{"id":254345,"date":"2025-01-25T16:07:18","date_gmt":"2025-01-25T15:07:18","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%81%a8%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%82%92%e9%96%a2%e9%80%a3%e3%81%a5%e3%81%91\/"},"modified":"2025-02-16T22:25:33","modified_gmt":"2025-02-16T21:25:33","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%81%a8%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%82%92%e9%96%a2%e9%80%a3%e3%81%a5%e3%81%91","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%ac%e3%83%a0%e3%83%8a%e3%83%b3%e3%83%88%e3%81%a8%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%82%92%e9%96%a2%e9%80%a3%e3%81%a5%e3%81%91\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u30ec\u30e0\u30ca\u30f3\u30c8\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u95a2\u9023\u3065\u3051\u308b\u3088\u308a\u591a\u304f\u306e\u8a3c\u62e0"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u30ec\u30e0\u30ca\u30f3\u30c8\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u95a2\u9023\u3065\u3051\u308b\u3088\u308a\u591a\u304f\u306e\u8a3c\u62e0<\/span><\/h2>\n
2018 \u5e74 11 \u6708 6 \u65e5<\/span><\/h5>\n

ARIC\uff08Atherosclerosis Risk in Communities\uff09\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u6b8b\u5b58\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08RLP-C\uff09\u3068\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08LDL-TG\uff09\u306e\u4e21\u5024\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308a\u3001APOE\u306e\u5909\u7570\u4f53\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

Saeed A\u3001Feofanova EV\u3001Yu B\u3089\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u69d8\u7c92\u5b50\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u3002J Am Coll Cardiol 2018;72:156-69. <\/span><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\nARIC\uff08Atherosclerosis Risk In Communities\uff09\u7814\u7a76\u306b\u304a\u3044\u3066\u3001RLP-C\u304a\u3088\u3073LDL-TG\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\uff08CVD\uff09\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u907a\u4f1d\u5b50\u5909\u7570\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\nARIC\u306f\u7c73\u56fd\u306e\u4e2d\u5e74\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u524d\u5411\u304d\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3\uff1a<\/strong><\/td>\n9,334\u4eba\u306e\u7537\u5973\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306bCVD\u306e\u6709\u75c5\u8005\u306a\u3057\u3002<\/td>\n<\/tr>\n
\u6709\u52b9\u6027\u306e\u5909\u6570\uff1a<\/strong><\/td>\n\n

– 16\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u30a4\u30d9\u30f3\u30c8\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3042\u308bCVD\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u3002<\/p>\n

– RLP-C\u5024\u3068LDL-TG\u5024<\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\n

LDL-TG\u3068RLP-C\u306f\u9023\u7d9a\u5909\u6570\u304a\u3088\u3073\u30ab\u30c6\u30b4\u30ea\u30fc\u5909\u6570\u3068\u3057\u3066\u30e2\u30c7\u30eb\u5316\u3057\u305f\u3002CVD\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u4eba\u7a2e\uff08\u30e2\u30c7\u30eb1\uff09\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u53ce\u7e2e\u671f\u8840\u5727\u3001\u964d\u5727\u85ac\u306e\u4f7f\u7528\u3001\u55ab\u7159\u306e\u6709\u7121\u3001\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\uff08\u30e2\u30c7\u30eb2\uff09\u3001\u30e2\u30c7\u30eb2\uff0b\u5bfe\u6570\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08\u30e2\u30c7\u30eb3\uff09\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3001Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u7528\u3044\u3066\u6c7a\u5b9a\u3057\u305f\u3002RLP-C\u3068LDL-TG\u306e\u56db\u5206\u4f4d\u306b\u304a\u3051\u308bCVD\u8ee2\u5e30\u306b\u3064\u3044\u3066Kaplan-Meier\u751f\u5b58\u66f2\u7dda\u3092\u8a08\u7b97\u3057\u305f\u3002RLP-C\u306b\u3064\u3044\u3066\u306f0.4-3.1\uff08\u56db\u5206\u4f4d1\uff09\u30013.2-5.9\uff08\u56db\u5206\u4f4d2\uff09\u30016.0-12.2\uff08\u56db\u5206\u4f4d3\uff09\u300112.3-259.1\uff08\u56db\u5206\u4f4d4\uff09mg\/dL\u3068\u5b9a\u7fa9\u3057\u3001LDL-TG\u306b\u3064\u3044\u3066\u306f0.7-17.0\uff08\u56db\u5206\u4f4d1\uff09\u300117.1-22.6\uff08\u56db\u5206\u4f4d2\uff09\u300122.7-29.6\uff08\u56db\u5206\u4f4d3\uff09\u300129.7-104.0\uff08\u56db\u5206\u4f4d4\uff09mg\/dL\u3068\u5b9a\u7fa9\u3057\u305f\u3002 <\/p>\n

LPL\u3001LIPC\u3001LIPG\u3001APOC3\u3001APOA5\u3001ANGPTL3\u3001ANGPTL4\u304a\u3088\u3073APOE\u306e\u907a\u4f1d\u5b50\u5909\u7570\u3068LDL-TG\u304a\u3088\u3073RLP-C\u5024\u3068\u306e\u95a2\u9023\u3092\u3001\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30af\u30a8\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308a\u3001\u4e00\u822c\u7684\u306a\u5909\u7570\u4f53\u306b\u3064\u3044\u3066\u306f\u5358\u4e00\u5909\u7570\u4f53\u89e3\u6790\u3092\u3001\u307e\u308c\u306a\u5909\u7570\u4f53\u306b\u3064\u3044\u3066\u306f\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u8ca0\u8377\u8a66\u9a13\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

<\/div>\n
\n

RLP-C\u3068LDL-TG\u306f\u3068\u3082\u306bCVD\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001\u8102\u8cea\u3092\u542b\u3080\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3067\u8abf\u6574\u3057\u305f\u30e2\u30c7\u30eb\u3067\u306f\u3001LDL-TG\u306e\u307f\u304cCHD\u304a\u3088\u3073\u8133\u5352\u4e2d\u306e\u767a\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u88681\uff09<\/strong>\u3002<\/p>\n

\u907a\u4f1d\u5b50\u89e3\u6790\u3067\u306f\u3001\u4e00\u822c\u7684\u306a <\/span>APOE<\/em> <\/span>\u5909\u7570\u4f53\u3001rs7412\u304cLDL-TG\u304a\u3088\u3073RLP-C\u3068\u6700\u3082\u5f37\u3044\u95a2\u9023\u3092\u793a\u3057\u305f\u3002<\/p>\n

 <\/p>\n

\u88681. RLP-C\u304a\u3088\u3073LDL-TG\u3068CVD\u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u306e\u95a2\u9023\uff08\u9023\u7d9a\u5909\u6570\u3068\u3057\u3066\u30e2\u30c7\u30eb\u5316\uff09<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u6210\u679c<\/strong><\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb<\/strong><\/p>\n<\/td>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff09<\/strong><\/p>\n<\/td>\n

\n

p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

RLP-C<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3<\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb1<\/p>\n<\/td>\n

\n

1.26 (1.19-1.34)<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb2<\/p>\n<\/td>\n

\n

0.99 (0.92-1.06)<\/p>\n<\/td>\n

\n

0.73<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb3<\/p>\n<\/td>\n

\n

0.85 (0.76-0.96)<\/p>\n<\/td>\n

\n

0.008<\/p>\n<\/td>\n<\/tr>\n

\n

\u865a\u8840\u6027\u8133\u5352\u4e2d<\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb1<\/p>\n<\/td>\n

\n

1.18 (1.07-1.30)<\/p>\n<\/td>\n

\n

0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb2<\/p>\n<\/td>\n

\n

1.05 (0.93-1.18)<\/p>\n<\/td>\n

\n

0.46<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb3<\/p>\n<\/td>\n

\n

0.82 (0.68-1.01)<\/p>\n<\/td>\n

\n

0.058<\/p>\n<\/td>\n<\/tr>\n

\n

CVD<\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb1<\/p>\n<\/td>\n

\n

1.25 (1.19-1.32)<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb2<\/p>\n<\/td>\n

\n

1.00 (0.94-1.06)<\/p>\n<\/td>\n

\n

0.97<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb3<\/p>\n<\/td>\n

\n

0.84 (0.76-0.93)<\/p>\n<\/td>\n

\n

0.001<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-TG<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3<\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb1<\/p>\n<\/td>\n

\n

1.97 (1.73-2.24)<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb2<\/p>\n<\/td>\n

\n

1.28 (1.10-1.50)<\/p>\n<\/td>\n

\n

0.002<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb3<\/p>\n<\/td>\n

\n

1.27 (1.07-1.50)<\/p>\n<\/td>\n

\n

0.006<\/p>\n<\/td>\n<\/tr>\n

\n

\u865a\u8840\u6027\u8133\u5352\u4e2d<\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb1<\/p>\n<\/td>\n

\n

1.64 (1.32-2.04)<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb2<\/p>\n<\/td>\n

\n

1.47 (1.13-1.92)<\/p>\n<\/td>\n

\n

0.005<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb3<\/p>\n<\/td>\n

\n

1.36 (1.01-1.82)<\/p>\n<\/td>\n

\n

0.040<\/p>\n<\/td>\n<\/tr>\n

\n

CVD<\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb1<\/p>\n<\/td>\n

\n

1.94 (1.73-2.17<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb2<\/p>\n<\/td>\n

\n

1.35 (1.17-1.55)<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

\u30e2\u30c7\u30eb3<\/p>\n<\/td>\n

\n

1.31 (1.13-1.53)<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\n

<\/strong><\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\nRLP-C\u5024\u3068LDL-TG\u5024\u306fCVD\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308a\u3001APOE\u5909\u7570\u4f53\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002LDL-TG\u306f\u3001CVD\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306b\u95a2\u9023\u3059\u308b\u6a5f\u80fd\u4e0d\u5168\u306e\u6b8b\u4f59\u30ea\u30dd\u86cb\u767d\u4ee3\u8b1d\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002LDL-TG\u304cCVD\u306e\u539f\u56e0\u7684\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u6cbb\u7642\u306e\u6a19\u7684\u3068\u306a\u308a\u5f97\u308b\u304b\u3069\u3046\u304b\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\uff1a\u6b27\u7c73\u306e29\u306e\u524d\u5411\u304d\u7814\u7a76262,525\u4eba\u4e2d10,158\u4eba\u306e\u767a\u75c7\u4f8b\u3002Circulation 2007;115:450-8. <\/p>\n

2.\u5bb6\u65cf\u6027\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u6b7b\u4ea1\u7387\uff1a20\u5e74\u9593\u306e\u524d\u5411\u304d\u7814\u7a76\u3002Circulation 2000;101:2777-82. <\/p>\n

3.Nordestgaard BG\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3002\u75ab\u5b66\u3001\u907a\u4f1d\u5b66\u3001\u751f\u7269\u5b66\u304b\u3089\u306e\u65b0\u305f\u306a\u6d1e\u5bdf\u3002Circ Res 2016;118:547-63. <\/p>\n

4.Varbo A, Benn M, Nordestgaard BG.\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u539f\u56e0\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a\u30a8\u30d3\u30c7\u30f3\u30b9\u3001\u5b9a\u7fa9\u3001\u6e2c\u5b9a\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u3001\u73fe\u5728\u304a\u3088\u3073\u5c06\u6765\u306e\u6cbb\u7642\u3002Pharmacol Ther 2014;141:358-67. <\/p>\n

5.Varbo A, Nordestgaard BG.\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u9032\u884c\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u8cea\u3002Arterioscler Thromb Vasc Biol 2016;36:2133-5. <\/p>\n

6.\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002J Am Coll Cardiol 2013;61:427-36. <\/p>\n

7.Joshi PH, Khokhar AA, Massaro JM, et al. Remnant lipoprotein cholesterol and incident coronary heart disease: Jackson Heart and Framingham Offspring Cohort Studies.J Am Heart Assoc 2016;5:e002765. <\/p>\n<\/td>\n<\/tr>\n

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