{"id":254410,"date":"2025-01-25T14:05:56","date_gmt":"2025-01-25T13:05:56","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e8%82%9dapoc3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%96%b0%e8%a6%8f%e3%82%a2%e3%83%b3%e3%83%81%e3%82%bb%e3%83%b3%e3%82%b9\/"},"modified":"2025-02-16T22:40:41","modified_gmt":"2025-02-16T21:40:41","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e8%82%9dapoc3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%96%b0%e8%a6%8f%e3%82%a2%e3%83%b3%e3%83%81%e3%82%bb%e3%83%b3%e3%82%b9","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e8%82%9dapoc3%e3%82%92%e6%a8%99%e7%9a%84%e3%81%a8%e3%81%99%e3%82%8b%e6%96%b0%e8%a6%8f%e3%82%a2%e3%83%b3%e3%83%81%e3%82%bb%e3%83%b3%e3%82%b9\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u809dAPOC3\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u898f\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u7642\u6cd5\u304c\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6539\u5584\u3059\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u809dAPOC3\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u7642\u6cd5\u304c\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6539\u5584\u3059\u308b<\/span><\/h2>\n
17 2020\u5e742\u6708<\/span><\/h5>\n
\n
\n
\n
\n
\n
\n
APOC3 mRNA\u306b\u5bfe\u3059\u308b\u3053\u306eN-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\uff08GalNAc3\uff09\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u8907\u6570\u56de\u6295\u4e0e\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u88ab\u9a13\u8005\u306b\u304a\u3044\u3066\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3092\u7d0470\uff05\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/span><\/div>\n
Alexander VJ\u3001Xia S\u3001Hurh E\u3089\u3001APOC3mRNA\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304a\u3088\u3073\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ec\u30d9\u30eb\u306b\u5bfe\u3059\u308bN-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u85ac\u3002Eur Heart Journal 2019;40, 2785’\u00c4\u00ec96. <\/span><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u8840\u6f3f\u4e2d\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306e\u4e0a\u6607\u304c\u7de9\u3084\u304b\u306a\u5065\u5e38\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09C-III\u306b\u5bfe\u3059\u308bGalNAc3\u4fee\u98fe\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08AKCEAAPOCIII-LRx\uff09\u306e\u5358\u56de\u304a\u3088\u3073\u8907\u6570\u56de\u76ae\u4e0b\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3001\u5fcd\u5bb9\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u7528\u91cf\u6f38\u5897\u7b2cI\/IIa\u76f8\u8a66\u9a13<\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3\uff1a<\/strong><\/td>\n\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\uff0818\uff5e65\u6b73\uff09\u3067\u3001TG\u5024\u304c>90mg\/dL\u307e\u305f\u306f>200mg\/dL\u3002<\/td>\n<\/tr>\n
\u4e3b\u306a\u7814\u7a76\u5909\u6570\uff1a<\/strong><\/td>\n\n

– \u6709\u52b9\u6027\uff1a\u4e8c\u6b21\u5909\u6570\uff1a\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u7dcfC\uff09\u3001\u30a2\u30ddB\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u3001\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08VLDL-C\uff09\u3002<\/p>\n

– \u5b89\u5168\u6027\uff1a\u6cbb\u7642\u306b\u8d77\u56e0\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\u3001\u5c3f\u691c\u67fb\u3001\u5316\u5b66\u691c\u67fb\u3001\u8840\u6db2\u691c\u67fb\u3001\u30d0\u30a4\u30bf\u30eb\u30b5\u30a4\u30f3\u3001\u5fc3\u96fb\u56f3\u6240\u898b\u3002 <\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u672c\u8a66\u9a13\u306f\u3001\u5358\u56de\u6295\u4e0e\u3068\u8907\u6570\u56de\u6295\u4e0e\u3067\u69cb\u6210\u3055\u308c\u305f\u3002\u5358\u56de\u6295\u4e0e\u8a66\u9a13\u3067\u306f\u300110\u300130\u300160\u300190\u3001120mg\u306e5\u3064\u306e\u30b3\u30db\u30fc\u30c8\uff08\u5404\u30b3\u30db\u30fc\u30c8N\uff1d8\u3001\u7121\u4f5c\u70ba\u53166\uff1a\u30d7\u30e9\u30bb\u30dc2\uff09\u304c\u8a2d\u5b9a\u3055\u308c\u305f\u3002\u88ab\u9a13\u8005\u306e\u7a7a\u8179\u6642TG\u5024\u306f\u300110\u300130\u300160mg\u6295\u4e0e\u7fa4\u3067\u306f>90mg\/dL\u300190\u3001120mg\u6295\u4e0e\u7fa4\u3067\u306f>200mg\/dL\u3067\u3042\u3063\u305f\u3002\u8907\u6570\u56de\u6295\u4e0e\u8a66\u9a13\u3067\u306f\u3001\u7a7a\u8179\u6642TG\u5024\u304c>200mg\/dL\u306e\u88ab\u9a13\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u6295\u4e0e\u91cf\u306f\u300115mg\u306830mg\u3092\u90311\u56de6\u9031\u9593\uff08\u30b3\u30db\u30fc\u30c8\u3042\u305f\u308aN=8\u3001\u7121\u4f5c\u70ba\u5316\u7dcf\u6570\uff1a\u6d3b\u60276\uff1a\u30d7\u30e9\u30bb\u30dc2\uff09\u300160mg\u30924\u9031\u3054\u3068\u306b6\u30f5\u6708\u9593\uff08N=10\u3001\u7121\u4f5c\u70ba\u5316\u7dcf\u6570\uff1a\u6d3b\u60276\uff1a\u30d7\u30e9\u30bb\u30dc4\uff09\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n<\/div>\n

\n
\n
\n
\n

\u5358\u56de\u6295\u4e0e\u8a66\u9a13\u3067\u306f40\u540d\u3001\u53cd\u5fa9\u6295\u4e0e\u8a66\u9a13\u3067\u306f27\u540d\uff08\u90311\u56de\u6295\u4e0e\u7fa417\u540d\u30014\u90311\u56de\u6295\u4e0e\u7fa410\u540d\uff09\u304c\u767b\u9332\u3055\u308c\u305f\u3002\u6709\u52b9\u6027\u306e\u7d50\u679c\u306f\u4ee5\u4e0b\u306e\u88681\u304a\u3088\u3073\u88682\u306b\u8981\u7d04\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

 <\/p>\n

\u88681. \u5358\u56de\u6295\u4e0e\u8a66\u9a13\uff1b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u4e2d\u592e\u5024\u3002 <\/span><\/strong>ND\u672a\u5b9a<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc<\/p>\n<\/td>\n

\n

10 mg<\/p>\n<\/td>\n

\n

30 mg<\/p>\n<\/td>\n

\n

60 mg<\/p>\n<\/td>\n

\n

90 mg<\/p>\n<\/td>\n

\n

120 mg<\/p>\n<\/td>\n<\/tr>\n

\n

(n=10)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n<\/tr>\n

\n

+11<\/strong><\/p>\n<\/td>\n

\n

0<\/strong><\/p>\n<\/td>\n

\n

-42<\/strong><\/p>\n<\/td>\n

\n

-73<\/strong><\/p>\n<\/td>\n

\n

-81<\/strong><\/p>\n<\/td>\n

\n

-92<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

+10<\/strong><\/p>\n<\/td>\n

\n

-12<\/strong><\/p>\n<\/td>\n

\n

-7<\/strong><\/p>\n<\/td>\n

\n

-42<\/strong><\/p>\n<\/td>\n

\n

-73<\/strong><\/p>\n<\/td>\n

\n

-77<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

+0.1<\/p>\n<\/td>\n

\n

-31<\/p>\n<\/td>\n

\n

-3<\/p>\n<\/td>\n

\n

-65<\/p>\n<\/td>\n

\n

-82<\/p>\n<\/td>\n

\n

-67<\/p>\n<\/td>\n<\/tr>\n

\n

-12.5<\/p>\n<\/td>\n

\n

-6<\/p>\n<\/td>\n

\n

-8<\/p>\n<\/td>\n

\n

-7<\/p>\n<\/td>\n

\n

-26<\/p>\n<\/td>\n

\n

-24<\/p>\n<\/td>\n<\/tr>\n

\n

-8<\/p>\n<\/td>\n

\n

-3<\/p>\n<\/td>\n

\n

-6<\/p>\n<\/td>\n

\n

-1<\/p>\n<\/td>\n

\n

-9<\/p>\n<\/td>\n

\n

-11<\/p>\n<\/td>\n<\/tr>\n

\n

-14<\/p>\n<\/td>\n

\n

ND<\/p>\n<\/td>\n

\n

ND<\/p>\n<\/td>\n

\n

ND<\/p>\n<\/td>\n

\n

-13<\/p>\n<\/td>\n

\n

-25<\/p>\n<\/td>\n<\/tr>\n

\n

+4<\/p>\n<\/td>\n

\n

+7<\/p>\n<\/td>\n

\n

+14<\/p>\n<\/td>\n

\n

+32<\/p>\n<\/td>\n

\n

+61<\/p>\n<\/td>\n

\n

+72<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\n

\u88682.\u53cd\u5fa9\u6295\u4e0e\u8a66\u9a13\uff1a\u6295\u4e0e1\u9031\u9593\u5f8c\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u4e2d\u592e\u5024 <\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u30d7\u30e9\u30bb\u30dc\u90311\u56de\u6295\u4e0e<\/p>\n<\/td>\n

\n

15mg\/\u9031<\/p>\n<\/td>\n

\n

30mg\/\u9031<\/p>\n<\/td>\n

\n

\u30d7\u30e9\u30bb\u30dc 4\u9031\u3054\u3068<\/p>\n<\/td>\n

\n

60mg\u30924\u9031\u9593\u3054\u3068\u306b\u6295\u4e0e<\/p>\n<\/td>\n<\/tr>\n

\n

(n=4)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n

\n

(n=7)<\/p>\n<\/td>\n

\n

(n=4)<\/p>\n<\/td>\n

\n

(n=6)<\/p>\n<\/td>\n<\/tr>\n

\n

+14<\/strong><\/p>\n<\/td>\n

\n

-66<\/strong><\/p>\n<\/td>\n

\n

-84<\/strong><\/p>\n<\/td>\n

\n

+4<\/strong><\/p>\n<\/td>\n

\n

-89<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

+18<\/strong><\/p>\n<\/td>\n

\n

-59<\/strong><\/p>\n<\/td>\n

\n

-73<\/strong><\/p>\n<\/td>\n

\n

-10<\/strong><\/p>\n<\/td>\n

\n

-66<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

-4<\/p>\n<\/td>\n

\n

-79<\/p>\n<\/td>\n

\n

-76<\/p>\n<\/td>\n

\n

-4<\/p>\n<\/td>\n

\n

-50<\/p>\n<\/td>\n<\/tr>\n

\n

-2<\/p>\n<\/td>\n

\n

-23<\/p>\n<\/td>\n

\n

-28<\/p>\n<\/td>\n

\n

+4<\/p>\n<\/td>\n

\n

-29<\/p>\n<\/td>\n<\/tr>\n

\n

-0.1<\/p>\n<\/td>\n

\n

-8<\/p>\n<\/td>\n

\n

-13<\/p>\n<\/td>\n

\n

+2<\/p>\n<\/td>\n

\n

-18<\/p>\n<\/td>\n<\/tr>\n

\n

+2.3<\/p>\n<\/td>\n

\n

-14<\/p>\n<\/td>\n

\n

-27<\/p>\n<\/td>\n

\n

+0.1<\/p>\n<\/td>\n

\n

-28<\/p>\n<\/td>\n<\/tr>\n

\n

0<\/p>\n<\/td>\n

\n

+44<\/p>\n<\/td>\n

\n

+66<\/p>\n<\/td>\n

\n

+6<\/p>\n<\/td>\n

\n

+80<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u5358\u56de\u6295\u4e0e\u8a66\u9a13\u3067\u306f\u3001AKCEA-APOCIII-LRx 120 mg\u6295\u4e0e\u5f8c\u306b\u30a2\u30ddC-III\u3068TG\u306e\u6e1b\u5c11\u7387\u304c\u6700\u5927\u3068\u306a\u3063\u305f\u3002\u8907\u6570\u56de\u6295\u4e0e\u8a66\u9a13\u3067\u306f\u300130mg\u3092\u90311\u56de6\u9031\u9593\u3001\u307e\u305f\u306f60mg\u30924\u9031\u9593\u3054\u3068\u306b6\u30f5\u6708\u9593\u6295\u4e0e\u3057\u305f\u5834\u5408\u306b\u3001\u4e21\u5909\u6570\u306e\u6e1b\u5c11\u304c\u6700\u5927\u3068\u306a\u3063\u305f\u3002\u7dcfC\u3001\u30a2\u30ddB\u3001\u975eHDL-C\u3001VLDL-C\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3082\u89b3\u5bdf\u3055\u308c\u305f\u3002\u307e\u305f\u300160mg\u300190mg\u3001120mg\u306eAKCEA-APOCIII-LRx\u306e\u5358\u56de\u6295\u4e0e\u3001\u90311\u56de\u304a\u3088\u30734\u90311\u56de\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001HDL-C\u306e\u6709\u610f\u306a\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002AKCEA-APOCIII-LRx\u306e\u5fcd\u5bb9\u6027\u306f\u826f\u597d\u3067\u3042\u308a\u3001\u6ce8\u5c04\u90e8\u4f4d\u306b\u304a\u3051\u308b\u91cd\u7be4\u306a\u6709\u5bb3\u4e8b\u8c61\u3001\u809d\u6a5f\u80fd\u3001\u814e\u6a5f\u80fd\u3001\u8840\u5c0f\u677f\u6570\u306b\u5bfe\u3059\u308b\u91cd\u7be4\u306a\u5f71\u97ff\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/span><\/p>\n\n\n\n
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\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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\u3053\u306e\u8a66\u9a13\u306e\u7d50\u679c\u306f\u6709\u671b\u3067\u3042\u308b\u3002\u3053\u306e\u65b0\u898f\u6cbb\u7642\u85ac\u306e\u76ae\u4e0b\u6295\u4e0e\uff08\u5358\u56de\u6295\u4e0e\u307e\u305f\u306f\u8907\u6570\u56de\u6f38\u5897\u6295\u4e0e\u6cd5\uff09\u306b\u3088\u308a\u3001\u8840\u6f3f\u30a2\u30ddC-III\u3068TG\u5024\u304c\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3001\u90311\u56de\u307e\u305f\u306f4\u9031\u3054\u3068\u306e\u6295\u4e0e\u3067TG\u304c\u7d0470\uff05\u4f4e\u4e0b\u3057\u305f\u3002TG\u4f4e\u4e0b\u52b9\u679c\u306f4\u9031\u6bce\u306e\u6295\u4e0e\u30ec\u30b8\u30e1\u30f3\u3067\u306f\u6295\u4e0e\u5f8c4\u30f5\u6708\u307e\u3067\u6301\u7d9a\u3057\u305f\u3002\u6cbb\u7642\u306e\u5fcd\u5bb9\u6027\u3082\u826f\u597d\u3067\u3001\u4ee5\u524d\u5225\u306eAPOC3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bvolanesorsen\u3067\u898b\u3089\u308c\u305f\u3088\u3046\u306a\u526f\u4f5c\u7528\u3092\u793a\u5506\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u306a\u304b\u3063\u305f9\u3002 <\/p>\n

\u8981\u7d04\u3059\u308b\u3068\u3001\u3053\u306e\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u9ad8TG\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u306e\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u7d99\u7d9a\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Laufs U, Parhofer KG, Ginsberg HN, Hegele RA.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u30ec\u30d3\u30e5\u30fc\u3002Eur Heart J 2020;41:99-109c. <\/p>\n

2.Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/p>\n

3.Sandesara PB\u3001Virani SS\u3001Fazio S\u3001Shapiro MD\u3002\u5fd8\u308c\u3089\u308c\u305f\u8102\u8cea\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3002Endocr Rev 2019;40:537-57. <\/p>\n

4.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/p>\n

5.\u306a\u305c\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\u8ceaCIII\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u6d6e\u4e0a\u3057\u3066\u3044\u308b\u306e\u304b\uff1fCurr Atheroscler Rep 2016;18:59. <\/p>\n

6.Crosby J, Peloso GM, Auer PL et al. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3001\u4e2d\u6027\u8102\u80aa\u3001\u51a0\u75be\u60a3\u3002N Engl J Med 2014;371:22-31. <\/p>\n

7.Jorgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybjaerg-Hansen A. APOC3\u306e\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u3068\u865a\u8840\u6027\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3002N Engl J Med 2014;371:32-41. <\/p>\n

8.Qamar A, Khetarpal SA, Khera AV et al. Plasma apolipoprotein C-III levels, triglycerides, and coronary artery calcification in type 2 diabetics.Arterioscler Thromb Vasc Biol 2015;35:1880-8. <\/p>\n

9.\u30ec\u30d3\u30f3AA\u3002\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u3088\u308bRNA\u30ec\u30d9\u30eb\u3067\u306e\u75be\u60a3\u6cbb\u7642\u3002N Engl J Med 2019;380:57-70. <\/p>\n<\/td>\n<\/tr>\n

\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III, \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9, \u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9, \u7528\u91cf\u4f9d\u5b58\u6027<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

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