{"id":254367,"date":"2025-01-31T15:38:53","date_gmt":"2025-01-31T14:38:53","guid":{"rendered":"https:\/\/r3i.org\/%e7%84%a6%e7%82%b9-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ae%e6%ae%8b%e5%ad%98%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e8%bb%bd%e6%b8%9b%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e3%80%81%e6%ae%8b\/"},"modified":"2025-03-06T22:49:27","modified_gmt":"2025-03-06T21:49:27","slug":"%e7%84%a6%e7%82%b9-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ae%e6%ae%8b%e5%ad%98%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e8%bb%bd%e6%b8%9b%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e3%80%81%e6%ae%8b","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e7%84%a6%e7%82%b9-%e8%84%b3%e5%8d%92%e4%b8%ad%e3%81%ae%e6%ae%8b%e5%ad%98%e3%83%aa%e3%82%b9%e3%82%af%e3%82%92%e8%bb%bd%e6%b8%9b%e3%81%99%e3%82%8b%e3%81%9f%e3%82%81%e3%81%ab%e3%80%81%e6%ae%8b\/","title":{"rendered":"\u7126\u70b9 – \u8133\u5352\u4e2d\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u3002"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u306b\u3057\u3066\u8133\u5352\u4e2d\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b<\/h2>\n

2024\u5e748\u6708<\/span><\/h5>\n

\u3053\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d
\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3042\u3063\u305f\u3053\u3068\u306f\u3001\u8133\u5352\u4e2d\u3001\u7279\u306b\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u3082\u305f\u3089\u3057\u305f\u3002<\/p>\n

Han M, Huang K, Shen C, et al. LDL-C\u3068\u4e0d\u4e00\u81f4\u306e\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001
\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\uff1a\u4e2d\u56fd\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002\u8133\u5352\u4e2d2024;55:2066-74\u3002 <\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n

\n
\n\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/b><\/p>\n<\/td>\n

\n

\u8133\u5352\u4e2d\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d\u3068\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u3068\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u4e0d\u4e00\u81f4\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3059\u308b\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/p>\n<\/td>\n

\n

\u4e0d\u4e00\u81f4\u5206\u6790\u3092\u7528\u3044\u305f\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u8005 <\/b><\/p>\n<\/td>\n

\n

China-PAR\uff08Prediction for Atherosclerotic Cardiovascular Disease Risk in China\uff09\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e3\u3064\u306e\u30b3\u30db\u30fc\u30c8\u306b\u5408\u8a08113,448\u4eba\u306e\u88ab\u9a13\u8005\u304c\u767b\u9332\u3055\u308c\u3001\u305d\u306e\u3046\u306198,967\u4eba\uff08\u5e73\u5747\u5e74\u9f6251.4\u6b73\u3001\u7537\u602740.5\uff05\uff09\u304c\u6700\u7d42\u89e3\u6790\u306e\u5bfe\u8c61\u3068\u306a\u3063\u305f\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/b><\/p>\n<\/td>\n

\n

\u8133\u5352\u4e2d\u767a\u75c7\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d<\/span><\/p>\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089LDL-C\u3092\u5dee\u3057\u5f15\u3044\u305f\u5024\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/b><\/p>\n<\/td>\n

\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068LDL-C\u306e\u4e00\u81f4\/\u4e0d\u4e00\u81f4\u306e\u5206\u985e\u306f\u3001LDL-C\u306f130mg\/dL\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u540c\u7b49\u306e\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff0832.5mg\/dL\uff09\u3092\u30ab\u30c3\u30c8\u30dd\u30a4\u30f3\u30c8\u3068\u3057\u305f\u3002\u8133\u5352\u4e2d\u767a\u75c7\u306e\u88dc\u6b63\u30cf\u30b6\u30fc\u30c9\u6bd4\u306895\uff05\u4fe1\u983c\u533a\u9593\uff08Cis\uff09\u306e\u63a8\u5b9a\u306b\u306fCox\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u7d50\u679c<\/b><\/p>\n<\/td>\n

\n

728,776\u4eba\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b2859\u4ef6\u306e\u8133\u5352\u4e2d\u304c\u767a\u751f\u3057\u3001\u305d\u306e\u5185\u8a33\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u304c1811\u4ef6\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d\u304c849\u4ef6\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n<\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u8133\u5352\u4e2d\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd41.06\u300195\uff05CI 1.02-1.10\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd41.09\u300195\uff05CI 1.04-1.13\uff09\u3068\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u305f\u304c\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd40.95\u300195\uff05CI 0.88-1.03\uff09\u3068\u306f\u76f8\u95a2\u3057\u306a\u304b\u3063\u305f\u3002LDL-C\u4f4e\u5024\/\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\u306e\u88ab\u9a13\u8005\uff08\u57fa\u6e96\u7fa4\uff09\u3068\u6bd4\u8f03\u3059\u308b\u3068\u3001LDL-C\u4f4e\u5024\/\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306e\u88ab\u9a13\u8005\u3067\u306f\u8133\u5352\u4e2d\u304a\u3088\u3073\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u304c\u3001LDL-C\u9ad8\u5024\/\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306e\u88ab\u9a13\u8005\u3067\u306f\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/span>–<\/span>-C\/\u4f4e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024 (<\/span>\u88681<\/b>). <\/span> <\/p>\n<\/p>\n

\u88681. \u8133\u5352\u4e2d\u3068\u865a\u8840\u6027\u8133\u6897\u585e\u306e\u30ea\u30b9\u30af\uff1a\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\/LDL-C\u30ab\u30c6\u30b4\u30ea\u30fc\u5225<\/b><\/p>\n\n\n\n\n\n\n\n
\n

\u30ab\u30c6\u30b4\u30ea\u30fc<\/span><\/p>\n<\/td>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8133\u5352\u4e2d<\/span><\/p>\n<\/td>\n

\n

\u865a\u8840\u6027\u8133\u5352\u4e2d<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0f\u4f4eLDL-C<\/span><\/p>\n<\/td>\n

\n

1.15 (1.02-1.30)<\/span><\/p>\n<\/td>\n

\n

1.19 (1.03-1.38)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u9ad8LDL-C\/\u4f4e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/span><\/p>\n<\/td>\n

\n

1.07 (0.95-1.20)<\/span><\/p>\n<\/td>\n

\n

1.09 (0.94-1.25)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u7d50\u8ad6<\/b><\/p>\n<\/td>\n

\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u9ad8\u5024\u306f\u8133\u5352\u4e2d\u304a\u3088\u3073\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u306f\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u4e0d\u4e00\u81f4\u306e\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4e0d\u4e00\u81f4\u306e\u9ad8LDL\u3067\u306f\u306a\u3044 <\/span>–<\/span>C\u306f\u8133\u5352\u4e2d\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u9ad8\u3044\u30ea\u30b9\u30af\u3092\u3082\u305f\u3089\u3057\u305f\u3002\u308f\u308c\u308f\u308c\u306e\u6240\u898b\u306f\u3001\u6b8b\u5b58\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u4ecb\u5165\u306b\u3088\u3063\u3066\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u3055\u3089\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30b3\u30e1\u30f3\u30c8<\/b><\/p>\n

\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u3068\u865a\u8840\u6027\u5fc3\u75be\u60a3\u304a\u3088\u3073\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u308b(1,2)\u3002Copenhagen General Population Study\u306e10\u4e07\u4eba\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u6bb5\u968e\u7684\u306b\u9ad8\u3044\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u306f\u3001\u6bb5\u968e\u7684\u306b\u9ad8\u3044\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f(3)\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u304c\u4ed6\u306e\u6c11\u65cf\u3001\u7279\u306bLDLC\u6fc3\u5ea6\u306f\u4f4e\u3044\u304c\u8133\u5352\u4e2d\u767a\u75c7\u7387\u306f\u6b27\u7c73\u306e\u96c6\u56e3\u3088\u308a\u9ad8\u3044\u4e2d\u56fd\u4eba\u306b\u5f53\u3066\u306f\u307e\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b(4)\u3002\u3053\u306e\u5927\u898f\u6a21\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306f\u3001\u3053\u306e\u7591\u554f\u306b\u5bfe\u3059\u308b\u91cd\u8981\u306a\u6d1e\u5bdf\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u4e2d\u56fd\u4eba\u96c6\u56e3\u306b\u304a\u3044\u3066\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u8133\u5352\u4e2d\u3001\u7279\u306b\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3068\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u305f\u304c\u3001\u51fa\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3068\u306f\u76f8\u95a2\u3057\u306a\u304b\u3063\u305f\u3002 <\/span><\/p>\n<\/p>\n

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\u53c2\u8003\u6587\u732e<\/b><\/p>\n

    \n
  1. Langsted A, Madsen CM, Nordestgaard BG.\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5bc4\u4e0e\u3002J Intern Med 2020;288:116-27. <\/span><\/li>\n
  2. \u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002J Am Coll Cardiol 2013;61:427-36. <\/span><\/li>\n
  3. Varbo A, Nordestgaard BG.\u4e00\u822c\u96c6\u56e3112,512\u4eba\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3002Ann Neurol 2019;85:550-9. <\/span><\/li>\n
  4. Tsai C-F, Thomas B, Sudlow CLM.\u4e2d\u56fd\u4eba\u96c6\u56e3\u3068\u767d\u4eba\u96c6\u56e3\u306b\u304a\u3051\u308b\u8133\u5352\u4e2d\u3068\u305d\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u306e\u75ab\u5b66\uff1a\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3002Neurology 2013;81:264-272. <\/span><\/li>\n
  5. \u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0d\u4e00\u81f4\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u4e88\u6e2c\u3059\u308b\uff1a\u30ab\u30a4\u30eb\u30a2\u30f3\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002Hellenic J Cardiol 2024;doi: 10.1016\/j.hjc.2024.05.002. <\/span><\/li>\n<\/ol>\n

    \u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u865a\u8840\u6027\u8133\u5352\u4e2d\uff1b\u4e2d\u56fd\u4eba\u96c6\u56e3\uff1b\u6b8b\u5b58\u30ea\u30b9\u30af\uff1b\u4e0d\u4e00\u81f4\u5206\u6790<\/span><\/i><\/p>\n<\/div>\n<\/div>\n

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