{"id":254356,"date":"2025-01-31T15:53:56","date_gmt":"2025-01-31T14:53:56","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-plozasiran%ef%bc%9a%e6%b7%b7%e5%90%88%e5%9e%8b%e9%ab%98%e8%84%82%e8%a1%80%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%96%b0%e8%a6%8fapoc3-sirna\/"},"modified":"2025-03-06T22:25:01","modified_gmt":"2025-03-06T21:25:01","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-plozasiran%ef%bc%9a%e6%b7%b7%e5%90%88%e5%9e%8b%e9%ab%98%e8%84%82%e8%a1%80%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%96%b0%e8%a6%8fapoc3-sirna","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-plozasiran%ef%bc%9a%e6%b7%b7%e5%90%88%e5%9e%8b%e9%ab%98%e8%84%82%e8%a1%80%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%96%b0%e8%a6%8fapoc3-sirna\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – Plozasiran\uff1a\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u304a\u3051\u308b\u65b0\u898fAPOC3 siRNA"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

Plozasiran\uff1a\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u304a\u3051\u308b\u65b0\u3057\u3044APOC3 siRNA\u85ac<\/h2>\n

2024\u5e748\u6708<\/span><\/h5>\n

\u809d\u7d30\u80de\u306eAPOC3\u3092\u6a19\u7684\u306b\u3057\u305f\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30af\u30e9\u30b9\u306e\u4f4e\u5206\u5b50\u5e72\u6e09RNA\uff08siRNA\uff09\u85ac\u3067\u3042\u308bplozasiran\u306f\u3001\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002
\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306e\u6cbb\u7642\u306e\u305f\u3081\u306eAPOC3\u3092\u6a19\u7684\u3068\u3059\u308bRNA\u5e72\u6e09\u85acplozasiran<\/p>\n

Ballantyne CM, Vasas S, Azizad M, et al. N Engl J Med 2024; doi: 10.1056\/NEJMoa2404143<\/i><\/p>\n

\u8a66\u9a13\u306e\u8981\u7d04<\/b><\/p>\n

\n
\n
\n\n\n\n\n\n\n\n\n\n
\n

\u76ee\u7684<\/b><\/b><\/p>\n<\/td>\n

\n

\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001plozasiran<\/span>\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u3092\u691c\u8a0e\u3059\u308b\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/b><\/b><\/p>\n<\/td>\n

\n

48<\/span>\u9031\u9593\u306e\u7b2c2b<\/span>\u76f8\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u7121\u4f5c\u70ba\u5316\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3002\u672c\u8a66\u9a13\u306f\u7c73\u56fd\u3001\u6b27\u5dde\u3001\u30cb\u30e5\u30fc\u30b8\u30fc\u30e9\u30f3\u30c9\u3001\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u3001\u30ab\u30ca\u30c0\u306e36<\/span>\u65bd\u8a2d\u3067\u5b9f\u65bd\u3055\u308c\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/b><\/b><\/p>\n<\/td>\n

\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG<\/span>\uff09\u5024150<\/span>\uff5e499 mg\/dL<\/span>\u3001\u304b\u3064\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C<\/span>\uff0970 mg\/dL<\/span>\u4ee5\u4e0a\u307e\u305f\u306f\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C<\/span>\uff09\u5024100 mg\/dL<\/span>\u4ee5\u4e0a\u3068\u5b9a\u7fa9\u3055\u308c\u308b\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306e\u60a3\u8005\u3002\u767b\u9332\u6642\u3001\u60a3\u8005\u306f2<\/span>\u9031\u9593\u4ee5\u4e0a\u5b89\u5b9a\u3057\u305f\u98df\u751f\u6d3b\u3092\u7d9a\u3051\u30014<\/span>\u9031\u9593\u4ee5\u4e0a\u5b89\u5b9a\u3057\u305f\u6700\u5927\u8010\u7528\u91cf\u306e\u30b9\u30bf\u30c1\u30f3\u3092\u670d\u7528\u3057\uff08\u30b9\u30bf\u30c1\u30f3\u670d\u7528\u304c\u3067\u304d\u306a\u3044\u5834\u5408\u307e\u305f\u306f\u305d\u306e\u610f\u601d\u304c\u306a\u3044\u5834\u5408\u3092\u9664\u304f\uff09\u3001\u5b89\u5b9a\u3057\u305f\u7528\u91cf\u306e\u57fa\u790e\u6cbb\u7642\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/b><\/b><\/p>\n

<\/b><\/p>\n<\/td>\n

\n

\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a<\/b>\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308924<\/span>\u9031\u307e\u3067\u306e\u7a7a\u8179\u6642TG<\/span>\u5024\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5909\u5316\u7387\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u65b9\u6cd5<\/b><\/b><\/p>\n<\/td>\n

\n

\u60a3\u8005\u30924<\/span>\u3064\u306e\u5404\u30b3\u30db\u30fc\u30c8\u5185\u3067plozasiran<\/span>\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306b3<\/span>\uff1a1<\/span>\u306e\u6bd4\u7387\u3067\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u3057\u305f\u3002\u7b2c1<\/span>\uff5e3<\/span>\u30b3\u30db\u30fc\u30c8\u306b\u306f\u30011<\/span>\u65e5\u76ee\u304a\u3088\u307312<\/span>\u9031\u76ee\uff08\u5e744<\/span>\u56de\u6295\u4e0e\uff09\u306bplozasiran<\/span>\uff0810 mg<\/span>\u300125 mg<\/span>\u307e\u305f\u306f50 mg<\/span>\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u76ae\u4e0b\u6295\u4e0e\u3057\u305f\u3002\u7b2c4<\/span>\u30b3\u30db\u30fc\u30c8\u306b\u306f\u30011<\/span>\u65e5\u76ee\u304a\u3088\u307324<\/span>\u9031\u76ee\uff08\u5e742<\/span>\u56de\u6295\u4e0e\uff09\u306bplozasiran 50 mg<\/span>\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3057\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u60a3\u8005\u306e\u30c7\u30fc\u30bf\u306f\u4f75\u5408\u3057\u305f\u3002\u6709\u52b9\u6027\u304a\u3088\u3073\u5b89\u5168\u6027\u306e\u89e3\u6790\u306f\u3001plozasiran<\/span>\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u30921<\/span>\u56de\u4ee5\u4e0a\u6295\u4e0e\u3055\u308c\u305f\u3059\u3079\u3066\u306e\u60a3\u8005\u306b\u57fa\u3065\u3044\u3066\u884c\u308f\u308c\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u7d50\u679c<\/b><\/b><\/p>\n<\/td>\n

\n

\u5168\u4f53\u3067353<\/span>\u4f8b\uff08\u5e73\u5747\u5e74\u9f6261<\/span>\u6b73\u3001\u5e73\u5747BMI 32 kg\/m2<\/sup><\/span>\uff09\u304cplozasiran<\/span>\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306e\u6295\u4e0e\u306b\u7121\u4f5c\u70ba\u5272\u308a\u4ed8\u3051\u3055\u308c\u3001\u305d\u306e\u3046\u3061324<\/span>\u4f8b\uff0891.8%<\/span>\uff09\u304c\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u305f\u3002\u5168\u4f53\u306753<\/span>\uff5e65%<\/span>\u304c\u7537\u6027\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u8102\u8cea\u5e73\u5747\u5024\u306f\u3001TG 244 mg\/dL<\/span>\u3001LDL-C 103 mg\/dL<\/span>\u3001non-HDL-C 151 mg\/dL<\/span>\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb47 mg\/dL<\/span>\u3067\u3042\u3063\u305f\u3002\u5168\u4f53\u306718%<\/span>\u306e\u60a3\u8005\u306fLDL-C<\/span>\u304c70 mg\/dL<\/span>\u672a\u6e80\u3067\u3042\u308a\u300192%<\/span>\u306e\u60a3\u8005\u304c\u30b9\u30bf\u30c1\u30f3\u3092\u670d\u7528\u3057\u3066\u3044\u305f\uff08\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f354%<\/span>\uff09\u3002<\/p>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308924<\/span>\u9031\u307e\u3067\u306eTG<\/span>\u5024\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5909\u5316\u7387\u3092\u88681<\/span>\u306b\u8981\u7d04\u3059\u308b\u3002plozasiran<\/span>\u6295\u4e0e\u306b\u3088\u308a\u3001TG<\/span>\u5024\u304c\u30d7\u30e9\u30bb\u30dc\u306b\u6bd4\u3079\u3066\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\uff08p<0.001<\/span>\uff09\u3002TG<\/span>\u5024\u306e\u4f4e\u4e0b\u52b9\u679c\u306f\u6295\u4e0e\u958b\u59cb\u5f8c4<\/span>\u9031\u3067\u8a8d\u3081\u3089\u308c\u305f\u3002\u307e\u305f\u3001plozasiran<\/span>\u6295\u4e0e\u306b\u3088\u308aAPOC3<\/span>\u3082\u30d7\u30e9\u30bb\u30dc\u306b\u6bd4\u3079\u3066\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\u3002\u305d\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5909\u5316\u7387\u306f\u300110 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\uff1a\u221257.3%<\/span>\uff0895% CI \u221266.6<\/span>\uff5e\u221248.1<\/span>\uff09\u300125 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\uff1a\u221272.5%<\/span>\uff0895% CI \u221281.7<\/span>\uff5e\u221263.3<\/span>\uff09\u300150 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\uff1a\u221278.5%<\/span>\uff0895% CI \u221287.8<\/span>\uff5e\u221269.3<\/span>\uff09\u3067\u3042\u308a\u3001TG<\/span>\u5024\u306e\u5909\u5316\u7387\u3068\u5f37\u3044\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u305f\u3002non-HDL-C<\/span>\u306e\u4f4e\u4e0b\u3082\u8a8d\u3081\u3089\u308c\u305f\u304c\uff0850 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\u3067\u221224.2%<\/span>\uff09\u3001\u3053\u308c\u306f\u4e3b\u306b\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4f4e\u4e0b\uff0850 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa447.5%<\/span>\u4f4e\u4e0b\u300195% CI 61.4<\/span>\uff5e33.7<\/span>\uff09\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002<\/p>\n

\n

24\u9031\u76ee\u306b\u304a\u3051\u308b\u7a7a\u8179\u6642<\/span>TG\u5024<\/span>150 mg\/dL\u672a\u6e80\u306e\u9054\u6210\u7387\u306f\u3001<\/span>10 mg\u5e74<\/span>4\u56de\u6295\u4e0e\u7fa4<\/span>79%\u3001<\/span>25 mg\u5e74<\/span>4\u56de\u6295\u4e0e\u7fa4<\/span>92%\u3001<\/span>50 mg\u5e74<\/span>4\u56de\u6295\u4e0e\u7fa4<\/span>92%\u3001<\/span>50 mg\u5e74<\/span>2\u56de\u6295\u4e0e\u7fa4<\/span>77%\u3067\u3042\u3063\u305f\u3002<\/span><\/p>\n

<\/b><\/p>\n

\u8868<\/b>1.<\/b><\/span>\u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e<\/b>TG<\/b><\/span>\u5024\u304a\u3088\u3073<\/b>24<\/b><\/span>\u9031\u76ee\u306e\u5909\u5316<\/b><\/b><\/p>\n

\n

\u4f75\u5408\u30d7\u30e9\u30bb\u30dc\u7fa4<\/p>\n

Plozasiran<\/p>\n

10 mg\u5e74<\/span>4\u56de\u6295\u4e0e\u7fa4<\/span><\/p>\n

Plozasiran<\/p>\n

25 mg\u5e74<\/span>4\u56de\u6295\u4e0e\u7fa4<\/span><\/p>\n

Plozasiran<\/p>\n

50 mg\u5e74<\/span>4\u56de\u6295\u4e0e\u7fa4<\/span><\/p>\n

Plozasiran<\/p>\n

50 mg\u5e74<\/span>2\u56de\u6295\u4e0e\u7fa4<\/span><\/p>\n

\n

N<\/p>\n

87<\/p>\n

67<\/p>\n

67<\/p>\n

66<\/p>\n

66<\/p>\n

\n

\u8102\u8cea\uff08<\/span>mg\/dL\uff09<\/span><\/p>\n

\n

\n

\n

\n

\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eTG<\/span><\/p>\n

237.2\u00b176.2<\/p>\n

253.2\u00b181.4<\/p>\n

234.1\u00b172.7<\/p>\n

250.3\u00b181.3<\/p>\n

248.0\u00b180.6<\/p>\n

\n

\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5909\u5316\u7387\uff0895% CI<\/span>\uff09vs. <\/span>\u30d7\u30e9\u30bb\u30dc<\/p>\n

\n

\u221249.8<\/p>\n

(\u221259.0, \u221240.6)<\/p>\n

\u221256.0<\/p>\n

(\u221265.1, \u221246.8)<\/p>\n

\u221262.4<\/p>\n

(\u221271.5, -53.2)<\/p>\n

\u221244.2<\/p>\n

(\u221253.4, \u221235.0)<\/p>\n

\n

\n

\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u60aa\u5316\u306f\uff0c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f10%<\/span>\u306e\u60a3\u8005\u306b\u8a8d\u3081\u3089\u308c\u3001plozasiran 10 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\u3067\u306f12%<\/span>\u300125 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\u3067\u306f7%<\/span>\u300150 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\u3067\u306f20%<\/span>\u300150 mg<\/span>\u5e742<\/span>\u56de\u6295\u4e0e\u7fa4\u3067\u306f21%<\/span>\u306e\u60a3\u8005\u306b\u8a8d\u3081\u3089\u308c\u305f\u3002<\/p>\n

\n<\/td>\n<\/tr>\n

\n

\u8457\u8005\u306e\u7d50\u8ad6<\/b><\/b><\/p>\n<\/td>\n

\n

\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u672c\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001plozasiran<\/span>\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u306624<\/span>\u9031\u76ee\u306eTG<\/span>\u5024\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u81e8\u5e8a\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3092\u5b9f\u65bd\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002 <\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30b3\u30e1\u30f3\u30c8<\/b><\/b><\/p>\n

TG<\/span>\u304a\u3088\u3073LDL-C<\/span>\u306e\u9ad8\u5024\u3092\u7279\u5fb4\u3068\u3059\u308b\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306f\u3001\u80a5\u6e80\u304a\u3088\u30732<\/span>\u578b\u7cd6\u5c3f\u75c5\u306e\u6709\u75c5\u7387\u306e\u5897\u52a0\u306b\u3064\u308c\u3066\u3001\u5897\u52a0\u306e\u4e00\u9014\u3092\u305f\u3069\u3063\u3066\u3044\u308b\u3002TG<\/span>\u5024\u9ad8\u5024\u306fTG-rich<\/span>\u30ea\u30dd\u86cb\u767d\u304a\u3088\u3073\u305d\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u30b5\u30ed\u30b2\u30fc\u30c8\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3068\u3055\u308c\u3066\u3044\u308b\u304c\uff0c\u3053\u308c\u306f\u30ea\u30dd\u86cb\u767d\u7c92\u5b501<\/span>\u500b\u304c\u6700\u5927\u3067LDL<\/span>\u306e4<\/span>\u500d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u904b\u3076\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u308b\u305f\u3081\u3067\u3042\u308b\uff081<\/span>\uff09\u3002TG-rich<\/span>\u30ea\u30dd\u86cb\u767d\u306e\u5897\u52a0\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\uff082<\/span>\uff09\u3001\u30d2\u30c8\u3067\u306f\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\uff081,3<\/span>\uff09\u304c\u30e1\u30ab\u30cb\u30ba\u30e0\u7814\u7a76\u3067\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u95a2\u9023\u3059\u308bTG<\/span>\u9ad8\u5024\u3068LDL-C<\/span>\u9ad8\u5024\u306e\u4e21\u65b9\u3092\u6cbb\u7642\u3059\u308b\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002<\/p>\n

\n

\u9ad9\u3044LDL-C<\/span>\u4f4e\u4e0b\u52b9\u679c\u304c\u5f97\u3089\u308c\u308b\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u3066\u3082\u3001TG<\/span>\u9ad8\u5024\u304c\u7d9a\u304f\u60a3\u8005\u306f\u3001\u4f9d\u7136\u3068\u3057\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u304c\u9ad8\u3044\uff081, 4-6<\/span>\uff09\u3002\u305d\u306e\u305f\u3081\u3001TG-rich<\/span>\u30ea\u30dd\u86cb\u767d\u4ee3\u8b1d\u306e\u69d8\u3005\u306a\u6a19\u7684\u3092\u5bfe\u8c61\u3068\u3057\u305f\u65b0\u3057\u3044\u6cbb\u7642\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u958b\u767a\u304c\u9032\u3093\u3060\u3002\u305d\u3046\u3057\u305f\u6a19\u7684\u306e\u4e00\u3064\u304c\u3001TG-rich<\/span>\u30ea\u30dd\u86cb\u767d\u4ee3\u8b1d\u306e\u91cd\u8981\u306a\u5236\u5fa1\u56e0\u5b50\u3067\u3042\u308b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC3<\/span>\uff08APOC3<\/span>\uff09\u3067\u3042\u308b\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001APOC3<\/span>\u6a5f\u80fd\u55aa\u5931\u578b\u5909\u7570\u3092\u6709\u3059\u308b\u4eba\u306fTG<\/span>\u5024\u304c\u4f4e\u304f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u3044\u3053\u3068\u3092\u793a\u3059\u7814\u7a76\u306b\u3088\u308a\u3001\u652f\u6301\u3055\u308c\u3066\u3044\u308b\uff087-9<\/span>\uff09\u3002<\/p>\n

\n

APOC3<\/span>\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308bsiRNA<\/span>\u3092\u7528\u3044\u305f\u6cbb\u7642\u306f\u3001\u305d\u306e\u7279\u7570\u6027\u3001\u52b9\u529b\u304a\u3088\u3073\u53ef\u9006\u6027\u306e\u9ad8\u3055\u304b\u3089\u3001\u5927\u304d\u306a\u95a2\u5fc3\u3092\u96c6\u3081\u3066\u3044\u308b\u3002plozasiran<\/span>\u306f\u3001\u809d\u81d3\u3067\u306eAPOC3<\/span>\u767a\u73fe\u3092\u6291\u5236\u3059\u308bN-<\/span>\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408siRNA<\/span>\u85ac\u3067\u3042\u308b\u3002\u5065\u5eb7\u88ab\u9a13\u8005\u304a\u3088\u3073\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5148\u884c\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001plozasiran<\/span>\u306fAPOC3<\/span>\u5024\u304a\u3088\u3073TG<\/span>\u5024\u306e\u7528\u91cf\u4f9d\u5b58\u7684\u306a\u4f4e\u4e0b\u4f5c\u7528\u3092\u793a\u3057\u305f\uff0810<\/span>\uff09\u3002<\/p>\n

\n

\u672c\u8a66\u9a13\u3067\u306f\u3001plozasiran<\/span>\u6295\u4e0e\u306b\u3088\u308a\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u306eTG<\/span>\u5024\u304c\u8457\u660e\u304b\u3064\u6301\u7d9a\u7684\u306b\u4f4e\u4e0b\u3057\u3001\u307b\u3068\u3093\u3069\u306e\u60a3\u8005\u304c24<\/span>\u9031\u76ee\u306bTG<\/span>\u5024150 mg\/dL<\/span>\u672a\u6e80\u3092\u9054\u6210\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5ef6\u9577\u8ffd\u8de1\u8abf\u67fb\u306e\u7d50\u679c\u3001plozasiran<\/span>\u306e\u52b9\u679c\u306f\u6700\u7d42\u6295\u4e0e\u5f8c36<\/span>\u9031\u9593\u3092\u7d4c\u904e\u3057\u3066\u3082\u6301\u7d9a\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u300250 mg<\/span>\u5e744<\/span>\u56de\u6295\u4e0e\u7fa4\u304a\u3088\u3073\u5e742<\/span>\u56de\u6295\u4e0e\u7fa4\u3067\u307f\u3089\u308c\u305f\u30b0\u30ea\u30b3\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u5024\u306e\u4e0a\u6607\u306f\u3001\u98df\u5f8c\u306e\u8840\u7cd6\u5909\u5316\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u540c\u69d8\u306e\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u60aa\u5316\u306f\u3001APOC3<\/span>\u306e\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u85acvolanesorsen<\/span>\u3092\u6295\u4e0e\u3055\u308c\u305f\u5bb6\u65cf\u6027\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u8840\u75c7\u75c7\u5019\u7fa4\u306e\u60a3\u8005\u3067\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u8840\u7cd6\u5024\u306e\u6052\u5e38\u6027\u306b\u5bfe\u3059\u308b\u9577\u671f\u7684\u306a\u6709\u5bb3\u4f5c\u7528\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u306a\u3044\uff0811<\/span>\uff09\u3002<\/p>\n

\n

\u4ee5\u4e0a\u3088\u308a\u3001\u7b2c2<\/span>\u76f8\u8a66\u9a13\u3067\u5f97\u3089\u308c\u305f\u6709\u671b\u306a\u7d50\u679c\u304b\u3089\u3001plozasiran<\/span>\u6295\u4e0e\u306b\u3088\u308bTG<\/span>\u5024\u4f4e\u4e0b\u306b\u95a2\u9023\u3057\u3066\u6b8b\u5b58\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3059\u308b\u304b\u5426\u304b\u3092\u8abf\u3079\u308b\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3092\u542b\u3081\u3001plozasiran<\/span>\u306e\u3055\u3089\u306a\u308b\u81e8\u5e8a\u958b\u767a\u304c\u652f\u6301\u3055\u308c\u308b\u3002<\/p>\n

\n

References<\/b><\/p>\n

1. Nordestgaard BG. Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology. Circ Res 2016;118:547-563.<\/p>\n

2. Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies \u2014 a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021;42:4791-806.<\/p>\n

3. Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet 2014;384:626-635.<\/p>\n

4. Langsted A, Madsen CM, Nordestgaard BG. Contribution of remnant cholesterol to cardiovascular risk. J Intern Med 2020;288:116-127.<\/p>\n

5. Varbo A, Benn M, Tybj\u00e6rg-Hansen A, et al. Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol 2013;61:427-436.<\/p>\n

6. Schwartz GG, Abt M, Bao W, et al. Fasting triglycerides predict recurrent ischemic events in patients with acute coronary syndrome treated with statins. J Am Coll Cardiol 2015;65:2267-2275.<\/p>\n

7. J\u00f8rgensen AB, Frikke-Schmidt R, Nordestgaard BG, Tybj\u00e6rg-Hansen A. Loss-of-function mutations in APOC3 and risk of ischemic vascular disease. N Engl J Med 2014;371:32-41.<\/p>\n

8. TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med 2014;371:22-31.<\/p>\n

9. Wulff AB, Nordestgaard BG, Tybj\u00e6rg-Hansen A. APOC3 loss-of-function mutations, remnant cholesterol, low-density lipoprotein cholesterol, and cardiovascular risk: mediation- and meta-analyses of 137895 individuals. Arterioscler Thromb Vasc Biol 2018;38:660-668.<\/p>\n

10. Gaudet D, Clifton P, Sullivan D, et al. RNA interference therapy targeting apolipoprotein C-III in hypertriglyceridemia. NEJM Evid 2023;2(12):EVIDoa2200325.<\/p>\n

11. Jones A, Peers K, Wierzbicki AS, et al. Long-term effects of volanesorsen on triglycerides and pancreatitis in patients with familial chylomicronaemia syndrome (FCS) in the UK Early Access to Medicines Scheme (EAMS). Atherosclerosis 2023;375:67-74.<\/p>\n

Key words: apolipoprotein C3; plozasiran; triglyceride-rich lipoproteins; remnant cholesterol; residual cardiovascular risk<\/i><\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n

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