{"id":254408,"date":"2025-01-21T13:33:10","date_gmt":"2025-01-21T12:33:10","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%9d%9ehdl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab\/"},"modified":"2025-02-16T22:40:13","modified_gmt":"2025-02-16T21:40:13","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%9d%9ehdl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%9d%9ehdl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – \u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” theme_builder_area=”post_content” sticky_enabled=”0″]

\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a
<\/span>\u9ad8\u6b8b\u7559\u30ea\u30b9\u30af\u306e\u8eab\u8fd1\u306a\u30de\u30fc\u30ab\u30fc<\/span><\/h2>\n
2024\u5e745\u670820\u65e5<\/span><\/h5>\n
\n
\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3092\u6709\u3057\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u800523,000\u4eba\u4ee5\u4e0a\u3092\u542b\u3080\u3053\u306e\u7814\u7a76\u306f\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u304c\u3001\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306e\u7c21\u4fbf\u3067\u9811\u5065\u306a\u6307\u6a19\u3067\u3042\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3057\u305f\u3002<\/div>\n
\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3067LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u826f\u597d\u306a\u60a3\u8005\u306b\u304a\u3051\u308b\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\uff1a\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002Lancet Regional Health – Europe 2024;36: 100774. <\/em><\/div>\n
<\/div>\n<\/div>\n
\n\n\n\n\n\n\n\n\n
\u7814\u7a76\u6982\u8981<\/strong><\/td>\n<\/tr>\n
\u76ee\u7684<\/strong><\/td>\n\u865a\u8840\u6027\u5fc3\u75be\u60a3\uff08IHD\uff09\u3067LDL-C\u304c1.8mmol\/L\u4ee5\u4e0b\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\uff0c\u975eHDL-C\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u540c\u5b9a\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\u30c7\u30f3\u30de\u30fc\u30af\u306e\u5730\u57df\u304a\u3088\u3073\u5168\u56fd\u5065\u5eb7\u767b\u9332\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/td>\n\u51a0\u52d5\u8108\u30b0\u30e9\u30d5\u30c8\u8853\u5f8c1\u5e74\u4ee5\u5185\u306eIHD\u3067LDL-C\u304c1.8mmol\/L\u4ee5\u4e0b\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u800523,641\u4f8b\u3002<\/td>\n<\/tr>\n
\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/td>\n\u4e00\u6b21\uff1a\u51a0\u52d5\u8108\u30b0\u30e9\u30d5\u30c8\u8853\u5f8c1\u5e74\u304b\u3089\u8ffd\u8de1\u7d42\u4e86\u307e\u3067\u306b\u767a\u751f\u3057\u305f\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\uff0cASCVD\uff08MI\u307e\u305f\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\uff09\uff0c\u5168\u6b7b\u4ea1\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\nCox\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u8ee2\u5e30\u306e\u88dc\u6b63\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u3092\u63a8\u5b9a\u3057\u305f\u3002non-HDL-C\u3068\u8ee2\u5e30\u306e\u95a2\u9023\u306f\u3001non-HDL-C\u3092\u9023\u7d9a\u5909\u6570\u3068\u3057\u3066\u89e3\u6790\u3057\u3001non-HDL-C\u304c1mmol\/L\u5897\u52a0\u3059\u308b\u3054\u3068\u306eHR\u3092\u63a8\u5b9a\u3057\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\u7d50\u679c<\/strong><\/div>\n
\n\n\n\n
<\/td>\n\n

\u60a3\u8005\u306e\u3046\u30615922\u4eba\uff0825.0\uff05\uff09\u304c\u975eHDL-C\u3067\u3042\u3063\u305f\uff08<25th<\/sup>\uff09\u3002 <\/span>\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff081.7mmol\/L\uff09\u300125\u301c74\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff081.7\u301c2.1mmol\/L\uff0910,950\u4f8b\uff0846.3\uff05\uff09\u300175\u301c94\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff082.2\u301c2.6mmol\/L\uff095454\u4f8b\uff0823.1\uff05\uff09\u300195\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff082.7mmol\/L\u4ee5\u4e0a\uff091315\u4f8b\uff085.6\uff05\uff09\u3067\u3042\u3063\u305f\u3002\u975eHDL-C\u304c\u9ad8\u5024\uff08\u226795\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff09\u306e\u60a3\u8005\u306f\u3001\u975eHDL-C\u304c\u9ad8\u5024\uff08<25th<\/sup>\uff09\u306e\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u82e5\u304f\u3001\u6d3b\u52d5\u7684\u306a\u55ab\u7159\u8005\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u75c5\u7684\u75be\u60a3\uff08\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\uff09\u306e\u6709\u75c5\u7387\u304c\u9ad8\u304f\u3001\u80a5\u6e80\u5ea6\u304c\u9ad8\u304b\u3063\u305f\u3002 <\/span>\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u3067\u3042\u308b\u3002<\/p>\n

 <\/p>\n

\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50244.1\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f22.4\u301c6.1\u5e74\uff09\u306e\u9593\u306b\u3001893\u4f8b\uff083.8\uff05\uff09\u304cMI\u3092\u767a\u75c7\u3057\u30011207\u4f8b\uff085.1\uff05\uff09\u304cASCVD\u3092\u767a\u75c7\u3057\u30013054\u4f8b\uff0812.9\uff05\uff09\u304c\u6b7b\u4ea1\u3057\u305f\u3002\u975eHDL-C\u306e\u4e0a\u6607\u306f\uff0cLDL-C\u5024\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\uff0cMI\uff0cASCVD\uff0c\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u305f\u3002 <\/p>\n

 <\/p>\n

\u88681. \u5404\u975eHDL-C\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u7fa4\u306e\u8abf\u6574*\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\n

\u975eHDL-C\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u7fa4<\/p>\n<\/td>\n

\n

MI<\/p>\n<\/td>\n

\n

ASCVD<\/p>\n<\/td>\n

\n

\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387<\/p>\n<\/td>\n<\/tr>\n

\n

<25<\/sup>\u65e5<\/p>\n<\/td>\n

\n

\u53c2\u7167<\/p>\n<\/td>\n<\/tr>\n

\n

25<\/sup>\u4f4d <\/span>–74<\/sup>\u4f4d<\/p>\n<\/td>\n

\n

1.0 (0.8-1.2)<\/p>\n<\/td>\n

\n

1.1 (0.9-1.3)<\/p>\n<\/td>\n

\n

1.0 (0.9-1.1)<\/p>\n<\/td>\n<\/tr>\n

\n

75<\/sup>\u4f4d <\/span>–94<\/sup>\u4f4d<\/p>\n<\/td>\n

\n

1.3 (1.0-1.6)<\/p>\n<\/td>\n

\n

1.4 (1.1-1.7)<\/p>\n<\/td>\n

\n

1.2 (1.1-1.4)<\/p>\n<\/td>\n<\/tr>\n

\n

\u226595<\/sup>\u4f4d<\/p>\n<\/td>\n

\n

1.7 (1.3-2.3)<\/p>\n<\/td>\n

\n

1.8 (1.4-2.4)<\/p>\n<\/td>\n

\n

1.4 (1.2-1.7)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u5e74\u9f62\u3001\u6027\u5225\u3001\u55ab\u7159\u3001\u9ad8\u8840\u5727\u3001LDL-C\u3067\u8abf\u6574\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\u7537\u5973\u3001<65\u6b73\u306865\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n

\u8457\u8005\u7d50\u8ad6<\/strong><\/td>\nLDL-C\u304c\u5341\u5206\u306b\u7ba1\u7406\u3055\u308c\u305f\u60a3\u8005\u304b\u3089\u306a\u308b\u73fe\u4ee3\u306e\u4e8c\u6b21\u4e88\u9632\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001non-HDL-C\u306f\u3001ASCVD\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u9ad8\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u76f4\u9762\u3057\u3066\u3044\u308b\u60a3\u8005\u3092\u691c\u51fa\u3059\u308b\u305f\u3081\u306e\u3001\u5bb9\u6613\u306b\u5165\u624b\u53ef\u80fd\u306a\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6d6e\u4e0a\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\uff0cLDL-C\u306e\u76ee\u6a19\u5024\u3092\u8d85\u3048\u305f\u4e88\u9632\u6226\u7565\u306b\u3068\u3063\u3066\u91cd\u8981\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n

\n

\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u5e83\u7bc4\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u88cf\u6253\u3061\u3055\u308c\u305fLDL-C\u306f\u3001ASCVD\u306e\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u306f\u660e\u767d\u3067\u3042\u308a\u3001ASCVD\u4e88\u9632\u306e\u305f\u3081\u306e\u6cbb\u7642\u6a19\u7684\u306e\u7126\u70b9\u3068\u306a\u3063\u3066\u3044\u308b\uff081-3\uff09\u3002\u3057\u304b\u3057\u3001LDL-C\u5024\u304c\u5341\u5206\u306b\u7ba1\u7406\u3055\u308c\u3066\u3044\u3066\u3082\u3001\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u306b\u306f\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u6b8b\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u8a8d\u8b58\u3055\u308c\u3066\u3044\u308b(4)\u3002\u305d\u306e\u305f\u3081\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4ecb\u5728\u3059\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3001\u4ed6\u306e\u6a19\u7684\u306b\u3082\u6ce8\u610f\u304c\u5411\u3051\u3089\u308c\u3066\u3044\u308b\u3002 <\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u306f\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u3092\u5f15\u304d\u8d77\u3053\u3059\u30021.\u907a\u4f1d\u5b66\u7684\u3001\u75ab\u5b66\u7684\u3001\u81e8\u5e8a\u7684\u7814\u7a76\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3002\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30d1\u30cd\u30eb\u304b\u3089\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Eur Heart J 2017;38:2459-72.
2.2019 ESC\/EAS Guidelines for the Management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Eur Heart J 2020;41:111-88.
3.2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.Eur Heart J 2021;42:3227-337.
4.\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3051\u308bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u5024\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\uff1a\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002jama 2012;307:1302-9.
5.Nordestgaard BG, Langlois MR, Langsted A, et al.\u8102\u8cea\u4f4e\u4e0b\u6226\u7565\u306e\u305f\u3081\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306e\u5b9a\u91cf\u5316\uff1aEAS\u3068EFLM\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306b\u57fa\u3065\u304f\u52e7\u544a\u3002Atherosclerosis 2020;294:46-61.
6.\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u3068\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002J Am Coll Cardiol 2009;53:316-22.
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