{"id":254341,"date":"2025-01-21T22:35:30","date_gmt":"2025-01-21T21:35:30","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e6%ae%8b%e7%95%99%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%ae%e7%ae%a1%e7%90%86%ef%bc%9a%e8%93%84%e7%a9%8d%e3%81%a8\/"},"modified":"2025-02-16T22:24:16","modified_gmt":"2025-02-16T21:24:16","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e6%ae%8b%e7%95%99%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%ae%e7%ae%a1%e7%90%86%ef%bc%9a%e8%93%84%e7%a9%8d%e3%81%a8","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e6%ae%8b%e7%95%99%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab%e3%81%ae%e7%ae%a1%e7%90%86%ef%bc%9a%e8%93%84%e7%a9%8d%e3%81%a8\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7ba1\u7406\uff1a\u84c4\u7a4d\u3068\u6765\u9662\u6642\u306e\u5909\u52d5\u306e\u4e21\u65b9\u3092\u8003\u616e\u3059\u308b"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7ba1\u7406\uff1a\u84c4\u7a4d\u3068\u6765\u9662\u6642\u306e\u5909\u52d5\u306e\u4e21\u65b9\u3092\u8003\u616e\u3059\u308b<\/span><\/h2>\n
2023\u5e749\u670826\u65e5<\/span><\/h5>\n

\u4e2d\u56fd\u306e\u3053\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u52d5\u304c\u5927\u304d\u3044\u3068\u3044\u3046\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u72ec\u7acb\u3057\u305f\u30ea\u30b9\u30af\u3092\u60aa\u5316\u3055\u305b\u308b\u3002<\/em><\/p>\n

Wang J, Jin R, Jin X, et al. \u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u84c4\u7a4d\u304a\u3088\u3073\u5909\u52d5\u3068\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3068\u306e\u500b\u5225\u7684\u304a\u3088\u3073\u5171\u540c\u7684\u95a2\u9023\uff1a\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002J Am Heart Assoc 2023;12:e029352.doi: 10.1161\/. jaha.122.029352 <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5909\u52d5\u3068\u305d\u306e\u5f8c\u306e\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u30ea\u30b9\u30af\u3068\u306e\u500b\u5225\u7684\u304a\u3088\u3073\u5171\u540c\u7684\u95a2\u9023\u3092\u8abf\u3079\u3001\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u4e88\u6e2c\u4fa1\u5024\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\nBHMC\uff08\u5317\u4eac\u5065\u5eb7\u7ba1\u7406\u30b3\u30db\u30fc\u30c8\uff09\u7814\u7a76\u306f\u3001\u73fe\u5728\u9032\u884c\u4e2d\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u3042\u308a\u3001\u5bfe\u8c61\u8005\u306f\u9838\u52d5\u8108\u306e\u8d85\u97f3\u6ce2\u691c\u67fb\u3092\u542b\u3080\u5305\u62ec\u7684\u306a\u5b9a\u671f\u5065\u5eb7\u8a3a\u65ad\u3092\u53d7\u3051\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/td>\n\u9838\u52d5\u8108\u8d85\u97f3\u6ce2\u691c\u67fb\u30923\u56de\u9023\u7d9a\u3057\u3066\u53d7\u8a3a\u3057\u305f6,213\u4eba\uff08\u7537\u602754\uff05\u3001\u5e74\u9f62\u4e2d\u592e\u502446\u6b73\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u7d50\u679c<\/strong><\/td>\n– \u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\uff1a\u9838\u52d5\u8108\u8d85\u97f3\u6ce2\u691c\u67fb\u306b\u3088\u308b\u9838\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u307e\u305f\u306f\u9838\u52d5\u8108\u5185\u819c\u4e2d\u819c\u539a\uff08CIMT\uff09\u7570\u5e38\u306e\u5b58\u5728\u3068\u5b9a\u7fa9\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\n\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u7a7a\u8179\u6642\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3092\u5f15\u3044\u305f\u5024\u304b\u3089\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u3092\u5f15\u3044\u305f\u5024\u3068\u3057\u3066\u63a8\u5b9a\u3057\u305f\u3002\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u9023\u7d9a\u3057\u305f\u8a3a\u5bdf\u306e\u5404\u7d44\u306e\u5e73\u5747\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u5408\u8a08\u306b\u3001\u3053\u308c\u3089\u306e\u9023\u7d9a\u3057\u305f\u8a3a\u5bdf\u306e\u9593\u306e\u6642\u9593\u9593\u9694\u3092\u4e57\u3058\u305f\u3082\u306e\u3068\u3057\u3066\u8a08\u7b97\u3055\u308c\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u52d5\u306f\u3001\u9023\u7d9a\u5909\u52d5\u3001\u5e73\u5747\u5024\u304b\u3089\u72ec\u7acb\u3057\u305f\u5909\u52d5\u3001\u5e73\u5747\u5b9f\u8cea\u5909\u52d5\u3001\u6a19\u6e96\u504f\u5dee\uff08SD\uff09\u3001\u5909\u52d5\u4fc2\u6570\u306b\u57fa\u3065\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002 <\/p>\n

Cox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5909\u52d5\u3068\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u304a\u3088\u3073\u9838\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u305f\u3002\u30e2\u30c7\u30eb\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u55ab\u7159\u306e\u6709\u7121\u3001\u98f2\u9152\u306e\u6709\u7121\u3001\u8eab\u4f53\u6d3b\u52d5\u3001\u80a5\u6e80\u5ea6\u3001\u9ad8\u8840\u5727\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u8102\u8cea\u4f4e\u4e0b\u85ac\u306e\u4f7f\u7528\u3001\u8840\u6e05\u5c3f\u9178\u3001\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff08\u30e2\u30c7\u30eb1\uff09\u3001LDL-C\uff08\u30e2\u30c7\u30eb2\uff09\u3067\u8abf\u6574\u3057\u305f\u3002\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5909\u52d5\u3068\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u30ea\u30b9\u30af\u3068\u306e\u500b\u5225\u7684\u304a\u3088\u3073\u5171\u540c\u7684\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002\u88ab\u9a13\u8005\u306f\u3001\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5909\u52d5\u306e\u4e2d\u592e\u5024\uff08\u4e2d\u592e\u5024\u4ee5\u4e0a\u3068\u4e2d\u592e\u5024\u672a\u6e80\uff09\u306b\u3088\u3063\u30664\u7fa4\u306b\u5206\u985e\u3055\u308c\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c
<\/strong><\/p>\n

\u4e2d\u592e\u50244\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u30012,613\u4eba\uff0842.1\uff05\uff09\u304c\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3092\u767a\u75c7\u3057\u30011327\u4eba\uff0821.4\uff05\uff09\u304c\u9838\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u3092\u767a\u75c7\u3057\u305f\u3002\u7d2f\u7a4d\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u304b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u52d5\u304c\u5927\u304d\u3044\u3053\u3068\u306f\u3001\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3084LDL-C\u3068\u306f\u7121\u95a2\u4fc2\u306b\u3001\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u30ea\u30b9\u30af\u306f\u4f75\u7528\u306b\u3088\u308a\u60aa\u5316\u3057\u305f\uff08\u88681\uff09\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5358\u4e00\u6642\u70b9\u6e2c\u5b9a\u5024\u3067\u306f\u306a\u304f\u3001\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u307e\u305f\u306f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5909\u52d5\u5e45\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u4e88\u6e2c\u5024\u306f\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3002 <\/p>\n

\u88681. \u7d2f\u7a4d\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08cRC\uff09\u304a\u3088\u3073\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5909\u52d5\uff08RCV\uff09\u3068\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3002<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u53ef\u5909<\/strong><\/p>\n<\/td>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/strong><\/p>\n<\/td>\n

\n

p\u5024<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u5de1\u56de\u5197\u9577\u691c\u67fb<\/p>\n<\/td>\n

\n

1.33 (1.17-1.52)*<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

1.16 (1.01-1.32**<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

RV<\/p>\n<\/td>\n

\n

1.22 (1.08-1.39)*<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

1.16 (1.02-1.31)**<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30b8\u30e7\u30a4\u30f3\u30c8\u30fb\u30a2\u30bd\u30b7\u30a8\u30fc\u30b7\u30e7\u30f3<\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u3044\u305a\u308c\u306e\u5909\u6570\u3082\u4e2d\u592e\u5024\u3088\u308a\u9ad8\u3044<\/p>\n<\/td>\n

\n

1.21 (1.09-1.34)**<\/p>\n<\/td>\n

\n

<0.001<\/p>\n<\/td>\n<\/tr>\n

\n

\u9ad8\u3044cRC\u3068\u4f4e\u3044RCV<\/p>\n<\/td>\n

\n

1.21 (1.06-1.37)**<\/p>\n<\/td>\n

\n

0.081<\/p>\n<\/td>\n<\/tr>\n

\n

\u4f4e\u3044cRC\u3068\u9ad8\u3044RCV<\/p>\n<\/td>\n

\n

1.14 (1.00-1.30)**<\/p>\n<\/td>\n

\n

0.057<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

* \u5e74\u9f62\u3001\u6027\u5225\u3001\u55ab\u7159\u306e\u6709\u7121\u3001\u98f2\u9152\u306e\u6709\u7121\u3001\u8eab\u4f53\u6d3b\u52d5\u91cf\u3001\u80a5\u6e80\u5ea6\u3001\u9ad8\u8840\u5727\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u8102\u8cea\u4f4e\u4e0b\u85ac\u306e\u4f7f\u7528\u3001\u8840\u6e05\u5c3f\u9178\u3001\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u3067\u8abf\u6574\u3002<\/p>\n

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 <\/p>\n\n\n\n
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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Stevens SL, Wood S, Koshiaris C, et al. Blood Pressure variability and cardiovascular disease: systematic review and meta-analysis.BMJ 2016;354:i4098.
2.Nuyujukian DS, Koska J, Bahn G, Reaven PD, Zhou JJ.ACCORD\u3068VADT\u306b\u304a\u3051\u308b\u8840\u5727\u5909\u52d5\u3068\u5fc3\u4e0d\u5168\u30ea\u30b9\u30af\u3002Diabetes Care.2020;43:1471-78.
3.IDEAL trial\u306e\u5fc3\u7b4b\u6897\u585e\u65e2\u5f80\u60a3\u8005\u306b\u304a\u3051\u308b\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8840\u5727\u306e\u5909\u52d5\u3068\u30a4\u30d9\u30f3\u30c8\u306e\u95a2\u4fc2\u3002Am J Cardiol 2017;119:379-87.
4.Segar MW, Patel KV, Vaduganathan M, et al. 2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u7cd6\u5024\u306e\u9577\u671f\u7684\u5909\u5316\u3068\u5909\u52d5\u3068\u5fc3\u4e0d\u5168\u767a\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\uff1aACCORD\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002Diabetes Care.2020;43:1920-8.
5.2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u3092\u4e88\u6e2c\u3059\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u305d\u306e\u6765\u9662\u9593\u5909\u52d5\uff1aACCORD\u30b3\u30db\u30fc\u30c8\u304b\u3089\u306e\u77e5\u898b\u3002Diabetes Care 2022;45:2136-43. <\/td>\n<\/tr>\n
\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1b\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\uff1b\u7d2f\u7a4d\u66b4\u9732\uff1b\u6765\u9662\u6642\u5909\u52d5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

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