{"id":254403,"date":"2025-01-25T15:55:49","date_gmt":"2025-01-25T14:55:49","guid":{"rendered":"https:\/\/r3i.org\/landmark-cantos%e3%81%8b%e3%82%89%e3%81%ae%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%ef%bc%9a%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%ad%e3%82%a4%e3%82%ad%e3%83%b36%e3%82%b7%e3%82%b0%e3%83%8a%e3%83%ab\/"},"modified":"2025-02-16T22:39:06","modified_gmt":"2025-02-16T21:39:06","slug":"landmark-cantos%e3%81%8b%e3%82%89%e3%81%ae%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%ef%bc%9a%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%ad%e3%82%a4%e3%82%ad%e3%83%b36%e3%82%b7%e3%82%b0%e3%83%8a%e3%83%ab","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/landmark-cantos%e3%81%8b%e3%82%89%e3%81%ae%e3%83%8b%e3%83%a5%e3%83%bc%e3%82%b9%ef%bc%9a%e3%82%a4%e3%83%b3%e3%82%bf%e3%83%bc%e3%83%ad%e3%82%a4%e3%82%ad%e3%83%b36%e3%82%b7%e3%82%b0%e3%83%8a%e3%83%ab\/","title":{"rendered":"Landmark – CANTOS\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9\uff1a\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u8abf\u7bc0\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

CANTOS\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9\uff1a\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u8abf\u7bc0\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b<\/span><\/h2>\n
2018 \u5e74 11 \u6708 6 \u65e5<\/span><\/h5>\n
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Canakinumab Anti-Inflammatory Thrombosis Outcomes Study\uff08CANTOS\uff09\u304b\u3089\u5f97\u3089\u308c\u305f\u65b0\u305f\u306a\u77e5\u898b\u306b\u3088\u308a\u3001\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306b\u3088\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff08IL-6\uff09\u7d4c\u8def\u306e\u6a19\u7684\u5316\u304c\u3001\u8102\u8cea\u4f4e\u4e0b\u3068\u306f\u7121\u95a2\u4fc2\u306b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3044\u3046\u6982\u5ff5\u5b9f\u8a3c\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u305f\u3002<\/span><\/div>\n
Ridker PM\u3001Libby P\u3001MacFadyen JG\u3089\uff1a\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u8abf\u7bc0\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u5168\u6b7b\u56e0\u6b7b\u4ea1\u306e\u767a\u751f\u7387\uff1a\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u6297\u708e\u75c7\u6027\u8840\u6813\u75c7\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\uff08CANTOS\uff09\u306e\u89e3\u6790\u3002Eur Heart J 2018; doi:10.1093\/eurheartj\/ehy310 <\/span><\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nCANTOS\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u6709\u76ca\u306a\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u304c\u3001IL-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u5bfe\u3059\u308b\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306e\u52b9\u679c\u306b\u3088\u3063\u3066\u3082\u5a92\u4ecb\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\nCANTOS\u306f\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3067\u3042\u308a\u3001\u52d5\u8108\u786c\u5316\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u9632\u3092\u76ee\u7684\u3068\u3057\u3066\u30013\u30f5\u6708\u306b1\u56de\u3001\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306e3\u7528\u91cf\uff0850mg\u3001150mg\u3001300mg\uff09\u3092\u8a55\u4fa1\u3057\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3<\/strong><\/td>\nCANTOS\u306e4,833\u4f8b\u306eIL-6\u5024\u3092\u7121\u4f5c\u70ba\u5316\u524d\u3068\u30d7\u30e9\u30bb\u30dc\u307e\u305f\u306f\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u6295\u4e0e3\u30f5\u6708\u5f8c\u306b\u6e2c\u5b9a\u3057\u305f\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u6709\u52b9\u6027\u306e\u5909\u6570\uff1a<\/strong><\/td>\n\n

– CANTOS\u306e\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u518d\u767a\u3001\u8133\u5352\u4e2d\u3001\u5fc3\u8840\u7ba1\u6b7b\u306e\u8907\u5408\uff08MACE\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n

– \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306b\u7dca\u6025\u51a0\u8840\u884c\u518d\u5efa\u8853\u3092\u5fc5\u8981\u3068\u3059\u308b\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u3092\u52a0\u3048\u305f\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u5fc3\u8840\u7ba1\u6b7b\u3068\u5168\u6b7b\u4ea1\u3067\u3042\u3063\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\n

\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u6295\u4e0e\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u60a3\u8005\u306f\u30013\u30f5\u6708\u5f8c\u306eIL-6\u6e2c\u5b9a\u5024\uff08<1.65 ng\/L\u307e\u305f\u306f\u22671.65 ng\/L\u3001\u521d\u56de\u6295\u4e0e\u5f8c\u306e\u7a4d\u6975\u7684\u6cbb\u7642\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u60a3\u8005\u306e\u6cbb\u7642\u4e2d\u4e2d\u592e\u5024\uff09\u306b\u57fa\u3065\u3044\u3066\u3001\u30a2\u30d7\u30ea\u30aa\u30ea\u306b2\u7fa4\u306b\u5206\u3051\u3089\u308c\u305f\u3002<\/p>\n

\u5fc3\u7b4b\u6897\u585e\u767a\u75c7\u304b\u3089\u306e\u7d4c\u904e\u6642\u9593\u3067\u5c64\u5225\u5316\u3057\u305fCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001MACE\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u4ea1\u306e\u76f8\u5bfe\u30cf\u30b6\u30fc\u30c9\u3092\u63a8\u5b9a\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eIL-6\u5024\u306f\u5c06\u6765\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u6700\u4f4e\u5024\u7fa4\u306b\u6bd4\u3079\u3001\u4e2d\u9593\u5024\u7fa4\u3067\u306f15\uff05\u3001\u6700\u9ad8\u5024\u7fa4\u3067\u306f47\uff05\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306f3\u30f5\u6708\u5f8c\u306eIL-6\u5024\u3092\u5168\u4f53\u306734.9\uff05\u6e1b\u5c11\u3055\u305b\u305f\uff08p< 0.001\uff09\u3002\u3053\u308c\u3089\u306e\u52b9\u679c\u306f\u7528\u91cf\u4f9d\u5b58\u7684\u3067\u3042\u308a\u3001\u6e1b\u5c11\u7387\u306e\u4e2d\u592e\u5024\u306f50mg\u7fa4\u306724.5\uff05\u3001150mg\u7fa4\u306735.8\uff05\u3001300mg\u7fa4\u306742.7\uff05\u3067\u3042\u3063\u305f\u3002 <\/p>\n

IL-6\u5024<1.65 ng\/L\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u3067\u306f\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u304a\u3088\u3073\u4e3b\u8981\u526f\u6b21\u7684MACE\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3001\u306a\u3089\u3073\u306b\u5fc3\u8840\u7ba1\u7cfb\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u7387\u304c\u6709\u610f\u306b\u6e1b\u5c11\u3057\u305f\uff08\u88681\uff09\u3002\u6cbb\u7642\u4e2d\u306eIL-6\u5024\u304c1.65ng\/L\u4ee5\u4e0a\u306e\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u7fa4\u3067\u306f\u6709\u610f\u306a\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/p>\n

 <\/p>\n

\u88681. IL-6\u5024\u304c1.65ng\/L\u306b\u9054\u3057\u305f\u60a3\u8005\u306b\u304a\u3051\u308bMACE\u304a\u3088\u3073\u6b7b\u4ea1\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<<\/strong><\/p>\n\n\n\n\n\n\n\n
\n

\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8<\/strong><\/p>\n<\/td>\n

\n

\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd4<\/strong><\/p>\n<\/td>\n

\n

p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e00\u6b21MACE<\/p>\n<\/td>\n

\n

0.68 (0.56-0.82)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u526f\u6b21\u7684MACE<\/p>\n<\/td>\n

\n

0.70 (0.59-0.84)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387<\/p>\n<\/td>\n

\n

0.48 (0.34-0.68)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387<\/p>\n<\/td>\n

\n

0.52 (0.40-0.68)<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u5e74\u9f62\u3001\u6027\u5225\u3001\u55ab\u7159\u306e\u6709\u7121\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u6e80\u5ea6\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068IL-6\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u3067\u8abf\u6574\u3002<\/span><\/strong><\/p>\n

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\u8457\u8005\u3089\u306e\u7d50\u8ad6<\/strong><\/td>\nCANTOS\u306f\u3001\u5c11\u306a\u304f\u3068\u3082\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306b\u3088\u308bIL-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u8abf\u7bc0\u304c\u3001\u8102\u8cea\u4f4e\u4e0b\u3068\u306f\u7121\u95a2\u4fc2\u306b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3059\u308b\u3068\u3044\u3046\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u6982\u5ff5\u5b9f\u8a3c\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u63d0\u4f9b\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u3057\u304b\u3057\u3001\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306e\u6a19\u7684\u3067\u3042\u308bIL-1\u03b2\u306b\u3088\u3063\u3066\u5f37\u304f\u8a98\u5c0e\u3055\u308c\u308bIL-6\u304c\u3001\u5c06\u6765\u306e\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u30892\u3001IL-6\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u3082\u5f37\u3044\u72b6\u6cc1\u8a3c\u62e0\u304c\u3042\u308b3\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001IL-6\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u8840\u6813\u75c7\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u76f4\u63a5\u7684\u306a\u8a3c\u62e0\u3067\u3042\u308a\u3001\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u5316\u7814\u7a764,5\u3084\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u3092\u62e1\u5927\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u7d50\u679c\u306f\u3001LDL-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u95a2\u3059\u308b\u8a66\u9a13\u3067\u898b\u3089\u308c\u305f\u3088\u3046\u306b\u3001\u5c11\u306a\u304f\u3068\u3082\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u6cbb\u7642\u306b\u95a2\u3057\u3066\u306f\u3001\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306f\u300c\u4f4e\u3044\u65b9\u304c\u826f\u3044\u300d\u3068\u3044\u3046\u6982\u5ff5\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b6\u3002 <\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Ridker PM, Everett BM, Thuren T et al. \u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306b\u3088\u308b\u6297\u708e\u75c7\u7642\u6cd5\u3002N Engl J Med 2017;377:1119-31. <\/p>\n

2.\u5897\u6b96\u6027\u3042\u308b\u3044\u306f\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-1\u6d3b\u6027\u5316\u30d2\u30c8\u8840\u7ba1\u5e73\u6ed1\u7b4b\u7d30\u80de\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u3092\u5927\u91cf\u306b\u5206\u6ccc\u3059\u308b\u3002J Clin Invest 1990;85:731-8. <\/p>\n

3.Ridker PM, Rifai N, Stampfer MJ, Hennekens CH.\u898b\u304b\u3051\u4e0a\u5065\u5eb7\u306a\u7537\u6027\u306b\u304a\u3051\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\u306e\u8840\u6f3f\u6fc3\u5ea6\u3068\u5c06\u6765\u306e\u5fc3\u7b4b\u6897\u585e\u30ea\u30b9\u30af\u3002Circulation 2000;101:1767-72. <\/p>\n

4.\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306b\u304a\u3051\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\u53d7\u5bb9\u4f53\u7d4c\u8def\uff1a82\u7814\u7a76\u306e\u5171\u540c\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002Lancet 2012;379:1205-13. <\/p>\n

5.Swerdlow DI, Holmes MV, Kuchenbaecker KB et al. Interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.Lancet 2012;379:1214-24. <\/p>\n

6.Sabatine MS\u3001Giugliano RP\u3001Keech AC\u3089\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u3068\u81e8\u5e8a\u8ee2\u5e30\u3002N Engl J Med 2017;376:1713-22. <\/p>\n

7.Fruchart JC, Davignon J, Hermans MP et al. Residual macrovascular risk in 2013: What have we learned?Cardiovasc Diabetol 2014;13:26. <\/p>\n<\/td>\n<\/tr>\n

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