{"id":254336,"date":"2025-01-25T13:32:55","date_gmt":"2025-01-25T12:32:55","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bda%ef%bc%9a%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e3%83%9e\/"},"modified":"2025-02-16T22:22:51","modified_gmt":"2025-02-16T21:22:51","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bda%ef%bc%9a%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e3%83%9e","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%83%aa%e3%83%9d%e8%9b%8b%e7%99%bda%ef%bc%9a%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e3%83%9e\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u30ea\u30dd\u86cb\u767d(a)\uff1a\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u30ea\u30dd\u86cb\u767d(a)\uff1a\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc<\/span><\/h2>\n
2020\u5e747\u670820\u65e5<\/span><\/h5>\n

\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306b\u4e88\u5f8c\u4e88\u6e2c\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u3001\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u5b9f\u81e8\u5e8a\u89e3\u6790\u3067\u793a\u3055\u308c\u305f\u3002<\/span><\/p>\n

Liu HH, Cao YX, Jin JL et al. \u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u5024\u3068\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u3068\u306e\u95a2\u9023\u3002Heart 2020; doi:10.1136\/heartjnl-2020-316586. <\/span><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u51a0\u52d5\u8108\u75be\u60a3\uff08CAD\uff09\u60a3\u8005\u306e\u5b9f\u4e16\u754c\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066\uff0c\u5165\u9662\u6642\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u5024\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u30ea\u30b9\u30af\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n\u591a\u65bd\u8a2d\u5171\u540c\u524d\u5411\u304d\u7814\u7a76<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n\u8840\u7ba1\u9020\u5f71\u3067CAD\u3068\u8a3a\u65ad\u3055\u308c\u3001\u521d\u56de\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u7d4c\u9a13\u3057\u305f7,562\u4f8b\uff08\u5e73\u5747\u5e74\u9f6257.3\u6b73\u3001\u7537\u602773.9\uff05\u3001\u8840\u884c\u518d\u5efa\u8853\u6b7477.1\uff05\uff09\u304c\u8a66\u9a13\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u85ac\u5264\u306f\u30b9\u30bf\u30c1\u30f3\uff0878\uff05\uff09\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\uff0874\uff05\uff09\u3001P2Y12\u963b\u5bb3\u85ac\uff0854\uff05\uff09\u3001\u03b2\u906e\u65ad\u85ac\uff0844\uff05\uff09\u3067\u3042\u3063\u305f\u3002 <\/td>\n<\/tr>\n
\u30e1\u30a4\u30f3\u306e\u7814\u7a76\u5909\u6570\uff1a<\/strong><\/td>\n-\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u306e\u8907\u5408\u3068\u5b9a\u7fa9\uff09\u3002-\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u306e\u5165\u9662\u6642\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u5024\u30923\u5206\u4f4d\u5024\u3067\u5206\u985e\uff1a<8.88mg\/dL\uff08n=2520\uff09\u30018.88\uff5e26.44mg\/dL\uff08n=2521\uff09\u3001\u226726.45mg\/dL\uff08n=2521\uff09\u3002 <\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\nKaplan-Meier\u89e3\u6790\u306b\u3088\u308a\u54043\u7fa4\u306b\u304a\u3051\u308b\u7121\u30a4\u30d9\u30f3\u30c8\u751f\u5b58\u7387\u3092\u7b97\u51fa\u3057\u3001log-rank\u691c\u5b9a\u306b\u3088\u308a\u6bd4\u8f03\u3057\u305f\u3002\u5165\u9662\u6642\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u30ec\u30d9\u30eb\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u73fe\u5728\u306e\u55ab\u7159\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u5de6\u5ba4\u99c6\u51fa\u7387\u3001\u8840\u884c\u518d\u5efa\u8853\uff08\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\/\u51a0\u52d5\u8108\u30d0\u30a4\u30d1\u30b9\u8853\uff09\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\u3001\u7cd6\u5316\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u3067\u8abf\u6574\u3057\u305f\u591a\u5909\u91cfCox\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u5e73\u5747\u8ffd\u8de1\u671f\u959361.4\u00b119.6\u30f5\u6708\u9593\u306b680\u4ef6\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u304c\u8a8d\u3081\u3089\u308c\u3001\u3053\u308c\u306f1000\u4eba\u5e74\u5f53\u305f\u308a17.5\u4ef6\u306b\u76f8\u5f53\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u518d\u767a\u3057\u305f\u60a3\u8005\u306f\u3001\u5165\u9662\u6642\u306e\u30ea\u30dd\u86cb\u767d(a)\u5024\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff1a20.58mg\/dL\u306b\u5bfe\u3057\u3001\u30a4\u30d9\u30f3\u30c8\u306e\u306a\u304b\u3063\u305f\u60a3\u8005\u3067\u306f14.95mg\/dL\u3001p<0.001.<br >
\u56de\u5e30\u5206\u6790\u306b\u3088\u308b\u3068\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u30ea\u30b9\u30af\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u88681\uff09\u3002\u5165\u9662\u6642\u306e\u30ea\u30dd\u86cb\u767d(a)\u304c1\u6a19\u6e96\u504f\u5dee\u5897\u52a0\u3059\u308b\u3054\u3068\u306b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u30ea\u30b9\u30af\u306f23\uff05\uff0810\uff05\u301c38\uff05\uff09\u5897\u52a0\u3057\u305f\uff08p<0.001\uff09\u3002 <\/p>\n

\u88681. \u5165\u9662\u4e2d\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\uff08RCVEs\uff09<\/strong><\/p>\n\n\n\n\n\n
<\/td>\n\n

\u30bf\u30fc\u30bf\u30a4\u30eb1<\/p>\n

(<8.88mg\/dL)<\/p>\n<\/td>\n

\n

\u968e\u5c642<\/p>\n

(8.88-26.44mg\/dL)<\/p>\n<\/td>\n

\n

\u7b2c3\u968e\u5c64<\/p>\n

(26.45mg\/dL\u4ee5\u4e0a\uff09\u3002<\/p>\n<\/td>\n<\/tr>\n

\n

RCVEs\/1000\u4eba\u5e74<\/p>\n

(95% CI)<\/p>\n<\/td>\n

\n

12.9\uff088.6\u301c17.2\uff09<\/p>\n<\/td>\n

\n

19.0\uff0813.7\uff5e24.3\uff09<\/p>\n<\/td>\n

\n

20.6\uff0815.3\uff5e26.7\u30d1\u30fc\u30bb\u30f3\u30c8\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/p>\n<\/td>\n

\n

\u53c2\u8003<\/p>\n<\/td>\n

\n

1.69\uff081.21\uff5e2.36\uff09*\u3002<\/p>\n<\/td>\n

\n

2.01\uff081.44\uff5e2.80\uff09***\u3002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*p<0.05; ** p<0.001<\/span><\/div>\n
<\/span><\/div>\n
\u3055\u3089\u306b\u3001SMART\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u78ba\u7acb\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u306b\u5165\u9662\u6642\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u306e\u30ea\u30b9\u30af\u5c64\u5225\u5316\u304c\u6709\u610f\u306b\u6539\u5584\u3057\u305f\uff08p<0.001\uff09\u3002<\/span><\/div>\n
<\/span><\/div>\n
\n
\n
\n
\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u5faa\u74b0\u30ea\u30dd\u86cb\u767d(a)\u6fc3\u5ea6\u306f\u3001\u5b9f\u81e8\u5e8a\u3067\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308bCAD\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u30ea\u30b9\u30af\u306e\u6709\u7528\u306a\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308a\u3001\u30ea\u30dd\u86cb\u767d(a)\u306e\u4eca\u5f8c\u306e\u81e8\u5e8a\u5fdc\u7528\u306b\u95a2\u3059\u308b\u8ffd\u52a0\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8
<\/strong><\/p>\n

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 <\/p>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Gencer B, Kronenberg F, Stroes ES, Mach F. Lipoprotein(a): the revenant.Eur Heart J 2017;38:1553-60.2.Dorresteijn JAN, Visseren FLJ, Wassink AMJ, et al. \u52d5\u8108\u75be\u60a3\u60a3\u8005\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u57fa\u3065\u304f\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u4e88\u6e2c\u30eb\u30fc\u30eb\u306e\u958b\u767a\u3068\u691c\u8a3c\uff1a\u30b9\u30de\u30fc\u30c8\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3002Heart 2013;99:866-72.3.Shah NP, Wang Q, Wolski KE, et al.\u81f3\u9069\u85ac\u7269\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30ea\u30b9\u30af\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u5f79\u5272\uff1aACCELERATE\u306e\u4e8b\u5f8c\u89e3\u6790\u3002Diabetes Care 2020;43(2): e22-e24. <\/td>\n<\/tr>\n
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