{"id":254412,"date":"2025-01-22T22:33:59","date_gmt":"2025-01-22T21:33:59","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/"},"modified":"2025-02-16T22:41:12","modified_gmt":"2025-02-16T21:41:12","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30aa\u30c7\u30c3\u30bb\u30a4\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b<\/span><\/h2>\n
21 2022\u5e749\u6708<\/span><\/h5>\n
\n
\n
\n
\n
\n
\n
ODYSSEY OUTCOMES\u8a66\u9a13\uff08Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab\uff09\u306e\u65b0\u305f\u306a\u89e3\u6790\u7d50\u679c\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u4e2d\u306e\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306e\u6f38\u5897\u7684\u96c6\u4e2d\u7684\u4f4e\u4e0b\u3092\u884c\u3046\u969b\u306e\u76ee\u5b89\u3068\u3057\u3066\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff08apoB\uff09\u3092\u7528\u3044\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/span><\/div>\n
Hagstr\u00f6m E, Steg PG, Szarek M, et al. \u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u52b9\u679c\u3002\u30b5\u30fc\u30ad\u30e5\u30ec\u30fc\u30b7\u30e7\u30f32022\u5e746\u670830\u65e5\uff1a101161CIRCULATIONAHA121057807\u3002 <\/span><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n<\/div>\n

\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nODYSSEY OUTCOMES\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\uff0c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u307e\u305f\u306f\u9054\u6210\u30ec\u30d9\u30eb\u306e\u30a2\u30ddB\u3068\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3092\u691c\u8a0e\u3057\uff0c\u30a2\u30ddB\u304c\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3092\u8d85\u3048\u308b\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u4ed8\u52a0\u7684\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\nODYSSEY OUTCOMES\u8a66\u9a13\u306f\u3001\u6700\u8fd1ACS\u3092\u767a\u75c7\u3057\u3001\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u5024\uff08LDL-C\u226770mg\/dL[1 .81 mmol\/L] \u3001\u975e\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb[HDL-C] \u2267100mg\/dL[2 .59 mmol\/L] \u3001\u307e\u305f\u306fapoB\u226780mg\/dL\uff09\u304c\u4e0a\u6607\u3057\u305f\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u4e26\u884c\u7fa4\u9593\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u308b\u3002\u60a3\u8005\u306f75mg\u306e\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306e\u3044\u305a\u308c\u304b\u30922\u9031\u9593\u3054\u3068\u306b\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u8a66\u9a13\u306e\u30c7\u30b6\u30a4\u30f3\u306f\u3001LDL-C\u304c\u76ee\u6a19\u7bc4\u56f2\uff0825-50mg\/dL\u307e\u305f\u306f0-64-1.29mmol\/L\uff09\u306b\u7559\u307e\u308b\u3088\u3046\u306b\u7528\u91cf\u6f38\u5897\u30c7\u30b6\u30a4\u30f3\u3092\u7d44\u307f\u8fbc\u3093\u3060\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3<\/strong><\/td>\n\u3053\u306e\u8a66\u9a13\u306b\u306f18,924\u4f8b\u306eACS\u60a3\u8005\u304c\u767b\u9332\u3055\u308c\u3001\u4e2d\u592e\u5024\u30672.8\u5e74\u9593\u8ffd\u8de1\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n
\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/strong><\/td>\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306fMACE\u3068\u3057\u3001\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u81f4\u6b7b\u7684\/\u975e\u81f4\u6b7b\u7684\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u3068\u5b9a\u7fa9\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u4e8b\u5f8c\u89e3\u6790\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30a2\u30ddB\u307e\u305f\u306f4\u30f5\u6708\u6642\u70b9\u306e\u30a2\u30ddB\u3068MACE\u3068\u306e\u95a2\u9023\u306f\u3001\u8abf\u6574Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u304a\u3088\u3073\u50be\u5411\u30b9\u30b3\u30a2\u30de\u30c3\u30c1\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
<\/em><\/div>\n
<\/em><\/div>\n
<\/em><\/div>\n
<\/em><\/div>\n<\/div>\n<\/div>\n
<\/div>\n
<\/div>\n<\/div>\n
<\/div>\n
\u7d50\u679c<\/strong><\/div>\n
\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30a2\u30ddB\u306e\u4e2d\u592e\u5024\u306f79mg\/dL\uff08\u56db\u5206\u4f4d\u7bc4\u56f2[IQR] 69-93 mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u3001apoB\u5024\u304c\u9ad8\u3044\u307b\u3069MACE\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\uff08\u88681\uff09\u3001\u3053\u306e\u95a2\u9023\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3082\u6301\u7d9a\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30a2\u30ddB\u304c10mg\/dL\u5897\u52a0\u3059\u308b\u3054\u3068\u306b\u3001MACE\u306e\u30ea\u30b9\u30af\u306f11\uff05\u5897\u52a0\u3057\u305f\uff081.11\u30011.09-1.14\uff1bp<0.0001\uff09\u3002 <\/p>\n

\u88681. \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30a2\u30ddB\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306eMACE\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023<\/strong><\/p>\n\n\n\n\n\n\n
\n

 <\/p>\n<\/td>\n

\n

ApoB\u4e09\u5206\u4f4d\u5024<\/p>\n<\/td>\n<\/tr>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

<75mg\/dL\uff08n=7330\uff09\u3002<\/p>\n<\/td>\n

\n

75 \u304a\u3088\u3073<90 (n=5874)<\/p>\n<\/td>\n

\n

\u226590mg\/dL\u4ee5\u4e0a\uff08n=5720\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

\u672a\u8abf\u6574<\/p>\n<\/td>\n

\n

\u53c2\u8003<\/p>\n<\/td>\n

\n

1.24 (1.06-1.45)<\/p>\n<\/td>\n

\n

1.71 (1.48-1.97)<\/p>\n<\/td>\n<\/tr>\n

\n

\u8abf\u6574\u6e08\u307f<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

1.19 (1.02-1.40)<\/p>\n<\/td>\n

\n

1.64 (1.41-1.90)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\n
\n

* \u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u304a\u3088\u3073\u8102\u8cea\u4ee5\u5916\u306e\u81e8\u5e8a\u5909\u6570\u306e\u8abf\u6574<\/p>\n

\u6cbb\u76424\u30f5\u6708\u5f8c\u306e\u30a2\u30ddB\u5024\u306e\u4e2d\u592e\u5024\u306f\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u7fa4\u306739mg\/dL\uff08IQR\u300135-53mg\/dL\uff09\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f80mg\/dL\uff08IQR\u300168-95mg\/dL\uff09\u3067\u3042\u3063\u305f\uff08\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u7d76\u5bfe\u6e1b\u5c11\u91cf\u306f36mg\/dL\uff09\u3002\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u7fa4\u3067\u306f\u30014\u30f5\u6708\u5f8c\u306e\u9054\u6210\u30a2\u30ddB\u304c\u4f4e\u3044\u307b\u3069\u30014\u30f5\u6708\u5f8c\u306eMACE\u306e\u76f8\u5bfe\u7684\u6e1b\u5c11\u304a\u3088\u3073\u7d76\u5bfe\u7684\u6e1b\u5c11\u304c\u5927\u304d\u304b\u3063\u305f\uff08\u88682<\/strong>\uff09\u3002\u3053\u306e\u95a2\u9023\u306fLDL-C\u3068non-HDL-C\u306e\u9054\u6210\u5024\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3082\u6709\u610f\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u4e00\u65b9\u3001LDL-C\u3084non-HDL-C\u306e\u9054\u6210\u5024\u306f\u3001\u9054\u6210\u3055\u308c\u305f\u30a2\u30ddB\u3092\u8003\u616e\u3057\u3066\u3082MACE\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u306f\u306a\u3089\u306a\u304b\u3063\u305f\u3002<\/p>\n

 <\/p>\n

\u88682.\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u6cbb\u7642\u306b\u3088\u308b\u30a2\u30ddB\u9054\u6210\u3068\u305d\u306e\u5f8c\u306eMACE\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023 <\/strong><\/p>\n\n\n\n
<\/td>\n\n

\u30a2\u30ddB\u4e09\u5206\u4f4d\u3092\u9054\u6210<\/p>\n<\/td>\n

\n

MACE\u767a\u751f\u7387\u306e\u6e1b\u5c11\uff0895\uff05CI\uff09\u3001<\/p>\n

100\u60a3\u8005\u5e74\u5f53\u305f\u308a<\/p>\n<\/td>\n

\n

\u226435mg\/dL\u4ee5\u4e0b<\/p>\n<\/td>\n

\n

>35\uff5e<50mg\/dL<\/p>\n<\/td>\n

\n

\u226550mg\/dL\u4ee5\u4e0a<\/p>\n<\/td>\n

\n

4.26 (3.78-4.79)<\/p>\n<\/td>\n

\n

3.09 (2.69-3.54)<\/p>\n<\/td>\n

\n

2.41 (2.11-2.76<\/p>\n<\/td>\n

\n

\u6cbb\u7642\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

0.73 (0.61-0.87)<\/p>\n<\/td>\n

\n

0.79 (0.66-0.95)<\/p>\n<\/td>\n

\n

0.99 (0.84-1.17)<\/p>\n<\/td>\n

\n

\u7d76\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u3001100\u60a3\u8005\u5e74\u5f53\u305f\u308a\u306e\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u6570<\/p>\n<\/td>\n

\n

0.90<\/p>\n<\/td>\n

\n

0.81<\/p>\n<\/td>\n

\n

0.03<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/strong><\/p>\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n<\/div>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u6700\u8fd1\u306eACS\u3067\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u304c\u9ad8\u5024\u3067\u3042\u3063\u305f\u60a3\u8005\u3067\u306f\u3001MACE\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eapoB\u306e\u5c64\u3067\u5897\u52a0\u3057\u305f\u3002\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30a2\u30ddB\u306e\u3059\u3079\u3066\u306e\u5c64\u3067MACE\u3092\u6e1b\u5c11\u3055\u305b\u305f\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5024\u304c\u9ad8\u3044\u60a3\u8005\u307b\u3069\u7d76\u5bfe\u7684\u6e1b\u5c11\u5e45\u304c\u5927\u304d\u304b\u3063\u305f\u3002\u9054\u6210\u3055\u308c\u305fLDL-C\u307e\u305f\u306f\u975eHDL-C\u3092\u8003\u616e\u3057\u305f\u5f8c\u3067\u3082\u3001\u9054\u6210\u3055\u308c\u305fapoB\u304c\u4f4e\u3044\u307b\u3069MACE\u30ea\u30b9\u30af\u306f\u4f4e\u304b\u3063\u305f\u3002apoB\u5024\u226635mg\/dL\u306e\u9054\u6210\u306fACS\u5f8c\u306e\u30ea\u30dd\u86cb\u767d\u306b\u8d77\u56e0\u3059\u308b\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

ApoB\u5024\u306f\u3001\u7c92\u5b50\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3084\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u542b\u91cf\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u7c92\u5b50\u6fc3\u5ea6\u3092\u793a\u3059\u3002\u5e83\u7bc4\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u88cf\u4ed8\u3051\u3089\u308c\u3001\u30a2\u30ddB\u306f\u30a2\u30ddB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u306b\u8d77\u56e0\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u4e3b\u8981\u306a\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b(1,2)\u3002\u3053\u306e\u3053\u3068\u306f\uff0cODYSSEY OUTCOMES\u306e\u4eca\u56de\u306e\u89e3\u6790\u3067\u691c\u8a3c\u3055\u308c\u305f\u3088\u3046\u306b\uff0c\u9ad8\u5ea6\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bACS\u60a3\u8005\u306e\u3088\u3046\u306a\u8d85\u9ad8\u30ea\u30b9\u30af\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30ea\u30dd\u86cb\u767d\u306b\u95a2\u9023\u3057\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u8a55\u4fa1\u306b\u3082\u95a2\u9023\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/p>\n

\u3053\u306e\u89e3\u6790\u306e\u4e3b\u8981\u306a\u77e5\u898b\u306f\u3001\u6700\u9069\u5316\u3055\u308c\u305f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u304a\u3051\u308bLDL-C\u5024\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u6cbb\u7642\u4e2d\u306e\u30a2\u30ddB\u5024\u304c\u9ad8\u3044\u307b\u3069MACE\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001apoB\u3068\u306e\u95a2\u4fc2\u306f\u3001\u9054\u6210\u3055\u308c\u305fLDL-C\u5024\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3067\u3082\u3001non-HDL-C\u3068MACE\u3068\u306e\u9593\u306b\u89b3\u5bdf\u3055\u308c\u305f\u95a2\u4fc2\u3088\u308a\u3082\u5f37\u304b\u3063\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001apoB\u306f\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bACS\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u597d\u307e\u3057\u3044\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027apoB\u542b\u6709\u7c92\u5b50\u306e\u6570\u304c\u3001\u305d\u308c\u3089\u306e\u7c92\u5b50\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u542b\u6709\u91cf\u306e\u5408\u8a08\u3088\u308a\u3082\u30ea\u30dd\u86cb\u767d\u95a2\u9023\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u512a\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3001\u4ed6\u306e\u5831\u544a\u3068\u4e00\u81f4\u3059\u308b(3)\u3002 <\/p>\n

\u3053\u306e\u89e3\u6790\u306f\u3001\u3053\u308c\u3089\u306e\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u7ba1\u7406\u306b\u793a\u5506\u3092\u4e0e\u3048\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u30b9\u30bf\u30c1\u30f3\uff0b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u4f75\u7528\u7642\u6cd5\u3067\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u63a8\u5968\u306eLDL-C\u76ee\u6a19\u5024\uff08<55mg\/dL\u307e\u305f\u306f<1.4mmol\/L\uff09\u3092\u9054\u6210\u3057\u305fACS\u60a3\u8005\u306e\u3046\u3061\u3001apoB\u226635mg\/dL\u3092\u9054\u6210\u3057\u305f\u306e\u306f\u534a\u6570\u4ee5\u4e0b\uff0840\uff05\uff09\u3067\u3042\u3063\u305f\u3002LDL-C\u5024<22mg\/dL\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u3067\u3082\u3001\u307b\u307c5\u4eba\u306b1\u4eba\uff0818\uff05\uff09\u306f\u30a2\u30ddB\u5024\u226635mg\/dL\u3092\u9054\u6210\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u3053\u306e\u3088\u3046\u306b\uff0c\u53b3\u683c\u306aLDL-C\u306e\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u3066\u3082\uff0c\u30ea\u30dd\u86cb\u767d\u306b\u8d77\u56e0\u3059\u308b\u6b8b\u4f59\u30ea\u30b9\u30af\u306f\u6301\u7d9a\u3059\u308b\u3002ACS\u60a3\u8005\u306b\u304a\u3044\u3066\u30ea\u30dd\u86cb\u767d\u306b\u8d77\u56e0\u3059\u308b\u6b8b\u4f59\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u3001apoB\u76ee\u6a19\u5024\u306b\u57fa\u3065\u304f\u6cbb\u7642\u304c\u671b\u307e\u3057\u3044\u6226\u7565\u3067\u3042\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002
<\/strong><\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Sniderman AD, Navar AM, Thanassoulis G. Apolipoprotein B vs low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol as the primary measure of Apolipoprotein B lipoprotein-related risk: the debate Is over.JAMA Cardiol 2022;7:257-8.
2.\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u6f5c\u5728\u7684\u6cbb\u7642\u6a19\u7684\u3002Metabolites 2021;11:690.
3.\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u3068\u5fc3\u7b4b\u6897\u585e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\uff1a\u7c92\u5b50\u6fc3\u5ea6\u3001\u30bf\u30a4\u30d7\u3001\u542b\u6709\u91cf\u306e\u533a\u5225\u3002JAMA Cardiol 2022;7:250-6. <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\uff1b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff1bODYSSEY OUTCOMES<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

\u30aa\u30c7\u30c3\u30bb\u30a4\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b 21 2022\u5e749\u6708 ODYSS […]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","footnotes":""},"class_list":["post-254412","page","type-page","status-publish","hentry"],"yoast_head":"\n\u30e9\u30f3\u30c9\u30de\u30fc\u30af - ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b - R3I<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b - R3I\" \/>\n<meta property=\"og:description\" content=\"\u30aa\u30c7\u30c3\u30bb\u30a4\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b 21 2022\u5e749\u6708 ODYSS […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/\" \/>\n<meta property=\"og:site_name\" content=\"R3I\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-16T21:41:12+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\\\/\",\"url\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\\\/\",\"name\":\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b - R3I\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/#website\"},\"datePublished\":\"2025-01-22T21:33:59+00:00\",\"dateModified\":\"2025-02-16T21:41:12+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\\\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/r3i.org\\\/ja\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/#website\",\"url\":\"https:\\\/\\\/r3i.org\\\/ja\\\/\",\"name\":\"R3I\",\"description\":\"Residual Risk Reduction Initiative\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/r3i.org\\\/ja\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b - R3I","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/","og_locale":"ja_JP","og_type":"article","og_title":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b - R3I","og_description":"\u30aa\u30c7\u30c3\u30bb\u30a4\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b 21 2022\u5e749\u6708 ODYSS […]","og_url":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/","og_site_name":"R3I","article_modified_time":"2025-02-16T21:41:12+00:00","twitter_card":"summary_large_image","twitter_misc":{"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"2\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/","url":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/","name":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b - R3I","isPartOf":{"@id":"https:\/\/r3i.org\/ja\/#website"},"datePublished":"2025-01-22T21:33:59+00:00","dateModified":"2025-02-16T21:41:12+00:00","breadcrumb":{"@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-odyssey-outcomes%ef%bc%9a%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bdb%e3%81%af%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/r3i.org\/ja\/"},{"@type":"ListItem","position":2,"name":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – ODYSSEY OUTCOMES\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u306f\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u5206\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b"}]},{"@type":"WebSite","@id":"https:\/\/r3i.org\/ja\/#website","url":"https:\/\/r3i.org\/ja\/","name":"R3I","description":"Residual Risk Reduction Initiative","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/r3i.org\/ja\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"}]}},"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Pgbfv2-14bq","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254412","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/users\/258497325"}],"replies":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/comments?post=254412"}],"version-history":[{"count":1,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254412\/revisions"}],"predecessor-version":[{"id":254413,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254412\/revisions\/254413"}],"wp:attachment":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/media?parent=254412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}