{"id":254372,"date":"2025-01-25T13:17:25","date_gmt":"2025-01-25T12:17:25","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-n-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e3%82%ac%e3%83%a9%e3%82%af%e3%83%88%e3%82%b5%e3%83%9f%e3%83%b3%e7%b5%90%e5%90%88%e5%9e%8bangptl3%e3%82%a2\/"},"modified":"2025-02-16T22:32:00","modified_gmt":"2025-02-16T21:32:00","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-n-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e3%82%ac%e3%83%a9%e3%82%af%e3%83%88%e3%82%b5%e3%83%9f%e3%83%b3%e7%b5%90%e5%90%88%e5%9e%8bangptl3%e3%82%a2","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-n-%e3%82%a2%e3%82%bb%e3%83%81%e3%83%ab%e3%82%ac%e3%83%a9%e3%82%af%e3%83%88%e3%82%b5%e3%83%9f%e3%83%b3%e7%b5%90%e5%90%88%e5%9e%8bangptl3%e3%82%a2\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – N-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\u578bANGPTL3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u85acVupanorsen\u306b\u6709\u671b\u6027"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –N-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\u578bANGPTL3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u85acVupanorsen\u306b\u6709\u671b\u6027<\/span><\/h2>\n
2020\u5e7410\u67085\u65e5<\/span><\/h5>\n

2\u578b\u7cd6\u5c3f\u75c5\u3001\u809d\u8102\u80aa\u75c7\u3001\u304a\u3088\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4e0a\u6607\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u809d\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d83\uff08ANGPTL3\uff09\u86cb\u767d\u5408\u6210\u3092\u6a19\u7684\u3068\u3057\u305fvupanorsen\uff08AKCEA-ANGPTL3-L Rx\uff09\u306f\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u542b\u6709\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/em><\/p>\n

Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia.Eur Heart J 2020 ; doi:10.1093\/eurheartj\/ehaa689 <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n2\u578b\u7cd6\u5c3f\u75c5\uff08T2DM\uff09\uff0c\u809d\u8102\u80aa\u75c7\uff0cTG\u4e0a\u6607\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\uff0c\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u304a\u3088\u3073\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306e\u30ec\u30d9\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306e\u81f3\u9069\u6295\u4e0e\u91cf\u304a\u3088\u3073\u30ec\u30b8\u30e1\u30f3\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u591a\u65bd\u8a2d\u5171\u540c\u3001\u7121\u4f5c\u70ba\u5316\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u7528\u91cf\u8a2d\u5b9a\u3001\u7b2c2\u76f8\u8a66\u9a13\u3002\u9069\u683c\u60a3\u8005\u306f3\u3064\u306e\u30b3\u30db\u30fc\u30c8\uff08\u6709\u52b9\u7fa4\uff1a\u30d7\u30e9\u30bb\u30dc\u7fa4\uff1d3\uff1a1\uff09\u306e\u3044\u305a\u308c\u304b\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\uff1avupanorsen 40mg\u307e\u305f\u306f80mg\u30924\u9031\u9593\u3054\u3068\u306b6\u30f5\u6708\u9593\u76ae\u4e0b\u6295\u4e0e\u3001\u307e\u305f\u306f20mg\u30921\u9031\u9593\u3054\u3068\u306b\u76ae\u4e0b\u6295\u4e0e\u3002 <\/td> \n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/td>\n\u7a7a\u8179\u6642\u8840\u6f3f\u4e2dTG\u4e0a\u6607\uff08>150mg\/dL\u307e\u305f\u306f>1.7mmol\/L\uff09\u3001T2DM\u3001\u809d\u8102\u80aa\u75c7\uff08\u78c1\u6c17\u5171\u9cf4\u753b\u50cf\u306b\u3088\u308b\u809d\u8102\u80aa\u7387>8\uff05\u3001\u80a5\u6e80\u5ea627\uff5e40kg\/m2\uff09\u306e\u60a3\u8005\u3002<\/td>\n<\/tr>\n
\u4e3b\u306a\u8a66\u9a13\u5909\u6570<\/strong><\/td>\n– \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30896\u30f5\u6708\u5f8c\uff084\u9031\u3054\u3068\u306e\u6295\u4e0e\u3067\u306f25\u9031\u76ee\u3001\u9031\u3054\u3068\u306e\u6295\u4e0e\u3067\u306f27\u9031\u76ee\uff09\u307e\u3067\u306e\u7a7a\u8179\u6642TG\u306e\u5909\u5316\u7387\u3002
– \u4e3b\u306a\u526f\u6b21\u7684\u6709\u52b9\u6027\/\u63a2\u7d22\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8ANGPTL3\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08TC\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL C\uff09\u3001\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08VLDL-C\uff09\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09B\u3001apoCIII\u3001apoAI\u3092\u542b\u3080\u7a7a\u8179\u6642\u8102\u8cea\/\u30ea\u30dd\u86cb\u767d\u306e\u5909\u5316\u3001\u8840\u7cd6\u30d1\u30e9\u30e1\u30fc\u30bf\uff1a\u8840\u7cd6\u30d1\u30e9\u30e1\u30fc\u30bf\uff1aHbA1c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6052\u5e38\u6027\u30e2\u30c7\u30eb\u8a55\u4fa1\uff08HOMA-IR\uff09\u3001\u809d\u8102\u80aa\u75c7\u95a2\u9023\u30d1\u30e9\u30e1\u30fc\u30bf
– \u5b89\u5168\u6027\uff1a\u8840\u5c0f\u677f\u6570\u3001\u814e\u6a5f\u80fd\u3001\u809d\u6a5f\u80fd\u3001\u6709\u5bb3\u4e8b\u8c61 <\/td> \n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\n\u5404\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u7fa4\u3068\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u4e00\u5bfe\u6bd4\u8f03\u306f\u3001\u6cbb\u7642\u7fa4\u3092\u56fa\u5b9a\u56e0\u5b50\u3068\u3057\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3092\u5bfe\u6570\u5909\u63db\u3057\u305f\u3082\u306e\u3092\u5171\u5909\u91cf\u3068\u3059\u308b\u5171\u5206\u6563\u5206\u6790\uff08ANCOVA\uff09\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u884c\u3063\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u53d7\u3051\u305f525\u4eba\u306e\u60a3\u8005\u306e\u3046\u3061105\u4eba\u304cvupanorsen 40 mg 4-weekly\u6295\u4e0e\u7fa4\uff08n=26\uff09\u3001vupanorsen 80 mg 4-weekly\u6295\u4e0e\u7fa4\uff08n=26\uff09\u3001vupanorsen 20 mg weekly\u6295\u4e0e\u7fa4\uff08n=26\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306f27\u4eba\u3067\u3042\u3063\u305f\u3002\u5168\u4f53\u306e93\uff05\u304c65\u6b73\u672a\u6e80\u300147\uff05\u304c\u5973\u6027\u300162\uff05\u304c\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u4e2d\u592e\u5024\u306f2.84mmol\/L\uff08252mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u5e73\u5747\u6cbb\u7642\u671f\u9593\uff08\u00b1\u6a19\u6e96\u504f\u5dee\uff09\u306f\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u7fa4\u3067134\u00b141\u65e5\uff08\u4e2d\u592e\u5024\u3001141\u65e5\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067150\u00b135\u65e5\uff08\u4e2d\u592e\u5024\u3001142\u65e5\uff09\u3067\u3042\u3063\u305f\u300291\u4f8b\uff0887\uff05\uff09\u304c\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u305f\u3002 <\/p>\n

\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e3\u3064\u306e\u30ec\u30b8\u30e1\u30f3\u306f\u3059\u3079\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u30666\u30f5\u6708\u5f8c\u306e\u7a7a\u8179\u6642TG\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\uff08\u88681\uff09\u3002\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5f8c\u306eTG\u4f4e\u4e0b\u7387\u306f\u3001\u30d6\u30d1\u30ce\u30eb\u30bb\u30f340mg 4\u9031\u6295\u4e0e\u306724\uff05\u3001p=0.0343\u3001\u30d6\u30d1\u30ce\u30eb\u30bb\u30f380mg 4\u9031\u6295\u4e0e\u306744\uff05\u3001p<0.0001\u3001\u30d6\u30d1\u30ce\u30eb\u30bb\u30f320mg \u9031\u6295\u4e0e\u306737\uff05\u3001p=0.0009\u3067\u3042\u3063\u305f\u30023\u3064\u306e\u30ec\u30b8\u30e1\u30f3\u306f\u3044\u305a\u308c\u3082ANGPTL3\u3001apoCIII\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001TC\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002\u30d6\u30d1\u30ce\u30eb\u30bb\u30f380mg\u90314\u56de\u6295\u4e0e\u306f\u30a2\u30ddB\u3082\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f\uff08\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u30669\uff05\u306e\u6e1b\u5c11\u3001p=0.0441\uff09\u3002 <\/p>\n

\u8840\u7cd6\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3084\u809d\u8102\u80aa\u7387\u306b\u6539\u5584\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u6295\u4e0e\u306f\u8840\u5c0f\u677f\u6570\u306b\u81e8\u5e8a\u7684\u306b\u6709\u610f\u306a\u5909\u5316\u3092\u8a8d\u3081\u306a\u304b\u3063\u305f\u3002\u6709\u5bb3\u4e8b\u8c61\u306f\u4e3b\u306b\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u3082\u306e\u3067\u3042\u3063\u305f\u3002\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u6709\u5bb3\u4e8b\u8c61\u306e\u305f\u3081\u306b\u6cbb\u7642\u3092\u4e2d\u6b62\u3057\u305f\u60a3\u8005\u306f\u3044\u306a\u304b\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u306f6\u4eba\u3067\u3042\u3063\u305f\u3002\u6ce8\u5c04\u90e8\u4f4d\u53cd\u5fdc\u306f16\u4f8b\uff0820.5\uff05\uff09\u306e\u60a3\u8005\u3067\u5831\u544a\u3055\u308c\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u5831\u544a\u3055\u308c\u306a\u304b\u3063\u305f\u3002 <\/p>\n

\u88681. \u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u7a7a\u8179\u6642TG\u3001ANGPTL3\u304a\u3088\u3073\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306b\u5bfe\u3059\u308b\u52b9\u679c<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

6\u30f5\u6708\u6642\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5e73\u5747\u5909\u5316\u7387<\/strong><\/p>\n<\/td>\n

\n

\u30f4\u30d1\u30ce\u30eb\u30bb\u30f3 4\u9031\u9023\u7d9a<\/strong><\/p>\n<\/td>\n

\n

\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u903120mg\uff08n=26\uff09<\/strong><\/p>\n<\/td>\n

\n

\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30d7\u30e9\u30bb\u30dc\uff08n=27\uff09<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

40 mg\uff08n=26\uff09<\/strong><\/p>\n<\/td>\n

\n

80 mg\uff08n=26\uff09<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u7a7a\u8179\u6642TG<\/p>\n<\/td>\n

\n

-36<\/p>\n<\/td>\n

\n

-53<\/p>\n<\/td>\n

\n

-47<\/p>\n<\/td>\n

\n

-16<\/p>\n<\/td>\n<\/tr>\n

\n

ANGPTL3<\/p>\n<\/td>\n

\n

-41<\/p>\n<\/td>\n

\n

-59<\/p>\n<\/td>\n

\n

-56<\/p>\n<\/td>\n

\n

+8<\/p>\n<\/td>\n<\/tr>\n

\n

\u30a2\u30ddCIII<\/p>\n<\/td>\n

\n

-40<\/p>\n<\/td>\n

\n

-61<\/p>\n<\/td>\n

\n

-52<\/p>\n<\/td>\n

\n

-6<\/p>\n<\/td>\n<\/tr>\n

\n

\u30ec\u30e0\u30ca\u30f3\u30c8C<\/p>\n<\/td>\n

\n

-35<\/p>\n<\/td>\n

\n

-47<\/p>\n<\/td>\n

\n

-40<\/p>\n<\/td>\n

\n

-14<\/p>\n<\/td>\n<\/tr>\n

\n

\u975eHDL-C<\/p>\n<\/td>\n

\n

-13<\/p>\n<\/td>\n

\n

-21<\/p>\n<\/td>\n

\n

-22<\/p>\n<\/td>\n

\n

-4<\/p>\n<\/td>\n<\/tr>\n

\n

\u30a2\u30ddB<\/p>\n<\/td>\n

\n

-7<\/p>\n<\/td>\n

\n

-12<\/p>\n<\/td>\n

\n

-10<\/p>\n<\/td>\n

\n

-3<\/p>\n<\/td>\n<\/tr>\n

\n

TC<\/p>\n<\/td>\n

\n

-11<\/p>\n<\/td>\n

\n

-21<\/p>\n<\/td>\n

\n

-19<\/p>\n<\/td>\n

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LDL-C<\/p>\n<\/td>\n

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+6<\/p>\n<\/td>\n

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-7<\/p>\n<\/td>\n

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-12<\/p>\n<\/td>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Kersten S. Angiopoietin-like3 in lipoprotein metabolism.Nat Rev Endocrinol 2017;13:731-739. <\/p>\n

2.Crooke ST, Baker BF, Xia S, et al. GalNAc3\u7d50\u54082′-\u30aa\u30e1\u30c8\u30ad\u30b7\u30a8\u30c1\u30eb\u30ad\u30e1\u30e9\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u81e8\u5e8a\u6027\u80fd\u306e\u7d71\u5408\u7684\u8a55\u4fa1\u3001I\uff1a\u30d2\u30c8\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306e\u7d4c\u9a13\u3002Nucleic Acid Ther 2019;29:16-32.3.VOLANESORSEN\uff08ISIS 304801\uff09\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\uff1a\u30d5\u30a7\u30fc\u30ba2\u3068\u30d5\u30a7\u30fc\u30ba3\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3002 <\/p>\n

3\u3064\u306e\u81e8\u5e8a\u8a66\u9a13\u3002Curr Atheroscler Rep 2020;22(5):18. <\/p>\n<\/td>\n<\/tr>\n

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