{"id":254393,"date":"2025-01-25T13:25:08","date_gmt":"2025-01-25T12:25:08","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/"},"modified":"2025-02-16T22:36:07","modified_gmt":"2025-02-16T21:36:07","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba<\/span><\/h2>\n
2020\u5e747\u670820\u65e5<\/span><\/h5>\n
\n
\n
\n
\n
\n
\n
Copenhagen General Population Study\u304b\u3089\u5f97\u3089\u308c\u305f\u65b0\u305f\u306a\u77e5\u898b\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9ad8\u3044\u975e\u671d\u98df\u6642\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306e\u91cd\u8981\u6027\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u305f\u3002<\/span><\/div>\n
Langsted A, Madsen CM, Nordestgaard BG.\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5bc4\u4e0e\u3002J Intern Med 2020; doi: 10.1111\/joim.13059.Online ahead of print. <\/em><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u975e\u7a7a\u8179\u6642\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u65e2\u5f80\u304c\u3042\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30cb\u30fc\u30ba\u304c\u5b58\u5728\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\u30c7\u30f3\u30de\u30fc\u30af\u306e\u6210\u4eba\u4e00\u822c\u4eba\u53e3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\uff08Copenhagen General Population Study\uff09<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u307e\u305f\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u3068\u8a3a\u65ad\u3055\u308c\u305f20\uff5e80\u6b73\u306e2973\u4eba\uff1b1984\u4eba\u306fMI\u306e\u307f\u30011210\u4eba\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u307f\u3001221\u4eba\u306f\u4e21\u65b9\u3067\u3042\u3063\u305f\u3002<\/td>\n<\/tr>\n
\u8a66\u9a13\u7d50\u679c<\/strong><\/td>\n– \u5fc3\u8840\u7ba1\u6b7b\u4ea1\uff0c\u5fc3\u7b4b\u6897\u585e\uff0c\u865a\u8840\u6027\u8133\u5352\u4e2d\uff0c\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\uff0c\u51a0\u52d5\u8108\u30d0\u30a4\u30d1\u30b9\u8853\uff08CABG\uff09\u306e\u8907\u5408\u3068\u5b9a\u7fa9\u3057\u305f\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u518d\u767a
– \u975e\u7834\u58ca\u7684\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n1,000\u4eba\u5e74\u5f53\u305f\u308a\u306eMACE\u518d\u767a\u7387\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e4\u3064\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\uff08<0.5mmol\/L\uff08<19mg\/dL\uff09\u30010.5\uff5e0.99mmol\/L\uff0819\uff5e38mg\/dL\uff09\u30011\uff5e1.49mmol\/L\uff0839\uff5e57mg\/dL\uff09\u30011.5mmol\/L\u4ee5\u4e0a\uff0858mg\/dL\u4ee5\u4e0a\uff09\uff09\u306b\u3064\u3044\u3066\u63a8\u5b9a\u3057\u305f\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4\u306895\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u306fCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u56de\u5e30\u3092\u7528\u3044\u3066\u63a8\u5b9a\u3057\u3001\u57fa\u790e\u3068\u306a\u308b\u6642\u9593\u5c3a\u5ea6\u3068\u3057\u3066\u5e74\u9f62\u3092\u30e2\u30c7\u30eb\u306b\u542b\u3081\u305f\u3002\u591a\u5909\u91cf\u8abf\u6574\u306f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3001\u55ab\u7159\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3001\u9ad8\u8840\u5727\u306b\u3064\u3044\u3066\u884c\u3063\u305f\u3002Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u56de\u5e30\u304b\u3089\u5f97\u3089\u308c\u305f\u591a\u5909\u91cf\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd4\u3092\u7528\u3044\u3066\u3001\u518d\u767aMACE\u306e\u6240\u5b9a\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u306b\u5fc5\u8981\u306a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u91cf\u306e\u63a8\u5b9a\u3092\u884c\u3063\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

19,831\u4eba\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u3001\u5fc3\u8840\u7ba1\u6b7b214\u4f8b\u3001\u5fc3\u7b4b\u6897\u585e218\u4f8b\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d236\u4f8b\u3001PCI152\u4f8b\u3001CABG51\u4f8b\u3092\u542b\u3080551\u4f8b\u306eMACE\u30a4\u30d9\u30f3\u30c8\u304c\u518d\u767a\u3057\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u6700\u3082\u9ad8\u3044\u56db\u5206\u4f4d\u7fa4\uff08\u22671.5mmol\/L\u307e\u305f\u306f\u226758mg\/dL\uff09\u3067\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u4f4e\u3044\u7fa4\u306b\u6bd4\u3057\u3066\u3001\u5e74\u9f62\u304c\u82e5\u304f\u3001\u7537\u6027\u304c\u591a\u304f\uff0875\uff05\u5bfe\u6700\u3082\u4f4e\u3044\u56db\u5206\u4f4d\u7fa4\u306e61\uff05\uff09\u3001\u8102\u8cea\u4f4e\u4e0b\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u50be\u5411\u304c\u4f4e\u304b\u3063\u305f\uff0868\uff05\u5bfe72\uff05\uff09\u3002\u518d\u767aMACE\u30ea\u30b9\u30af\u309220\uff05\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u30010.83mmol\/L\uff0832mg\/dL\uff09\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u304c\u5fc5\u8981\u3068\u63a8\u5b9a\u3055\u308c\u308b\u304c\u3001\u3053\u308c\u306fCholesterol Treatment Trialists Collaboration\uff081\uff09\u304b\u3089\u5f97\u3089\u308c\u305fLDL-C\u307e\u305f\u306f\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5bfe\u5fdc\u3059\u308b\u5fc5\u8981\u4f4e\u4e0b\u3088\u308a\u3082\u5c11\u306a\u3044\u3002 <\/span><\/p>\n

\u88681. \u518d\u767aMACE\uff1a\u975e\u7a7a\u8179\u6642\u8840\u4e2d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u56db\u5206\u4f4d\u30ec\u30d9\u30eb\u5225<\/strong><\/p>\n

<\/strong><\/p>\n\n\n\n\n\n\n\n
<\/td>\n\n

<0.5mmol\/L<\/p>\n

(<19mg\/dL\uff09<\/p>\n

N=793<\/p>\n<\/td>\n

\n

0.5-0.99mmol\/L<\/p>\n

(19-38mg\/dL\uff09<\/p>\n

N=1400<\/p>\n<\/td>\n

\n

1-1.49mmol\/L<\/p>\n

(39-57mg\/dL\uff09<\/p>\n

N=567<\/p>\n<\/td>\n

\n

\u22651.5mmol\/L\u4ee5\u4e0a<\/p>\n

(58mg\/dL\u4ee5\u4e0a\uff09<\/p>\n

N=213<\/p>\n<\/td>\n<\/tr>\n

\n

MACE\/1000\u60a3\u8005\u5e74\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u5168\u60a3\u8005<\/p>\n<\/td>\n

\n

23 (19-27)<\/p>\n<\/td>\n

\n

27 (24-31)<\/p>\n<\/td>\n

\n

31 (26-37)<\/p>\n<\/td>\n

\n

39 (30-50)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C<\/p>\n

<2.5 mmol\/L<\/p>\n<\/td>\n

\n

24 (19-30)<\/p>\n<\/td>\n

\n

26 (22-31)<\/p>\n<\/td>\n

\n

32 (25-42)<\/p>\n<\/td>\n

\n

42 (29-61)<\/p>\n<\/td>\n<\/tr>\n

\n

MACE\u518d\u767a\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI<\/p>\n<\/td>\n

\n

\u53c2\u8003<\/p>\n<\/td>\n

\n

1.23<\/p>\n

(0.98-1.55)<\/p>\n<\/td>\n

\n

1.48<\/p>\n

(1.14-1.92)<\/p>\n<\/td>\n

\n

1.79<\/p>\n

(1.28-2.49)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u307e\u305f\u306f<97mg\/dL\uff1bLDL-C\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/p>\n

 <\/p>\n<\/div>\n

\n\n\n\n
\u7d50\u8ad6<\/strong><\/td>\n\u5fc3\u7b4b\u6897\u585e\/\u865a\u8840\u6027\u8133\u5352\u4e2d\u3068\u8a3a\u65ad\u3055\u308c\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u30010.8mmol\/L\uff0832mg\/dL\uff09\u306e\u4f4e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u3001\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3044\u3066MACE\u518d\u767a\u309220\uff05\u6e1b\u5c11\u3055\u305b\u308b\u3068\u63a8\u5b9a\u3055\u308c\u305f\u3002\u308f\u308c\u308f\u308c\u306e\u30c7\u30fc\u30bf\u306f\uff0c\u975e\u7a7a\u8179\u6642\u8840\u4e2d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u4eba\u306e\u4e8c\u6b21\u4e88\u9632\u306b\u5bfe\u3059\u308b\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30cb\u30fc\u30ba\u3092\u793a\u3057\u3066\u3044\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u84c4\u7a4d\u3055\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308c\u3070\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u3059\u306a\u308f\u3061\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u86cb\u767d\u3084\u305d\u306e\u6b8b\u7559\u7c92\u5b50\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6fc3\u5ea6\u304c\u9ad8\u3044\u307b\u3069\u3001ASCVD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b(2)\u3002\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\u3001\u89b3\u5bdf\u7814\u7a76\u3001\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u304b\u3089\u5f37\u3044\u652f\u6301\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u304c\u3001\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u8a3c\u62e0\u306f\u9650\u3089\u308c\u3066\u3044\u308b(3)\u3002\u6700\u3082\u78ba\u8a3c\u304c\u3042\u308b\u306e\u306fREDUCE-IT\u8a66\u9a13\uff08Reduction of Cardiovascular Events With Icosapent Ethyl-Intervention Trial\uff09\u3067\u3001\u3053\u306e\u8a66\u9a13\u3067\u306fLDL-C\u5024\u304c\u6bd4\u8f03\u7684\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3001\u3059\u3067\u306b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30e9\u30a4\u30c9\u304c\u9ad8\u304f\u3001ASCVD\u306e\u65e2\u77e5\u307e\u305f\u306f\u9ad8\u30ea\u30b9\u30af\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\uff084g\/\u65e5\uff09\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u5fc3\u8840\u7ba1\u6b7b\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f\uff084\uff09\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u5f8c\u306e\u89e3\u6790\u306b\u3088\u308a\u3001\u3053\u306e\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u6709\u76ca\u6027\u306f\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u6fc3\u5ea6\u306b\u3088\u3063\u3066\u5a92\u4ecb\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u305f\uff085\uff09\u3002 <\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068MACE\u518d\u767a\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u91cd\u8981\u306a\u30c7\u30fc\u30bf\u304c\u8ffd\u52a0\u3055\u308c\u305f\u3002ASCVD\u304c\u78ba\u7acb\u3057\u3066\u3044\u308b\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u30920.8mmol\/L\uff0832mg\/dL\uff09\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u3001MACE\u518d\u767a\u304c20\uff05\u6e1b\u5c11\u3059\u308b\u3068\u63a8\u5b9a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f2\u3064\u306e\u7406\u7531\u304b\u3089\u9069\u5207\u3067\u3042\u308b\u3002\u7b2c\u4e00\u306b\uff0c\u3053\u306e\u7d50\u679c\u306f\uff0c\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u9ad8\u3044\u518d\u767a\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\uff0c\u9ad8\u5024\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u7684\u30cb\u30fc\u30ba\u304c\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u3053\u3068\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u7b2c\u4e8c\u306b\u3001\u3053\u306e\u7814\u7a76\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u309220\uff05\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u306e\u7a0b\u5ea6\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u8005\u306b\u304a\u3044\u3066\u4e0a\u6607\u3057\u305f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u306e\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\u306b\u5f79\u7acb\u3064\u306b\u9055\u3044\u306a\u3044\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Cholesterol Treatment Trialists C, Baigent C, Blackwell L, et al. LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u3088\u308a\u5f37\u529b\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\uff1a26\u306e\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306b\u304a\u3051\u308b17\u4e07\u4eba\u306e\u53c2\u52a0\u8005\u306e\u30c7\u30fc\u30bf\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u3002Lancet 2010; 376:1670-81.
2.Varbo A, Nordestgaard BG.\u52d5\u8108\u786c\u5316\u306e\u9032\u884c\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u8cea\u3002Arterioscler Thromb Vasc Biol 2016;36:2133-5.
3.Nordestgaard BG.Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology.Circ Res 2016; 118:547-63.
4.Bhatt DL, Steg PG, Miller M, et al; REDUCE-IT Investigators.\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22.
5.Bhatt DL\u3089\uff1aReduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial\u306b\u304a\u3051\u308bEPA\u30ec\u30d9\u30eb\u3068\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3002\u7c73\u56fd\u5fc3\u81d3\u75c5\u5b66\u4f1a2020\u5e74\u5b66\u8853\u96c6\u4f1a\uff08ACC.20\uff09\/\u4e16\u754c\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08WCC\uff09\uff1a\u6284\u9332\u756a\u53f720-LB-20501-ACC\u30022020\u5e743\u670830\u65e5\u767a\u8868\u3002 <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\uff1b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\uff1b\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30af\u30ea\u30cb\u30ab\u30eb\u30fb\u30cb\u30fc\u30ba<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba 2020\u5e747\u670820\u65e5 Copenhagen […]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-254393","page","type-page","status-publish","hentry"],"yoast_head":"\n\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba - R3I<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba - R3I\" \/>\n<meta property=\"og:description\" content=\"\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba 2020\u5e747\u670820\u65e5 Copenhagen […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/\" \/>\n<meta property=\"og:site_name\" content=\"R3I\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-16T21:36:07+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\\\/\",\"url\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\\\/\",\"name\":\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba - R3I\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/#website\"},\"datePublished\":\"2025-01-25T12:25:08+00:00\",\"dateModified\":\"2025-02-16T21:36:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\\\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/r3i.org\\\/ja\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/#website\",\"url\":\"https:\\\/\\\/r3i.org\\\/ja\\\/\",\"name\":\"R3I\",\"description\":\"Residual Risk Reduction Initiative\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/r3i.org\\\/ja\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba - R3I","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/","og_locale":"ja_JP","og_type":"article","og_title":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba - R3I","og_description":"\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba 2020\u5e747\u670820\u65e5 Copenhagen […]","og_url":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/","og_site_name":"R3I","article_modified_time":"2025-02-16T21:36:07+00:00","twitter_card":"summary_large_image","twitter_misc":{"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"2\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/","url":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/","name":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba - R3I","isPartOf":{"@id":"https:\/\/r3i.org\/ja\/#website"},"datePublished":"2025-01-25T12:25:08+00:00","dateModified":"2025-02-16T21:36:07+00:00","breadcrumb":{"@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e9%ab%98%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e5%80%a4%ef%bc%9a%e4%ba%8c%e6%ac%a1%e4%ba%88%e9%98%b2\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/r3i.org\/ja\/"},{"@type":"ListItem","position":2,"name":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af-\u9ad8\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff1a\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u81e8\u5e8a\u30cb\u30fc\u30ba"}]},{"@type":"WebSite","@id":"https:\/\/r3i.org\/ja\/#website","url":"https:\/\/r3i.org\/ja\/","name":"R3I","description":"Residual Risk Reduction Initiative","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/r3i.org\/ja\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"}]}},"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Pgbfv2-14b7","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254393","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/users\/258497325"}],"replies":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/comments?post=254393"}],"version-history":[{"count":1,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254393\/revisions"}],"predecessor-version":[{"id":254394,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254393\/revisions\/254394"}],"wp:attachment":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/media?parent=254393"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}