{"id":254343,"date":"2025-01-25T14:11:28","date_gmt":"2025-01-25T13:11:28","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%ef%bc%9a%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e\/"},"modified":"2025-02-16T22:24:58","modified_gmt":"2025-02-16T21:24:58","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%ef%bc%9a%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%a1%e3%82%bf%e3%82%a2%e3%83%8a%e3%83%aa%e3%82%b7%e3%82%b9%ef%bc%9a%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e4%bd%8e\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023<\/span><\/h2>\n
2020\u5e743\u670819\u65e5<\/span><\/h5>\n

\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4f4e\u4e0b\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u4f4e\u4e0b\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3067\u3082\u3001\u4e3b\u8981\u306a\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

Marston NA, Giugliano RP, Im KA, et al.\u8907\u6570\u306e\u8102\u8cea\u4f4e\u4e0b\u85ac\u6cbb\u7642\u30af\u30e9\u30b9\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u56de\u5e30\u5206\u6790\u3002Circulation 2019;140:1308-17. <\/span><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u3001LDL-C\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306e\u4f4e\u4e0b\u306e\u7a0b\u5ea6\u3068\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6e1b\u5c11\u3068\u306e\u95a2\u9023\u3092\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3001\u6d77\u6d0b\u6027\u30aa\u30e1\u30ac-3\u8102\u80aa\u9178\u3001\u30b9\u30bf\u30c1\u30f3\uff08\u53c2\u8003\u85ac\uff09\u306e\u5404\u8a66\u9a13\u306b\u304a\u3044\u3066\u8abf\u67fb\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u3068\u8a66\u9a13\u30ec\u30d9\u30eb\u306e\u30e1\u30bf\u56de\u5e30\u5206\u6790\u3002\u4e3b\u306a\u7d44\u307f\u5165\u308c\u57fa\u6e96\u306f\u3001\u5927\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u5831\u544a\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\nTG\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u975e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306b\u95a2\u3059\u308b24\u306e\u8a66\u9a13\uff08\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7cfb9\u8a66\u9a13\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u7cfb3\u8a66\u9a13\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u7cfb13\u8a66\u9a13\uff1b1\u8a66\u9a13\u306f\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7cfb\u3068\u30ca\u30a4\u30a2\u30b7\u30f3\u7cfb\u306e\u4e21\u65b9\u306e\u8a66\u9a13\u7fa4\uff09\u306b\u304a\u3044\u3066\u3001\u4e2d\u592e\u502443.8\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b25,218\u4ef6\u306e\u91cd\u5927\u306a\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f197,270\u4eba\u306e\u88ab\u9a13\u8005\u304c\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u88ab\u9a13\u8005\u306e\u5e73\u5747\u5e74\u9f62\u306f63\u6b73\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5e73\u5747TG\u5024\u306f163mg\/dL\uff08\u4e2d\u592e\u5024151mg\/dL\u3001\u56db\u5206\u4f4d\u7bc4\u56f2143-165mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u306b\u95a2\u3059\u308b25\u306e\u8a66\u9a13\u306b\u304a\u3051\u308b177,088\u4f8b\u306e\u30c7\u30fc\u30bf\uff0820,962\u4f8b\u306e\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff09\u3068\u6bd4\u8f03\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n
\u8a66\u9a13\u7d50\u679c<\/strong><\/td>\n\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e\u7d76\u5bfe\u7684\u4f4e\u4e0b\u306b\u4f34\u3046\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u6bd4\uff08RR\uff09\u3067\u3042\u3063\u305f\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\n\u3053\u306e\u7814\u7a76\u3067\u306f2\u3064\u306e\u91cd\u8981\u306a\u89e3\u6790\u304c\u884c\u308f\u308c\u305f\u3002\u6700\u521d\u306e\u89e3\u6790\u3067\u306f\u3001non-HDL-C\u306e\u7d76\u5bfe\u7684\u4f4e\u4e0b\uff082\u3064\u306e\u6cbb\u7642\u7fa4\u9593\u3067\u9054\u6210\u3055\u308c\u305fnon-HDL-C\u5024\u306e\u5dee\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u305f\uff09\u3068\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306eRR\u3068\u306e\u95a2\u9023\u304c\u78ba\u7acb\u3055\u308c\u305f\u3002\u7d9a\u3044\u3066\u3001LDL-C\u3068TG\u306e\u5bc4\u4e0e\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u3001LDL-C\u3068TG\u306e\u4f4e\u4e0b\u3068\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306eRR\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n\n\n\n
\n

\u4e3b\u306a\u8abf\u67fb\u7d50\u679c\u306f\u4ee5\u4e0b\u306e\u88681\u306b\u307e\u3068\u3081\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n

    \n
  • non-HDL-C\u306e\u4f4e\u4e0b\u306f\u3001\u8102\u8cea\u4f4e\u4e0b\u85ac\u306e\u7a2e\u985e\u306b\u95a2\u4fc2\u306a\u304f\u3001\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/li>\n
  • TG\u306e\u4f4e\u4e0b\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001LDL-C\u306b\u6bd4\u3079\u3001\u4f4e\u4e0b\u91cf\u306e\u7d76\u5bfe\u5024\u3042\u305f\u308a\u306e\u30ea\u30b9\u30af\u306f\u4f4e\u304b\u3063\u305f\u3002<\/li>\n
  • \u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u30921g\/\u65e5\u6442\u53d6\u3059\u308b\u3054\u3068\u306b\u3001\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u304c7\uff05\u6e1b\u5c11\u3057\u305f\uff080.93\uff3b95\uff05CI\u30010.91-0.95\uff3d\uff1bp<0.0001\uff09\u3002\u30c9\u30b3\u30b5\u30d8\u30ad\u30b5\u30a8\u30f3\u9178\u306e\u6295\u4e0e\u91cf\u3068\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u6e1b\u5c11\u3068\u306e\u9593\u306b\u306f\u6709\u610f\u306a\u95a2\u9023\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u9ad8\u7528\u91cf\u306e\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u6709\u76ca\u6027\u306f\u8102\u8cea\u4f4e\u4e0b\u4f5c\u7528\u3092\u4e0a\u56de\u308b\u3088\u3046\u3067\u3042\u308b\u3002 <\/li>\n<\/ul>\n

     <\/p>\n

    \u88681. \u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u306e1mmol\/L\u5f53\u305f\u308a\u306e\u76f8\u5bfe\u30ea\u30b9\u30af<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

    \n\n\n\n\n\n\n\n\n\n
    \n

    \u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf<\/strong><\/p>\n<\/td>\n

    		\n

    1mmol\/L\u4f4e\u4e0b\u5f53\u305f\u308a\u306eRR\uff0895\uff05\u4fe1\u983c\u533a\u9593<\/strong><\/p>\n<\/td>\n

    		\n

    p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n

    \n

    \u975eHDL-C<\/p>\n<\/td>\n

    		\n

    0.79\uff080.76-0.82\uff09\uff1b40mg\/dL\u3042\u305f\u308a0.78<\/p>\n<\/td>\n

    		\n

    <0.0001<\/p>\n<\/td>\n<\/tr>\n

    \n

    LDL-C<\/p>\n<\/td>\n

    		\n

    0.80\uff080.76-0.85\uff09\uff1b40mg\/dL\u3042\u305f\u308a0.79<\/p>\n<\/td>\n

    		\n

    <0.0001<\/p>\n<\/td>\n<\/tr>\n

    \n

    TG<\/p>\n<\/td>\n

    		\n

    0.84\uff080.75-0.94\uff09\uff1b40mg\/dL\u3042\u305f\u308a0.92<\/p>\n<\/td>\n

    		\n

    0.0026<\/p>\n<\/td>\n<\/tr>\n

    \n

    REDUCE-IT\u3092\u9664\u304f<\/p>\n<\/td>\n

    		\n

     <\/p>\n<\/td>\n

    		\n

     <\/p>\n<\/td>\n<\/tr>\n

    \n

    LDL-C<\/p>\n<\/td>\n

    		\n

    0.79\uff080.76-0.83\uff09\uff1b40mg\/dL\u3042\u305f\u308a0.78<\/p>\n<\/td>\n

    		\n

    <0.0001<\/p>\n<\/td>\n<\/tr>\n

    \n

    TG<\/p>\n<\/td>\n

    		\n

    0.91\uff080.81-1.006\uff09\uff1b40mg\/dL\u3042\u305f\u308a0.96<\/p>\n<\/td>\n

    		\n

     <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

    \n
    \n
    \n
    \n
    \n

     <\/p>\n\n\n\n
    \u7d50\u8ad6<\/strong><\/td>\n\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u306f\uff0cLDL-C\u4f4e\u4e0b\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3067\u3082\uff0cTG\u4f4e\u4e0b\u306f\u4e3b\u8981\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u304c\uff0c\u305d\u306e\u52b9\u679c\u306fLDL-C\u306e\u5834\u5408\u3088\u308a\u3082\u5c0f\u3055\u304f\uff0cREDUCE-IT\u3092\u9664\u5916\u3059\u308b\u3068\u6e1b\u5f31\u3059\u308b\u3002\u3055\u3089\u306b\uff0c\u6d77\u6d0b\u7531\u6765\u306e\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\uff0c\u7279\u306b\u9ad8\u7528\u91cf\u306e\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u6709\u76ca\u6027\u306f\uff0c\u8102\u8cea\u4f4e\u4e0b\u52b9\u679c\u3092\u4e0a\u56de\u308b\u3088\u3046\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
    \n

    \u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

    \u3057\u304b\u3057\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7cfb\u85ac\u5264\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u306a\u3069\u3001TG\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u6cbb\u7642\u85ac\u306e\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u30c7\u30fc\u30bf\u306f\u3001\u6c7a\u5b9a\u7684\u306a\u3082\u306e\u3067\u306f\u306a\u3044\u3002REDUCE-IT\u8a66\u9a13\u3067\u306f\u3001ASCVD\u306e\u9ad8\u30ea\u30b9\u30af\u304b\u3089\u8d85\u9ad8\u30ea\u30b9\u30af\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u9ad8\u7528\u91cf\u306e\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u304c\u4e3b\u8981\u306a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u309225\uff05\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u304c\u3001\u89b3\u5bdf\u3055\u308c\u305f\u6709\u76ca\u6027\u306fTG\u4f4e\u4e0b\u306e\u5927\u304d\u3055\u3068\u7b49\u3057\u304f\u306a\u304f\u3001\u591a\u9762\u7684\u52b9\u679c\u306e\u95a2\u4e0e\u3092\u793a\u5506\u3057\u3066\u3044\u308b11,12\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001TG\u4f4e\u4e0b\u306b\u3088\u308b\u81e8\u5e8a\u7684\u6709\u76ca\u6027\u306b\u3064\u3044\u3066\u306f\u3001\u7279\u306bLDL-C\u4f4e\u4e0b\u306b\u3088\u308b\u6709\u76ca\u6027\u3068\u6bd4\u8f03\u3057\u305f\u5834\u5408\u3001\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u78ba\u5b9f\u6027\u304c\u6b8b\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

    \u4eca\u56de\u306e\u89e3\u6790\u3067\u306f\u3001LDL\uff08LDL-C\uff09\u3068\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08VLDL\u3001TG\uff09\u3092\u542b\u3080\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u306e\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8ca0\u8377\u91cf\u306e\u6307\u6a19\u3067\u3042\u308bnon-HDL-C\u3092\u53c2\u7167\u6307\u6a19\u3068\u3057\u3066\u3001\u3053\u306e\u7591\u554f\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002TG\u4f4e\u4e0b\u306f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u305f\u304c\uff0c\u305d\u306e\u52b9\u679c\u306fLDL-C\u4f4e\u4e0b\u3067\u793a\u3055\u308c\u305f\u52b9\u679c\u3088\u308a\u3082\u5c0f\u3055\u304f\uff0cREDUCE-IT\u304c\u89e3\u6790\u304b\u3089\u9664\u5916\u3055\u308c\u305f\u5834\u5408\u306b\u306f\u6e1b\u5f31\u3057\u305f\u3002 <\/p>\n

    \u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u3001\u3053\u306e\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u308b\u91cd\u8981\u306a\u30e1\u30c3\u30bb\u30fc\u30b8\u304c\u3042\u308b\u3002\u7b2c\u4e00\u306b\u3001\u4ee5\u524d\u306e\u77e5\u898b13\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u304c\u3001non-HDL-C\u306e\u4f4e\u4e0b\u306f\u4e3b\u8981\u306a\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u304a\u308a\uff08\u4eca\u56de\u306e\u5831\u544a\u3067\u306f1mmol\/L\u4f4e\u4e0b\u3042\u305f\u308a21\uff05\u306e\u4f4e\u4e0b\uff09\u3001\u3053\u308c\u306f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u30af\u30e9\u30b9\u306b\u304b\u304b\u308f\u3089\u305a\u4e00\u8cab\u3057\u3066\u3044\u305f\u3002\u7b2c2\u306b\u3001TG\u4f4e\u4e0b\u3068\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306f\u95a2\u9023\u3057\u3066\u3044\u308b\u304c\u3001\u305d\u306e\u5927\u304d\u3055\u306fLDL-C\u4f4e\u4e0b\u3067\u89b3\u5bdf\u3055\u308c\u305f\u3082\u306e\u3088\u308a\u3082\u5c0f\u3055\u3044\u3002\u7b2c\u4e09\u306b\uff0cTG\u4f4e\u4e0b\u6cbb\u7642\uff08REDUCE-IT\u4ee5\u5916\uff09\u306e\u904e\u53bb\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u3067\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6709\u610f\u306a\u6e1b\u5c11\u304c\u793a\u3055\u308c\u306a\u304b\u3063\u305f\u7406\u7531\u306f\uff0c\u901a\u5e38\uff0c\u60a3\u8005\u96c6\u56e3\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u304c\u9ad8\u304f\u306a\u304b\u3063\u305f\u305f\u3081\uff0c\u975eHDL-C\u4f4e\u4e0b\u306e\u5927\u304d\u3055\u304c\u4e0d\u5341\u5206\u3067\u3042\u3063\u305f\u305f\u3081\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001TG\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u65b0\u898f\u85ac\u5264\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u3068\u3063\u3066\u6709\u76ca\u3067\u3042\u308b\u3002\u81e8\u5e8a\u8a66\u9a13\u304c\u9069\u5207\u306a\u60a3\u8005\u7fa4\uff08\u3059\u306a\u308f\u3061\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u304c\u9ad8\u3044\u60a3\u8005\u7fa4\uff09\u3067\u5b9f\u65bd\u3055\u308c\u308b\u306e\u3067\u3042\u308c\u3070\uff0c\u4eca\u5f8c2\u301c3\u5e74\u306e\u3046\u3061\u306b\uff0c\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308bTG\u4f4e\u4e0b\u306b\u3088\u308b\u81e8\u5e8a\u7684\u5229\u76ca\u306b\u95a2\u3059\u308b\u6c38\u7d9a\u7684\u306a\u4e0d\u78ba\u5b9f\u6027\u3092\u89e3\u6c7a\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u308b\u306b\u9055\u3044\u306a\u3044\u3002 <\/p>\n<\/div>\n\n\n\n\n
    \u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

    1.Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35. <\/p>\n

    2.Rubins HB, Robins SJ, Collins D, et al. \u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u5024\u7537\u6027\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u4e8c\u6b21\u4e88\u9632\u306e\u305f\u3081\u306e\u30b2\u30e0\u30d5\u30a3\u30d6\u30ed\u30b8\u30eb\uff1a\u9000\u5f79\u8ecd\u4eba\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4ecb\u5165\u8a66\u9a13\u30b0\u30eb\u30fc\u30d7\u3002N Engl J Med 1999;341:410-8. <\/p>\n

    3.\u30d9\u30b6\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6897\u585e\u4e88\u9632\u8a66\u9a13\u3002\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308bHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u6e1b\u5c11\u306b\u3088\u308b\u4e8c\u6b21\u4e88\u9632\u3002Circulation 2000;102:21-7. <\/p>\n

    4.Ginsberg HN, Elam MB, Lovato LC, et al; ACCORD Study Group.2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u4f75\u7528\u7642\u6cd5\u306e\u52b9\u679c\u3002N Engl J Med 2010;362:1563-74. <\/p>\n

    5.Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study\uff1a\u8102\u8cea\u7570\u5e38\u75c7\u306e\u4e2d\u5e74\u7537\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b2\u30e0\u30d5\u30a3\u30d6\u30ed\u30b8\u30eb\u306b\u3088\u308b\u4e00\u6b21\u4e88\u9632\u8a66\u9a13\uff1a\u6cbb\u7642\u306e\u5b89\u5168\u6027\u3001\u5371\u967a\u56e0\u5b50\u306e\u5909\u5316\u3001\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u767a\u751f\u7387\u3002N Engl J Med.1987;317:1237-45. <\/p>\n

    6.Keech A, Simes RJ, Barter P, et al; FIELD Study Investigators.2\u578b\u7cd6\u5c3f\u75c5\u60a3\u80059795\u4eba\u306b\u304a\u3051\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u9577\u671f\u6295\u4e0e\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff08FIELD\u8a66\u9a13\uff09\uff1a\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3002Lancet 2005;366:1849-61. <\/p>\n

    7.Boden WE, Probstfield JL, Anderson T, et al; AIM-HIGH Investigators.\u96c6\u4e2d\u7684\u306a\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4f4e\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u30ca\u30a4\u30a2\u30b7\u30f3\u3002N Engl J Med.2011;365:2255-67. <\/p>\n

    8.Landray MJ, Haynes R, Hopewell JC, et al; HPS2-THRIVE Collaborative Group.\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u30e9\u30ed\u30d4\u30d7\u30e9\u30f3\u30c8\u4f75\u7528\u5f90\u653e\u6027\u30ca\u30a4\u30a2\u30b7\u30f3\u306e\u52b9\u679c\u3002N Engl J Med 2014;371:203-12. <\/p>\n

    9.Kromhout D, Giltay EJ, Geleijnse JM; Alpha Omega Trial Group. n-3\u8102\u80aa\u9178\u3068\u5fc3\u7b4b\u6897\u585e\u5f8c\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3002N Engl J Med.2010;363:2015-26. <\/p>\n

    10.n-3\u7cfb\u8102\u80aa\u9178\u3068\u8840\u7cd6\u7570\u5e38\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3002N Engl J Med 2012;367:309-18. <\/p>\n

    11.Bhatt DL, Steg PG, Miller M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3002N Engl J Med 2019;380:11-22. <\/p>\n

    12.Laufs U, Parhofer KG, Ginsberg HN, Hegele RA.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u30ec\u30d3\u30e5\u30fc\u3002Eur Heart J 2020;41:99-109c. <\/p>\n

    13.Brunner FJ, Waldeyer C, Ojeda F, et al. \u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u5c64\u5225\u5316\u306e\u305f\u3081\u306e\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u9069\u7528\uff1a\u591a\u56fd\u7c4d\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u30b3\u30f3\u30bd\u30fc\u30b7\u30a2\u30e0\u306e\u7d50\u679c\u3002Lancet 2019;394:2173-83. <\/p>\n<\/td>\n<\/tr>\n

    \u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff1b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\uff1b\u975eHDL-C\uff1b\u30e1\u30bf\u89e3\u6790<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

     <\/p>\n

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