{"id":254328,"date":"2025-01-21T23:35:42","date_gmt":"2025-01-21T22:35:42","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e7%89%b9%e5%ae%9a%ef%bc%9a%e6%9c%80%e9%81%a9%e3%81%aa\/"},"modified":"2025-02-16T22:19:48","modified_gmt":"2025-02-16T21:19:48","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e7%89%b9%e5%ae%9a%ef%bc%9a%e6%9c%80%e9%81%a9%e3%81%aa","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e6%ae%8b%e5%ad%98%e5%bf%83%e8%a1%80%e7%ae%a1%e7%b3%bb%e3%83%aa%e3%82%b9%e3%82%af%e3%81%ae%e7%89%b9%e5%ae%9a%ef%bc%9a%e6%9c%80%e9%81%a9%e3%81%aa\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u7279\u5b9a\uff1a\u6700\u9069\u306a\u8102\u8cea\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3069\u308c\u304b\uff1f"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u7279\u5b9a\uff1a\u6700\u9069\u306a\u8102\u8cea\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3069\u308c\u304b\uff1f<\/span><\/h2>\n
21 2021\u5e745\u6708<\/span><\/h5>\n

Copenhagen General Population Study\u306e\u3053\u306e\u5831\u544a\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u3088\u308a\u3088\u304f\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3088\u308a\u3082\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u307e\u305f\u306f\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u304c\u512a\u5148\u3055\u308c\u305f\u3002<\/em><\/p>\n

Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG.\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3068\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u3088\u304f\u53cd\u6620\u3059\u308b\u3002J Am Coll Cardiol 2021;77:1439-50. <\/em><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u3069\u306e\u8102\u8cea\u30de\u30fc\u30ab\u30fc\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\u3092\u6700\u3082\u3088\u304f\u53cd\u6620\u3059\u308b\u304b\u3092\u691c\u8a0e\u3059\u308b\uff1a\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08\u30a2\u30dd\uff09B\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u975eHDL-C\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\nCopenhagen General Population\u7814\u7a76\u306f\u524d\u5411\u304d\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u96c6\u56e3\uff1a<\/strong><\/td>\nCopenhagen General Population Study\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u800513,015\u4eba\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50248\u5e74\u3002<\/td>\n<\/tr>\n
\u4e3b\u306a\u7814\u7a76\u5909\u6570\uff1a<\/strong><\/td>\n– Danish\u5e02\u6c11\u767b\u9332\u30b7\u30b9\u30c6\u30e0\u304b\u3089\u540c\u5b9a\u3055\u308c\u305f\u5168\u6b7b\u56e0\u6b7b\u4ea1\u75c7\u4f8b\u3068Danish\u60a3\u8005\u767b\u9332\u304b\u3089\u540c\u5b9a\u3055\u308c\u305f\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u75c7\u4f8b\u3002
– \u975eHDL-C\u306e\u8a08\u7b97\u5024\u3068apoB\u306e\u6e2c\u5b9a\u5024\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c<4.0mmol\/L\u306e\u5834\u5408\u306fLDL-C\u3092\u8a08\u7b97\u3057\u3001\u305d\u308c\u4ee5\u4e0a\u306e\u5834\u5408\u306f\u76f4\u63a5\u6e2c\u5b9a\u3057\u305f\u3002<\/td>\n<\/tr>\n
\u65b9\u6cd5\uff1a<\/strong><\/td>\nCox\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066apoB\u3001\u975eHDL-C\u3001LDL-C\u3068\u5168\u6b7b\u4ea1\u307e\u305f\u306f\u5fc3\u7b4b\u6897\u585e\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002\u30c7\u30fc\u30bf\u306f\u4e2d\u592e\u5024\u3067\u5b9a\u7fa9\u3055\u308c\u305f\u4e00\u81f4\u5024\u3068\u4e0d\u4e00\u81f4\u5024\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u3067\u5206\u6790\u3055\u308c\u305f\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50248\u5e74\u9593\u3067\u30012,499\u4eba\u304c\u6b7b\u4ea1\u3057\u3001537\u4eba\u304c\u5fc3\u7b4b\u6897\u585e\u3092\u767a\u75c7\u3057\u305f\u3002 <\/p>\n

\u8102\u8cea\u306e\u4e2d\u592e\u5024\u306fapoB\u304c92mg\/dL\u3001non-HDL-C\u304c3.1mmol\/L\uff08120mg\/dL\uff09\u3001LDL-C\u304c2.3mmol\/L\uff0889mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002apoB\u307e\u305f\u306fnon-HDL-C\u306e\u9ad8\u5024\u306f\u305d\u308c\u305e\u308c\u3001\u5168\u6b7b\u4ea1\u304a\u3088\u3073\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002 <\/p>\n

\u4e2d\u592e\u5024\u4ee5\u4e0b\uff08\u3059\u306a\u308f\u3061\u3001\u4f4e\u3044\u30a2\u30ddB\u5024\u3068\u4f4e\u3044LDL-C\u5024\u306e\u4e21\u65b9\uff09\u306e\u4e00\u81f4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u9ad8\u3044\u30a2\u30ddB\u5024\uff08\u4e2d\u592e\u5024\u4ee5\u4e0a\uff09\u3068\u4f4e\u3044LDL-C\u5024\uff08\u4e2d\u592e\u5024\u4ee5\u4e0b\uff09\u306f\u3001\u5168\u6b7b\u4ea1\u304a\u3088\u3073\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3055\u3089\u306b\u3001non-HDL-C\u304c\u9ad8\u5024\u3067\u3082LDL-C\u304c\u4f4e\u5024\u3067\u3082\u3001\u4f4e\u5024\u304c\u4e00\u81f4\u3059\u308b\u5834\u5408\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4e21\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u88681<\/strong>\uff09\u3002 <\/p>\n

\u5bfe\u7167\u7684\u306b\u3001LDL-C\u5024\u304c\u9ad8\u304f\u3001\u30a2\u30ddB\u5024\u307e\u305f\u306f\u975eHDL-C\u5024\u304c\u4f4e\u3044\u5834\u5408\u306f\u3001\u5168\u6b7b\u4ea1\u307e\u305f\u306f\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u306f\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\uff08\u88681\uff09<\/strong>\u3002<\/p>\n

\u88681. \u8ee2\u5e30\u306b\u5bfe\u3059\u308b\u30ea\u30b9\u30af\uff1a\u4f4e\u4e00\u81f4\u8102\u8cea\u5024\u3068\u4e0d\u4e00\u81f4\u8102\u8cea\u5024\u3002<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895\uff05CI\uff09<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387<\/strong><\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

\u30a2\u30ddB\u304c\u9ad8\u304fLDL-C\u304c\u4f4e\u3044<\/strong><\/p>\n<\/td>\n

\n

1.21\uff081.07\u301c1.36\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

\u975eHDL-C\u304c\u9ad8\u304fLDL-C\u304c\u4f4e\u3044<\/strong><\/p>\n<\/td>\n

\n

1.18\uff081.02\u301c1.36\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C\u304c\u9ad8\u304f\u30a2\u30ddB\u304c\u4f4e\u3044<\/p>\n<\/td>\n

\n

0.86 (0.75-0.99)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C\u304c\u9ad8\u304f\u3001\u975eHDL-C\u304c\u4f4e\u3044\u3002<\/p>\n<\/td>\n

\n

0.97 (0.82-1.14)<\/p>\n<\/td>\n<\/tr>\n

\n

 <\/p>\n<\/td>\n

\n

 <\/p>\n<\/td>\n<\/tr>\n

\n

MI<\/strong><\/p>\n<\/td>\n

 <\/td>\n<\/tr>\n
\n

\u30a2\u30ddB\u304c\u9ad8\u304fLDL-C\u304c\u4f4e\u3044<\/strong><\/p>\n<\/td>\n

1.49\uff081.15\u301c1.92\uff09<\/td>\n<\/tr>\n
\n

\u975eHDL-C\u304c\u9ad8\u304fLDL-C\u304c\u4f4e\u3044<\/strong><\/p>\n<\/td>\n

\n

1.78\uff081.35\u301c2.34\uff09<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C\u304c\u9ad8\u304f\u30a2\u30ddB\u304c\u4f4e\u3044<\/strong><\/p>\n<\/td>\n

\n

0.94 (0.69-1.29)<\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C\u304c\u9ad8\u304f\u3001\u975eHDL-C\u304c\u4f4e\u3044\u3002<\/strong><\/p>\n<\/td>\n

\n

0.97 (0.66-1.41)<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

*<IHD\u304a\u3088\u3073MI\u306e80\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u3001C\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002<\/p>\n

\u9ad8\u5024\u306f80\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u4ee5\u4e0a\u3068\u5b9a\u7fa9\u3057\u305f\u3002<\/p>\n

\u5fc3\u7b4b\u6897\u585e\u306e10\u5e74\u30ea\u30b9\u30af\u306e\u4e88\u6e2c\u306f\uff0c\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3092\u542b\u3080\u30e2\u30c7\u30eb\u306b\uff0c\u76f4\u63a5\u6e2c\u5b9a\u307e\u305f\u306f\u8a08\u7b97\u3057\u305f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u52a0\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6539\u5584\u3057\u305f\u3002\u76f4\u63a5\u6e2c\u5b9a\u307e\u305f\u306f\u8a08\u7b97\u3055\u308c\u305f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u30ab\u30c3\u30c8\u30dd\u30a4\u30f3\u30c8\u226780\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u3092\u7528\u3044\u305f\u5834\u5408\u3001\u6b63\u5473\u306e\u518d\u5206\u985e\u6307\u6570\u306f\u305d\u308c\u305e\u308c4.7\uff05\uff081.4-8.0\uff05\uff1bp= 0.006\uff09\u304a\u3088\u30737.5\uff05\uff083.5-11.5\uff05\uff1bp< 0.001\uff09\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8a08\u7b97\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e21\u65b9\u304c\u9ad8\u6fc3\u5ea6\u3067\u3042\u308b\u3053\u3068\u306f\u3001IHD\u3068\u5fc3\u7b4b\u6897\u585e\u306e\u9ad8\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u76f4\u63a5\u6e2c\u5b9a\u3057\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8a08\u7b97\u3067\u6c42\u3081\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u8c4a\u5bcc\u3067TG\u304c\u4e4f\u3057\u3044\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6709\u3059\u308b\u4e00\u822c\u96c6\u56e3\u306e\u898b\u843d\u3068\u3055\u308c\u305f\u4eba\u306e5\uff05\u304c\u540c\u5b9a\u3055\u308c\u3001\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u304c1.8\u500d\u4e0a\u6607\u3059\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u6b8b\u6e23\u3001\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08VLDL\uff09\u3001\u4e2d\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08IDL\uff09\u3092\u542b\u3080TG\u30ea\u30c3\u30c1\u306a\u30ea\u30dd\u86cb\u767d\u6b8b\u6e23\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5b9a\u7fa9\u3055\u308c\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3068\u306e\u95a2\u9023\u3092\u652f\u6301\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u84c4\u7a4d\u3055\u308c\u308b\u306b\u3064\u308c\u3066\u3001\u518d\u3073\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u308b\u3002\u5b9f\u969b\u3001\u89b3\u5bdf\u7814\u7a76\u3084\u907a\u4f1d\u5b66\u7684\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304c\u539f\u56e0\u3068\u306a\u308b\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b(1-4)\u3002\u3057\u304b\u3057\u3001PROMINENT\uff085\uff09\u306e\u3088\u3046\u306a\u5fc3\u8840\u7ba1\u7cfb\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u306b\u3088\u308b\u6c7a\u5b9a\u7684\u306a\u8a3c\u660e\u304c\u307e\u3060\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u76f4\u63a5\u6e2c\u5b9a\u3067\u304d\u308b\u65b0\u3057\u3044\u691c\u67fb\u6cd5\u304c\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u3063\u305f\u3053\u3068\u3067\u3001\u7b97\u51fa\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u304c\u3001\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3082\u5f53\u3066\u306f\u307e\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u6027\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u3055\u3089\u306b\u3001\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u63a8\u5b9a\u306b\u76f4\u63a5\u6e2c\u5b9a\u3057\u305f\u8840\u4e2d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u52a0\u3048\u308b\u304b\u3069\u3046\u304b\u3082\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002 <\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u306e2\u3064\u306e\u7591\u554f\u3092\u691c\u8a3c\u3057\u305f\u3002\u7b2c\u4e00\u306b\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3082\u3001\u8a08\u7b97\u4e0a\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5831\u544a\u3068\u540c\u69d8\u306b\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u7b2c2\u306b\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u8a08\u7b97\u4e0a\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u3001\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u3001\u305d\u308c\u306b\u5fdc\u3058\u3066\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4e00\u822c\u96c6\u56e3\u306e\u3055\u3089\u306b5\uff05\u3092\u540c\u5b9a\u3057\u3001\u3057\u305f\u304c\u3063\u3066\u30ea\u30b9\u30af\u4e88\u6e2c\u30b9\u30b3\u30a2\u306b\u4ed8\u52a0\u4fa1\u5024\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002 <\/p>\n

\u3053\u306e\u77e5\u898b\u306f\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u7528\u3044\u305fPROMINENT\u8a66\u9a13\u306b\u95a2\u9023\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001PROMINENT\u8a66\u9a13\u3067\u306f\u8a66\u9a13\u65b9\u6cd5\u306b\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u306e\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u3092\u771f\u306b\u691c\u8a3c\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/p>\n\n\n\n
\u8457\u8005\u306e\u7d50\u8ad6<\/strong><\/td>\n\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3044\u3066\u3001LDL-C\u3067\u306f\u306a\u304fapoB\u3068non-HDL-C\u306e\u4e0a\u6607\u304c\u5168\u6b7b\u4ea1\u3068\u5fc3\u7b4b\u6897\u585e\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u4e0d\u4e00\u81f4\u89e3\u6790\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u5168\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3001LDL-C\u3084non-HDL-C\u3088\u308a\u3082\u30a2\u30ddB\u306e\u65b9\u304c\u3088\u308a\u6b63\u78ba\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002ApoB\u306f\u307e\u305fLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u6b63\u78ba\u306a\u5fc3\u7b4b\u6897\u585e\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

\u3053\u306e\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001LDL-C\u304c\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306e\u6700\u826f\u306e\u8102\u8cea\u30de\u30fc\u30ab\u30fc\u3067\u306f\u306a\u3044\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u4ee3\u308f\u308a\u306b\u3001\u8457\u8005\u3089\u306f\u3053\u306e\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u671b\u307e\u3057\u3044\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066apoB\u304bnon-HDL-C\u306e\u4f7f\u7528\u3092\u63d0\u6848\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u975eLDL\u30ea\u30dd\u86cb\u767d\uff08\u975eHDL-C\u3001\u30a2\u30ddB\u3001\u6b8b\u4f59\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff09\u3092\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u6f5c\u5728\u7684\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u307f\u306a\u3057\u305f\u5c02\u9580\u5bb6\u306e\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306b\u3088\u3063\u3066\u3082\u652f\u6301\u3055\u308c\u3066\u3044\u308b\uff081\uff09\u3002\u3053\u306e\u8a55\u4fa1\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u306b\u57fa\u3065\u304d\u3001\u975eHDL-C\u306f\u3001LDL-C\u76ee\u6a19\u5024\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u3088\u304f\u307f\u3089\u308c\u308b\u3001\u4f4eHDL-C\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607\u3092\u7279\u5fb4\u3068\u3059\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306b\u4f34\u3046\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u3088\u308a\u3088\u304f\u53cd\u6620\u3059\u308b\u3082\u306e\u3068\u3057\u3066\u63d0\u6848\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u3001\u8102\u8cea\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u7279\u306bLDL-C\u5024\u304c\u5fc5\u305a\u3057\u3082\u9ad8\u304f\u306a\u3044\u5fc3\u4ee3\u8b1d\u6027\u75be\u60a3\u60a3\u8005\u3067\u306f\u3001\u7279\u306bLDL-C\u5024\u304c\u5c0f\u3055\u304f\u9ad8\u5bc6\u5ea6\u3067\u3042\u308b\u305f\u3081\u306b\u3001apoB\u307e\u305f\u306fnon-HDL-C\u306e\u3044\u305a\u308c\u304b\u3092\u4e8c\u6b21\u7684\u306a\u8102\u8cea\u76ee\u6a19\u3068\u3057\u3066\u63a8\u5968\u3057\u3066\u3044\u308b(2)\u3002
\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30a2\u30ddB\u304c\u671b\u307e\u3057\u3044\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306b\u304a\u3051\u308b\u30a2\u30ddB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u306e\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u306b\u95a2\u3059\u308b\u73fe\u5728\u306e\u7406\u89e3\u3092\u8003\u616e\u3059\u308c\u3070\u3001\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u30ea\u30dd\u86cb\u767d\u306f\u305d\u308c\u305e\u308c1\u5206\u5b50\u306e\u30a2\u30ddB\u3092\u542b\u3093\u3067\u3044\u308b\u3002\u3057\u305f\u304c\u3063\u3066\u3001apoB\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u4ed6\u306e\u8102\u8cea\u76ee\u6a19\u5024\u3088\u308a\u3082\u3001\u3088\u308a\u6b63\u78ba\u306a\u6b8b\u5b58\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044(3)\u3002 <\/p>\n

\u3053\u306e\u7814\u7a76\u304b\u3089\u3001LDL-C\u306f\u6b8b\u5b58\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306f\u3082\u306f\u3084\u306a\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u8aa4\u89e3\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3053\u308c\u306f\uff0c\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\uff0cLDL-C\u5024\u304c\u9ad8\u304f\u3066\u3082apoB\u5024\u307e\u305f\u306fnon-HDL-C\u5024\u304c\u4f4e\u3051\u308c\u3070\uff0c\u5168\u6b7b\u4ea1\u307e\u305f\u306f\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u306f\u95a2\u9023\u3057\u306a\u3044\u3068\u3044\u3046\u4e0d\u4e00\u81f4\u89e3\u6790\u306e\u6240\u898b\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001LDL-C\u306f\u4f9d\u7136\u3068\u3057\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u4e88\u9632\u306e\u305f\u3081\u306e\u4e3b\u8981\u306a\u4ecb\u5165\u5bfe\u8c61\u8102\u8cea\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308b\u3002LDL-C\u5024\u304c\u9ad8\u3044\u60a3\u8005\u306f\uff0cLDL-C\u306b\u95a2\u9023\u3057\u305f\u30ea\u30b9\u30af\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306b\uff0c\u5f37\u5316\u7642\u6cd5\uff0c\u3067\u304d\u308c\u3070\u4f75\u7528\u7642\u6cd5\u3092\u53d7\u3051\u308b\u3079\u304d\u3067\u3042\u308b(2,4)\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n1.Averna M, Stroes E; LDL\u3092\u8d85\u3048\u308b\u8102\u8cea\u5909\u5316\u5c02\u9580\u5bb6\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u3002LDL\u3092\u8d85\u3048\u308b\u8102\u8cea\u5909\u5316\u306b\u95a2\u9023\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u3069\u306e\u3088\u3046\u306b\u8a55\u4fa1\u3057\u3001\u7ba1\u7406\u3059\u308b\u304b\u3002Atheroscler Suppl 2017;26:16-24.
2.2019 ESC\/EAS Guidelines for the Management of dyslipidaemias: lipid modification to reduce cardiovascular risk.Eur Heart J 2020;41:111-88.
3.Sniderman AD, Thanassoulis G, Glavinovic T, et al. Apolipoprotein B particle and cardiovascular disease: a narrative review.JAMA Cardiol 2019;4:1287-95.
4.Packard CJ, Chapman MJ, Sibartie M, et al. \u5fc3\u8840\u7ba1\u75be\u60a3\u4e88\u9632\u306b\u304a\u3051\u308b\u96c6\u4e2d\u7684\u306a\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\uff1a\u6a5f\u4f1a\u3068\u8ab2\u984c\u3002Heart 2021; https:\/\/heart.bmj.com\/content\/early\/2021\/03\/31\/heartjnl-2020-318760<\/a> <\/td>\n<\/tr>\n
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