{"id":254414,"date":"2025-01-23T23:35:20","date_gmt":"2025-01-23T22:35:20","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9apcsk9%e9%98%bb%e5%ae%b3%e3%81%af%e7%b3%96%e5%b0%bf%e7%97%85%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e5%a2%97%e5%8a%a0\/"},"modified":"2025-02-16T22:41:40","modified_gmt":"2025-02-16T21:41:40","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9apcsk9%e9%98%bb%e5%ae%b3%e3%81%af%e7%b3%96%e5%b0%bf%e7%97%85%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e5%a2%97%e5%8a%a0","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9apcsk9%e9%98%bb%e5%ae%b3%e3%81%af%e7%b3%96%e5%b0%bf%e7%97%85%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e5%a2%97%e5%8a%a0\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – ODYSSEY OUTCOMES\uff1aPCSK9\u963b\u5bb3\u306f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u304b\uff1f"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30aa\u30c7\u30c3\u30bb\u30a4\u306e\u6210\u679cPCSK9\u963b\u5bb3\u306f\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u304b\uff1f<\/span><\/h2>\n
21 2021\u5e745\u6708<\/span><\/h5>\n
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\u30ea\u30dd\u86cb\u767d(a)[Lp(a)] \u306e\u4e0a\u6607\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u3001\u708e\u75c7\u6027\u3001\u8840\u6813\u4fc3\u9032\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u5371\u967a\u56e0\u5b50\u3068\u307f\u306a\u3055\u308c\u3066\u3044\u308b\u3002\u89b3\u5bdf\u7814\u7a76\u3067\u306f\uff0cLp(a)\u306e\u4f4e\u5024\u304c\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\uff08\u65b0\u898f\u767a\u75c7\uff09\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u3082\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002Lp(a)\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u85ac\u7406\u5b66\u7684\u85ac\u5264\u304c\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u306b\u3064\u3044\u3066\u306f\u307e\u3060\u8b70\u8ad6\u306e\u4f59\u5730\u304c\u3042\u308b\u3002\u3053\u306e\u7591\u554f\u306b\u5bfe\u3057\u3066\uff0cODYSSEY OUTCOMES\u306e\u89e3\u6790\u3067\u306f\uff0cLp(a)\u5024\u304c\u6700\u3082\u4f4e\u4e0b\u3057\u305f\u60a3\u8005\u3067\u306f2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u308f\u305a\u304b\u306b\u4e0a\u6607\u3059\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\uff0c\u3053\u306e\u30ea\u30b9\u30af\u306f\u3053\u306e\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306b\u3088\u3063\u3066\u306f\u308b\u304b\u306b\u51cc\u99d5\u3055\u308c\u308b\u3068\u601d\u308f\u308c\u308b\u3002 <\/span><\/div>\n
Schwartz GG, Szarek M, Bittner VA et al. \u30ea\u30dd\u86cb\u767d(a)\u30ec\u30d9\u30eb\u30682\u578b\u7cd6\u5c3f\u75c5\u767a\u75c7\u3068\u306e\u95a2\u4fc2\u304a\u3088\u3073\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u6cbb\u7642\u306b\u3088\u308b\u4fee\u98fe\u3002Diabetes Care 2021; https:\/\/care.diabetesjournals.org\/content\/early\/2021\/03\/10\/dc20-2842<\/a> <\/em><\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u76ee\u7684<\/strong><\/td>\nLp(a)\u6fc3\u5ea6\u30682\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3068\u306e\u95a2\u4fc2\uff0c\u304a\u3088\u3073PCSK9\u963b\u5bb3\u85ac\u3067\u3042\u308balirocumab\u306b\u3088\u308b\u6cbb\u7642\u306e\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\nODYSSEY OUTCOMES\u8a66\u9a13\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u6700\u8fd1\u306e\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308b\u6cbb\u7642\u3068\u30d7\u30e9\u30bb\u30dc\u306b\u3088\u308b\u6cbb\u7642\u3092\u6bd4\u8f03\u3057\u305f\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u81e8\u5e8a\u8a66\u9a13\u3067\u3042\u308b\u3002\u3053\u306e\u6700\u65b0\u306e\u5831\u544a\u306f\u3053\u306e\u8a66\u9a13\u306epost hoc\u89e3\u6790\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\nACS\u60a3\u800518,924\u4f8b\uff1b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u7cd6\u5c3f\u75c5\u304c\u5b58\u5728\u3057\u305f\u60a3\u8005\u306f5,444\u4f8b\uff0829\uff05\uff09\u3001\u5b58\u5728\u3057\u306a\u304b\u3063\u305f\u60a3\u8005\u306f13,480\u4f8b\u3067\u3042\u3063\u305f\u3002\u3053\u306epost hoc\u89e3\u6790\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u7cd6\u5c3f\u75c5\u304c\u306a\u304b\u3063\u305f\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u57fa\u3065\u3044\u3066\u3044\u308b\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u7d50\u679c\uff1a<\/strong><\/td>\n\u691c\u67fb\u30c7\u30fc\u30bf\uff0c\u6295\u85ac\u30c7\u30fc\u30bf\uff0c\u6709\u5bb3\u4e8b\u8c61\u30c7\u30fc\u30bf\u304b\u3089\u540c\u5b9a\u3055\u308c\u305f\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\nLp(a)\u5024\u306e\u56db\u5206\u4f4d\u4e2d\u592e\u5024\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u7cd6\u5c3f\u75c5\u306e\u306a\u304b\u3063\u305f\u60a3\u8005\u3067\u6bd4\u8f03\u3055\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eLp(a)\u306e\u95a2\u6570\u3068\u3057\u3066\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u306b2\u578b\u7cd6\u5c3f\u75c5\u304c\u767a\u75c7\u3059\u308b\u78ba\u7387\u3092\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u306b\u3088\u308a\u6cbb\u7642\u7fa4\u3054\u3068\u306b\u63a8\u5b9a\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30894\u30f5\u6708\u76ee\u307e\u3067\u306e\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u6295\u4e0e\u306b\u3088\u308bLp(a)\u6fc3\u5ea6\u306e\u5909\u5316\u3092\u8a08\u7b97\u3057\u3001\u5404\u7fa4\u5185\u3067\u3053\u306e\u5909\u5316\u3092Cox\u56de\u5e30\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u305d\u306e\u5f8c\u306e2\u578b\u7cd6\u5c3f\u75c5\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u4ed8\u3051\u305f\u3002Lp(a)\u306e\u6e1b\u5c1110mg\/dL\u3042\u305f\u308a\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\u304c\u5831\u544a\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u4e3b\u306a\u7d50\u679c<\/strong><\/td>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u7cd6\u5c3f\u75c5\u306e\u306a\u304b\u3063\u305f\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u4e2d\u592e\u50242.7\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b1,324\u4f8b\u304c2\u578b\u7cd6\u5c3f\u75c5\u3092\u767a\u75c7\u3057\u3001648\u4f8b\u304c\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u7fa4\u3001676\u4f8b\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u5024\u304c\u4f4e\u3044\u307b\u30692\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u3002\u4e00\u65b9\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u7fa4\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u5024\u306e\u7bc4\u56f2\u306b\u304b\u304b\u308f\u3089\u305a\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u7387\u306f\u57fa\u672c\u7684\u306b\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002
\u3002\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u306bLp(a)\u6fc3\u5ea6\u3092\u4e2d\u592e\u5024\u306723.2\uff05\u6e1b\u5c11\u3055\u305b\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306eLp(a)\u306e\u7d76\u5bfe\u6e1b\u5c11\u306e\u4e2d\u592e\u5024\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u5024\u304c\u9ad8\u3044\u60a3\u8005\u307b\u3069\u5927\u304d\u304f\u3001\u56db\u5206\u4f4d\u65701\u306e0\u304b\u3089\uff08Lp(a) <6.9mg\/dL\uff09\u304b\u3089\u3001\u56db\u5206\u4f4d4\uff0861.1mg\/dL\u4ee5\u4e0a\uff09\u3067\u306f20.2mg\/dL\u3067\u3042\u3063\u305f\u3002
\u3057\u304b\u3057\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u5024\u304c\u9ad8\u3044\u60a3\u8005\u3067\u306f\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u6cbb\u7642\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066Lp(a)\u306e\u7d76\u5bfe\u7684\u6e1b\u5c11\u3092\u3088\u308a\u5927\u304d\u304f\u3057\u30012\u578b\u7cd6\u5c3f\u75c5\u767a\u75c7\u306e\u63a8\u5b9a\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u50be\u5411\u304c\u3042\u3063\u305f\u3002
\u5168\u4f53\u3068\u3057\u3066\u3001Lp(a)\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308910mg\/dL\u6e1b\u5c11\u3059\u308b\u3054\u3068\u306b2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306f7\uff05\u5897\u52a0\u3057\u305f\uff08\u672a\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd41.07\u300195\uff05CI 1.0321.12\u3001p\uff1d0.0002\uff09\u3002\u3053\u306e\u95a2\u9023\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u5024\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u304a\u3088\u3073\u81e8\u5e8a\u7684\u7279\u5fb4\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3082\u540c\u69d8\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u7d50\u8ad6<\/strong><\/td>\nACS\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u306f2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3068\u9006\u76f8\u95a2\u3057\u305f\u3002\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e2\u578b\u7cd6\u5c3f\u75c5\u767a\u75c7\u306b\u5bfe\u3059\u308b\u5168\u4f53\u7684\u52b9\u679c\u306f\u4e2d\u7acb\u3067\u3042\u3063\u305f\u3002\u3057\u304b\u3057\u3001\u6cbb\u7642\u306b\u95a2\u9023\u3057\u305fLp(a)\u306e\u4f4e\u4e0b\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u9ad8\u5024\u304b\u3089\u3088\u308a\u9855\u8457\u3067\u3042\u308a\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u304cLp(a)\u3092\u6e1b\u5c11\u3055\u305b\u308b\u4ed6\u306e\u6cbb\u7642\u6cd5\u306b\u95a2\u9023\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Hoogeveen RC\u3001Ballantyne CM\u3002\u4f4eLDL\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\uff1a\u6b8b\u5b58\u7269\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3001\u708e\u75c7\u3002Clin Chem 2021;67:143-53.
2.Bittner VA, Szarek M, Aylward PE, et al. \u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u52b9\u679c\u3002J Am Coll Cardiol 2020;75:133-44.
3.Tsimikas S, Fazio S, Ferdinand KC, et al. NHLBI Working Group recommendations to reduce lipoprotein(a)-mediated risk of cardiovascular disease and aortic stenosis.J Am Coll Cardiol 2018;71:177-92.
4.Kamstrup PR, Nordestgaard BG.\u30ea\u30dd\u86cb\u767d(a)\u6fc3\u5ea6\u3001\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u30b5\u30a4\u30ba\u30012\u578b\u7cd6\u5c3f\u75c5\u30ea\u30b9\u30af\uff1a\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a76\u3002Lancet Diabetes Endocrinol 2013;1:220-7.
5.Ye Z, Haycock PC, Gurdasani D, et al. \u5faa\u74b0\u30ea\u30dd\u86cb\u767d(a)\u30682\u578b\u7cd6\u5c3f\u75c5\u3068\u306e\u95a2\u9023\uff1a\u56e0\u679c\u95a2\u4fc2\u306f\u3042\u308b\u306e\u304b\uff1fDiabetes 2014;63:332-42.
6.Paige E, Masconi KL, Tsimikas S, et al. Lipoprotein(a) and incident type-2 diabetes: Results from the prospective Bruneck study and a meta-analysis of published literature.Cardiovasc Diabetol 2017;16:38.
7.Langsted A, Nordestgaard BG, Kamstrup PR.\u73fe\u4ee3\u306e\u5927\u898f\u6a21\u4e00\u822c\u96c6\u56e3\u7814\u7a76\u306b\u304a\u3051\u308b\u4f4e\u30ea\u30dd\u86cb\u767d(a)\u5024\u3068\u75be\u60a3\u30ea\u30b9\u30af\u3002Eur Heart J 2021;42:1147-56.
8.Gudbjartsson DF, Thorgeirsson G, Sulem P, et al. \u30ea\u30dd\u86cb\u767d(a)\u6fc3\u5ea6\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3002J Am Coll Cardiol 2019;74:2982-94.
9.Sattar N, Preiss D, Murray HM, et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials.Lancet 2010;375:735-42. <\/td>\n<\/tr>\n
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