{"id":254330,"date":"2025-01-21T18:54:46","date_gmt":"2025-01-21T17:54:46","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-clear-outcomes%e8%a9%a6%e9%a8%93%e3%81%8b%e3%82%89%e3%81%ae%e6%b4%9e%e5%af%9f%ef%bc%9aldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab\/"},"modified":"2025-02-16T22:20:22","modified_gmt":"2025-02-16T21:20:22","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-clear-outcomes%e8%a9%a6%e9%a8%93%e3%81%8b%e3%82%89%e3%81%ae%e6%b4%9e%e5%af%9f%ef%bc%9aldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-clear-outcomes%e8%a9%a6%e9%a8%93%e3%81%8b%e3%82%89%e3%81%ae%e6%b4%9e%e5%af%9f%ef%bc%9aldl%e3%82%b3%e3%83%ac%e3%82%b9%e3%83%86%e3%83%ad%e3%83%bc%e3%83%ab\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – CLEAR-Outcomes\u8a66\u9a13\u304b\u3089\u306e\u6d1e\u5bdf\uff1aLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u3060\u3051\u3067\u306f\u5341\u5206\u3067\u306f\u306a\u3044"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –CLEAR-Outcomes\u8a66\u9a13\u304b\u3089\u306e\u6d1e\u5bdf\uff1aLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u3060\u3051\u3067\u306f\u5341\u5206\u3067\u306f\u306a\u3044<\/span><\/h2>\n
2024\u5e745\u670820\u65e5<\/span><\/h5>\n

\u3053\u306e\u8a66\u9a13\u306e\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\uff08hsCRP\uff09\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3088\u308a\u3082\u5f37\u529b\u306b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u4e88\u6e2c\u3059\u308b\u3002<\/em><\/p>\n

Ridker PM, Lei L, Louie MJ, et al. \u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u306e\u73fe\u4ee3\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u800513970\u4eba\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306e\u708e\u75c7\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002Circulation 2024;149:28-35. <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306e\u708e\u75c7\u3068\u9ad8\u8102\u8840\u75c7\u306e\u76f8\u5bfe\u7684\u5f71\u97ff\u3092\u8abf\u3079\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\nCLEAR-Outcomes\uff08Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen Outcomes Trial\uff09\u306f\u3001\u30d9\u30e0\u30da\u30c9\u9178180mg\u30921\u65e51\u56de\u7d4c\u53e3\u6295\u4e0e\u3059\u308b\u304b\u3001\u30d7\u30e9\u30bb\u30dc\u3092\u4f75\u7528\u3059\u308b\u304b\u3092\u6bd4\u8f03\u3057\u305f\u7121\u4f5c\u70ba\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u591a\u56fd\u7c4d\u8a66\u9a13\u3067\u3042\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u60a3\u800513,970\u4f8b\uff08\u5e73\u5747\u5e74\u9f6265.5\u6b73\u3001\u7cd6\u5c3f\u75c548.2\uff05\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u65e2\u5f8069.9\uff05\uff09\u304cCLEAR-Outcomes\u3067\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u3002\u60a3\u8005\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u65e2\u5f80\u304c\u3042\u308b\u304b\u3001\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u4e2d\u306b\u767a\u73fe\u307e\u305f\u306f\u5897\u52a0\u3057\u3001\u30b9\u30bf\u30c1\u30f3\u4e2d\u6b62\u5f8c\u306b\u6d88\u5931\u307e\u305f\u306f\u6539\u5584\u3057\u305f\u526f\u4f5c\u7528\u306e\u305f\u3081\u306b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u304b\u3001\u307e\u305f\u306f\u53d7\u3051\u305f\u304f\u306a\u3044\u3068\u5831\u544a\u3057\u305f\u3002 <\/td>\n<\/tr>\n
\u8a66\u9a13\u7d50\u679c<\/strong><\/td>\n\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff1a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u5fc3\u8840\u7ba1\u6b7b\u306e4\u70b9\u8907\u5408\u30a2\u30a6\u30c8\u30ab\u30e0\uff09\u3001\u5168\u6b7b\u4ea1\u7387<\/td>\n<\/tr>\n
\u65b9\u6cd5<\/strong><\/td>\n\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306ehsCRP\u3068LDL-C\u306e\u5897\u52a0\u306e\u56db\u5206\u4f4d\u3092\u5c06\u6765\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u8a55\u4fa1\u3057\u305f\u3002\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\uff08\u5e74\u9f62\u3001\u6027\u5225\u3001\u6c11\u65cf\u3001\u7cd6\u5c3f\u75c5\u3001\u80a5\u6e80\u5ea6\u3001\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u3001\u8840\u5727\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f7f\u7528\u3001\u55ab\u7159\u306e\u6709\u7121\u3001\u65e2\u77e5\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff09\u304a\u3088\u3073\u30e9\u30f3\u30c0\u30e0\u5316\u6cbb\u7642\u5272\u308a\u4ed8\u3051\u3092\u8abf\u6574\u3057\u305f\u5f8c\u306e\u5404\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3057\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c
<\/strong><\/p>\n

\u8ffd\u8de1\u671f\u9593\u306e\u4e2d\u592e\u502440.6\u30f5\u6708\u9593\u306b1746\u4ef6\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u3001854\u4eba\u304c\u6b7b\u4ea1\u3057\u3001\u3046\u3061526\u4eba\u304c\u5fc3\u8840\u7ba1\u6b7b\u3068\u5224\u5b9a\u3055\u308c\u305f\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306ehsCRP\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u3088\u308a\u3082\u5fc3\u8840\u7ba1\u7cfb\u30a4\u30d9\u30f3\u30c8\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3068\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u88681\uff09\u3002<\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306ehsCRP\u304c\u4e2d\u592e\u5024\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u4e2d\u592e\u5024\u4ee5\u4e0b\u3088\u308a\u3082\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\uff08p<0.001\uff09\u3002<\/p>\n

\u88681. \u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306ehsCRP\u304a\u3088\u3073LDL-C\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u3068\u306e\u95a2\u9023\u6027<\/strong><\/p>\n\n\n\n\n\n
\n

\u5909\u6570\uff08\u6700\u9ad8\u56db\u5206\u4f4d\u3068\u6700\u4f4e\u56db\u5206\u4f4d\uff09<\/p>\n<\/td>\n

\n

\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8<\/p>\n<\/td>\n

\n

\u5fc3\u81d3\u8840\u7ba1\u6b7b<\/p>\n<\/td>\n

\n

\u5168\u6b7b\u56e0\u6b7b\u4ea1<\/p>\n<\/td>\n<\/tr>\n

\n

hsCRP<\/p>\n<\/td>\n

\n

1.43 (1.24-1.65)<\/p>\n<\/td>\n

\n

2.00 (1.53-2.61)<\/p>\n<\/td>\n

\n

2.21 (1.79-2.73)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C<\/p>\n<\/td>\n

\n

1.19 (1.04-1.37)<\/p>\n<\/td>\n

\n

0.90 (0.70-1.17)<\/p>\n<\/td>\n

\n

0.95 (0.78-1.16)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u30c7\u30fc\u30bf\u306f\u30cf\u30b6\u30fc\u30c9\u6bd4\u306895\uff05\u4fe1\u983c\u533a\u9593\u3067\u793a\u3057\u305f\u3002<\/p>\n\n\n\n
\u8457\u8005\u7d50\u8ad6<\/strong><\/td>\n\u73fe\u4ee3\u306e\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u60a3\u8005\u306b\u304a\u3044\u3066\u3001hsCRP\u3067\u8a55\u4fa1\u3055\u308c\u308b\u708e\u75c7\u306fLDL-C\u3067\u8a55\u4fa1\u3055\u308c\u308b\u9ad8\u8102\u8840\u75c7\u3088\u308a\u3082\u5c06\u6765\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3092\u5f37\u304f\u4e88\u6e2c\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u708e\u75c7\u306f\u3001\u52d5\u8108\u786c\u5316\u3068\u305d\u306e\u5408\u4f75\u75c7\u306e\u539f\u52d5\u529b\u3067\u3042\u308a\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6b8b\u5b58\u3055\u305b\u308b\u4e00\u56e0\u3067\u3042\u308b\u3053\u3068\u306f\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b(1)\u3002\u3055\u3089\u306b\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u3044\u305f\u4e88\u9632\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u708e\u75c7\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u7387\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u81e8\u5e8a\u8a66\u9a13\u3067\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b(2,3)\u3002\u30b9\u30bf\u30c1\u30f3\u7cfb\u85ac\u5264\u306f\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u306e\u60a3\u8005\u3084\u305d\u306e\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u5bfe\u3059\u308b\u4e3b\u8981\u306a\u4e88\u9632\u6cbb\u7642\u306e\u3072\u3068\u3064\u3067\u3042\u308a\u3001hsCRP\u3068LDL-C\u306e\u4e21\u65b9\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3002\u30b9\u30bf\u30c1\u30f3\u3092\u542b\u3080\u6700\u65b0\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u6cbf\u3063\u305f\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u306e\u6700\u8fd1\u306e\u89e3\u6790\u3067\u306f\u3001hsCRP\u306fLDL-C\u3088\u308a\u3082\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5f37\u3044\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u3063\u305f(4)\u3002\u3057\u304b\u3057\u3001\u30b9\u30bf\u30c1\u30f3\u306b\u8010\u3048\u3089\u308c\u306a\u3044\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308bhsCRP\u3068LDL-C\u306e\u76f8\u5bfe\u7684\u306a\u5bc4\u4e0e\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002 <\/p>\n

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\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Everett BM.\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\uff1a\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u306e\u4e00\u822c\u7684\u3067\u91cd\u8981\u306a\u5371\u967a\u56e0\u5b50\u3002J Am Coll Cardiol 2019;73:2410-2.
2.Ridker PM, Everett BM, Thuren T, et al; CANTOS Trial Group.\u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30ab\u30ca\u30ad\u30cc\u30de\u30d6\u306b\u3088\u308b\u6297\u708e\u75c7\u7642\u6cd5\u3002N Engl J Med 2017;377:1119-31.
3.Tardif JC, Kouz S, Waters DD, et al. \u5fc3\u7b4b\u6897\u585e\u5f8c\u306e\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f3\u306e\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3002N Engl J Med 2019;381:2497-505.
4.Ridker PM, Bhatt DL, Pradhan AD, et al. \u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306e\u708e\u75c7\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a3\u3064\u306e\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u306e\u5171\u540c\u89e3\u6790\u3002Lancet 2023;401:1293-301. <\/td>\n<\/tr>\n
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