{"id":254401,"date":"2025-01-23T23:18:10","date_gmt":"2025-01-23T22:18:10","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e6%96%b0%e3%81%97%e3%81%84%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%e3%81%ab%e3%82%88%e3%82%8a%e3%80%812%e5%9e%8b\/"},"modified":"2025-02-16T22:38:21","modified_gmt":"2025-02-16T21:38:21","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e6%96%b0%e3%81%97%e3%81%84%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%e3%81%ab%e3%82%88%e3%82%8a%e3%80%812%e5%9e%8b","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e6%96%b0%e3%81%97%e3%81%84%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%e3%81%ab%e3%82%88%e3%82%8a%e3%80%812%e5%9e%8b\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – \u65b0\u3057\u3044\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308a\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u518d\u78ba\u8a8d\u3055\u308c\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u65b0\u305f\u306a\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308a\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u518d\u78ba\u8a8d\u3055\u308c\u308b<\/span><\/h2>\n
2 2021\u5e7411\u6708<\/span><\/h5>\n
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6\u4e07\u4eba\u4ee5\u4e0a\u306e2\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\u60a3\u8005\u306e\u30c7\u30fc\u30bf\u3092\u542b\u3080\u3053\u306e\u6700\u65b0\u306e\u5831\u544a\u3067\u306f\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff08GLP-1\uff09\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u5168\u6b7b\u4ea1\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3001\u814e\u6a5f\u80fd\u60aa\u5316\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/div>\n
Sattar N, Lee MMY, Kristensen SL, et al. 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u3001\u6b7b\u4ea1\u7387\u3001\u814e\u81d3\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002Lancet Diabetes Endocrinol 2021; doi: 10.1016\/S2213-8587(21)00203-5.Online ahead of print. <\/em><\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nT2DM\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u6700\u65b0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7528\u3044\u3066\uff0cGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u5fc3\u8840\u7ba1\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3068\u30ea\u30b9\u30af\u3092\u691c\u8a0e\u3059\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\nT2DM\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\uff08>500\u4f8b\uff09\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n60,080\u4eba\u306e\u60a3\u8005\u304b\u3089\u306a\u308b8\u3064\u306e\u8a66\u9a13\u3002\u3059\u3079\u3066\u306e\u8a66\u9a13\u306e\u4e3b\u8981\u8ee2\u5e30\u306f\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u8a66\u9a13\u306e\u7d50\u679c<\/strong><\/td>\n– \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u3001\u3059\u306a\u308f\u3061\u5fc3\u8840\u7ba1\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3002
– \u305d\u306e\u4ed6\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u5168\u6b7b\u4ea1\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3001\u8907\u5408\u814e\u30a2\u30a6\u30c8\u30ab\u30e0\uff08\u30de\u30af\u30ed\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u306e\u767a\u73fe\u3001\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u306e\u500d\u52a0\u3001\u307e\u305f\u306f\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff08eGFR\uff09\u306e40\uff05\u4ee5\u4e0a\u306e\u4f4e\u4e0b\u3001\u814e\u4ee3\u66ff\u7642\u6cd5\u3001\u814e\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u3068\u5b9a\u7fa9\uff09\u3001\u814e\u6a5f\u80fd\u306e\u60aa\u5316\uff08eGFR\u306e\u5909\u5316\u306b\u57fa\u3065\u304f\uff09
\u30fb\u4e3b\u8981\u5b89\u5168\u6027\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u91cd\u75c7\u4f4e\u8840\u7cd6\u3001\u7db2\u819c\u75c7\u3001\u81b5\u708e\u3001\u81b5\u304c\u3093<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\n\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u3088\u308a\u3001\u4e0a\u8a18\u3067\u5b9a\u7fa9\u3057\u305f\u5404\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5168\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u63a8\u5b9a\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306fMACE\u309214\uff05\u3001\u5168\u6b7b\u4ea1\u309212\uff05\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u309211\uff05\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u3001\u814e\u81d3\u306e\u8ee2\u5e30\u309221\uff05\u6539\u5584\u3057\u305f\uff08\u88681<\/strong>\uff09\u3002\u307e\u305f\u3001GLP\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u6cbb\u7642\u306b\u95a2\u9023\u3057\u305f\u91cd\u75c7\u4f4e\u8840\u7cd6\u3001\u7db2\u819c\u75c7\u3001\u81b5\u81d3\u306e\u6709\u5bb3\u4f5c\u7528\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u69cb\u9020\u7684\u76f8\u540c\u6027\u306b\u3088\u308b\u6709\u610f\u306a\u4e0d\u5747\u4e00\u6027\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/p>\n

\u88681. \u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u306e\u8ee2\u5e30\u3068\u5168\u6b7b\u4ea1\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05\u4fe1\u983c\u533a\u9593<\/strong><\/p>\n\n\n\n\n\n\n\n
\n

\u6210\u679c<\/strong><\/p>\n<\/td>\n

\n

HR\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff09<\/strong><\/p>\n<\/td>\n

\n

p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

MACE<\/p>\n<\/td>\n

\n

0.86\uff0895\uff05\u4fe1\u983c\u533a\u9593 0.80-0.93\uff09<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n<\/tr>\n

\n

\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662<\/p>\n<\/td>\n

\n

0.89\uff0895\uff05\u4fe1\u983c\u533a\u9593 0.82-0.98\uff09<\/p>\n<\/td>\n

\n

0.013<\/p>\n<\/td>\n<\/tr>\n

\n

\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387<\/p>\n<\/td>\n

\n

0.88\uff0895\uff05\u4fe1\u983c\u533a\u9593 0.82-0.94\uff09<\/p>\n<\/td>\n

\n

0.0001<\/p>\n<\/td>\n<\/tr>\n

\n

\u814e\u81d3\u306e\u8907\u5408\u8ee2\u5e30<\/p>\n<\/td>\n

\n

0.79\uff0895\uff05\u4fe1\u983c\u533a\u9593 0.73-0.87\uff09<\/p>\n<\/td>\n

\n

<0.0001<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\nGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u69cb\u9020\u7684\u76f8\u540c\u6027\u306b\u304b\u304b\u308f\u3089\u305a\u3001T2DM\u60a3\u8005\u306b\u304a\u3051\u308b\u500b\u3005\u306eMACE\u69cb\u6210\u56e0\u5b50\u3001\u5168\u6b7b\u4ea1\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3001\u814e\u6a5f\u80fd\u60aa\u5316\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3088\u308b\u6cbb\u7642\u304c\u3001\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u306f\u7121\u95a2\u4fc2\u306b\u5fc3\u8840\u7ba1\u7cfb\u306e\u8ee2\u5e30\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u3044\u3046\u5e83\u7bc4\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u793a\u3055\u308c\u3066\u3044\u308b(1-4)\u3002\u305d\u306e\u7d50\u679c\u3001GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u6709\u3059\u308b\u304b\u3001\u307e\u305f\u306f\u30ea\u30b9\u30af\u306e\u9ad8\u3044T2DM\u60a3\u8005\u306b\u5bfe\u3059\u308b\u56fd\u969b\u7684\u306a\u5185\u5206\u6ccc\u30fb\u5faa\u74b0\u5668\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u512a\u5148\u7684\u306b\u652f\u6301\u3055\u308c\u3066\u3044\u308b\u65b0\u3057\u3044\u7cd6\u5c3f\u75c5\u6cbb\u7642\u85ac\u306e\u4e00\u3064\u3067\u3042\u308b(5,6)\u3002\u3057\u304b\u3057\u3001\u814e\u81d3\u306e\u8ee2\u5e30\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u306f\u4e0d\u660e\u306a\u70b9\u304c\u591a\u3044(7-9)\u3002 <\/p>\n

\u4eca\u56de\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u3001\u3053\u308c\u3089\u306e\u4e0d\u78ba\u5b9f\u6027\u3092\u89e3\u6c7a\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u305d\u306e\u7d50\u679c\u3001T2DM\u60a3\u8005\u306b\u304a\u3051\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u3068\u814e\u81d3\u306e\u4e21\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u7684\u6709\u7528\u6027\u304c\u660e\u3089\u304b\u306b\u793a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u30a8\u30ad\u30bb\u30f3\u30c7\u30a3\u30f3-4\u3092\u30d9\u30fc\u30b9\u3068\u3059\u308bGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306b\u5dee\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u672c\u5831\u544a\u306e\u77e5\u898b\u306f\u3001T2DM\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u4e88\u9632\u306e\u305f\u3081\u306eGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u4f7f\u7528\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u63a8\u5968\u3092\u5f37\u5316\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306f\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u7f79\u60a3\u7387\u3068\u6b7b\u4ea1\u7387\u306e\u4e3b\u8981\u306a\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u814e\u81d3\u306e\u8ee2\u5e30\u306b\u597d\u307e\u3057\u3044\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u975e\u5e38\u306b\u91cd\u8981\u3067\u3042\u308b\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.McGuire DK, Pagidipati NJ.GLP1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\uff1a\u6297\u9ad8\u8840\u7cd6\u85ac\u304b\u3089\u5fc3\u8840\u7ba1\u6cbb\u7642\u85ac\u3078\u3002Lancet Diabetes Endocrinology 2021; https:\/\/doi.org\/10.1016\/S2213-8587(21)00212-6<\/a>
2.Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes.N Engl J Med 2016;375:311-22.
3.Hernandez AF, Green JB, Janmohamed S, et al. Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomized placebo-controlled trial.Lancet 2018;392:1519-29.
4.Gerstein HC, Colhoun HM, Dagenais GR, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.Lancet 2019;394:121-30
5.Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS Guidelines for the Management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Eur Heart J 2020;41:111-88.
6.Cosentino F, Grant PJ, Ab V, et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD\uff1aThe Task Force for diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and the European Association for the Study of Diabetes (EASD).Eur Heart J 2020;41255-323.
7.2\u578b\u7cd6\u5c3f\u75c5\u3068\u6162\u6027\u814e\u81d3\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bSGLT-2\u963b\u5bb3\u85ac\u3068GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u30a2\u30a6\u30c8\u30ab\u30e0\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u30e1\u30bf\u89e3\u6790\u3002Cardiovasc Diabetol 2021;20(1):14.
8.Bellary S, Tahrani AA, Barnett AH.\u7cd6\u5c3f\u75c5\u6027\u814e\u75be\u60a3\u306e\u7ba1\u7406\u6539\u5584\uff1aGLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306e\u5f79\u5272\u306f\u3042\u308b\u304b\uff1fLancet Diabetes Endocrinol 2020 Nov;8(11):870-871.
9.SGLT-2\u963b\u5bb3\u85ac\u3068GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u7cd6\u5c3f\u75c5\u3068\u6162\u6027\u814e\u81d3\u75c5\u60a3\u8005\u306e\u814e\u4fdd\u8b77\u3068\u5fc3\u4fdd\u8b77\u306b\u6709\u7528\u3067\u3042\u308b\u3002ERA-EDTA\u306eEURECA-m\u3068DIABESITY\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u30b9\u30c6\u30fc\u30c8\u30e1\u30f3\u30c8\u3002Nephrol Dial Transplant.2020\u5e7410\u67081\u65e5;35(10):1825 <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n:\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff08GLP-1\uff09\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3001\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3001MACE\u3001\u814e\u30a2\u30a6\u30c8\u30ab\u30e0<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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