{"id":254406,"date":"2025-01-23T23:31:23","date_gmt":"2025-01-23T22:31:23","guid":{"rendered":"https:\/\/r3i.org\/landmark-reduce-it%e3%81%8b%e3%82%89%e3%81%ae%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%ef%bc%9a%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%8c%e8%99%9a%e8%a1%80\/"},"modified":"2025-02-16T22:39:40","modified_gmt":"2025-02-16T21:39:40","slug":"landmark-reduce-it%e3%81%8b%e3%82%89%e3%81%ae%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%ef%bc%9a%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%8c%e8%99%9a%e8%a1%80","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/landmark-reduce-it%e3%81%8b%e3%82%89%e3%81%ae%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%ef%bc%9a%e3%82%a4%e3%82%b3%e3%82%b5%e3%83%9a%e3%83%b3%e3%83%88%e3%82%a8%e3%83%81%e3%83%ab%e3%81%8c%e8%99%9a%e8%a1%80\/","title":{"rendered":"Landmark – REDUCE-IT\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u304c\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

REDUCE-IT\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u304c\u865a\u8840\u6027\u8133\u6897\u585e\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b<\/span><\/h2>\n
9 2021\u5e748\u6708<\/span><\/h5>\n
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REDUCE-IT\u306e\u65b0\u3057\u3044\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u6700\u521d\u306e\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u309236\uff05\u6e1b\u5c11\u3055\u305b\u308b\u3002<\/span><\/div>\n
Bhatt DL, Steg PG, Miller M, et al. Icosapent Ethyl\u306b\u3088\u308b\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u6e1b\u5c11-REDUCE-IT\u304b\u3089\u306e\u77e5\u898b\u3002Stroke 2021; 52 (Suppl_1).\u56fd\u969b\u8133\u5352\u4e2d\u5b66\u4f1a2021\u53e3\u982d\u767a\u8868\u8981\u65e8 <\/em><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3092\u6709\u3057\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u4e0a\u6607\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b45\u6b73\u4ee5\u4e0a\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9ad8\u7528\u91cf\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u304c\u5168\u8133\u5352\u4e2d\u304a\u3088\u3073\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\nREDUCE-IT\u306f\u591a\u56fd\u7c4d\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002\u60a3\u8005\u306f\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u7cbe\u88fd\u3055\u308c\u305f\u5b89\u5b9a\u306a\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u3067\u3042\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff084g\/\u65e5\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u3088\u308b\u6cbb\u7642\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u60a3\u8005\u306f\u4e2d\u592e\u5024\u30674.9\u5e74\u9593\u8ffd\u8de1\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\nREDUCE-IT\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u4e2d\u592e\u502475mg\/dL\u307e\u305f\u306f1.94mmol\/L\uff09\u3068\u9ad8TG\uff08\u4e2d\u592e\u5024216mg\/dL\u307e\u305f\u306f2.44mmol\/L\uff09\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u80058179\u4eba\u3092\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e71\uff05\u304c\u4e8c\u6b21\u4e88\u9632\u3092\u53d7\u3051\u3066\u304a\u308a\u300129\uff05\u304c\u7cd6\u5c3f\u75c5\u3068\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u4ed8\u52a0\u7684\u5371\u967a\u56e0\u5b50\u3092\u6709\u3057\u3066\u3044\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u7d50\u679c<\/strong><\/td>\n\u521d\u767a\u8133\u5352\u4e2d\u3001\u521d\u767a\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u521d\u767a\u51fa\u8840\u6027\u8133\u5352\u4e2d<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\n\u4e8b\u524d\u898f\u5b9a\u304a\u3088\u3073\u4e8b\u5f8c\u5206\u6790<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n\n\n\n\n\n\n
\n

 <\/p>\n<\/td>\n

\n

\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff08N=4089\uff09<\/p>\n<\/td>\n

\n

\u30d7\u30e9\u30bb\u30dc\uff08N=4090\uff09<\/p>\n<\/td>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

p\u5024<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30a4\u30d9\u30f3\u30c8\u6599\u91d1<\/p>\n<\/td>\n<\/tr>\n

\n

\u8133\u5352\u4e2d<\/p>\n<\/td>\n

\n

2.4%<\/p>\n<\/td>\n

\n

3.3%<\/p>\n<\/td>\n

\n

0.72 (0.55-0.93)<\/p>\n<\/td>\n

\n

0.01<\/p>\n<\/td>\n<\/tr>\n

\n

\u865a\u8840\u6027\u8133\u5352\u4e2d<\/p>\n<\/td>\n

\n

2.0%<\/p>\n<\/td>\n

\n

3.0%<\/p>\n<\/td>\n

\n

0.64 (0.49-0.85)<\/p>\n<\/td>\n

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0.002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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<\/div>\n
\u7d50\u8ad6<\/strong><\/div>\n
\n\n\n\n
REDUCE-IT\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u3001\u9ad8TG\u3067\u52d5\u8108\u786c\u5316\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u3092\u6709\u3059\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f\u304c\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d\u3067\u306f\u904e\u5270\u3067\u306f\u306a\u304b\u3063\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u6291\u5236\u8a66\u9a13\uff09\u306f\u3001\u9ad8\u7528\u91cf\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff084g\/\u65e5\uff09\u6295\u4e0e\u304c\u3001\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u306b\u3082\u304b\u304b\u308f\u3089\u305aTG\u5024\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u9ad8\u30ea\u30b9\u30af\u306e\u4e00\u6b21\u4e88\u9632\u304a\u3088\u3073\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6709\u610f\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\uff081\uff09\u3002\u3053\u306e\u52b9\u679c\u306b\u306fTG\u4f4e\u4e0b\u4f5c\u7528\u4ee5\u5916\u306e\u4f5c\u7528\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u304c\uff082\uff09\uff0c\u3053\u306e\u7814\u7a76\u306f\uff0cTG\u4e0a\u6607\uff08TG\u30ea\u30c3\u30c1\u306a\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u5b58\u7269\u306e\u4ee3\u66ff\u7269\uff09\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u3044\u3046\u6982\u5ff5\u3092\u793a\u3059\u753b\u671f\u7684\u306a\u3082\u306e\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u307e\u305f\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308bTG\u4e0a\u6607\u306e\u7ba1\u7406\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u63a8\u5968\u3092\u5909\u66f4\u3059\u308b\u306e\u306b\u5f79\u7acb\u3063\u305f(3)\u3002 <\/p>\n

REDUCE-IT\u306b\u3088\u308b\u3053\u306e\u6700\u65b0\u306e\u89e3\u6790\u306f\u3001\u9ad8\u7528\u91cf\u306e\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u304c\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306e\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u3082\u6e1b\u5c11\u3055\u305b\u305f\u3053\u3068\u3092\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u8ffd\u52a0\u3055\u308c\u305f\u3002\u7279\u306b\u3001\u6700\u521d\u306e\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c36\uff05\u6e1b\u5c11\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u8133\u5352\u4e2d\u304c\u793e\u4f1a\u3001\u533b\u7642\u30b7\u30b9\u30c6\u30e0\u3001\u60a3\u8005\u3068\u305d\u306e\u4ecb\u8b77\u8005\u306b\u4e0e\u3048\u308b\u8ca0\u62c5\u3092\u8003\u3048\u308b\u3068\u91cd\u8981\u3067\u3042\u308b(4)\u3002\u4e16\u754c\u7684\u306b\u3001\u5e74\u9f62\u6a19\u6e96\u5316\u3055\u308c\u305f\u8133\u5352\u4e2d\u306e\u8ca0\u62c5\u306f\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u4e3b\u306b\u4eba\u53e3\u306e\u5897\u52a0\u3068\u9ad8\u9f62\u5316\u306b\u8d77\u56e0\u3059\u308b\u75c7\u4f8b\u6570\u306e\u5897\u52a0\uff081990\u5e74\u304b\u30892017\u5e74\u306e\u9593\u306b\u307b\u307c\u500d\u5897\uff09\u306f\u3001\u53ef\u9006\u7684\u306a\u5371\u967a\u56e0\u5b50\u3092\u7279\u5b9a\u3059\u308b\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\uff085\uff09\u3002REDUCE-IT\u304b\u3089\u5f97\u3089\u308c\u305f\u3053\u308c\u3089\u306e\u6700\u65b0\u306e\u77e5\u898b\u306f\u3001\u8133\u5352\u4e2d\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306bTG\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3059\u308b\u5f79\u5272\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/p>\n

\u3053\u306e\u5206\u6790\u306e\u5b8c\u5168\u306a\u5831\u544a\u304c\u5f85\u305f\u308c\u308b\u3002<\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/p>\n

2.Sharma G, Martin SS, Blumenthal RS.\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306e\u52b9\u679c\uff1a\u4f55\u304c\u6700\u3082\u91cd\u8981\u304b\uff1a\u85ac\u7269\u3001\u7528\u91cf\u3001\u30d7\u30e9\u30bb\u30dc\uff1fJAMA 2020;324:2262-4. <\/p>\n

3.\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306e2019\u5e74ESC\/EAS\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u8102\u8cea\u4fee\u98fe\u3002Eur Heart J 2020;41:111-88. <\/p>\n

4.Khan SU, Khan MZ, Khan MU, et al. \u7c73\u56fd\u306b\u304a\u3051\u308b\u82e5\u5e74\u30fb\u4e2d\u5e74\u30fb\u9ad8\u9f62\u8005\u306e\u8133\u5352\u4e2d\u306e\u81e8\u5e8a\u7684\u30fb\u7d4c\u6e08\u7684\u8ca0\u62c5\u30012002-2017\u5e74\u3002Mayo Clin Proc Innov Qual Outcomes.2021;5:431-41. <\/p>\n

5.Morovatdar N, Avan A, Azarpazhooh MR, et al. 1990\u5e74\u304b\u30892017\u5e74\u307e\u3067\u306e\u9ad8\u6240\u5f97\u56fd\u306b\u304a\u3051\u308b\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3001\u8133\u5352\u4e2d\u3001\u8a8d\u77e5\u75c7\u306e\u7d4c\u5e74\u7684\u50be\u5411\uff1aGlobal Burden of Disease Study 2017.Neurol Sci 2021; doi: 10.1007\/s10072-021-05259-2. <\/p>\n<\/td>\n<\/tr>\n

\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\uff1b\u8133\u5352\u4e2d\uff1b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff1bREDUCE-IT<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

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