{"id":254347,"date":"2025-01-21T23:18:26","date_gmt":"2025-01-21T22:18:26","guid":{"rendered":"https:\/\/r3i.org\/focus-%e4%b8%80%e6%ac%a1%e4%ba%88%e9%98%b2%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e9%96%a2%e9%80%a3%e6%ae%8b%e5%ad%98\/"},"modified":"2025-02-16T22:26:17","modified_gmt":"2025-02-16T21:26:17","slug":"focus-%e4%b8%80%e6%ac%a1%e4%ba%88%e9%98%b2%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e9%96%a2%e9%80%a3%e6%ae%8b%e5%ad%98","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/focus-%e4%b8%80%e6%ac%a1%e4%ba%88%e9%98%b2%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e6%ae%8b%e5%ad%98%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e9%96%a2%e9%80%a3%e6%ae%8b%e5%ad%98\/","title":{"rendered":"Focus – \u4e00\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95a2\u9023\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u540c\u5b9a\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u7814\u7a76\u7d50\u679c"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

Focus –\u4e00\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95a2\u9023\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u540c\u5b9a\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u7814\u7a76\u7d50\u679c<\/span><\/h2>\n
2 2021\u5e7411\u6708<\/span><\/h5>\n

\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u4eba\u306e\u30d7\u30fc\u30eb\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3001\u975e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u5024\u306a\u3069\u306e\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3068\u306f\u7121\u95a2\u4fc2\u306bASCVD\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/em><\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001LDL\u3084ApoB\u3092\u8d8a\u3048\u3066\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u4e88\u6e2c\u3059\u308b\uff1a\u4e00\u6b21\u4e88\u9632\u7814\u7a76\u3002Eur Heart J 2021 doi: 10.1093\/eurheartj\/ehab432.Online ahead of print. <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nASCVD\u304c\u5224\u660e\u3057\u3066\u3044\u306a\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\uff0cLDL-C\u3068apolipoprotein B\uff08apoB\uff09\u4ee5\u5916\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95a2\u9023\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u9577\u671f\u8ffd\u8de1\u3092\u4f34\u3046\u4e00\u6b21\u4e88\u9632\u30b3\u30db\u30fc\u30c8\u306e\u30d7\u30fc\u30eb\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3\uff1a<\/strong><\/td>\nAtherosclerosis Risk in Communities[ARIC] study\uff08n = 9748\uff09\u3001Multi-Ethnic Study of Atherosclerosis\uff08n = 3049\uff09\u3001Coronary Artery Risk Development in Young Adults\uff08n = 4735\uff09\u304b\u3089\u5f97\u3089\u308c\u305fASCVD\u975e\u767a\u75c7\u800517,532\u4eba\uff08\u5e73\u5747\u5e74\u9f6252.3\u6b73\u3001\u5973\u602756.7\uff05\u3001\u9ed2\u4eba34\uff05\uff09\u3002<\/td>\n<\/tr>\n
\u4e3b\u306a\u7814\u7a76\u5909\u6570<\/strong><\/td>\n– \u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089HDL-C\u3092\u5f15\u3044\u305f\u5024\u304b\u3089LDL-C\u3092\u8a08\u7b97\u3057\u305f\u5024\u3002
– \u5fc3\u7b4b\u6897\u585e\u3001\u51a0\u52d5\u8108\u6b7b\u3001\u8133\u5352\u4e2d\u306e\u767a\u75c7\uff083\u3064\u306e\u30b3\u30db\u30fc\u30c8\u3059\u3079\u3066\uff09\u3002ARIC\u306e\u7814\u7a76\u8005\u3089\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u95a2\u9023\u3057\u305f\u3059\u3079\u3066\u306e\u5165\u9662\u3068\u6b7b\u4ea1\u306b\u3064\u3044\u3066\u3082\u7d99\u7d9a\u7684\u306a\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u3092\u5b9f\u65bd\u3057\u3001\u3053\u308c\u3089\u306fARIC\u306e\u7814\u7a76\u8005\u3089\u306b\u3088\u3063\u3066\u5224\u5b9a\u3055\u308c\u305f\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\n

Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u306e\u5165\u308c\u5b50\u3092\u7528\u3044\u3066\u3001\u9023\u7d9a\u5bfe\u6570\u5909\u63db\u3057\u305f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068ASCVD\u767a\u75c7\u3068\u306e\u72ec\u7acb\u3057\u305f\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002<\/p>\n

\u4e0d\u4e00\u81f4\u306e\u5b9a\u7fa9\u306f\u3001>10 \u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u5358\u4f4d\u306e\u5dee\uff08\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u304b\u3089LDL-C\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u3092\u5f15\u3044\u305f\u5024\uff09\u3092\u7528\u3044\u3066\u884c\u3063\u305f\u3002\u96c6\u56e3\u306f\u6b21\u306e\u3088\u3046\u306b\u5206\u3051\u3089\u308c\u305f\uff1a
– \u4e0d\u4e00\u81f4\u306e\u3042\u308b\u4f4e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a< >10\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u5358\u4f4d\u306eLDL-C\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb
– \u4e00\u81f4\uff1a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068LDL-C\u304c\u00b110\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u5358\u4f4d\u4ee5\u5185\uff1b\u304a\u3088\u3073
– \u4e0d\u4e00\u81f4\u306b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\uff1a > > 10\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u5358\u4f4d\u306b\u3088\u308bLDL-C\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u3002
\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u5358\u4f4d\u306e\u5dee\u3001LDL-C\u81e8\u5e8a\u30ab\u30c3\u30c8\u30dd\u30a4\u30f3\u30c8\u3001\u4e2d\u592e\u5024\u3092\u7528\u3044\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073LDL-C\u4e00\u81f4\uff0f\u4e0d\u4e00\u81f4\u7fa4\u3068ASCVD\u767a\u75c7\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u4e2d\u592e\u502418.7\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b2,143\u4ef6\u306eASCVD\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f\u3002LDL-C\u3068\u30a2\u30ddB\u3092\u542b\u3080\u591a\u5909\u91cf\u88dc\u6b63\u3092\u7528\u3044\u308b\u3068\u3001\u5bfe\u6570\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f65\uff05\u9ad8\u3044ASCVD\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.65\u300195\uff05\u4fe1\u983c\u533a\u95931.45-1.89\uff09\u3002\u7d043\u5206\u306e1\uff0834.2\uff05\uff09\u304c\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\/\u4f4eLDL-C\u4e0d\u4e00\u81f4\u7fa4\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u7fa4\u3067\u306fLDL-C\u304c\u4f4e\u304f\u3066\u3082ASCVD\u306e\u767a\u75c7\u304c21\uff05\u5897\u52a0\u3057\u305f\uff08HR 1.21\u300195\uff05\u4fe1\u983c\u533a\u95931.08-1.35\uff09\u3002\u4e00\u65b9\u3001\u4f4e\u6b8b\u57fa\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\/\u9ad8LDL-C\u4e0d\u4e00\u81f4\u7fa4\u3067\u306f\u3001\u4e0d\u4e00\u81f4\u7fa4\u3068\u6bd4\u8f03\u3057\u3066ASCVD\u30ea\u30b9\u30af\u306f\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\uff08\u8868<\/strong>\uff09\u3002\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\/\u4f4eLDL-C\u4e0d\u4e00\u81f4\u7fa4\u306e\u60a3\u8005\u306e\u5272\u5408\u306fLDL-C\u5024\u304c\u4f4e\u3044\u307b\u3069\u5897\u52a0\u3057\u3001LDL-C< 70mg\/dl (<1.8mmol\/L)\u306e\u60a3\u8005\u3067\u306f81\uff05\u3067\u3042\u3063\u305f\u3002 <\/p>\n

 <\/p>\n

\u8868.ASCVD\u767a\u75c7\uff1a\u4e0d\u4e00\u81f4\u7fa4\u5225\uff1b\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff09 <\/strong><\/p>\n\n\n\n\n\n\n
\n

\u30ab\u30c6\u30b4\u30ea\u30fc<\/p>\n<\/td>\n

\n

<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u6b8b\u57fa\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\/\u9ad8LDL-C\u306e\u4e0d\u4e00\u81f4<\/p>\n<\/td>\n

\n

0.93 (0.83-1.04)<\/p>\n<\/td>\n<\/tr>\n

\n

\u30b3\u30f3\u30b3\u30eb\u30c0\u30f3\u30c8<\/p>\n<\/td>\n

\n

\u53c2\u8003<\/p>\n<\/td>\n<\/tr>\n

\n

\u9ad8\u6b8b\u6e23\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0f\u4f4eLDL-C\u306e\u4e0d\u4e00\u81f4<\/strong><\/p>\n<\/td>\n

\n

1.21 (1.08-1.34)<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\nASCVD\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u60a3\u8005\u3067\u306f\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3001LDL-C\u3001\u30a2\u30ddB\u5024\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u304cASCVD\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u610f\u5916\u306b\u3082apoB\u3092\u8d8a\u3048\u3066\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304cASCVD\u3068\u95a2\u9023\u3059\u308b\u6a5f\u5e8f\u3084\u3001\u4e00\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6a19\u7684\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u306e\u6f5c\u5728\u7684\u4fa1\u5024\u306b\u3064\u3044\u3066\u306f\u3001\u3055\u3089\u306b\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u672c\u7814\u7a76\u306e\u76ee\u7684\u306f\u3001\u4e00\u6b21\u4e88\u9632\u306e\u8a2d\u5b9a\u306b\u304a\u3044\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u95a2\u9023\u3059\u308bASCVD\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002\u91cd\u8981\u306a\u6240\u898b\u306f\u3001LDL-C\u3084\u30a2\u30ddB\u3092\u542b\u3080\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u304cASCVD\u767a\u75c7\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002LDL-C\u5024\u304c\u4f4e\u3044\u5834\u5408\u3067\u3082\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306b\u3088\u308b\u904e\u5270\u30ea\u30b9\u30af\u306f\u660e\u3089\u304b\u3067\u3042\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u4e00\u6b21\u4e88\u9632\u306b\u304a\u3044\u3066\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u95a2\u9023\u3057\u305f\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u540c\u5b9a\u3059\u308b\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u7279\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u542b\u3080\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u30ea\u30dd\u86cb\u767d\u3092\u6a19\u7684\u3068\u3057\u305f\u65b0\u898f\u6cbb\u7642\u6cd5\u306e\u81e8\u5e8a\u958b\u767a\u304c\u9032\u884c\u4e2d\u3067\u3042\u308b\u73fe\u5728\u3001\u6642\u5b9c\u3092\u5f97\u305f\u3082\u306e\u3067\u3042\u308b(1)\u3002 <\/p>\n

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\u8457\u8005\u3089\u306f\u3001\u3053\u306e\u7814\u7a76\u306e\u3044\u304f\u3064\u304b\u306e\u9577\u6240\u3068\u9650\u754c\u3092\u8a8d\u3081\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u306f\u5927\u898f\u6a21\u306a\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30c7\u30fc\u30bf\u30b3\u30db\u30fc\u30c8\u3092\u7528\u3044\u3066\u304a\u308a\u3001\u3088\u308a\u5e83\u3044\u4e00\u822c\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30b3\u30db\u30fc\u30c8\u306e\u5404\u7814\u7a76\u306b\u304a\u3044\u3066\u3001ASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u306f\u72ec\u7acb\u3057\u3066\u5224\u5b9a\u3055\u308c\u305f\u3002\u8457\u8005\u3089\u306f\u307e\u305f\u3001Martin\/Hopkins\u65b9\u7a0b\u5f0f\u3092\u7528\u3044\u3066LDL-C\u3092\u7b97\u51fa\u3057\u305f\u304c\u3001\u3053\u308c\u306fFriedewald\u65b9\u7a0b\u5f0f\u3092\u7528\u3044\u305f\u5834\u5408\u3088\u308a\u3082\u6b63\u78ba\u306a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u63a8\u5b9a\u304c\u53ef\u80fd\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u8457\u8005\u3089\u306f\u3059\u3079\u3066\u306e\u89b3\u5bdf\u7814\u7a76\u306e\u9650\u754c\u3067\u3042\u308b\u6b8b\u4f59\u4ea4\u7d61\u306e\u53ef\u80fd\u6027\u3092\u8a8d\u3081\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u8ffd\u8de1\u671f\u9593\u304c18\u5e74\u9593\u3068\u9577\u304b\u3063\u305f\u305f\u3081\u3001\u65e9\u671f\u306b\u767b\u9332\u3055\u308c\u305f\u4eba\u306f\u5f8c\u306b\u767b\u9332\u3055\u308c\u305f\u4eba\u3088\u308a\u3082\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304b\u3063\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u9650\u754c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u4eca\u56de\u306e\u77e5\u898b\u306f\u3001\u7279\u306b\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001LDL-C\u3001non-HDL-C\u3001apoB\u4ee5\u5916\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u91cd\u8981\u306a\u60c5\u5831\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u8a55\u4fa1\u3092\u8003\u616e\u3059\u308b\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Nordestgaard BG\u3002Triglyceride-rich lipoproteins and atherosclerotic cardiovascular disease: new insights from epidemiology, genetics, and biology.Circ Res 2016;118:547-63.
2.Ference BA, Kastelein JJP, Ray KK, et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0bLPL\u30d0\u30ea\u30a2\u30f3\u30c8\u304a\u3088\u3073LDL-C\u4f4e\u4e0bLDLR\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3002JAMA 2019;321:364-373.
3.Elshazly MB, Mani P, Nissen S, et al. \u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u51a0\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u9032\u884c\u3001\u81e8\u5e8a\u30a4\u30d9\u30f3\u30c8\u3002Eur J Prev Cardiol 2020;27:1091-1100 <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3001\u30a2\u30ddB\u3001\u4e0d\u4e00\u81f4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

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