{"id":254349,"date":"2025-01-21T22:54:36","date_gmt":"2025-01-21T21:54:36","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%96%e3%83%91%e3%83%8e%e3%83%ab%e3%82%bb%e3%83%b3%e3%80%81angplt3%e3%82%a2%e3%83%b3%e3%83%81%e3%82%bb%e3%83%b3%e3%82%b9%e3%82%aa%e3%83%aa%e3%82%b4\/"},"modified":"2025-02-16T22:26:46","modified_gmt":"2025-02-16T21:26:46","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%96%e3%83%91%e3%83%8e%e3%83%ab%e3%82%bb%e3%83%b3%e3%80%81angplt3%e3%82%a2%e3%83%b3%e3%83%81%e3%82%bb%e3%83%b3%e3%82%b9%e3%82%aa%e3%83%aa%e3%82%b4","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%96%e3%83%91%e3%83%8e%e3%83%ab%e3%82%bb%e3%83%b3%e3%80%81angplt3%e3%82%a2%e3%83%b3%e3%83%81%e3%82%bb%e3%83%b3%e3%82%b9%e3%82%aa%e3%83%aa%e3%82%b4\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u3001ANGPLT3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3092\u7528\u3044\u305fTRANSLATE-TIMI 70\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u3001ANGPLT3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3092\u7528\u3044\u305fTRANSLATE-TIMI 70\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9<\/span><\/h2>\n
21 2022\u5e749\u6708<\/span><\/h5>\n

TRANSLATE-TIMI 70\uff08ClinicalTrials.gov Identifier: NCT04516291\uff09\u306b\u304a\u3044\u3066\u3001\u809d\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d83\uff08ANGPTL3\uff09\u86cb\u767d\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bvupanorsen\u306e\u6295\u4e0e\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u60a3\u8005\u306b\u304a\u3044\u3066\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3082\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u6e1b\u5c11\u3057\u305f\u3002 <\/em><\/p>\n

Bergmark BA, Marston NA, Bramson CR, et al.\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u5bfe\u3059\u308b\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u52b9\u679c\uff1aTRANSLATE-TIMI 70\u3002Circulation 2022;145:1377-1386. <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nTRANSLATE\uff08Targeting ANGPTL3 with an Antisense Oligonucleotide in Adults with Dyslipidemia\uff09-TIMI\uff08Thrombolysis in Myocardial Infarction\uff0970\u8a66\u9a13\u3067\u306f\u3001\u9ad8\u8102\u8840\u75c7\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u6210\u4eba\u306b\u304a\u3044\u3066\u3001vupanorsen\u306e\u6f38\u5897\u6295\u4e0e\u304c\u975eHDL-C\u5024\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u691c\u8a0e\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u672c\u8a66\u9a13\u306f\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u7b2c2b\u76f8\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002\u60a3\u8005\u306f2\uff1a1\uff1a1\uff1a1\uff1a2\uff1a1\uff1a2\uff1a2\uff1a2\u306e\u9806\u5217\u30d6\u30ed\u30c3\u30af\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306b\u3088\u308a\u3001\u30d7\u30e9\u30bb\u30dc\u307e\u305f\u306f7\u7528\u91cf\u306e\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u76ae\u4e0b\u6295\u4e0e\uff0880mg\u3001120mg\u3001160mg\u30924\u9031\u9593\u3054\u3068\u3001\u307e\u305f\u306f60mg\u300180mg\u3001120mg\u3001160mg\u30922\u9031\u9593\u3054\u3068\uff09\u306e\u3044\u305a\u308c\u304b\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u6cbb\u7642\u671f\u9593\u306f24\u9031\u9593\u3067\u3001\u8a66\u9a13\u85ac\u6700\u7d42\u6295\u4e0e\u5f8c\u3055\u3089\u306b12\u9031\u9593\u306e\u5b89\u5168\u6027\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0\u3092\u884c\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b40\u6b73\u4ee5\u4e0a\u306e\u6210\u4eba\u3067\uff0c\u975eHDL-C\u304c100mg\/dL\u4ee5\u4e0a\uff0c\u30c8\u30ea\u30b0\u30ea\u30bb\u30e9\u30a4\u30c9\u304c150\uff5e500mg\/dL\u306e\u8005\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u306e\u6210\u679c\uff1a<\/strong><\/td>\n\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f24\u9031\u6642\u70b9\u306b\u304a\u3051\u308b\u975eHDL-C\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u306b\u3088\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u3067\u3042\u3063\u305f\u3002\u526f\u6b21\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff08ApoB\uff09\u3001ANGPTL3\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u306b\u3088\u308b\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u4e3b\u8981\u6709\u52b9\u6027\u89e3\u6790\u306f\u3001\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u8a66\u9a13\u85ac\u3092\u5c11\u306a\u304f\u3068\u30821\u56de\u6295\u4e0e\u3055\u308c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306enon-HDL-C\u5024\u304c\u3042\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5f8c\u306enon-HDL-C\u5024\u304c\u5c11\u306a\u304f\u3068\u30821\u56de\u3042\u3063\u305f\u60a3\u8005\u6570\u306b\u57fa\u3065\u3044\u3066\u884c\u308f\u308c\u305f\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u5bfe\u3059\u308bvupanorsen\uff08\u30d7\u30fc\u30eb\u7528\u91cf\uff09\u306e\u52b9\u679c\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u5024\u3001\u6cbb\u7642\u7fa4\u3001\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306e\u72b6\u614b\u3001\u304a\u3088\u3073\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u3088\u308b\u6cbb\u7642\u306e\u4ea4\u4e92\u4f5c\u7528\u9805\u3092\u8abf\u6574\u3057\u305fANCOVA\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u3053\u306e\u8a66\u9a13\u3067\u306f286\u4eba\u306e\u60a3\u8005\uff08\u5e74\u9f62\u4e2d\u592e\u502464\u6b73\u3001\u5973\u602744\uff05\uff09\u304c\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u300144\u4eba\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u3001242\u4eba\u304c\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u60a3\u8005\u7279\u6027\u306f\u6cbb\u7642\u7fa4\u9593\u3067\u985e\u4f3c\u3057\u3066\u3044\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e50\uff05\u304c2\u578b\u7cd6\u5c3f\u75c5\u3092\u6709\u3057\u300151\uff05\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u3092\u670d\u7528\u3057\u3066\u304a\u308a\u30015\uff05\u306e\u307f\u304c\u30a8\u30bc\u30c1\u30df\u30d6\u3092\u670d\u7528\u3057\u3066\u3044\u305f\u3002 <\/p>\n

\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001ANGPLT3\u306f\u6700\u592795\uff05\u963b\u5bb3\u3055\u308c\u305f\uff08\u88681<\/strong>\uff09\u3002\u975eHDL-C\u306e\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u306b\u3088\u308b\u6e1b\u5c11\u306f22\uff05\uff0880mg\u30924\u9031\u6bce\uff09\u304b\u308926.5\uff05\uff08160mg\u30922\u9031\u6bce\uff09\u306e\u7bc4\u56f2\u3067\u3042\u3063\u305f\uff1b\u3059\u3079\u3066\u306e\u6e1b\u5c11\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u3067\u3042\u3063\u305f\uff08p<0.001\uff09\u3002\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306fTG\u3082\u7528\u91cf\u306b\u95a2\u9023\u3057\u3066\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\uff08p<0.001\uff09\u3001\u305d\u306e\u7bc4\u56f2\u306f120mg 4\u9031\u6295\u4e0e\u306741\uff05\u3001160mg 2\u9031\u6295\u4e0e\u306757\uff05\u3067\u3042\u3063\u305f\u3002LDL-C\u3068ApoB\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306f\u3088\u308a\u7de9\u3084\u304b\u3067\u3001\u660e\u78ba\u306a\u7528\u91cf\u53cd\u5fdc\u95a2\u4fc2\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\uff08\u88681\uff09\u3002 <\/p>\n

\u88681. \u4e3b\u8981\u8102\u8cea\u5909\u6570\u306b\u5bfe\u3059\u308b\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u52b9\u679c\u3002<\/strong> <\/span>\u30c7\u30fc\u30bf\u306f24\u9031\u6642\u70b9\u306e\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5909\u5316\u7387\u306e\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\u5024\uff0895\uff05CI\uff09\u3067\u793a\u3057\u305f\u3002<\/p>\n\n\n\n\n\n\n\n\n\n
\n

\u53ef\u5909<\/p>\n<\/td>\n

\n

4\u9031\u9593\u3054\u3068\u306e\u30ec\u30b8\u30e1\u30f3<\/p>\n<\/td>\n

\n

2\u9031\u9593\u3054\u3068\u306e\u30ec\u30b8\u30e1\u30f3<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

80 mg\uff08n=23\uff09<\/p>\n<\/td>\n

\n

120 mg<\/p>\n

(n=23)<\/p>\n<\/td>\n

\n

160 mg<\/p>\n

(n=45)<\/p>\n<\/td>\n

\n

60 mg\uff08n=24\uff09<\/p>\n<\/td>\n

\n

80 mg\uff08n=45\uff09<\/p>\n<\/td>\n

\n

120 mg\uff08n=46\uff09<\/p>\n<\/td>\n

\n

160 mg\uff08n=36\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

\u975eHDL-C<\/p>\n<\/td>\n

\n

-22.4<\/p>\n

(-32.1 to -12.7<\/p>\n<\/td>\n

\n

-24.1<\/p>\n

(-34.1 to -14.2)<\/p>\n<\/td>\n

\n

-26.6<\/p>\n

(-34.5 to -18.8)<\/p>\n<\/td>\n

\n

-22.0<\/p>\n

(-31.7 to -12.4)<\/p>\n<\/td>\n

\n

-27.7<\/p>\n

(-35.7 to -19.6)<\/p>\n<\/td>\n

\n

-24.7<\/p>\n

(-32.5 to -16.9)<\/p>\n<\/td>\n

\n

-26.5<\/p>\n

(-35.4 to -17.6)<\/p>\n<\/td>\n<\/tr>\n

\n

TG<\/p>\n<\/td>\n

\n

-44.0<\/p>\n

(-57.1 to -30.8)<\/p>\n<\/td>\n

\n

-41.3<\/p>\n

(-54.8 to 27.8)<\/p>\n<\/td>\n

\n

-45.9<\/p>\n

(-56.5 to -35.2)<\/p>\n<\/td>\n

\n

-43.8<\/p>\n

(-56.9 to -30.7)<\/p>\n<\/td>\n

\n

-50.5<\/p>\n

(-61.4 to -39.6)<\/p>\n<\/td>\n

\n

-50.7<\/p>\n

(-61.2 to -40.1)<\/p>\n<\/td>\n

\n

-56.8<\/p>\n

(-68.9 to -44.7)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C<\/p>\n<\/td>\n

\n

-10.0<\/p>\n

(-22.9 to 2.9)<\/p>\n<\/td>\n

\n

-11.4<\/p>\n

(-24.7 to 1.8)<\/p>\n<\/td>\n

\n

-14.5<\/p>\n

(-25.1 to -3.9)<\/p>\n<\/td>\n

\n

-7.9<\/p>\n

(-21.0 to 5.2)<\/p>\n<\/td>\n

\n

-16.0<\/p>\n

(-26.7 to -5.3)<\/p>\n<\/td>\n

\n

-7.9<\/p>\n

(-18.3 to 2.5)<\/p>\n<\/td>\n

\n

-9.0<\/p>\n

(-20.8 to 2.9)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30a2\u30ddB<\/p>\n<\/td>\n

\n

-15.1<\/p>\n

(-23.7 to -6.5)<\/p>\n<\/td>\n

\n

-11.5<\/p>\n

(-20.3 to -2.7)<\/p>\n<\/td>\n

\n

-12.6<\/p>\n

(-19.5 to -5.6)<\/p>\n<\/td>\n

\n

-10.6<\/p>\n

(-19.2 to -2.1)<\/p>\n<\/td>\n

\n

-12.5<\/p>\n

(-19.7 to -5.3)<\/p>\n<\/td>\n

\n

-6.0<\/p>\n

(-13.0 to 1.0)<\/p>\n<\/td>\n

\n

-8.5<\/p>\n

(-16.4 to -0.6)<\/p>\n<\/td>\n<\/tr>\n

\n

ANGPLT3<\/p>\n<\/td>\n

\n

-69.9<\/p>\n

(-81.6 to -58.1)<\/p>\n<\/td>\n

\n

-77.1<\/p>\n

(-89.4 to -64.9)<\/p>\n<\/td>\n

\n

-80.4<\/p>\n

(-89.9 to -70.9)<\/p>\n<\/td>\n

\n

-79.6<\/p>\n

(-91.5 to -67.7)<\/p>\n<\/td>\n

\n

-86.3<\/p>\n

(-96.2 to -76.3)<\/p>\n<\/td>\n

\n

-92.2<\/p>\n

(-101.9 to -82.6)<\/p>\n<\/td>\n

\n

-95.2<\/p>\n

(-106.2 to -84.2)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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<\/strong><\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies-a consensus statement from the European Atherosclerosis Society.Eur Heart J 2021;42:4791-806.
2.Dewey FE, Gusarova V, Dunbar RL, et al. ANGPTL3\u306e\u907a\u4f1d\u7684\u304a\u3088\u3073\u85ac\u7406\u5b66\u7684\u4e0d\u6d3b\u6027\u5316\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002N Engl J Med 2017;377:211-21.
3.Stitziel NO, Khera AV, Wang X, et al. ANGPTL3\u306e\u6b20\u640d\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u3002J Am Coll Cardiol 2017;69:2054-63.
4.Gaudet D, Karwatowska-Prokopczuk E, Baum SJ, et al. Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia.Eur Heart J 2020;41:3936-45.
5.Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG.\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3068\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u3088\u304f\u53cd\u6620\u3059\u308b\u3002J Am Coll Cardiol 2021;77:1439-50. <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\nANGPTL3\uff1b\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\uff1b\u975eHDL-C\uff1b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff1b\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af<\/td>\n<\/tr>\n<\/tbody>\n<\/table>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

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