{"id":254397,"date":"2025-01-21T13:34:07","date_gmt":"2025-01-21T12:34:07","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%e3%81%8b%e3%82%89%e3%81%ae%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e6%83%85%e5%a0%b1\/"},"modified":"2025-02-16T22:37:23","modified_gmt":"2025-02-16T21:37:23","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%e3%81%8b%e3%82%89%e3%81%ae%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e6%83%85%e5%a0%b1","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-reduce-it%e3%81%8b%e3%82%89%e3%81%ae%e3%81%9d%e3%81%ae%e4%bb%96%e3%81%ae%e6%83%85%e5%a0%b1\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – REDUCE-IT\u304b\u3089\u306e\u305d\u306e\u4ed6\u306e\u60c5\u5831"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” theme_builder_area=”post_content” sticky_enabled=”0″]

Landmark –REDUCE-IT\u306e\u8a18\u4e8b
\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u30ea\u30b9\u30af\u8efd\u6e1b\u3092\u4fee\u98fe\u3059\u308b\u304b\uff1f<\/span><\/h2>\n
2024\u5e746\u670827\u65e5<\/span><\/h5>\n
REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial\uff09\u306epost hoc\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306aLp(a)\u5024\u4e0a\u6607\u60a3\u8005\u3092\u542b\u3081\u3001\u30ea\u30dd\u86cb\u767d(a)[Lp(a)] \u306e\u7bc4\u56f2\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u30ea\u30b9\u30af\u3092\u4e00\u8cab\u3057\u3066\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/div>\n
\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u8840\u4e2d\u6fc3\u5ea6\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002J Am Coll Cardiol 2024; 83:1529-39. <\/div>\n\n\n\n\n\n\n\n\n
\u7814\u7a76\u6982\u8981<\/strong><\/td>\n<\/tr>\n
\u76ee\u7684<\/strong><\/td>\nREDUCE-IT\u8a66\u9a13\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306eLp(a)\u5024\u306e\u7bc4\u56f2\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u7cfb\u3078\u306e\u6709\u76ca\u6027\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13REDUCE-IT\u306epost hoc\u89e3\u6790\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/td>\nREDUCE-IT\u8a66\u9a13\u306b\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u307e\u305f\u306f50\u6b73\u4ee5\u4e0a\u3067\u7cd6\u5c3f\u75c5\u30681\u3064\u4ee5\u4e0a\u306e\u8ffd\u52a0\u5371\u967a\u56e0\u5b50\u3092\u6709\u3057\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c91.69\uff5e5.63mmol\/L\uff08150\uff5e499mg\/dL\uff09\u3067\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c\u5b89\u5b9a\u3057\u3066\u3044\u308b\u60a3\u80058,179\u4f8b\u304c\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002\u60a3\u8005\u306f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb2g\u30921\u65e52\u56de\u6295\u4e0e\u3059\u308b\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u4f75\u7528\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u3053\u306e\u89e3\u6790\u306b\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u8a55\u4fa1\u3092\u884c\u3063\u305f7,026\u4f8b\uff08\u7121\u4f5c\u70ba\u5316\u30b3\u30db\u30fc\u30c8\u306e86\uff05\uff09\u304c\u542b\u307e\u308c\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u7fa43,515\u4f8b\u3001\u30d7\u30e9\u30bb\u30dc\u7fa43,511\u4f8b\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/td>\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0<\/strong>REDUCE-IT\u304a\u3088\u3073\u672c\u89e3\u6790\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u521d\u56deMACE\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306e\u8907\u5408\uff09\u3068\u3057\u305f\u3002
\u4e3b\u8981\u526f\u6b21\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1a\u521d\u56de\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u306e\u8907\u5408\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u65b9\u6cd5<\/strong><\/td>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u9023\u7d9a\u7684\u306aLp(a)\u91cf\u6fc3\u5ea6\u3068\u521d\u56deMACE\u304a\u3088\u3073\u5168MACE\uff08\u521d\u56de\u304a\u3088\u3073\u305d\u306e\u5f8c\u306eMACE\uff09\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3001\u306a\u3089\u3073\u306b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u306e\u7bc4\u56f2\u3001\u304a\u3088\u3073Lp(a)\u6fc3\u5ea6\u304c50mg\/dL\u4ee5\u4e0a\u307e\u305f\u306f<50mg\/dL\u306e\u60a3\u8005\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u306e\u521d\u56deMACE\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u52b9\u679c\u3092\u89e3\u6790\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
<\/div>\n
\u7d50\u679c<\/strong><\/div>\n
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\n\n\n\n
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2\u3064\u306e\u6cbb\u7642\u7fa4\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u306f\u985e\u4f3c\u3057\u3066\u304a\u308a\u3001\u5e74\u9f62\u4e2d\u592e\u5024\u306f64\u6b73\u300128\u301c29\uff05\u304c\u5973\u6027\u300171\u301c72\uff05\u304c\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u300130\u301c32\uff05\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u3092\u53d7\u3051\u3066\u3044\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eLp(a)\u6fc3\u5ea6\u306e\u4e2d\u592e\u5024\u306f\u3001\u5168\u7814\u7a76\u30b3\u30db\u30fc\u30c8\u306711.6mg\/dL\uff08\u56db\u5206\u4f4d\u7bc4\u56f2[IQR] 5.0-37.4mg\/dL\uff09\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eLp(a)\u6fc3\u5ea6\u304c50mg\/dL\u4ee5\u4e0a\u306e\u7fa4\u3067\u306f77.1mg\/dL\uff08IQR 63.1-102.3mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002Lp(a)\u306e\u5206\u5e03\u306f\u53f3\u5bc4\u308a\u3067\u3042\u308a\u300150mg\/dL\u4ee5\u4e0a\u306e\u60a3\u8005\u306f20.4\uff05\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u4e2d\u592e\u50244.9\u5e74\uff08IQR 3.6-5.3\u5e74\uff09\u306b\u308f\u305f\u308b\u6700\u521d\u306eMACE\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067804\u4f8b\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u7fa4\u3067635\u4f8b\u304c\u7d4c\u9a13\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u306f\u521d\u56de\u304a\u3088\u3073\u5168MACE\u3068\u6709\u610f\u306a\u95a2\u4fc2\u3092\u793a\u3057\u305f\uff08p< 0.0001\uff09\u3002\u3053\u308c\u3089\u306e\u95a2\u4fc2\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u3084LDL-C\u306e\u5024\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u306a\u304b\u3063\u305f\u3002Lp(a)\u306e\u4e2d\u592e\u5024\u306b\u5bfe\u3059\u308b\u63a8\u5b9a\u521d\u56deMACE\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff08HR\uff09\u306f\u300125mg\/dL\u30671.03\uff0895\uff05CI\uff1a0.98-1.09\uff09\u300150mg\/dL\u30671.12\uff0895\uff05CI\uff1a1.06-1.19\uff09\u3001100mg\/dL\u30671.32\uff0895\uff05CI\uff1a1.17-1.49\uff09\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u304c\u9ad8\u304f\u3066\u3082\u4f4e\u304f\u3066\u3082\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u6709\u52b9\u6027\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u306a\u304b\u3063\u305f\u3002\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001Lp(a)\u6fc3\u5ea6\u304c50mg\/dL\u4ee5\u4e0a\u304a\u3088\u3073<50mg\/dL\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3092\u542b\u3081\u3001Lp(a)\u6fc3\u5ea6\u306e\u7bc4\u56f2\u306b\u308f\u305f\u3063\u3066\u6700\u521d\u306eMACE\u3092\u6e1b\u5c11\u3055\u305b\u305f\uff08\u88681<\/strong>\uff09\u3002 <\/p>\n

 <\/p>\n

\u88681. REDUCE-IT\u306b\u304a\u3051\u308bLp(a)\u5024\u306e\u9055\u3044\u306b\u3088\u308b\u521d\u56deMACE\u306e\u63a8\u5b9a\u30cf\u30b6\u30fc\u30c9\u6bd4<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n
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\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3Lp(a)\u3001mg\/dL<\/p>\n<\/td>\n

\n

HR\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

25<\/p>\n<\/td>\n

\n

0.78 (0.65-0.94)<\/p>\n<\/td>\n<\/tr>\n

\n

50<\/p>\n<\/td>\n

\n

0.79 (0.68-0.92)<\/p>\n<\/td>\n<\/tr>\n

\n

100<\/p>\n<\/td>\n

\n

0.81 (0.66-0.99)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

<50<\/p>\n<\/td>\n

\n

0.75\uff080.66-0.84\uff09\u3001p<0.0001<\/p>\n<\/td>\n<\/tr>\n

\n

\u226550<\/p>\n<\/td>\n

\n

0.79 (0.64-0.97), p=0.0248<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n

\u8457\u8005\u7d50\u8ad6<\/strong><\/td>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bTG\u9ad8\u5024\u306e\u53c2\u52a0\u8005\u306b\u304a\u3051\u308bMACE\u306e\u4e88\u5f8c\u3092\u6c7a\u5b9a\u3057\u305f\u3002\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306f\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u4e0a\u6607\u3092\u793a\u3057\u305f\u60a3\u8005\u3092\u542b\u3081\u3001Lp(a)\u5024\u306e\u7bc4\u56f2\u306b\u308f\u305f\u3063\u3066\u4e00\u8cab\u3057\u3066MACE\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3053\u3068\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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REDUCE-IT\u3067\u306f\u3001Lp(a)\u5024\u304c\u4e0a\u6607\u3057\u305f\u60a3\u8005\u304c\u307b\u3068\u3093\u3069\u3044\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u4e8b\u5b9f\u3084\u3001post hoc\u89e3\u6790\u306b\u4f34\u3046\u6ce8\u610f\u70b9\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u672c\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001Lp(a)\u4f4e\u4e0b\u6cbb\u7642\u85ac\u304b\u3089\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u5229\u76ca\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3067\u89b3\u5bdf\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3092\u88dc\u5b8c\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Kronenberg F, Mora S, Stroes ESG, et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.Eur Heart J. 2022;43:3925-46\u3002
2.Bittner VA, Szarek M, Aylward PE, et al. \u6025\u6027\u51a0\u75c7\u5019\u7fa4\u5f8c\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306e\u52b9\u679c\u3002J Am Coll Cardiol 2020;75:133-44.
3.O’Donoghue ML, Fazio S, Giugliano RP, et al. Lipoprotein(a)\u3001PCSK9\u963b\u5bb3\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3002Circulation 2019;139:1483-92.
4.Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS Guidelines for the Management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Eur Heart J 2020;41:111-88. <\/td>\n<\/tr>\n
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