{"id":254361,"date":"2025-01-25T14:16:16","date_gmt":"2025-01-25T13:16:16","guid":{"rendered":"https:\/\/r3i.org\/%e7%84%a6%e7%82%b9-%e5%ae%9f%e9%9a%9b%e3%81%ae%e3%83%87%e3%83%bc%e3%82%bf%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%af%e5%bf%83%e8%a1%80%e7%ae%a1\/"},"modified":"2025-02-16T22:29:28","modified_gmt":"2025-02-16T21:29:28","slug":"%e7%84%a6%e7%82%b9-%e5%ae%9f%e9%9a%9b%e3%81%ae%e3%83%87%e3%83%bc%e3%82%bf%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%af%e5%bf%83%e8%a1%80%e7%ae%a1","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e7%84%a6%e7%82%b9-%e5%ae%9f%e9%9a%9b%e3%81%ae%e3%83%87%e3%83%bc%e3%82%bf%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%af%e5%bf%83%e8%a1%80%e7%ae%a1\/","title":{"rendered":"\u7126\u70b9-\u5b9f\u969b\u306e\u30c7\u30fc\u30bf\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u591a\u304f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u7126\u70b9-\u5b9f\u969b\u306e\u30c7\u30fc\u30bf\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u591a\u304f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b<\/span><\/h2>\n
17 2020\u5e742\u6708<\/span><\/h5>\n

\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\u306e4\u4eba\u306b1\u4eba\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\uff08135\u301c499mg\/dL\u30011.52\u301c5.63mmol\/L\uff09\u304c\u9ad8\u3044\u3002\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u4e0a\u6607\u3059\u308b\u306b\u3064\u308c\u3066\u5897\u52a0\u3059\u308b\u3002 <\/span><\/p>\n

Lawler PR, Kotrri G, Koh M et al.\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u95a2\u9023\u3059\u308b\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5b9f\u4e16\u754c\u30ea\u30b9\u30af\u3068\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u6f5c\u5728\u7684\u9069\u683c\u6027\u3002Eur Heart J 2019; doi:10.1093\/eurheartj\/ehz767 <\/span><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u4f34\u3046\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u30a4\u30d9\u30f3\u30c8\u306e\u5b9f\u4e16\u754c\u3067\u306e\u30ea\u30b9\u30af\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\nCANHEART\u30b3\u30db\u30fc\u30c8\u3092\u7528\u3044\u305f\u96c6\u56e3\u89e3\u6790\u3067\u300117\u306e\u500b\u4eba\u30ec\u30d9\u30eb\u306e\u96fb\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u9023\u7d50\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n>\u30b5\u30f3\u30d7\u30eb\u306f\u30aa\u30f3\u30bf\u30ea\u30aa\u5dde\u306e40\u6b73\u4eba\u53e3\u304b\u3089\u62bd\u51fa\u3055\u308c\u3001\u305d\u306e\u3046\u30612,424,865\u4eba\u304c\u8102\u8cea\u30c7\u30fc\u30bf\uff08\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9[TG] \u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb[LDL\u2011C] \u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb[HDL-C] \u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u542b\u3080\uff09\u3092\u6709\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u3046\u3061196,717\u4eba\u306fASCVD\u304c\u78ba\u7acb\u3057\u3066\u3044\u305f\uff08\u4e2d\u592e\u5024[interquartile range] \u5e74\u9f6266[58\u201373] \uff1b\u5973\u602730.1\uff05\uff09\uff1b\u88ab\u9a13\u8005\u306e23.9\uff05\u306fTG> 2.0mmol\/L\u307e\u305f\u306f177mg\/dL\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5909\u6570\uff1a<\/strong><\/td>\n\n

– TG\u5024\uff08\u958b\u59cb1\u5e74\u524d\u306b\u6e2c\u5b9a\uff09<\/p>\n

– \u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306fASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u521d\u56de\u767a\u751f\u3068\u3057\u3001\u5fc3\u7b4b\u6897\u585e\uff08[MI] \uff09\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3001\u8133\u5352\u4e2d\u307e\u305f\u306f\u4e00\u904e\u6027\u8133\u865a\u8840\u767a\u4f5c\uff08TIA\uff09\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u5fc3\u8840\u7ba1\u6b7b\u3068\u5b9a\u7fa9\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\nTG\u5024\u306f\u3001<1\u30011.0-1.5\u30011.5-2.0\u30012.0-2.5\u30012.5-3.0\u30013.0-3.5\u30013.5-4.0\u3001>4.0mmol\/L\u306b\u5206\u985e\u3055\u308c\u305f\u3002\u5e74\u9f62\u3001\u6027\u5225\u3001\u6240\u5f97\u3001LDL-C\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7cd6\u5c3f\u75c5\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u9ad8\u8840\u5727\u3067\u8abf\u6574\u3057\u305fCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001TG\u30ab\u30c6\u30b4\u30ea\u30fc\u3068\u306e\u95a2\u9023\u3067ASCVD\u8ee2\u5e30\u3092\u89e3\u6790\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306f\u5168\u4f53\u7684\u306b\u8a55\u4fa1\u3055\u308c\u305f\u3060\u3051\u3067\u306a\u304f\u3001\u6027\u5225\u3001\u7cd6\u5c3f\u75c5\u306e\u72b6\u614b\u3001LDL-C\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\uff08\u2267\u307e\u305f\u306f< LDL-C\u306e\u4e2d\u592e\u5024\u30011.9mmol\/L\u307e\u305f\u306f74mg \/dL \uff09\u306b\u3088\u3063\u3066\u5c64\u5225\u5316\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\n

– \u5e73\u57472.9\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b24,097\u4ef6\u306eASCVD\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f\u3002\u5e74\u9f62\u3068\u6027\u3067\u6a19\u6e96\u5316\u3057\u305f\u4e00\u6b21\u30a2\u30a6\u30c8\u30ab\u30e0\u767a\u751f\u7387\u306f1000\u4eba\u5e74\u5f53\u305f\u308a38.6\u4eba\u3067\u3001TG\u304c\u6700\u3082\u4f4e\u3044\u7fa4\u304b\u3089\u6700\u3082\u9ad8\u3044\u7fa4\u3067\u306f\u305d\u308c\u305e\u308c32.2\u301c57.6\u4eba\u5e74\u3067\u3042\u3063\u305f\u3002 <\/span>
– \u57fa\u6e96\u30ab\u30c6\u30b4\u30ea\u30fc\uff08TG<1.0mmol\/L\uff09\u3068\u6bd4\u8f03\u3057\u3066\u3001TG\u306e\u5897\u52a0\u306fASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u6bb5\u968e\u7684\u306b\u9ad8\u3044\u30cf\u30b6\u30fc\u30c9\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002TG\u304c\u6700\u3082\u9ad8\u3044\u30ab\u30c6\u30b4\u30ea\u30fc\uff08> 4.0mmol\/L\uff09\u306e\u60a3\u8005\u306f\u3001\u6700\u3082\u4f4e\u3044\u30ab\u30c6\u30b4\u30ea\u30fc\u306e\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001ASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c52\uff05\u9ad8\u304b\u3063\u305f\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd41.52\u300195\uff05\u4fe1\u983c\u533a\u95931.36-1.71\uff1bp< 0.0001\uff09\u3002 <\/span>
– \u3053\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306e\u4e3b\u306a\u8981\u56e0\u306f\u3001MI\/\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3068\u8840\u884c\u518d\u5efa\u8853\u306e\u5897\u52a0\u3067\u3042\u3063\u305f\u3002<\/span>
– \u5168\u4f53\u3068\u3057\u3066\u300149,886\u4eba\uff0825\uff05\uff09\u306eASCVD\u5bfe\u8c61\u8005\u306fLDL-C\uff0841-100mg\/dL\u307e\u305f\u306f1.06-2.59mmol\/L\uff09\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3001TG\u5024\u304c\u4e0a\u6607\u3057\u3066\u3044\u305f\u3002\u5e73\u57472.9\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b6,327\u4f8b\uff0812.7\uff05\uff09\u304cASCVD\u30a4\u30d9\u30f3\u30c8\u3092\u7d4c\u9a13\u3057\u305f\u3002 <\/span><\/p>\n\n\n\n
\u7d50\u8ad6<\/strong><\/td>\nASCVD\u60a3\u8005\u3067\u306f\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u304c\u4e00\u822c\u7684\u3067\u3042\u308a\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u69d8\u3005\u306aTG\u30ec\u30d9\u30eb\u306b\u304a\u3044\u3066ASCVD\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002ASCVD\u60a3\u8005\u306e4\u4eba\u306b1\u4eba\u304c\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u5019\u88dc\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u3053\u306e\u7814\u7a76\u306f\u3001ASCVD\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u6709\u75c5\u7387\u306b\u95a2\u3057\u3066\u3001\u73fe\u5728\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6cbb\u7642\u6cd5\u3092\u80cc\u666f\u306b\u3001\u5b9f\u81e8\u5e8a\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u305d\u306e\u7d50\u679c\u3001\u9ad8TG\uff08> 2.0mmol\/L\u307e\u305f\u306f177mg\/dL\uff09\u306f\u3001LDL-C\u5024\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u4e00\u822c\u7684\u3067\u3042\u308a\u3001\u7d0425\uff05\u306b\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001TG\u5024\u306e\u4e0a\u6607\u306b\u4f34\u3044ASCVD\u30ea\u30b9\u30af\u304c\u9023\u7d9a\u7684\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u91cd\u8981\u3067\u3042\u308b1,2\u3002\u4f8b\u3048\u3070\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u76f8\u5bfe\u7684ASCVD\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306f\u3001\u5883\u754c\u57df\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff08TG\u50241.5\u301c2.0mmol\/L\uff09\u306e\u4eba\u306e11\uff05\u304b\u3089\u3001TG\u50244.0mmol\/L\u4ee5\u4e0a\u306e\u4eba\u306e52\uff05\u306b\u53ca\u3093\u3060\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001TG\u306e\u4e0a\u6607\u304c\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308bTG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u306e\u4e0a\u6607\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb1\u304c\u3001\u5b9f\u793e\u4f1a\u306b\u304a\u3051\u308b\u8102\u8cea\u95a2\u9023\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u91cd\u8981\u306a\u4e00\u56e0\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002 <\/p>\n

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\u305d\u306e\u4ed6\u306e\u7814\u7a76\u3067\u306f\uff0c\u4ee3\u66ff\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u3046\u3061\u3001PROMINENT\u8a66\u9a13\uff08Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes\uff09\u3067\u306f\u3001TG\u4e0a\u6607\u304c\u91cd\u8981\u306a\u8981\u7d20\u3067\u3042\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM-\u03b1\uff09\u3067\u3042\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u8a55\u4fa1\u304c\u884c\u308f\u308c\u3066\u3044\u308b4\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/p>\n

2.Laufs U, Parhofer KG, Ginsberg HN, Hegele RA.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u30ec\u30d3\u30e5\u30fc\u3002Eur Heart J 2020;41:99-109c. <\/p>\n

3.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/p>\n

4.Pemafibrate to Reduce Cardiovascular Outcomes by Reducing Triglycerides in Patients with Diabetes\uff08PROMINENT\uff09\u8a66\u9a13\u306e\u6839\u62e0\u3068\u30c7\u30b6\u30a4\u30f3\u3002Am Heart J 2018;206:80-93 <\/p>\n<\/td>\n<\/tr>\n

\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff1b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\uff1b\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u8a2d\u5b9a\uff1bREDUCE-IT\uff1bPROMINENT\uff1b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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