{"id":254385,"date":"2025-01-23T23:12:14","date_gmt":"2025-01-23T22:12:14","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/"},"modified":"2025-02-16T22:34:17","modified_gmt":"2025-02-16T21:34:17","slug":"%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/","title":{"rendered":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u305f\u3081\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f<\/span><\/h2>\n
19 2022\u5e747\u6708<\/span><\/h5>\n
\n
\n
\n
\n
\n
\n
EMPA-KIDNEY\uff08ClinicalTrials.gov\u8b58\u5225\u5b50\uff1aNCT03594110\uff09\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0-\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f53-2\uff08SGLT-2\uff09\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u304c\u3001\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u814e\u81d3\u75c5\u306e\u9032\u884c\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u6b7b\u3092\u4e88\u9632\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3057\u3066\u3044\u305f\u3002\u672c\u8a66\u9a13\u306f\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u304c\u30d7\u30e9\u30bb\u30dc\u3088\u308a\u3082\u6709\u52b9\u3067\u3042\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u305f\u305f\u3081\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u52e7\u544a\u306b\u3088\u308a3\u670816\u65e5\u306b\u4e2d\u6b62\u3055\u308c\u305f\u3002 <\/span><\/div>\n
EMPA-KIDNEY https:\/\/www.empakidney.org\/news\/empa-kidney-trial-stops-early-due-to-evidence-of-efficacy\u3002<\/a> <\/span><\/div>\n
<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n
\n

\u7814\u7a76\u6982\u8981<\/strong><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

\n
\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nCKD\u306e\u65e2\u5f80\u306e\u3042\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6a19\u6e96\u6cbb\u7642\u306b\u52a0\u3048\u3066\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3092\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3001\u814e\u81d3\u75c5\u306e\u9032\u884c\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u6b7b\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u591a\u65bd\u8a2d\u5171\u540c\uff0c\u56fd\u969b\u5171\u540c\uff0c\u7121\u4f5c\u70ba\u5316\uff0c\u4e26\u884c\u7fa4\u9593\uff0c\u4e8c\u91cd\u76f2\u691c\uff0c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3002\u7cd6\u5c3f\u75c5\uff08DM\uff09\u306e\u6709\u7121\u3092\u554f\u308f\u305a\u9069\u683c\u306a\u60a3\u8005\u3092\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f31\u65e510mg\u6295\u4e0e\u7fa4\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u6b27\u5dde\u3001\u5317\u7c73\u3001\u6771\u30a2\u30b8\u30a2\u306e8\u30ab\u56fd\u306e\u60a3\u8005\u304c\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u5bfe\u8c61\u60a3\u8005\u306f\u3001CKD\u306e\u6240\u898b\u304c\u3042\u308a\u3001\u304b\u3064\u814e\u81d3\u75c5\u9032\u884c\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u60a3\u8005\u3067\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u53d7\u8a3a\u306e\u5c11\u306a\u304f\u3068\u30823\u30f5\u6708\u524d\u3068\u53d7\u8a3a\u6642\u306b\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u5b9a\u7fa9\u3055\u308c\u305f\uff1a
– \u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff08eGFR\uff09\u226720\uff5e<45mL\/\u5206\/1.73m\u00b2\u307e\u305f\u306f
– eGFR\u226745\uff5e<90mL\/\u5206\/1.73m\u00b2\u3067\u3001\u5c3f\u4e2d\u30a2\u30eb\u30d6\u30df\u30f3\uff1a\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u2267200mg\/g\uff08\u307e\u305f\u306f\u86cb\u767d\uff1a\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u2267300mg\/g\uff09\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u306e\u6210\u679c<\/strong><\/td>\n\u8907\u5408\u4e3b\u8981\u8ee2\u5e30\u306f\u3001\u4ee5\u4e0b\u306e\u6700\u521d\u306e\u767a\u751f\u307e\u3067\u306e\u671f\u9593\u3068\u3057\u305f\uff1a
(i) \u814e\u81d3\u75c5\u9032\u884c\uff08End Stage Kidney Disease[ESKD] \u3001eGFR\u306e\u6301\u7d9a\u7684\u4f4e\u4e0b\uff08<10mL\/min\/1.73m\u00b2\uff09\u3001\u814e\u6b7b\u3001\u307e\u305f\u306f\u7121\u4f5c\u70ba\u5316\u304b\u3089\u306eeGFR\u306e40\uff05\u4ee5\u4e0a\u306e\u6301\u7d9a\u7684\u4f4e\u4e0b\u3068\u5b9a\u7fa9\uff09\u3002ESKD\u306f\u3001\u7dad\u6301\u900f\u6790\u306e\u958b\u59cb\u3001\u814e\u79fb\u690d\u306e\u53d7\u9818\u3001\u307e\u305f\u306f
(ii) \u5fc3\u8840\u7ba1\u6b7b\u3002 <\/td>\n<\/tr>\n
\u65b9\u6cd5\uff0f\u7d50\u679c<\/strong><\/td>\n\n

\u516c\u8868\u3055\u308c\u305f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u30c7\u30fc\u30bf\uff081\uff09\u306b\u3088\u308b\u3068\u3001EMPA-KIDNEY\u306b\u306f2019\u5e745\u670815\u65e5\u304b\u30892021\u5e744\u670816\u65e5\u306e\u9593\u306b6609\u4eba\u306e\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f6263.8\u6b73\u3001\u5973\u602733\uff05\u300154\uff05\u304cDM\u65e2\u5f80\u306a\u3057\uff09\u304c\u767b\u9332\u3055\u308c\u305f\u3002\u5e73\u5747eGFR\u306f37.5\uff0814.8\uff09mL\/\u5206\/1.73m2\u30015185\u4eba\uff0878\uff05\uff09\u306feGFR<45mL\/\u5206\/1.73m2\u3067\u3042\u3063\u305f\u3002\u814e\u81d3\u75c5\u306e\u539f\u56e0\u306f\u3001\u7cd6\u5c3f\u75c5\u6027\u814e\u81d3\u75c5\uff08n=2057[31%] \uff09\u3001\u7cf8\u7403\u4f53\u75be\u60a3\uff08n=1669[25%] \uff09\u3001\u9ad8\u8840\u5727\u6027\/\u8840\u7ba1\u75be\u60a3\uff08n=1445[22%] \uff09\u3001\u305d\u306e\u4ed6\uff08n=808[12%] \uff09\u3001\u539f\u56e0\u4e0d\u660e\uff08n=630[10%] \uff09\u306a\u3069\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u672c\u8a66\u9a13\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3059\u308b\u6709\u610f\u306a\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u5f97\u3089\u308c\u305f\u305f\u3081\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u52e7\u544a\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f\u3002\u6709\u52b9\u6027\u306e\u7d50\u679c\u306b\u95a2\u3059\u308b\u8a73\u7d30\u306f\u73fe\u6642\u70b9\u3067\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u306a\u3044\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

CKD\u306f\u5927\u304d\u306a\u8ca0\u62c5\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u3059\u3067\u306b\u4e16\u754c\u4eba\u53e3\u306e15\uff05\u304c\u7f79\u60a3\u3057\u3066\u304a\u308a\u3001\u5730\u57df\u306b\u3088\u3063\u3066\u306f\u904e\u53bb30\u5e74\u9593\u3067\u6709\u75c5\u7387\u304c\u307b\u307c\u500d\u5897\u3057\u3066\u3044\u308b(2,3)\u3002\u7cd6\u5c3f\u75c5\u304c\u4e3b\u306a\u539f\u56e0\u3067\u3042\u308b\u304c(4)\u3001CKD\u306f\u7cd6\u5c3f\u75c5\u306e\u306a\u3044\u4eba\u306e\u9593\u3067\u3082\u6d41\u884c\u3057\u3066\u3044\u308b(4)\u3002CKD\u304c\u672b\u671f\u814e\u4e0d\u5168\uff08ESRD\uff09\u306b\u9032\u884c\u3057\u306a\u3044\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u306f\u3001\u60a3\u8005\u306e\u7f79\u60a3\u7387\u3084QOL\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\uff084\uff09\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u5897\u5927\u3055\u305b\u308b\uff085\uff09\u3053\u3068\u304b\u3089\u3001\u512a\u5148\u4e8b\u9805\u3068\u306a\u3063\u3066\u3044\u308b\u3002 <\/p>\n

\u5927\u898f\u6a21\u306a\u524d\u5411\u304d\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3067\u306f\u3001SGLT-2\u963b\u5bb3\u85ac\uff08\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u307e\u305f\u306f\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff09\u306b\u3088\u308b\u6cbb\u7642\u304c\u3001\u9ad8\u30ea\u30b9\u30af\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u307e\u305f\u3001\u63a2\u7d22\u7684\u89e3\u6790\u3067\u306f\u814e\u81d3\u75c5\u306e\u9032\u884c\u306b\u5bfe\u3059\u308b\u6709\u76ca\u6027\u3082\u793a\u5506\u3055\u308c\u3066\u304a\u308a(6-8)\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002SGLT-2\u963b\u5bb3\u85ac\u304c\u7cd6\u5c3f\u75c5\u6027\u814e\u81d3\u75c5\u306e\u9032\u884c\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8a55\u4fa1\u3057\u305f\u6700\u521d\u306e\u5927\u898f\u6a21\u8a66\u9a13\uff08CREDENCE\u3001Evaluation of the Effects of Canagliflozin on Renal and Cardiovascular Outcomes in Participants with Diabetic Nephropathy\uff09\u306f\u3001\u6cbb\u7642\u7fa4\u306b\u304a\u3051\u308b\u6709\u76ca\u6027\u306e\u305f\u3081\u3001\u72ec\u7acb\u30c7\u30fc\u30bf\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u306e\u52e7\u544a\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f\u30022\u578b\u7cd6\u5c3f\u75c5\u3067\u30de\u30af\u30ed\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3092\u6709\u3059\u308b4,401\u4f8b\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u6295\u4e0e\u306f\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b\u672b\u671f\u814e\u81d3\u75c5\u30d1\u30e9\u30e1\u30fc\u30bf\u306e\u8907\u5408\u309230\uff05\u6e1b\u5c11\u3055\u305b\uff08p=0.00001\uff09\u3001\u3055\u3089\u306b\u5fc3\u8840\u7ba1\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\uff0820\uff05\u6e1b\u5c11\u3001p=0.01\uff09(9)\u3002\u30c0\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08DAPA-CKD\uff09\u30922,152\u4f8b\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3068\u975e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u6295\u4e0e\u3057\u305f\u5225\u306e\u8a66\u9a13\u3082\u6709\u52b9\u6027\u304c\u8a8d\u3081\u3089\u308c\u305f\u305f\u3081\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f\u3002\u30c0\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u4e3b\u8981\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff08eGFR\u306e50\uff05\u4ee5\u4e0a\u306e\u6301\u7d9a\u7684\u4f4e\u4e0b\u3001ESRD\u3001\u814e\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\uff09\u309242\uff05\u6e1b\u5c11\u3055\u305b\u305f\uff08p<0.001\uff09(10)\u3002\u3053\u306e\u3088\u3046\u306b\u3001DAPA-CKD\u306f\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305aSGLT-2\u963b\u5bb3\u306b\u3088\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u793a\u3057\u305f\u3002 <\/p>\n

SGLT-2\u963b\u5bb3\u85ac\u306e3\u756a\u76ee\u306e\u8a66\u9a13\u3067\u3042\u308bEMPA-KIDNEY\u306f\u3001\u814e\u81d3\u75c5\u9032\u884c\u30ea\u30b9\u30af\u306e\u3042\u308bCKD\u60a3\u8005\u3092\u5e83\u304f\u4e00\u822c\u5316\u3067\u304d\u308b\u96c6\u56e3\u3067\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002EMPA-KIDNEY\u306fCREDENCE\u3084DAPA-CKD\u3068\u306f\u60a3\u8005\u69cb\u6210\u304c\u7570\u306a\u3063\u3066\u3044\u305f\u3002EMPA-KIDNEY\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306f\u534a\u6570\u4ee5\u4e0b\u3067\u3042\u3063\u305f\u3002\u3055\u3089\u306b\u3001EMPA-KIDNEY\u306e\u5e73\u5747eGFR\u306f\u7d0438mL\/\u5206\/1.73m2\u3067\u3042\u308a\u3001eGFR\u304c45mL\/\u5206\/1.73m2\u4ee5\u4e0a\u306e\u60a3\u8005\u306e\u307f\u304c\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3092\u8981\u6c42\u3055\u308c\u305f(1)\u3002\u4e00\u65b9\u3001DAPA-CKD\u3067\u306f\u5e73\u5747eGFR\u306f\u301c43mL\/\u5206\/1.73m2\u3067\u3042\u308a\u3001\u5168\u4f8b\u306b\u5c11\u306a\u304f\u3068\u3082\u5fae\u91cf\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u3055\u3089\u306bCREDENCE\u3067\u306f\u3001\u5e73\u5747eGFR\u306f\u301c56mL\/\u5206\/1.73m2\u3067\u3001\u5168\u4f8b\u304c\u30de\u30af\u30ed\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3067\u3042\u3063\u305f(9,10)\u3002EMPA-KIDNEY\u306e\u6240\u898b\u306e\u767a\u8868\u304c\u5f85\u3061\u671b\u307e\u308c\u308b\u3002\u4e00\u65b9\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u3067\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u30012\u578bDM\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u3001CKD\u60a3\u8005\u306e\u7ba1\u7406\u306b\u91cd\u8981\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.EMPA-KIDNEY\u5171\u540c\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u3002EMPA-KIDNEY\u8a66\u9a13\u306e\u30c7\u30b6\u30a4\u30f3\u3001\u52df\u96c6\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u3002Nephrol Dial Transplant 2022; doi: 10.1093\/ndt\/gfac040.Online ahead of print.
2. GBD 2015\u6771\u5730\u4e2d\u6d77\u5730\u57df\u7cd6\u5c3f\u75c5\u30fb\u6162\u6027\u814e\u81d3\u75c5\u5171\u540c\u7814\u7a76\u8005\u3002\u6771\u5730\u4e2d\u6d77\u5730\u57df\u306b\u304a\u3051\u308b\u7cd6\u5c3f\u75c5\u3068\u6162\u6027\u814e\u81d3\u75c5\uff1aGlobal Burden of Disease 2015\u7814\u7a76\u306e\u77e5\u898b\u3002Int J Public Health 2018;63 (Suppl 1):S177-186.
3.Hill NR, Fatoba ST, Oke JL, et al. Global prevalence of chronic kidney disease – a systematic review and meta-analysis.Plos One 2016;11(7):e0158765.
4.Jha V, Garcia-Garcia G, Iseki K. et al. Chronic kidney disease: global dimension and perspectives.Lancet 2013; 382: 260-272.
5.\u4e00\u822c\u96c6\u56e3\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3051\u308b\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u304a\u3088\u3073\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u3068\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u3068\u306e\u95a2\u9023\uff1a\u5171\u540c\u30e1\u30bf\u89e3\u6790\u3002Lancet 2010;375:2073-2081.
6.Neal B, Perkovic V, Mahaffey KW. et al. Canagliflozin and cardiovascular and renal events in type 2 diabetes.N Engl J Med 2017;377: 644-657.
7.Zinman B, Wanner C, Lachin JM. et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes.N Engl J Med 2015; 373: 2117-2128.
8.Wanner C, Inzucchi SE, Lachin JM. et al. Empagliflozin and progression of kidney disease in type 2 diabetes.N Engl J Med 2016; 375\uff1a323-334.
9.Perkovic V, Jardine MJ, Neal B, et al. Canagliflozin and renal outcomes in type 2 diabetes and nephropathy.N Engl J Med 2019;380:2295-2306.
10.Heerspink HJL, Stef\u00e1nsson BV, Correa-Rotter R, et al. \u6162\u6027\u814e\u81d3\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30c0\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3002N Engl J Med 2020;383:1436-1446. <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\nSGLT-2\u963b\u5bb3\u85ac\uff1b\u6162\u6027\u814e\u81d3\u75c5\uff1b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff1b\u814e\u81d3\u75c5\u9032\u884c\uff1b\u5fc3\u8840\u7ba1\u6b7b<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u305f\u3081\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f 19 2022\u5e747\u6708 EMPA-KIDN […]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_wpcom_ai_launchpad_about_page":false,"_wpcom_ai_launchpad_gallery_page":false,"_wpcom_ai_launchpad_contact_page":false,"_wpcom_ai_launchpad_events_page":false,"_wpcom_ai_launchpad_video_page":false,"_wpcom_ai_launchpad_portfolio_piece":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"footnotes":""},"class_list":["post-254385","page","type-page","status-publish","hentry"],"yoast_head":"\n\u30e9\u30f3\u30c9\u30de\u30fc\u30af - EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f - R3I<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f - R3I\" \/>\n<meta property=\"og:description\" content=\"EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u305f\u3081\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f 19 2022\u5e747\u6708 EMPA-KIDN […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/\" \/>\n<meta property=\"og:site_name\" content=\"R3I\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-16T21:34:17+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data1\" content=\"2\u5206\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\\\/\",\"url\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\\\/\",\"name\":\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f - R3I\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/#website\"},\"datePublished\":\"2025-01-23T22:12:14+00:00\",\"dateModified\":\"2025-02-16T21:34:17+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\\\/#breadcrumb\"},\"inLanguage\":\"ja\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/r3i.org\\\/ja\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/r3i.org\\\/ja\\\/#website\",\"url\":\"https:\\\/\\\/r3i.org\\\/ja\\\/\",\"name\":\"R3I\",\"description\":\"Residual Risk Reduction Initiative\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/r3i.org\\\/ja\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ja\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f - R3I","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/","og_locale":"ja_JP","og_type":"article","og_title":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f - R3I","og_description":"EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u305f\u3081\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f 19 2022\u5e747\u6708 EMPA-KIDN […]","og_url":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/","og_site_name":"R3I","article_modified_time":"2025-02-16T21:34:17+00:00","twitter_card":"summary_large_image","twitter_misc":{"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"2\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/","url":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/","name":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af - EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f - R3I","isPartOf":{"@id":"https:\/\/r3i.org\/ja\/#website"},"datePublished":"2025-01-23T22:12:14+00:00","dateModified":"2025-02-16T21:34:17+00:00","breadcrumb":{"@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/r3i.org\/ja\/%e3%83%a9%e3%83%b3%e3%83%89%e3%83%9e%e3%83%bc%e3%82%af-empa-kidney%e8%a9%a6%e9%a8%93%e3%81%af%e6%9c%89%e5%8a%b9%e6%80%a7%e3%81%ae%e3%82%a8%e3%83%93%e3%83%87%e3%83%b3%e3%82%b9%e3%81%ab%e3%82%88\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/r3i.org\/ja\/"},{"@type":"ListItem","position":2,"name":"\u30e9\u30f3\u30c9\u30de\u30fc\u30af – EMPA-KIDNEY\u8a66\u9a13\u306f\u6709\u52b9\u6027\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u3088\u308a\u65e9\u671f\u306b\u4e2d\u6b62\u3055\u308c\u305f"}]},{"@type":"WebSite","@id":"https:\/\/r3i.org\/ja\/#website","url":"https:\/\/r3i.org\/ja\/","name":"R3I","description":"Residual Risk Reduction Initiative","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/r3i.org\/ja\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ja"}]}},"jetpack_likes_enabled":true,"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/Pgbfv2-14aZ","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254385","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/users\/258497325"}],"replies":[{"embeddable":true,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/comments?post=254385"}],"version-history":[{"count":1,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254385\/revisions"}],"predecessor-version":[{"id":254386,"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/pages\/254385\/revisions\/254386"}],"wp:attachment":[{"href":"https:\/\/r3i.org\/ja\/wp-json\/wp\/v2\/media?parent=254385"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}