{"id":254389,"date":"2025-01-21T23:53:22","date_gmt":"2025-01-21T22:53:22","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%83%9f%e3%83%a5%e3%83%bc%e3%83%90%e3%83%a9%e3%83%97%e3%83%aa%e3%83%b3%e3%81%ae%e5%88%9d%e3%83%87%e3%83%bc%e3%82%bf\/"},"modified":"2025-02-16T22:35:09","modified_gmt":"2025-02-16T21:35:09","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%83%9f%e3%83%a5%e3%83%bc%e3%83%90%e3%83%a9%e3%83%97%e3%83%aa%e3%83%b3%e3%81%ae%e5%88%9d%e3%83%87%e3%83%bc%e3%82%bf","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-%e3%83%9f%e3%83%a5%e3%83%bc%e3%83%90%e3%83%a9%e3%83%97%e3%83%aa%e3%83%b3%e3%81%ae%e5%88%9d%e3%83%87%e3%83%bc%e3%82%bf\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – \u30df\u30e5\u30fc\u30d0\u30e9\u30d7\u30ea\u30f3\u306e\u521d\u30c7\u30fc\u30bf"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” theme_builder_area=”post_content” sticky_enabled=”0″]

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2024\u5e741\u67088\u65e5<\/span><\/h5>\n
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Nicholls SJ\u3001Nissen SE\u3001Fleming C\u3001\u4ed6\u3002\u7d4c\u53e3\u4f4e\u5206\u5b50\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u5f62\u6210\u963b\u5bb3\u85acMuvalaplin\uff1a\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u3002doi: 10.1001\/jama.2023.16503. <\/em><\/div>\n<\/div>\n<\/div>\n
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\u7814\u7a76\u6982\u8981<\/strong><\/td>\n<\/tr>\n
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\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u7b2cI\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u30d1\u30e9\u30ec\u30eb\u30c7\u30b6\u30a4\u30f3\u8a66\u9a13\u3002\u672c\u8a66\u9a13\u306f\u3001\u5358\u56de\u6295\u4e0e\u671f\u9593\uff08Lp(a)\u5024\u304c\u3044\u305a\u308c\u3067\u3042\u3063\u3066\u3082\uff09\u3068\u53cd\u5fa9\u6295\u4e0e\u671f\u9593\uff08Lp(a)\u5024\u304c30mg\/dL\u4ee5\u4e0a\uff09\u306e\u4e21\u65b9\u3067\u69cb\u6210\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n
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\u7d50\u679c<\/strong><\/div>\n
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 <\/p>\n<\/td>\n<\/tr>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Kronenberg F, Mora S, Stroes ESG, et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.Eur Heart J 2022;43:3925-46.
2.Julius U, Tselmin S, Schatz U, et al. \u30ea\u30dd\u86cb\u767d(a)\u5024\u4e0a\u6607\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d\u30a2\u30d5\u30a7\u30ec\u30fc\u30b7\u30b9\u306e\u5b9f\u969b\u3002Atheroscler Supp. 2019;40:1-7.
3.Tsimikas S, Karwatowska-Prokopczuk E, Gouni-Berthold I, et al. \u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)\u306e\u6e1b\u5c11\u3002N Engl J Med 2020;382:244-55.
4.O’Donoghue ML, Rosenson RS, Gencer B, et al; OCEAN(a)-DOSE Trial Investigators.\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)\u3092\u6e1b\u5c11\u3055\u305b\u308b\u5c0f\u5e72\u6e09RNA\u3002N Engl J Med 2022;387:1855-64.
5.NissenSE\u3001Wolski K\u3001Balog C\u3001et al. \u8840\u6f3f\u4e2d\u306e\u30ea\u30dd\u86cb\u767d(a)\u6fc3\u5ea6\u304c\u9ad8\u3044\u4eba\u306b\u304a\u3051\u308b\u3001\u30ea\u30dd\u86cb\u767d(a)\u7523\u751f\u3092\u6a19\u7684\u3068\u3057\u305f\u77ed\u9396\u5e72\u6e09RNA\u306e\u5358\u56de\u6607\u9806\u6295\u4e0e\u8a66\u9a13\u3002
6.\u5fc3\u8840\u7ba1\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u8a55\u4fa1\u3092\u76ee\u7684\u3068\u3057\u305f\u7b2cIII\u76f8\u8a66\u9a13\u304c2020\u5e74\u306b\u958b\u59cb\u3055\u308c\u305f\uff08HORIZON\u8a66\u9a13\uff1bClinicalTrials.gov Identifier: NCT04023552\uff09
7. Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction (OCEAN(a)) – Outcomes Trial (ClinicalTrials.gov Identifier: NCT05581303). <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u30ea\u30dd\u86cb\u767d(a)\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3001\u30e0\u30d0\u30e9\u30d7\u30ea\u30f3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n
\n
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