7684\u691c\u5b9a\uff09<\/strong><\/p>\n<\/div>\n

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\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/strong><\/p>\n<\/td>\n

\n

\u30d7\u30e9\u30bb\u30dc<\/strong><\/p>\n

(N=4090)<\/strong><\/p>\n<\/td>\n

\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff08N=4089\uff09<\/strong><\/p>\n<\/td>\n

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\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/strong><\/p>\n<\/td>\n

\n

p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n

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 <\/p>\n<\/td>\n

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\u30a4\u30d9\u30f3\u30c8\u306e\u6570(%)<\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n

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 <\/p>\n<\/td>\n<\/tr>\n

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\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/p>\n<\/td>\n

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901 (22.0%)<\/p>\n<\/td>\n

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705 (17.2%)<\/p>\n<\/td>\n

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0.75 (0.68-0.83)<\/p>\n<\/td>\n

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<0.001<\/p>\n<\/td>\n<\/tr>\n

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\u4e3b\u8981\u526f\u6b21\u8a55\u4fa1\u9805\u76ee<\/p>\n<\/td>\n

\n

606 (14.8%)<\/p>\n<\/td>\n

\n

459 (11.2%)<\/p>\n<\/td>\n

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0.74 (0.65-0.83)<\/p>\n<\/td>\n

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<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387<\/p>\n<\/td>\n

\n

213 (5.2%)<\/p>\n<\/td>\n

\n

174 (4.3%)<\/p>\n<\/td>\n

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0.80 (0.66-0.98)<\/p>\n<\/td>\n

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0.01<\/p>\n<\/td>\n<\/tr>\n

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\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387<\/p>\n<\/td>\n

\n

310 (7.6%)<\/p>\n<\/td>\n

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274 (6.7%)<\/p>\n<\/td>\n

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0.87 (0.74-1.02)<\/p>\n<\/td>\n

\n

–<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u7fa4\u3067\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3088\u308a\u3082\u5fc3\u623f\u7d30\u52d5\u307e\u305f\u306f\u7c97\u52d5\u3067\u5165\u9662\u3057\u305f\u60a3\u8005\u306e\u5272\u5408\u304c\u9ad8\u304b\u3063\u305f\uff083.1\uff05\u5bfe2.1\uff05\u3001p=0.004\uff09\u3002\u91cd\u7be4\u306a\u51fa\u8840\u30a4\u30d9\u30f3\u30c8\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u7fa4\u30672.7\uff05\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30672.1\uff05\u306b\u307f\u3089\u308c\u305f\uff08p=0.06\uff09\u3002 <\/p>\n

\u305d\u306e\u5f8c\u306e\u7dcf\u30a4\u30d9\u30f3\u30c8\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u306f\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u7dcf\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u305f\uff081,000\u60a3\u8005\u5e74\u3042\u305f\u308a61\u4ef6\u5bfe\u30d7\u30e9\u30bb\u30dc\u7fa489\u4ef6\u3001\u7387\u6bd40.70\uff1b95\uff05CI 0.62\uff5e0.78\uff1bp<0.0001\uff09\u3002\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u306f\u4e3b\u8981\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306e\u7dcf\u6570\u3082\u6e1b\u5c11\u3055\u305b\u305f\uff081,000\u60a3\u8005\u5e74\u3042\u305f\u308a32\u4f8b\u5bfe\u30d7\u30e9\u30bb\u30dc44\u4f8b\u3001\u7387\u6bd40.72\uff1b95\uff05CI 0.63\u301c0.82\uff1bp<0.0001\uff09\u3002 <\/span><\/strong><\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u7528\u3057\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305aTG\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u6b7b\u3092\u542b\u3080\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb2g\u30921\u65e52\u56de\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u3067\u3001\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u3088\u308a\u3082\u6709\u610f\u306b\u4f4e\u304b\u3063\u305f\u3002\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u6295\u4e0e\u306f\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u8ca0\u62c5\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u30b9\u30bf\u30c1\u30f3\u3092\u542b\u3080\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u533b\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\/\u307e\u305f\u306f2\u578b\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u542b\u3080\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u306f\u3001\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u6b8b\u5b58\u3057\u3066\u3044\u308b1\u3002TG\u306e\u4e0a\u6607\uff08TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u304a\u3088\u3073\u305d\u306e\u6b8b\u6e23\u306e\u5897\u52a0\u306e\u4ee3\u7528\uff09\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u4fee\u6b63\u53ef\u80fd\u306a\u8102\u8cea\u95a2\u9023\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b2\u3002\u3055\u3089\u306b\u3001\u30b9\u30bf\u30c1\u30f3\u8a66\u9a13\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001TG\u5024\u304c\u9ad8\u3044\u60a3\u8005\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b9-11\u3002 <\/p>\n

\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff08EPA\u3068\u30c9\u30b3\u30b5\u30d8\u30ad\u30b5\u30a8\u30f3\u9178\uff09\u306a\u3069\u306eTG\u4f4e\u4e0b\u7642\u6cd5\u3092\u7279\u5225\u306b\u691c\u8a0e\u3057\u305f\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u539f\u56e0\u306e\u5927\u90e8\u5206\u306f\u3001\u60a3\u8005\u306e\u9078\u629e\u57fa\u6e96\u304c\u4e0d\u5341\u5206\u3067\u3042\u3063\u305f\u3053\u3068\u3067\u3042\u308d\u3046\u3002\u4f8b\u3048\u3070\u3001Action to Control Cardiovascular Risk in Diabetes Lipid Study\u3067\u306f\u3001TG\u4e0a\u6607\u306e\u57fa\u6e96\u306f\u306a\u304f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u4e2d\u592e\u5024\u306f1-8mmol\/L\uff08\u56db\u5206\u4f4d\u7bc4\u56f21-3-2-6mmol\/L\uff09\u3067\u3042\u3063\u305f12\u3002 <\/p>\n

REDUCE-IT\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306bTG\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306e\u7406\u8ad6\u7684\u6839\u62e0\u3092\u652f\u6301\u3059\u308b\u3001\u73fe\u5728\u306e\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6cbb\u7642\u6cd5\u306e\u6700\u521d\u306e\u8a66\u9a13\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u7559\u610f\u3059\u3079\u304d\u3044\u304f\u3064\u304b\u306e\u6ce8\u610f\u70b9\u304c\u3042\u308b\u3002\u7279\u306b\u3001EPA\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u306e\u7a0b\u5ea6\u306fTG\u306e\u6e1b\u5c11\u306e\u7a0b\u5ea6\uff0818.3\uff05\uff09\u3068\u7b49\u3057\u304f\u306a\u3044\u3002\u5b9f\u969b\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306f\u3001\u8840\u5c0f\u677f\u51dd\u96c6\u4f5c\u7528\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u4e0d\u6574\u8108\u4f5c\u7528\u306a\u3069\u3001TG\u4f4e\u4e0b\u4ee5\u5916\u306b\u3082\u3044\u304f\u3064\u304b\u306e\u751f\u7269\u5b66\u7684\u4f5c\u7528\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b13\u3002\u3055\u3089\u306b\u3001REDUCE-IT\u3067\u306f\u3001LDL-C\u5024\u3092\u6709\u610f\u306b\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u305f\u3081\u3001\u4e0d\u6d3b\u6027\u30d7\u30e9\u30bb\u30dc\uff08\u9271\u6cb9\uff09\u3092\u9078\u629e\u3057\u305f\u3053\u3068\u304c\u4ea4\u7d61\u56e0\u5b50\u3068\u306a\u3063\u305f\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u6ce8\u610f\u70b9\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001REDUCE-IT\u304b\u3089\u5f97\u3089\u308c\u305f\u30e1\u30c3\u30bb\u30fc\u30b8\u306f\u3001\u9ad8TG\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u73fe\u5728\u9032\u884c\u4e2d\u306ePROMINENT\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u65b0\u898f\u306e\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u5264\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\u03b1\uff09\u3067\u3042\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\uff08TG\u4e0a\u6607\u3068\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u6f3f\u4e2d\u6fc3\u5ea6\u4f4e\u4e0b\uff09\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3067\u8a66\u9a13\u3059\u308b\u7406\u8ad6\u7684\u6839\u62e0\u3068\u306a\u308b14\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Jernberg T, Hasvold P, Henriksson M et al. \u5fc3\u7b4b\u6897\u585e\u5f8c\u306e\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\uff1a\u5168\u56fd\u7684\u306a\u5b9f\u30c7\u30fc\u30bf\u304c\u9577\u671f\u7684\u8996\u70b9\u306e\u91cd\u8981\u6027\u3092\u793a\u3059\u3002Eur Heart J 2015;36:1163-70. <\/p>\n

2.Fruchart JC, Davignon J, Hermans MP et al. Residual macrovascular risk in 2013: What have we learned?Cardiovasc Diabetol 2014;13:26. <\/p>\n

3.Holmes MV, Asselbergs FW, Palmer TM, et al. Mendelian randomization of blood lipids for coronary heart disease.Eur Heart J 2015;36:539’\u00ea50. <\/p>\n

4.Musunuru K, Kathiresan S. Surprises from genetic analyses of lipid risk factors for atherosclerosis.Circ Res 2016;118:579’\u00c4\u00ea85. <\/p>\n

5.Crosby J, Peloso GM, Auer PL, et al. Loss’\u00ea\u00eaof’\u00eafunction mutations in APOC3, triglycerides, and coronary disease.N Engl J Med 2014;371:22’\u00c4\u00ea31. <\/p>\n

6.Jorgensen AB, Frikke’\u00c4\u00eaSchmidt R, Nordestgaard BG, et al. Loss’\u00ea\u00eaof’\u00eafunction mutations in APOC3 and risk of ischemic vascular disease.N Engl J Med 2014;371:32’\u00c4\u00ea41. <\/p>\n

7.\u5fc3\u7b4b\u6897\u585e\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u907a\u4f1d\u7684\u306b\u4e0a\u6607\u3057\u305f\u975e\u7834\u58ca\u7684\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u8a08\u7b97\u4e0a\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002Eur Heart J 2013;34:1826’\u00ea\u00ea33. <\/p>\n

8.\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002J Am Coll Cardiol 2013;61:427’\u00c4\u00ea36. <\/p>\n

9.PROVE IT-TIMI 22\u8a66\u9a13\u306b\u304a\u3051\u308b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ee5\u5916\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u5f71\u97ff\u3002J Am Coll Cardiol 2008;51:724-30. <\/p>\n

10.\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b9\u30bf\u30c1\u30f3\u306e\u81e8\u5e8a\u8a66\u9a13\uff08Treatating to New Targets and Incremental Decrease in End-Points through Aggressive Lipid Lowering\uff09\u306b\u304a\u3051\u308b\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3002Am J Cardiol 2009;104:459-63. <\/p>\n

11.Kastelein JJ, van der Steeg WA, et al. \u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u8102\u8cea\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\u3001\u304a\u3088\u3073\u305d\u308c\u3089\u306e\u6bd4\u7387\u306e\u95a2\u4fc2\u3002Circulation.2008;117:3002-9. <\/p>\n

12.ACCORD Study Group, Ginsberg HN, Elam MB, Lovato LC, et al. 2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u306e\u52b9\u679c\u3002N Eng J Med.2010;362:1563-74. <\/p>\n

13.Baum SJ, Scholz KP.\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u89d2\u306e\u4e38\u307f\uff1a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u306e\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u30aa\u30e1\u30ac3\u591a\u4fa1\u4e0d\u98fd\u548c\u8102\u80aa\u9178\u6cbb\u7642\u306b\u5bfe\u3059\u308bREDUCE-IT\u306e\u610f\u7fa9\u3002Clin Cardiol 2019. doi: 10.1002\/clc.23220. [Epub ahead of print]<\/p>\n

14.Pradhan AD, Paynter NP, Everett BM et al. Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes\uff08PROMINENT\uff09\u8a66\u9a13\u306e\u6839\u62e0\u3068\u30c7\u30b6\u30a4\u30f3\u3002Am Heart J 2018;206:80-93. <\/p>\n<\/td>\n<\/tr>\n

\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\nREDUCE-IT\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3001\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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