{"id":254399,"date":"2025-01-25T13:51:40","date_gmt":"2025-01-25T12:51:40","guid":{"rendered":"https:\/\/r3i.org\/landmark-reduce-it%e3%81%ab%e3%82%88%e3%82%8b%e3%81%95%e3%82%89%e3%81%aa%e3%82%8b%e6%b4%9e%e5%af%9f%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4%e3%83%99%e3%83%b3%e3%83%88%e7%b7%8f%e6%95%b0%e3%81%b8\/"},"modified":"2025-02-16T22:37:54","modified_gmt":"2025-02-16T21:37:54","slug":"landmark-reduce-it%e3%81%ab%e3%82%88%e3%82%8b%e3%81%95%e3%82%89%e3%81%aa%e3%82%8b%e6%b4%9e%e5%af%9f%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4%e3%83%99%e3%83%b3%e3%83%88%e7%b7%8f%e6%95%b0%e3%81%b8","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/landmark-reduce-it%e3%81%ab%e3%82%88%e3%82%8b%e3%81%95%e3%82%89%e3%81%aa%e3%82%8b%e6%b4%9e%e5%af%9f%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4%e3%83%99%e3%83%b3%e3%83%88%e7%b7%8f%e6%95%b0%e3%81%b8\/","title":{"rendered":"Landmark – REDUCE-IT\u306b\u3088\u308b\u3055\u3089\u306a\u308b\u6d1e\u5bdf\uff1a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u7dcf\u6570\u3078\u306e\u5f71\u97ff"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

REDUCE-IT\u306b\u3088\u308b\u3055\u3089\u306a\u308b\u6d1e\u5bdf\uff1a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u7dcf\u6570\u3078\u306e\u5f71\u97ff<\/span><\/h2>\n
2020\u5e743\u670819\u65e5<\/span><\/h5>\n
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\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u3001\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u3067\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b2\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4e0a\u6607\u306e\u3042\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u5168\u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u30a4\u30d9\u30f3\u30c8\u306e\u8ca0\u62c5\u3092\u8efd\u6e1b\u3057\u305f\u3002<\/span><\/div>\n
Bhatt DL\u3001Steg PG\u3001Miller M\u3089\u3001\u7dcf\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u52b9\u679c\u3002REDUCE-IT\u3088\u308a\u3002J Am Coll Cardiol 2019;73:2791’\u00c4\u00ec802. <\/span><\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u865a\u8840\u30a4\u30d9\u30f3\u30c8\uff08\u521d\u56de\u30a4\u30d9\u30f3\u30c8\u3068\u305d\u308c\u4ee5\u964d\u306e\u30a4\u30d9\u30f3\u30c8\uff09\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u8a55\u4fa1\u3057\uff0c\u8a66\u9a13\u96c6\u56e3\u5168\u4f53\u306b\u304a\u3051\u308b\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u8ca0\u62c5\u3092\u3088\u308a\u660e\u78ba\u306b\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3002\u60a3\u8005\u3092\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb4g\/\u65e5\uff081\u56de2g\u30011\u65e52\u56de\u98df\u4e8b\u3068\u3068\u3082\u306b\u3001n=4,089\uff09\u3068\u30d7\u30e9\u30bb\u30dc\uff08n=4,090\uff09\u306b1\uff1a1\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3<\/strong><\/td>\n\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09135mg\/dL\u4ee5\u4e0a\u3001<500mg\/dL\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u4e2d\u592e\u5024216mg\/dL\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb>40mg\/dL\u4ee5\u4e0a100mg\/dL\u672a\u6e80\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u4e2d\u592e\u502475mg\/dL\uff09\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\uff08\u51a0\u52d5\u8108\u3001\u8133\u3001\u672b\u68a2\uff09\u306e\u65e2\u5f80\u304c\u3042\u308b\u304b\u3001\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u80058,179\u4f8b\u3002<\/td>\n<\/tr>\n
\u4e3b\u8981\u5909\u6570\uff1a<\/strong><\/td>\n– \u4e00\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff1a\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u304b\u3089\u306a\u308b\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u8a08\uff08\u3059\u306a\u308f\u3061\u3001\u521d\u56de\uff0b\u305d\u306e\u5f8c\uff09
– \u4e3b\u8981\u4e8c\u6b21\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff1a\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u306e\u7dcf\u8a08\uff08\u3059\u306a\u308f\u3061\u3001\u521d\u56de\uff0b\u305d\u306e\u5f8c\uff09\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u8907\u6570\u306e\u7d71\u8a08\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305fREDUCE-IT\u306e\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3002\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u3068\u767a\u751f\u7387\u6bd4\u3092\u7b97\u51fa\u3059\u308b\u4e8c\u9805\u56de\u5e30\u30e2\u30c7\u30eb\u304c\u4e3b\u8981\u306a\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3067\u3042\u3063\u305f\u3002\u88dc\u52a9\u7684\u306a\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3068\u3057\u3066\u306f\u3001\u4fee\u6b63Wei-Lin-Weissfeld\u6cd5\uff08\u6700\u521d\u306e\u30a4\u30d9\u30f3\u30c8\u30012\u56de\u76ee\u306e\u30a4\u30d9\u30f3\u30c8\u30013\u56de\u76ee\u306e\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u307e\u3067\u306e\u6642\u9593\u306b\u95a2\u3059\u308b\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u7b97\u51fa\uff09\u3001\u304a\u3088\u3073\u5168\u30a4\u30d9\u30f3\u30c8\u3092\u30e2\u30c7\u30eb\u5316\u3059\u308b\u305f\u3081\u306eCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u3092\u7528\u3044\u305fAndersen-Gill\u30e2\u30c7\u30eb\u304c\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n<\/div>\n

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 <\/p>\n

\u88681. \u4e00\u6b21\u304a\u3088\u3073\u4e8c\u6b21\u4e3b\u8981\u4e8b\u8c61\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u306e\u5f71\u97ff<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n\n\n\n\n\n
\u6cbb\u7642<\/strong><\/td>\n\u7387\uff081,000\u60a3\u8005\u5e74\u5f53\u305f\u308a\uff09<\/strong><\/td>\n\u7387\u6bd4\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff09, P<\/strong><\/td>\n<\/tr>\n
\u30d7\u30e9\u30a4\u30de\u30ea\u30fc<\/strong><\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb<\/td>\n61<\/td>\n0.70 (0.62\uff5e0.78); p<0.0001<\/td>\n<\/tr>\n
\u30d7\u30e9\u30bb\u30dc<\/td>\n89<\/td>\n <\/td> \n<\/tr>\n
\u30ad\u30fc\u30fb\u30bb\u30ab\u30f3\u30c0\u30ea\u30fc<\/strong><\/td>\n <\/td>\n <\/td>\n<\/tr>\n
\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb<\/td>\n32<\/td>\n0.72\uff080.63\uff5e0.82\uff09; p< 0.0001<\/td>\n<\/tr>\n
\u30d7\u30e9\u30bb\u30dc<\/td>\n44<\/td>\n <\/td> \n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u307e\u305f\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u521d\u56de\u30012\u56de\u76ee\u4ee5\u964d\u3001\u304a\u3088\u3073\u5168\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u8ca0\u62c5\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u8907\u6570\u306e\u7d71\u8a08\u30e2\u30c7\u30eb\u306b\u3088\u3063\u3066\u8a3c\u660e\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
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\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\uff08ASCVD\uff09\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u542b\u3080\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3067\u306f\u3001\u5f93\u6765\u3001\u975e\u81f4\u6b7b\u7684\u307e\u305f\u306f\u81f4\u6b7b\u7684\u306a\u30a4\u30d9\u30f3\u30c8\u304c\u6700\u521d\u306b\u8d77\u3053\u308b\u307e\u3067\u306e\u671f\u9593\u3092\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3068\u3057\u3066\u9078\u629e\u3057\u3066\u304d\u305f\u3002\u3057\u304b\u3057\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u304c\u60a3\u8005\u3001\u81e8\u5e8a\u533b\u3001\u533b\u7642\u8cc7\u6e90\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8003\u616e\u3057\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u9ad8\u30ea\u30b9\u30af\u304a\u3088\u3073\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308bASCVD\u306e\u7dcf\u8ca0\u62c5\u3092\u8868\u3059\u306b\u306f\u3001\u521d\u56de\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u307e\u3067\u306e\u671f\u9593\u304c\u6700\u9069\u3067\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001PCSK9\u963b\u5bb3\u85ac\u3092\u542b\u3080\u3088\u3046\u306a\u4e3b\u8981\u306a\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u767a\u751f\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u652f\u6301\u3055\u308c\u3064\u3064\u3042\u308b1,2\u3002\u3053\u308c\u306f\u3072\u3044\u3066\u306f\u3001\u60a3\u8005\u306e\u5165\u9662\u3084ASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u306e\u969c\u5bb3\u306e\u6307\u6a19\u306b\u3088\u3063\u3066\u6e2c\u5b9a\u3055\u308c\u308b\u3088\u3046\u306a\u75be\u60a3\u306e\u8ca0\u62c5\u306e\u3088\u308a\u826f\u3044\u63a8\u5b9a\u3092\u63d0\u4f9b\u3059\u308b\u3053\u3068\u306b\u306a\u308b3\u3002 <\/p>\n

REDUCE-IT\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb4g\/\u65e5\u306e\u6295\u4e0e\u306f\u3001\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u304a\u3044\u306625\uff05\u306e\u6709\u610f\u306a\u76f8\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b\u30684.8\uff05\u306e\u7d76\u5bfe\u30ea\u30b9\u30af\u4f4e\u4e0b\u306b\u95a2\u9023\u3057\u305f\u3002\u4e3b\u8981\u306a\u526f\u6b21\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u3082\u540c\u69d8\u3067\u3042\u3063\u305f\uff08\u76f8\u5bfe\u7684\u30ea\u30b9\u30af26\uff05\u6e1b\u5c11\u3001\u7d76\u5bfe\u7684\u30ea\u30b9\u30af3.6\uff05\u6e1b\u5c11\uff094\u3002\u4eca\u56de\u306e\u89e3\u6790\u3067\u306f\u3001REDUCE-IT\u306e\u7814\u7a76\u8005\u3089\u306f\u865a\u8840\u6027\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u6570\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u3092\u5b9a\u91cf\u5316\u3057\u305f\u3002\u3053\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb4g\/\u65e5\u6295\u4e0e\u306f\u7dcf\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u8ca0\u8377\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u51a0\u52d5\u8108\u3001\u8133\u3001\u81f4\u6b7b\u7684\u3001\u975e\u81f4\u6b7b\u7684\u30a4\u30d9\u30f3\u30c8\u3001\u8840\u884c\u518d\u5efa\u8853\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001TG\u4f4e\u4e0b\u306e\u307f\u304c\u539f\u56e0\u3067\u3042\u308b\u3068\u306f\u8003\u3048\u3089\u308c\u305a\u3001REDUCE-IT\u306b\u304a\u3051\u308bicosapent ethyl\u306e\u8907\u6570\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u95a2\u4e0e\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Murphy SA, Pedersen TR, Gaciong ZA, et al. \u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u7dcf\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308bPCSK9\u963b\u5bb3\u85ac\u30a8\u30dc\u30ed\u30af\u30de\u30d6\u306e\u52b9\u679c\uff1aFOURIER\u8a66\u9a13\u306e\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3002JAMA Cardiol 2019;4:613-9. <\/p>\n

2.Szarek M\u3001White HD\u3001Schwartz GG\u3001\u4ed6\uff1a\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306f\u975e\u81f4\u6b7b\u7684\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u81f4\u6b7b\u7684\u30a4\u30d9\u30f3\u30c8\u306e\u5408\u8a08\u3092\u6e1b\u5c11\u3055\u305b\u308b\uff1aODYSSEY OUTCOMES\u8a66\u9a13\u3002J Am Coll Cardiol 2019;73:387-96. <\/p>\n

3.Szarek M, Steg PG, DiCenso D, et al. ODYSSEY OUTCOMES\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306f\u7dcf\u5165\u9662\u3092\u6e1b\u3089\u3057\u3001\u751f\u5b58\u65e5\u6570\u3068\u9000\u9662\u65e5\u6570\u3092\u5897\u52a0\u3055\u305b\u305f\u3002Circ Cardiovasc Qual Outcomes 2019;12(11):e005858. <\/p>\n

4.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/p>\n<\/td>\n<\/tr>\n

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REDUCE-IT\u306b\u3088\u308b\u3055\u3089\u306a\u308b\u6d1e\u5bdf\uff1a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u7dcf\u6570\u3078\u306e\u5f71\u97ff 2020\u5e743\u670819\u65e5 \u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u3001 […]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-254399","page","type-page","status-publish","hentry"],"yoast_head":"\nLandmark - REDUCE-IT\u306b\u3088\u308b\u3055\u3089\u306a\u308b\u6d1e\u5bdf\uff1a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u7dcf\u6570\u3078\u306e\u5f71\u97ff - R3I<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/r3i.org\/ja\/landmark-reduce-it%e3%81%ab%e3%82%88%e3%82%8b%e3%81%95%e3%82%89%e3%81%aa%e3%82%8b%e6%b4%9e%e5%af%9f%ef%bc%9a%e5%bf%83%e8%a1%80%e7%ae%a1%e3%82%a4%e3%83%99%e3%83%b3%e3%83%88%e7%b7%8f%e6%95%b0%e3%81%b8\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Landmark - 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