{"id":254351,"date":"2025-01-21T18:43:40","date_gmt":"2025-01-21T17:43:40","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%82%aa%e3%83%ac%e3%82%b6%e3%83%ab%e3%82%bb%e3%83%b3%e3%81%af%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80\/"},"modified":"2025-03-01T16:08:35","modified_gmt":"2025-03-01T15:08:35","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%82%aa%e3%83%ac%e3%82%b6%e3%83%ab%e3%82%bb%e3%83%b3%e3%81%af%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%82%aa%e3%83%ac%e3%82%b6%e3%83%ab%e3%82%bb%e3%83%b3%e3%81%af%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u306f\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u6709\u671b\u3067\u3042\u308b"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]<\/p>\n

Olezarsen\u306f\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u6cbb\u7642\u85ac\u3068\u3057\u3066\u6709\u671b\u3067\u3042\u308b<\/span><\/h2>\n
2024\u5e7406\u670827\u65e5<\/span><\/h5>\n
Bridge\u2013TIMI 73a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III\uff08APOC3\uff09\u306emRNA\u3092\u6a19\u7684\u3068\u3059\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bolezarsen\uff08\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\uff09\u306f\u3001\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3057\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002<\/div>\n
Bergmark BA, Marston NA, Prohaska TA, et al. Olezarsen for hypertriglyceridemia in patients at high cardiovascular risk. N Engl J Med 2024; DOI: 10.1056\/NEJMoa2402309<\/em><\/div>\n

\u8a66\u9a13\u306e\u8981\u7d04<\/strong><\/p>\n\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3057\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u304a\u3088\u3073\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001olezarsen\u306e\u6709\u52b9\u6027\u304a\u3088\u3073\u5b89\u5168\u6027\u3092\u691c\u8a0e\u3059\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\u7b2cIIb\u76f8\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3002\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3057\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u6210\u4eba\u304a\u3088\u3073\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3059\u308b\u6210\u4eba\u3092\u300150 mg\u30b3\u30db\u30fc\u30c8\u306880 mg\u30b3\u30db\u30fc\u30c8\u306b1\uff1a1\u306e\u6bd4\u3067\u5272\u308a\u4ed8\u3051\u305f\u3002\u6b21\u306b\u3001\u5404\u30b3\u30db\u30fc\u30c8\u5185\u3067\u3001olezarsen\u3092\u67081\u56de\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u7fa4\u3068\u5bfe\u5fdc\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u3001\u60a3\u8005\u30923\uff1a1\u306e\u6bd4\u3067\u5272\u308a\u4ed8\u3051\u305f\u3002\u6295\u4e0e\u671f\u9593\u306f12\u30f5\u6708\u3068\u3057\u3001\u305d\u306e\u5f8c\u306b13\u9031\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u3092\u8a2d\u3051\u305f\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u96c6\u56e3<\/strong><\/td>\n\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff08128\u4f8b\u3001TG\uff1d150\uff5e499 mg\/dL\uff09\u307e\u305f\u306f\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff08TG\u2267500 mg\/dL\uff09\u3092\u6709\u3059\u308b\u60a3\u8005154\u4f8b\uff08\u5e73\u5747\u5e74\u9f62\uff1a62\u6b73\u3001\u5973\u6027\u306e\u5272\u5408\uff1a42%\uff09\u3092\u3001olezarsen 50 mg\u3001olezarsen 80 mg\u304a\u3088\u3073\u5bfe\u5fdc\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u306e\u67081\u56de\u6295\u4e0e\u7fa4\uff08\u305d\u308c\u305e\u308c58\u4f8b\u300157\u4f8b\u304a\u3088\u307339\u4f8b\uff09\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u672c\u8a66\u9a13\u3067\u306f\u3001\u72ec\u7acb\u3057\u305f\u30c7\u30fc\u30bf\u5b89\u5168\u6027\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u59d4\u54e1\u4f1a\u304c\u5b89\u5168\u6027\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u4e3b\u8981\u7814\u7a76\u8a55\u4fa1\u9805\u76ee<\/strong><\/td>\n\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1aTG\u5024\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30896\u30f5\u6708\u5f8c\u307e\u3067\u306e\u5909\u5316\u7387\uff08olezarsen\u306e\u5404\u7528\u91cf\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u5dee\u3068\u3057\u3066\u5831\u544a\uff09
\u4e3b\u306a\u526f\u6b21\u8a55\u4fa1\u9805\u76ee<\/strong>\uff1aAPOC3\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09B\u3001non-HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u304a\u3088\u3073\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u306e\u5909\u5316\u91cf<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\nOlezarsen\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u30921\u56de\u4ee5\u4e0a\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u3092\u89e3\u6790\u5bfe\u8c61\u3068\u3057\u305f\uff08modified intention-to-treat\u96c6\u56e3\uff09\u3002\u5171\u5206\u6563\u5206\u6790\u30e2\u30c7\u30eb\uff08TG\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u306e\u5bfe\u6570\u5909\u63db\u5024\u3092\u30e2\u30c7\u30eb\u306b\u6295\u5165\uff09\u3092\u7528\u3044\u3066\u3001olezarsen\u7fa4\u3092\u7528\u91cf\u5225\u306b\u4f75\u5408\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u306b\u95a2\u3059\u308b\u7fa4\u9593\u5dee\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u63a8\u5b9a\u5024\u3092\u7b97\u51fa\u3057\u305f\u5f8c\u3001\u30c7\u30fc\u30bf\u3092\u4f75\u5408\u3057\u3001\u5168\u4f53\u306e\u63a8\u5b9a\u5024\u3068\u305d\u306e95%\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u3092\u6c42\u3081\u305f\u3002<\/td>\n<\/tr>\n
\u7d50\u679c<\/strong><\/td>\n\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u306f\u3001\u307b\u307c\u3059\u3079\u3066\uff0897%\uff09\u306e\u60a3\u8005\u304c\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u304a\u308a\u300131%\u306e\u60a3\u8005\u304c2\u7a2e\u985e\u4ee5\u4e0a\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u305f\u3002TG\u5024\u306e\u4e2d\u592e\u5024\u306f241.5 mg\/dL\uff082.7 mmol\/L\uff09\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u7279\u6027\u306f\u3001\u6982\u3057\u3066\u8a66\u9a13\u7fa4\u9593\u3067\u3088\u304f\u30d0\u30e9\u30f3\u30b9\u304c\u3068\u308c\u3066\u3044\u305f\u3002<\/p>\n

TG\u5024\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u30896\u30f5\u6708\u5f8c\u307e\u3067\u306e\u5e73\u5747\u4f4e\u4e0b\u7387\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30677.8%\uff0895% CI\uff1a0.2%\uff5e15.3%\uff09\u306b\u5bfe\u3057\u3001olezarsen 50 mg\u7fa4\u306757.1%\uff0895% CI\uff1a50.9%\uff5e63.2%\uff09\u3001olezarsen 80 mg\u7fa4\u306760.9%\uff0895% CI\uff1a54.7%\uff5e67.1%\uff09\u3067\u3042\u3063\u305f\u3002olezarsen\u306e\u5404\u7528\u91cf\u7fa4\u306b\u304a\u3051\u308b\u5e73\u5747\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee\u306e\u7d76\u5bfe\u5024\u306f\u300150 mg\u7fa4\u3067-49.3%\uff0895% CI\uff1a-39.5%\uff5e-59.0%\uff09\u300180 mg\u7fa4\u3067-53.1%\uff0895% CI\uff1a-43.4%\uff5e-62.9%\uff09\u3067\u3042\u3063\u305f\uff08\u5404\u7528\u91cf\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u6bd4\u8f03\uff1ap\uff1c0.001\uff09\uff08\u88681<\/strong>\uff09\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3057\u3066\u3044\u305f128\u4f8b\u306e\u3046\u3061\u30016\u30f5\u6708\u5f8c\u306bTG\u5024\u304c150 mg\/dL\u672a\u6e80\u3068\u306a\u3063\u305f\u60a3\u8005\u306e\u5272\u5408\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30674\/34\u4f8b\uff0812%\uff09\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u300150 mg\u7fa4\u306742\/49\u4f8b\uff0886%\uff09\u300180 mg\u7fa4\u306742\/45\u4f8b\uff0893%\uff09\u3067\u3042\u3063\u305f\uff08\u5404\u7528\u91cf\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u6bd4\u8f03\uff1ap\uff1c0.001\uff09\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u88681.\u3000\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304a\u3088\u30736\u30f5\u6708\u5f8c\u306e\u4e3b\u306a\u8102\u8cea\u8a55\u4fa1\u9805\u76ee<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u8a55\u4fa1\u9805\u76ee<\/strong><\/p>\n

mg\/dL<\/strong><\/p>\n<\/td>\n

\n

Olezarsen 50 mg\u7fa4<\/strong><\/p>\n

(58\u4f8b)<\/strong><\/p>\n<\/td>\n

\n

Olezarsen 80 mg\u7fa4<\/strong><\/p>\n

(57\u4f8b)<\/strong><\/p>\n<\/td>\n

\n

\u30d7\u30e9\u30bb\u30dc\u7fa4<\/p>\n

(39\u4f8b)<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eTG\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

230.0<\/p>\n

(182.5\u2013331.5)<\/p>\n<\/td>\n

\n

241.5<\/p>\n

(179.5\u2013357.5)<\/p>\n<\/td>\n

\n

249.3<\/p>\n

(219.5\u2013284.5)<\/p>\n<\/td>\n<\/tr>\n

\n

6\u30f5\u6708\u5f8c\u306b\u304a\u3051\u308b\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee<\/p>\n<\/td>\n

\n

49.3%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

53.1%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

–<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eAPOC3\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

15.3 (12.0\u201319.3)<\/p>\n<\/td>\n

\n

13.4 (11.5\u201317.9)<\/p>\n<\/td>\n

\n

15.8 (13.2\u201318.7)<\/p>\n<\/td>\n<\/tr>\n

\n

6\u30f5\u6708\u5f8c\u306b\u304a\u3051\u308b\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee<\/p>\n<\/td>\n

\n

64.2%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

73.2%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eVLDL-C\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

41.0 (34.0\u201362.5)<\/p>\n<\/td>\n

\n

43.0 (31.0\u201356.7)<\/p>\n<\/td>\n

\n

41.5 (36.0\u201361.0)<\/p>\n<\/td>\n<\/tr>\n

\n

6\u30f5\u6708\u5f8c\u306b\u304a\u3051\u308b\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee<\/p>\n<\/td>\n

\n

46.2%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

49.7%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306enon-HDL-C\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

132.2<\/p>\n

(103.5\u2013156.5)<\/p>\n<\/td>\n

\n

126.0<\/p>\n

(110.0\u2013150.5)<\/p>\n<\/td>\n

\n

134.5<\/p>\n

(110.0\u2013161.5)<\/p>\n<\/td>\n<\/tr>\n

\n

6\u30f5\u6708\u5f8c\u306b\u304a\u3051\u308b\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee<\/p>\n<\/td>\n

\n

25.4%<\/p>\n<\/td>\n

\n

23.1%<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eapoB\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

90.8 (75.5\u2013105.0)<\/p>\n<\/td>\n

\n

93.0 (78.0\u2013107.0)<\/p>\n<\/td>\n

\n

94.0 (78.0\u2013114.5)<\/p>\n<\/td>\n<\/tr>\n

\n

6\u30f5\u6708\u5f8c\u306b\u304a\u3051\u308b\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee<\/p>\n<\/td>\n

\n

18.2%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

18.5%<\/p>\n

p<0.001<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eLDL-C\u3001\u4e2d\u592e\u5024\uff08IQR\uff09<\/p>\n<\/td>\n

\n

83.8 (59.5\u2013106.0)<\/p>\n<\/td>\n

\n

80.5 (62.0\u2013102.0)<\/p>\n<\/td>\n

\n

81.5 (62.0\u2013104.5)<\/p>\n<\/td>\n<\/tr>\n

\n

6\u30f5\u6708\u5f8c\u306b\u304a\u3051\u308b\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee<\/p>\n<\/td>\n

\n

9.9%<\/p>\n

NS<\/p>\n<\/td>\n

\n

7.7%<\/p>\n

NS<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

NS\uff1a\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u3067\u306a\u3044\u3001VLDL-C\uff1a\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/p>\n

 <\/p>\n

Olezarsen\u306e\u5404\u7528\u91cf\u7fa4\u3067\u306f\u3001APOC3\u3001apoB\u304a\u3088\u3073non-HDL C\u5024\u3082\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\u304c\u3001LDL-C\u5024\u306e\u6709\u610f\u306a\u5909\u5316\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u88681\uff09\u3002<\/p>\n

 <\/p>\n

\u81e8\u5e8a\u7684\u306b\u610f\u5473\u306e\u3042\u308b\u809d\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\u5024\u306e\u767a\u73fe\u983b\u5ea6\u306f\u6975\u3081\u3066\u4f4e\u304f\u3001\u8a66\u9a13\u7fa4\u9593\u3067\u6709\u610f\u5dee\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u30d3\u30ea\u30eb\u30d3\u30f3\u5024\u306e\u5927\u5e45\u306a\u4e0a\u6607\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002Olezarsen\u6295\u4e0e\u671f\u9593\u4e2d\u3001\u91cd\u5ea6\u306e\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\u3092\u767a\u73fe\u3057\u305f\u60a3\u8005\u306f\u3044\u306a\u304b\u3063\u305f\u3002<\/span><\/p>\n

 <\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3092\u6709\u3057\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u4e3b\u306a\u5bfe\u8c61\u3068\u3057\u3066\u3001olezarsen\u309250 mg\u307e\u305f\u306f80 mg\u306e\u7528\u91cf\u3067\u67081\u56de\u6295\u4e0e\u3057\u305f\u3068\u304d\u3001TG\u5024\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3001\u91cd\u5927\u306a\u5b89\u5168\u6027\u306e\u61f8\u5ff5\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002Olezarsen\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bapoB\u5024\u304a\u3088\u3073non-HDL-C\u5024\u3082\u610f\u5473\u306e\u3042\u308b\u4f4e\u4e0b\u3092\u793a\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u304a\u3088\u3073\u305d\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u306e\u9ad8\u5024\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u539f\u56e0\u3068\u306a\u308b\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u306b\u3064\u3044\u3066\u306f\u3001\u89b3\u5bdf\u7814\u7a76\u304a\u3088\u3073\u907a\u4f1d\u5b66\u7684\u7814\u7a76\u304b\u3089\u306e\u69d8\u3005\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3084\u3001\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u306e\u60c5\u5831\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\uff081\uff09\u3002\u3057\u304b\u3057\u73fe\u6642\u70b9\u3067\u306f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6700\u5584\u306e\u4e88\u9632\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001TG\u5024\u306e\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u304c\u95a2\u9023\u3059\u308b\u3068\u3044\u3046\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\uff3bREDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl\u2013Intervention Trial\uff09\uff081\uff09\u4ee5\u5916\u306b\u306f\uff3d\u5341\u5206\u306b\u5f97\u3089\u308c\u3066\u3044\u306a\u3044\uff083,4\uff09\u3002TG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u306e\u4ee3\u8b1d\u306f\u8907\u96d1\u3067\u3042\u308b\u305f\u3081\u3001\u69d8\u3005\u306a\u4ee3\u8b1d\u6a5f\u69cb\u3092\u6a19\u7684\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u793a\u3059\u65b0\u898fTG\u4f4e\u4e0b\u7642\u6cd5\u306e\u63a2\u7d22\u304c\u7d9a\u3051\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n

Olezarsen\uff08ISIS 678354\uff09\u306f\u3001\u958b\u767a\u6bb5\u968e\u306b\u3042\u308bN-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\u578b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308a\u3001APOC3\u306emRNA\u306b\u4f5c\u7528\u3057\u3066TG\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002\u5065\u5eb7\u88ab\u9a13\u8005\u3092\u5bfe\u8c61\u3068\u3059\u308b\u7b2cI\u76f8\u8a66\u9a13\uff085\uff09\u304a\u3088\u3073\u5c0f\u898f\u6a21\u306a\u7b2cII\u76f8\u7528\u91cf\u8a2d\u5b9a\u8a66\u9a13\uff086\uff09\u3067\u826f\u597d\u306a\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3053\u3068\u306b\u57fa\u3065\u304d\u3001Bridge\u2013TIMI 73a\u8a66\u9a13\u3067\u306f\u3001\u4e2d\u7b49\u75c7\u307e\u305f\u306f\u91cd\u75c7\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3001olezarsen\u306e\u6709\u52b9\u6027\u304a\u3088\u3073\u5b89\u5168\u6027\u304c\u691c\u8a0e\u3055\u308c\u305f\u3002\u672c\u8a66\u9a13\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u60a3\u8005\u306e\u5927\u534a\u304c\u4e2d\u7b49\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff3b150\uff5e499 mg\/dL\uff081.7\uff5e5.6 mmol\/L\uff09\uff3d\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u60a3\u8005\u306e22%\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u7f79\u60a3\u3057\u3066\u3044\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eTG\u5024\u306e\u4e2d\u592e\u5024\u306f241.5 mg\/dL\uff082.7 mmol\/L\uff09\u3067\u3042\u308a\u3001\u3053\u306e\u60a3\u8005\u96c6\u56e3\u304cTG\u4f4e\u4e0b\u85ac\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306e\u5bfe\u8c61\u3068\u3057\u3066\u9069\u5207\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n

\u672c\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001olezarsen\u6295\u4e0e\u304cTG\u5024\u306e\u4f4e\u4e0b\u306b\u6709\u52b9\u3067\u3042\u308a\u3001\u6295\u4e0e\u958b\u59cb6\u30f5\u6708\u5f8c\u306eTG\u5024\u304c\u7d0450%\u4f4e\u4e0b\u3057\u305f\u3053\u3068\uff08\u4f4e\u4e0b\u7387\u306e\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u306e\u5dee\uff1a50 mg\u7fa4\u306749.3%\u300180 mg\u7fa4\u306753.1%\uff09\u3001\u307e\u305f\u3001olezarsen\u306e\u52b9\u679c\u304c\u8ffd\u8de1\u8abf\u67fb\u671f\u9593\u306b\u308f\u305f\u308a\u6301\u7d9a\u3057\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002Olezarsen\u6295\u4e0e\u306b\u4f34\u3044\u3001\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u306e\u4ed6\u306e\u30de\u30fc\u30ab\u30fc\u306b\u3082\u610f\u5473\u306e\u3042\u308b\u4f4e\u4e0b\uff3bnon-HDL-C\uff08\u7d0425%\u4f4e\u4e0b\uff09\u3001apoB\uff0818%\u4f4e\u4e0b\uff09\u306a\u3069\uff09\uff3d\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002LDL-C\u5024\u306e\u4f4e\u4e0b\uff08\u7d048\uff5e10%\uff09\u3082\u8a8d\u3081\u3089\u308c\u305f\u304c\u3001\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u3082\u306e\u3067\u306a\u304b\u3063\u305f\u3002\u91cd\u8981\u306a\u70b9\u3068\u3057\u3066\u3001olezarsen\u6295\u4e0e\u306b\u95a2\u9023\u3057\u3066\u3001\u6709\u5bb3\u306a\u5b89\u5168\u6027\u30b7\u30b0\u30ca\u30eb\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001Bridge\u2013TIMI 73a\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001olezarsen\u306e\u3088\u308a\u5927\u898f\u6a21\u3067\u3088\u308a\u9577\u671f\u306e\u8a66\u9a13\u306e\u5b9f\u65bd\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n<\/div>\n\n\n\n\n
References<\/strong><\/td>\n1. Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular dis ease, and emerging therapeutic strategies: a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021;42:4791-806.
2. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.
3. Nicholls SJ, Lincoff AM, Garcia M, et al. Effect of high-dose omega-3 fatty acids vs corn oil on major adverse cardiovascular events in patients at high cardiovascular risk: the STRENGTH randomized clinical trial. JAMA 2020;324: 2268-80.
4. Das Pradhan A, Glynn RJ, Fruchart JC, et al. Triglyceride lowering with pemafibrate to reduce cardiovascular risk. N Engl J Med 2022;387:1923-34.
5. Alexander VJ, Xia S, Hurh E, et al. N-acetyl galactosamine-conjugated antisense drug to APOC3 mRNA, triglycerides and atherogenic lipoprotein levels. Eur Heart J 2019;40:2785-9.
6. Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J 2022;43:1401-12.<\/td>\n<\/tr>\n
Key words<\/strong><\/td>\ntriglycerides; triglyceride-rich lipoproteins; cardiovascular disease; apolipoprotein CIII; olezarsen<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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