{"id":254326,"date":"2025-01-21T23:46:55","date_gmt":"2025-01-21T22:46:55","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%82%a8%e3%83%b3%e3%83%91%e3%82%b0%e3%83%aa%e3%83%95%e3%83%ad%e3%82%b8%e3%83%b3%e3%81%af%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%82%92\/"},"modified":"2025-02-16T22:19:22","modified_gmt":"2025-02-16T21:19:22","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%82%a8%e3%83%b3%e3%83%91%e3%82%b0%e3%83%aa%e3%83%95%e3%83%ad%e3%82%b8%e3%83%b3%e3%81%af%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%82%92","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e3%82%a8%e3%83%b3%e3%83%91%e3%82%b0%e3%83%aa%e3%83%95%e3%83%ad%e3%82%b8%e3%83%b3%e3%81%af%e5%bf%83%e8%a1%80%e7%ae%a1%e7%96%be%e6%82%a3%e3%82%92\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 &#8211; 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width=&#8221;99%&#8221; custom_margin=&#8221;|-147px||||&#8221; custom_padding=&#8221;|0px||||&#8221; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}&#8221; sticky_enabled=&#8221;0&#8243;]<h2>\u30d5\u30a9\u30fc\u30ab\u30b9 &#8211;<span>\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u7dcf\u8ca0\u62c5\u3092\u6e1b\u5c11\u3055\u305b\u305f<\/span><\/h2>\n<h5><span>4 2021\u5e741\u6708<\/span><\/h5>\n<p><em>\u3053\u306eEMPA-REG OUTCOME\u8a66\u9a13\u306e\u6700\u65b0\u5831\u544a\u3067\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f53-2\uff08SGLT2\uff09\u963b\u5bb3\u85ac\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u304c\u3001\u73fe\u5728\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u52a0\u3048\u3066\u3001\u6700\u521d\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u8d85\u3048\u3066\u3082\u5f15\u304d\u7d9a\u304d\u6709\u76ca\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/em><\/p>\n<p><em>McGuire DK, Zinman B, Inzucchi SE, et al. 2\u578b\u7cd6\u5c3f\u75c5\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u521d\u56de\u304a\u3088\u3073\u518d\u767a\u81e8\u5e8a\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u52b9\u679c\uff1aEMPA-REG OUTCOME\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002Lancet Diabetes Endocrinol 2020;8:949-59.  <\/em><\/p>\n<p><b>\u7814\u7a76\u6982\u8981<\/b><\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"3\" bgcolor=\"#CCCCCC\">\n<tbody>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\" width=\"17%\"><strong>\u76ee\u7684<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\" width=\"83%\">EMPA-REG OUTCOME\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001empagliflozin\u304c\u7dcf\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u5165\u9662\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\u672c\u8a66\u9a13\u306f\u30012010\u5e748\u6708\uff5e2015\u5e744\u6708\u306b\u5b9f\u65bd\u3055\u308c\u305f\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u975e\u52a3\u6027\u8a66\u9a13\u3067\u3042\u308bEMPA-REG OUTCOME\u8a66\u9a13\u306e\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3067\u3042\u308b\u3002<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td valign=\"top\" bgcolor=\"#E9E9E9\"><strong>\u8a66\u9a13\u96c6\u56e3\uff1a<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">18\u6b73\u4ee5\u4e0a\u306e2\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u3092\u6709\u3059\u308b\u60a3\u80057020\u4f8b\u3092empagliflozin 10mg\u7fa4\uff08n=2345\uff09\u3001empagliflozin 25mg\u7fa4\uff08n=2342\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n=2333\uff09\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u4e3b\u306a\u7814\u7a76\u5909\u6570\uff1a<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\n<p>-\u4e3b\u8981\u5fc3\u8840\u7ba1\u7cfb\u6709\u5bb3\u4e8b\u8c61\uff08MACE\uff09\uff1a\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u306e\u8907\u5408\u3002<\/p>\n<p>-\u6709\u52b9\u6027\u306e\u8ffd\u52a0\u8a55\u4fa1\u9805\u76ee\uff1a\u81f4\u6b7b\u7684\u307e\u305f\u306f\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u81f4\u6b7b\u7684\u307e\u305f\u306f\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3002<\/p>\n<\/td>\n<\/tr>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u65b9\u6cd5<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\u7dcf\u30a4\u30d9\u30f3\u30c8\u89e3\u6790\uff08\u521d\u56de\u30a4\u30d9\u30f3\u30c8\uff0b\u518d\u767a\u30a4\u30d9\u30f3\u30c8\uff09\u3067\u306f\u3001\u7121\u4f5c\u70ba\u5316\u3092\u7dad\u6301\u3057\u3001\u518d\u767a\u30a4\u30d9\u30f3\u30c8\u306e\u76f8\u95a2\u3092\u8003\u616e\u3057\u305f\u7d71\u8a08\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001ASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u7dcf\u8ca0\u62c5\u306b\u5bfe\u3059\u308b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\uff08\u30d7\u30fc\u30eb\u7528\u91cf\uff09\u3068\u30d7\u30e9\u30bb\u30dc\u306e\u52b9\u679c\u3092\u6bd4\u8f03\u3057\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: center;\"><strong>\u7d50\u679c<\/strong><\/p>\n<div>\n<div>\n<p>\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u7fa4\u3067\u306f3.2\u5e74\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f3.1\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306b\u304a\u3044\u3066\u3001\u5168\u8a66\u9a13\u96c6\u56e3\u306e772\u4f8b\uff0811\uff05\uff09\u306bMACE\u304c\u8a8d\u3081\u3089\u308c\u3001\u305d\u306e\u3046\u3061129\u4f8b\uff0816.7\uff05\uff09\u306b\u518d\u767aMACE\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u521d\u56de\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u3088\u308a\u3082\u7dcfMACE\u3092\u3088\u308a\u5927\u304d\u304f\u6e1b\u5c11\u3055\u305b\u305f\u3002\u7387\u6bd4\u306f\u7dcf\u30a4\u30d9\u30f3\u30c8\u30670.78\u300195\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff09\u30670.67-0.91\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u521d\u56de\u30a4\u30d9\u30f3\u30c8\u3067\u306f0.86\u300195\uff05CI\u30670.74-0.99\u3067\u3042\u3063\u305f\u3002\u3055\u3089\u306b\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u7dcf\u6570\u304c42\uff05\u6e1b\u5c11\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u521d\u56de\u5165\u9662\u3067\u306f35\uff05\u6e1b\u5c11\u3057\u305f\uff08\u7387\u6bd4\uff1a0-58\u300195\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff090.42-0.81\u3001\u5bfe\u3057\u30660.65\u300195\uff05CI0.50-0.85\uff09\u3002    <\/p>\n<p>\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u6cbb\u7642\u306b\u3088\u308a\u30011000\u60a3\u8005\u5e74\u5f53\u305f\u308a\u306e\u7dcfMACE\uff0812.9\u4ef6\u300195\uff05\u4fe1\u983c\u533a\u95933.74-22.02\uff09\u306f\u3001\u521d\u56de\u30a4\u30d9\u30f3\u30c8\uff086.5\u4ef6\u300195\uff05\u4fe1\u983c\u533a\u95930.37-12.59\uff09\u3068\u6bd4\u8f03\u3057\u30662\u500d\u4e88\u9632\u3055\u308c\u3001\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\uff081000\u60a3\u8005\u5e74\u5f53\u305f\u308a\u306e\u7dcf\u30a4\u30d9\u30f3\u30c89.7\u4ef6\u306b\u5bfe\u3057\u3066\u521d\u56de\u30a4\u30d9\u30f3\u30c85.1\u4ef6\uff09\u30822\u500d\u4e88\u9632\u3055\u308c\u305f\u3053\u3068\u3067\u3042\u308b\u3002  <\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"3\" bgcolor=\"#CCCCCC\">\n<tbody>\n<tr valign=\"middle\">\n<td bgcolor=\"#E9E9E9\"><strong>\u8457\u8005\u3089\u306e\u7d50\u8ad6<\/strong><\/td>\n<td align=\"left\" bgcolor=\"#FFFFFF\">\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f2\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073ASCVD\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u3068\u5168\u6b7b\u56e0\u5165\u9662\u306e\u7dcf\u8ca0\u62c5\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<div>\n<p><strong>\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n<p>\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u3067\u306f\u3001\u4e3b\u306b\u521d\u767a\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u9632\u306b\u7126\u70b9\u304c\u5f53\u3066\u3089\u308c\u3066\u3044\u308b\u3002\u3057\u304b\u3057\uff0c\u533b\u7642\u30b7\u30b9\u30c6\u30e0\uff0c\u652f\u6255\u8005\uff0c\u653f\u7b56\u7acb\u6848\u8005\u306e\u89b3\u70b9\u304b\u3089\u306f\uff0c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u518d\u767a\u3084\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u9032\u884c\u306b\u3088\u3063\u3066\u793e\u4f1a\u7684\u30b3\u30b9\u30c8\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\uff0c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u7dcf\u8ca0\u62c5\u306e\u65b9\u304c\u3088\u308a\u91cd\u8981\u3067\u3042\u308b\u3002\u4f8b\u3048\u3070\u3001REACH\uff08Reduction of Atherothrombosis for Continued Health\uff09\u767b\u9332\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u3068ASCVD\u3092\u6709\u3059\u308b\u60a3\u8005\u306e\u7d045\u4eba\u306b1\u4eba\u304c4\u5e74\u9593\u3067MACE\uff08\u521d\u56de\u307e\u305f\u306f\u518d\u767a\uff09\u3092\u7d4c\u9a13\u3057\u3066\u304a\u308a(1)\u3001EMPA-REG 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    <strong><br><\/strong><\/p>\n<\/div>\n<table border=\"0\" width=\"100%\" cellspacing=\"1\" cellpadding=\"3\" bgcolor=\"#CCCCCC\">\n<tbody>\n<tr>\n<td valign=\"top\" bgcolor=\"#E9E9E9\" width=\"13%\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/td>\n<td valign=\"top\" bgcolor=\"#FFFFFF\" width=\"87%\">1.Cavender MA, Steg PG, Smith SC Jr, et al. \u7cd6\u5c3f\u75c5\u304c\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u6b7b\u4ea1\u306b\u53ca\u307c\u3059\u5f71\u97ff\uff1aREACH\uff08Reduction of atherothrombosis for continued health\uff09\u30ec\u30b8\u30b9\u30c8\u30ea\u306e4\u5e74\u5f8c\u306e\u30a2\u30a6\u30c8\u30ab\u30e0\u3002Circulation 2015;132:923-31.<br>2.Zinman B, Wanner C, Lachin JM, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes.N Engl J Med 2015;373: 2117-28.<br>3.Verma S, Bain SC, Buse JB, et al. 2\u578b\u7cd6\u5c3f\u75c5\u3067\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30e9\u30b0\u30eb\u30c1\u30c9\u6cbb\u7642\u306b\u3088\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u521d\u56de\u304a\u3088\u3073\u518d\u767a\u306e\u767a\u751f\uff1a\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u306e\u4e8b\u5f8c\u89e3\u6790\u3002JAMA Cardiol 2019;4:1214-20.<br>4.Aroda VR, Sabatine MS.EMPA-REG OUTCOME\u3068\u305d\u306e\u5148\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u9577\u671f\u6226\u3002Lancet Diabetes Endocrinol 2020;8:932-3.       <\/td>\n<\/tr>\n<tr>\n<td valign=\"top\" bgcolor=\"#E9E9E9\"><strong>\u30ad\u30fc\u30ef\u30fc\u30c9<\/strong><\/td>\n<td valign=\"top\" bgcolor=\"#FFFFFF\">\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u7dcf\u8ca0\u62c5<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>\u30d5\u30a9\u30fc\u30ab\u30b9 -\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u7dcf\u8ca0\u62c5\u3092\u6e1b\u5c11\u3055\u305b\u305f 4 [&hellip;]<\/p>\n","protected":false},"author":258497325,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_crdt_document":"","jetpack_post_was_ever_published":false,"footnotes":""},"class_list":["post-254326","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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