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Obicetrapib\u304c\u30ea\u30dd\u30d7\u30ed\u30c6\u30a4\u30f3(a)\u4f4e\u4e0b\u4f5c\u7528\u3092\u793a\u3059<\/h5>\n
Nicholls SJ, Nelson AJ, Ray KK, et al. Obicetrapib and lipoprotein(a) levels in patients at high cardiovascular risk: a pooled analysis of trials. Eur Heart j 2026; doi.org\/10.1093\/eurheartj\/ehag399 <\/h6>\n

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2026 <\/span><\/h2>\n

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Wadstrom BN, Wulff AB, Pedersen KM, Nordestgaard BG. Inflammation may explain part of atherosclerotic cardiovascular disease risk conferred by elevated remnant lipoproteins: a cohort and Mendelian randomization study. Atherosclerosis 2026; doi.org\/10.1016\/j.atherosclerosis.2026.120772 .<\/h6>\n

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Essence\u2013TIMI 73b\u753b\u50cf\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u306e\u7d50\u679c\u306f\u7591\u554f\u3092\u63d0\u8d77\u3059\u308b<\/h3>\n

Marston NA, Bergmark BA, Prohaska TA, et al. Effect of APOC3 inhibition with olezarsen on coronary atherosclerosis: Essence\u2013TIMI 73b Imaging Study. Circulation 2026; doi: 10.1161\/CIRCULATIONAHA.126.080012 <\/h6>\n

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Hoshino T, Mizuno T, Arai S, et al. Cumulative association of triglycerides and interleukin-6 with recurrent vascular events after ischemic stroke . J Clin Lipidol 2026; doi.org: 10.1016\/j.jacl.2026.01.001. <\/h6>\n

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2025 <\/span><\/h2>\n

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ACS\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u306e\u305f\u3081\u306e\u65b0\u305f\u306a\u6a19\u7684\u304b\uff1f<\/h3>\n

Kraler S, Liberale L, Tirandi A, et al. The junctional protein associated with coronary artery disease predicts adverse cardiovascular events in patients with acute coronary syndromes at high residual risk. Eur Heart J 2025; doi.org\/10.1093\/eurheartj\/ehaf979. <\/h6>\n

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\u4e00\u6b21\u4e88\u9632\u306b\u304a\u3051\u308bhsCRP\u306e\u30eb\u30fc\u30c1\u30f3\u6e2c\u5b9a<\/h3>\n

Kurt B, Reugels M, Schneider KM, et al. C-reactive protein and cardiovascular risk in the general population. Eur Heart J 2025; doi.org\/10.1093\/eurheartj\/ehaf937 <\/h6>\n

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ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u3057\u3044\u6226\u7565\uff1f<\/h3>\n

Laffin LJ, Nicholls SJ, Scott RS, et al. Phase 1 trial of CRISPR-Cas9 gene editing targeting ANGPTL3. N Engl J Med 2025; DOI: 10.1056\/NEJMoa2511778<\/h6>\n

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McClintick DJ, Biery DW, Berman AN, et al. Association between lipoprotein(a) and cardiovascular events in patients with peripheral artery disease: the Mass General Brigham Lp(a) registry. Eur J Prevent Cardiol 2025; https:\/\/doi.org\/10.1093\/eurjpc\/zwaf475<\/a><\/g> <\/h6>\n

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Schuitema PCE, Visseren FLJ, Nordestgaard BG, et al. Elevated triglycerides are related to higher residual cardiovascular disease and mortality risk independent of lipid targets and intensity of lipid-lowering therapy in patients with established cardiovascular disease. Atherosclerosis 2025 <\/h6>\n

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Kitahara S, Kataoka Y, Nicholls SJ, et al. Apolipoprotein CIII in statin-treated type 2 diabetic patients: its implications for plaque progression and instability: the pre-specified analysis from the OPTIMAL randomized controlled trial. Atherosclerosis 2025; https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.120470<\/a> <\/h6>\n

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ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308bsiRNA\u6cbb\u7642\u85ac\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\u3067\u6709\u671b\u306a\u7d50\u679c\u3092\u793a\u3059<\/h3>\n
Ray KK, Oru E, Rosenson RS, et al. Durability and efficacy of solbinsiran, a GalNAc-conjugated siRNA targeting ANGPTL3, in adults with mixed dyslipidaemia (PROLONG-ANG3): a double-blind, randomised, placebo-controlled, phase 2 trial. <\/h6>\n

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APOC3\u3068LDL-C\u3092\u6a19\u7684\u3068\u3059\u308b\u4f75\u7528\u7642\u6cd5\u306e\u53ef\u80fd\u6027<\/h3>\n

Wang W, Li R, Song Z, Huang N, et al. Joint associations of APOC3 and LDL-C\u2013lowering variants with the risk of coronary heart disease. <\/h6>\n

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2024 <\/span><\/h2>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u306b\u3057\u3066\u8133\u5352\u4e2d\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b<\/h3>\n

Han M, Huang K, Shen C, et al. LDL-C\u3068\u4e0d\u4e00\u81f4\u306e\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f
\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\uff1a\u4e2d\u56fd\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002\u8133\u5352\u4e2d2024;55:2066-74\u3002 <\/h6>\n

\u3053\u306e\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3067\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u5834\u5408\u3001\u8133\u5352\u4e2d\u3001\u7279\u306b\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u9ad8\u3044\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/p>\n

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\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u6709\u671b<\/span><\/h3>\n
\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u3002N Engl J Med 2024; DOI: 10.1056\/NEJMoa2402309<\/span><\/h6>\n

Bridge-TIMI 73a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III\uff08APOC3\uff09\u306e\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u3092\u6a19\u7684\u3068\u3059\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308b\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u306b\u3088\u308b\u6cbb\u7642\u306f\u3001\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u3092\u6709\u610f\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/span><\/p>\n

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Plozasiran\uff1a\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u304a\u3051\u308b\u65b0\u898fAPOC3 siRNA<\/h3>\n

Ballantyne CM\u3001Vasas S\u3001Azizad M\u3001\u4ed6\u3002 APOC3\u3092\u6a19\u7684\u3068\u3059\u308bRNA\u5e72\u6e09\u5264Plozasiran\u306f\u3001
\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u6709\u52b9\u3067\u3042\u308b\u3002N Engl J Med 2024; doi: 10.1056\/NEJMoa2404143 <\/h6>\n

\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30af\u30e9\u30b9\u306e\u809d\u7d30\u80de\u6a19\u7684APOC3\u4f4e\u5206\u5b50\u5e72\u6e09RNA\u6cbb\u7642\u85ac\u3067\u3042\u308bPlozasiran\u306f\u3001
\u3001\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3092\u5927\u5e45\u306b\u4f4e\u4e0b\u3055\u305b\u305f\u3002<\/p>\n

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PROMINENT\u306e\u8a73\u7d30<\/h3>\n

Doi T, Langsted A, Nordestgaard BG. Remnant cholesterol, LDL cholesterol, and apoB absolute mass
changes explain results of the PROMINENT trial. Atherosclerosis 2024;393:117556 <\/h6>\n

Copenhagen General Population Study Group\u306e\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306ePROMINENT\u8a66\u9a13\u306b\u304a\u3051\u308b\u4e2d\u7acb\u7684\u306a\u7d50\u679c\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09B\u306e\u7d76\u5bfe\u8cea\u91cf\u5909\u5316\u91cf\u306b\u3088\u3063\u3066\u8aac\u660e\u3067\u304d\u308b\u3002<\/p>\n

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CLEAR-Outcomes\u8a66\u9a13\u304b\u3089\u306e\u6d1e\u5bdf\uff1aLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3059\u308b\u3060\u3051\u3067\u306f\u5341\u5206\u3067\u306f\u306a\u3044<\/span><\/h3>\n
Ridker PM, Lei L, Louie MJ, et al. \u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u306e\u73fe\u4ee3\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u800513970\u4eba\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u306e\u708e\u75c7\u3068\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002Circulation 2024;149:28-35. <\/span><\/h6>\n

\u3053\u306e\u8a66\u9a13\u306e\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\uff08hsCRP\uff09\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3088\u308a\u3082\u5f37\u529b\u306b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u4e88\u6e2c\u3059\u308b\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY1NiIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u672b\u68a2\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u5fae\u5c0f\u8840\u7ba1\u75be\u60a3\u306e\u4f75\u5b58\uff1a\u6df1\u523b\u5316\u3059\u308b\u554f\u984c<\/span><\/h3>\n
Grubman S, Algara M, Smolderen KG, et al. \u672b\u68a2\u52d5\u8108\u75be\u60a3\u3068\u5fae\u5c0f\u8840\u7ba1\u75be\u60a3\u3092\u5408\u4f75\u3057\u3066\u5165\u9662\u3057\u305f\u60a3\u8005\u306b\u304a\u3051\u308b\u8ee2\u5e30\u306e\u691c\u8a0e\u3002J Am Heart Assoc 2024;13:e030710.<\/span><\/h6>\n

\u7c73\u56fd\u306b\u304a\u3051\u308b3,300\u4e07\u4ef6\u4ee5\u4e0a\u306e\u5165\u9662\u30c7\u30fc\u30bf\u3092\u7528\u3044\u308b\u3068\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u3067\u5165\u9662\u3057\u305f\u60a3\u8005\u306e25\uff05\u4ee5\u4e0a\u304c\u5fae\u5c0f\u8840\u7ba1\u75be\u60a3\u3092\u4f75\u767a\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u56db\u80a2\u3084\u5fc3\u8840\u7ba1\u7cfb\u306e\u6709\u5bb3\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u3002 <\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY2MyIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)\u306e\u4e0a\u6607\u3068\u51a0\u52d5\u8108\u30ea\u30b9\u30af<\/span><\/h3>\n
Shiyovich A, Berman AN, Besser SA, et al. \u51a0\u52d5\u8108\u75be\u60a3\u3068\u30ea\u30dd\u86cb\u767d(a)\u4e0a\u6607\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\uff1aOCEAN(a)-outcomes\u8a66\u9a13\u96c6\u56e3\u3078\u306e\u793a\u5506\u3002Eur Heart J Open 2023;3, 1-4. <\/span><\/h6>\n

\u51a0\u52d5\u8108\u75be\u60a3\u3092\u6709\u3057\u3001\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\uff3bLp(a)\uff3d\u5024\u304c\u9ad8\u3044\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u89b3\u5bdf\u7814\u7a76\u306f\u3001\u73fe\u5728\u9032\u884c\u4e2d\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\u4f4e\u6e1b\u3092\u8a55\u4fa1\u3059\u308bOlpasiran\u8a66\u9a13\uff3bOCEAN(a)\uff3d-Outcomes\u8a66\u9a13\u306b\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u96c6\u56e3\u3068\u4e00\u81f4\u3057\u3066\u304a\u308a\u3001\u8cb4\u91cd\u306a\u77e5\u898b\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY3MCIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”15px” header_2_text_color=”gcid-primary-color” header_2_font_size=”32px” custom_margin=”||-13px|||” custom_padding=”9px|||27px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22header_2_text_color%22%93}”]<\/p>\n

2023 <\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7ba1\u7406\uff1a\u84c4\u7a4d\u3068\u53d7\u8a3a\u5909\u52d5\u306e\u4e21\u65b9\u3092\u8003\u616e\u3059\u308b<\/span><\/h3>\n
Wang J, Jin R, Jin X, et al. \u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u84c4\u7a4d\u304a\u3088\u3073\u5909\u52d5\u3068\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3068\u306e\u500b\u5225\u7684\u304a\u3088\u3073\u5171\u540c\u7684\u95a2\u9023\uff1a\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002J Am Heart Assoc 2023;12:e029352.doi: 10.1161\/. jaha.122.029352<\/span><\/h6>\n

\u4e2d\u56fd\u306e\u3053\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u7d2f\u7a4d\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u52d5\u304c\u5927\u304d\u3044\u3068\u3044\u3046\u7d44\u307f\u5408\u308f\u305b\u306f\u3001\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u9838\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u72ec\u7acb\u3057\u305f\u30ea\u30b9\u30af\u3092\u60aa\u5316\u3055\u305b\u308b\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY3OCIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\uff1a\u5973\u6027\u306f\u4f9d\u7136\u3068\u3057\u3066\u7537\u6027\u3088\u308a\u9045\u308c\u3066\u3044\u308b<\/span><\/h3>\n
Dong W, Yang Z. \u7c73\u56fd\u6210\u4eba\u306e\u8133\u5352\u4e2d\u307e\u305f\u306f\u5fc3\u7b4b\u6897\u585e\u751f\u5b58\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u8102\u8cea\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u50be\u5411\u30012001-2018\u5e74\u3002Front Endocrinol 2023;14:1128878<\/span><\/h6>\n

\u7c73\u56fd\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08NHANES\uff092001-2018\u306e\u30c7\u30fc\u30bf\u3067\u306f\u3001\u8133\u5352\u4e2d\u307e\u305f\u306f\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u306e\u751f\u5b58\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6539\u5584\u50be\u5411\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u5973\u6027\u306f\u7537\u6027\u306b\u6bd4\u3079\u3066\u8102\u8cea\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u826f\u3067\u3042\u308b\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY4MyIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3059\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607<\/span><\/h3>\n
\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u4e2d\u7b49\u5ea6\u306b\u9ad8\u304f\u3001\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u3067LDL-C\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u7c73\u56fd\u9000\u5f79\u8ecd\u4eba\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3002Front Cardiovasc Med 2022; 9:982815.<\/span><\/h6>\n

\u7c73\u56fd\u306e\u9000\u5f79\u8ecd\u4eba40\u4e07\u4eba\u8fd1\u304f\u3092\u542b\u3080\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306e\u4e0a\u6607\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u306e\u3042\u308b\u4eba\u3001\u3042\u308b\u3044\u306f\u7cd6\u5c3f\u75c5\u306e\u307f\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u6b8b\u5b58\u3057\u3066\u3044\u308b\u4eba\u3092\u540c\u5b9a\u3059\u308b\u306e\u306b\u5f79\u7acb\u3063\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY4OSIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”15px” header_2_text_color=”gcid-primary-color” header_2_font_size=”32px” custom_margin=”||-13px|||” custom_padding=”9px|||27px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22header_2_text_color%22%93}”]<\/p>\n

2022 <\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

RESPECT-EPA-\u30b9\u30bf\u30c1\u30f3\u3068\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u4f75\u7528\u7642\u6cd5\u306e\u4e8c\u6b21\u4e88\u9632\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u7121\u4f5c\u70ba\u8a66\u9a13<\/span><\/h3>\n
Daida H, et al. RESPECT-EPA-\u30b9\u30bf\u30c1\u30f3\u3068\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u306e\u4f75\u7528\u7642\u6cd5\u306e\u4e8c\u6b21\u4e88\u9632\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u7121\u4f5c\u70ba\u8a66\u9a13\u3002\u7c73\u56fd\u5fc3\u81d3\u5354\u4f1a\u5b66\u8853\u96c6\u4f1a2022\u3067\u767a\u8868\u3002 <\/span><\/h6>\n

RESPECT-EPA\u8a66\u9a13\u3067\u306f\u3001\u9ad8\u5ea6\u306b\u7cbe\u88fd\u3055\u308c\u305f\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u304c\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\uff08\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\uff3bMI\uff3d\u3001\u975e\u81f4\u6b7b\u6027\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3001\u307e\u305f\u306f\u51a0\u52d5\u8108\u518d\u8840\u884c\u518d\u5efa\u306e\u8907\u5408\uff09\u306b\u5bfe\u3057\u3066\u3001\u308f\u305a\u304b\u306b\u6709\u610f\u306a\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u672c\u7814\u7a76\u3067\u306f\u8131\u843d\u7387\u304a\u3088\u3073\u30d7\u30ed\u30c8\u30b3\u30eb\u9055\u53cd\u7387\u304c\u9ad8\u304b\u3063\u305f\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002 <\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTY5NCIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u3001ANGPLT3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u3088\u308bTRANSLATE-TIMI 70\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9<\/span><\/h3>\n
Bergmark BA, Marston NA, Bramson CR, et al.\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u5bfe\u3059\u308b\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u306e\u52b9\u679c\uff1aTRANSLATE-TIMI 70\u3002Circulation 2022;145:1377-1386. <\/span><\/h6>\n

TRANSLATE-TIMI 70\uff08ClinicalTrials.gov Identifier: NCT04516291\uff09\u306b\u304a\u3044\u3066\u3001\u809d\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d83\uff08ANGPTL3\uff09\u86cb\u767d\u5408\u6210\u3092\u963b\u5bb3\u3059\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308bvupanorsen\u306e\u6295\u4e0e\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6295\u4e0e\u60a3\u8005\u306b\u304a\u3044\u3066\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3082\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u6e1b\u5c11\u3057\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTcwMiIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30ea\u30dd\u86cb\u767d(a)\u306e\u4e0a\u6607\u306f\u8106\u5f31\u30d7\u30e9\u30fc\u30af\u306e\u9032\u884c\u3092\u4fc3\u9032\u3059\u308b<\/span><\/h3>\n
Kaiser Y, Daghem M, Tzolos E, et al. \u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u9032\u884c\u3068\u306e\u95a2\u9023\u3002J Am Coll Cardiol 2022;79:223-233. <\/span><\/h6>\n

\u9032\u884c\u3057\u305f\u51a0\u52d5\u8108\u75be\u60a3\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u8840\u6e05\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\uff3bLp(a)\uff3d\u5024\u306e\u4e0a\u6607\u306f\u3001\u51a0\u52d5\u8108CT\u8840\u7ba1\u9020\u5f71\u3067\u8a55\u4fa1\u3055\u308c\u305f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u30d7\u30e9\u30fc\u30af\u306e\u4f4e\u6e1b\u8870\u58ca\u6b7b\u30b3\u30a2\u306e\u9032\u884c\u306e\u52a0\u901f\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTcwNyIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u6b7b\u4ea1\u30ea\u30b9\u30af<\/span><\/h3>\n
Wadstr\u00f6m BN, Wang Y. \u9ad8\u3044\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306f\u3001\u7c73\u56fd\u6210\u4eba\u306b\u304a\u3051\u308b\u7cd6\u5c3f\u75c5\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3092\u4e88\u6e2c\u3059\u308b\u3002Lipids in Health and Disease 2021;20:181. <\/span><\/h6>\n

NHANES\uff08National Health and Nutrition Examination Surveys\uff09\u306b\u3088\u308b\u3053\u306e\u5831\u544a\u3067\u306f\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u9ad8\u3044\u307b\u3069\u7cd6\u5c3f\u75c5\u306b\u95a2\u9023\u3057\u305f\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTcxMyIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”15px” header_2_text_color=”gcid-primary-color” header_2_font_size=”32px” custom_margin=”||-13px|||” custom_padding=”9px|||27px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22header_2_text_color%22%93}”]<\/p>\n

2021 <\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u4e00\u6b21\u4e88\u9632\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95a2\u9023\u30ea\u30b9\u30af\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u7814\u7a76\u304c\u767a\u8868\u3055\u308c\u305f\u3002<\/span><\/h3>\n
\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001LDL\u3084ApoB\u3092\u8d8a\u3048\u3066\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u4e88\u6e2c\u3059\u308b\uff1a\u4e00\u6b21\u4e88\u9632\u7814\u7a76\u3002Eur Heart J 2021 doi: 10.1093\/eurheartj\/ehab432.Online ahead of print. <\/span><\/h6>\n

\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u4eba\u306e\u30d7\u30fc\u30eb\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3001\u975e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u5024\u306a\u3069\u306e\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u3068\u306f\u7121\u95a2\u4fc2\u306bASCVD\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTcxOSIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

PESA\u8a66\u9a13\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607\u306f\u6f5c\u5728\u6027\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3068\u95a2\u9023\u3059\u308b<\/span><\/h3>\n
\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u6b8b\u5b58\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u3002J Am Coll Cardiol 2021;22: 3031 – 41. <\/span><\/h6>\n

\u3053\u306ePESA\uff08Progression of Early Subclinical Atherosclerosis\uff09\u8a66\u9a13\u306e\u5831\u544a\u3067\u306f\u3001\u305f\u3068\u3048\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c\u6b63\u5e38\u3067\u3042\u3063\u3066\u3082\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024150mg\/dL\uff081.7mmol\/L\uff09\u4ee5\u4e0a\u304c\u6f5c\u5728\u6027\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/span><\/p>\n

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\u76f4\u63a5\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u8a08\u7b97\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\uff1a\u305d\u308c\u306f\u91cd\u8981\u304b\uff1f<\/span><\/h3>\n
Varbo A, Nordestgaard BG.\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4e00\u822c\u96c6\u56e3\u306e\u898b\u843d\u3068\u3055\u308c\u305f\u500b\u4eba\u3092\u3001\u76f4\u63a5\u6e2c\u5b9a\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8a08\u7b97\u3055\u308c\u305f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u3067\u540c\u5b9a\u3002Eur Heart J 2021 ; doi: 10.1093\/eurheartj\/ehab293.Online ahead of print. <\/span><\/h6>\n

Copenhagen General Population Study\u304b\u3089\u306e\u3053\u306e\u5831\u544a\u3067\u306f\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u76f4\u63a5\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5fc3\u7b4b\u6897\u585e\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u8c4a\u5bcc\u3067\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u304c\u4e4f\u3057\u3044\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6709\u3059\u308b\u4e00\u822c\u96c6\u56e3\u306e\u3055\u3089\u306b5\uff05\u304c\u540c\u5b9a\u3055\u308c\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTczMiIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u7279\u5b9a\uff1a\u6700\u9069\u306a\u8102\u8cea\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306f\u3069\u308c\u304b\uff1f<\/span><\/h3>\n
Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG.\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3068\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u3088\u304f\u53cd\u6620\u3059\u308b\u3002J Am Coll Cardiol 2021;77:1439-50. <\/span><\/h6>\n

Copenhagen General Population Study\u306e\u3053\u306e\u5831\u544a\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306e\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u3088\u308a\u3088\u304f\u540c\u5b9a\u3059\u308b\u305f\u3081\u306b\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3088\u308a\u3082\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u307e\u305f\u306f\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u304c\u512a\u5148\u3055\u308c\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTczOCIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

PREDIMED\u304c\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u767a\u75c7\u3068\u306e\u95a2\u9023\u3092\u793a\u3059<\/span><\/h3>\n
\u30ab\u30b9\u30bf\u30cb\u30a7\u30fc\u30ebO\u3001\u30d4\u30f3\u30c8X\u3001\u30b9\u30d3\u30e9\u30fc\u30caI\u3089\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u306f\u306a\u304f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002J Am Coll Cardiol 2020;76: 2712-24. <\/span><\/h6>\n

\u904e\u4f53\u91cd\u307e\u305f\u306f\u80a5\u6e80\u306e\u9ad8\u30ea\u30b9\u30af\u4e00\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306f\u5fc3\u8840\u7ba1\u8ee2\u5e30\u3068\u95a2\u9023\u3059\u308b\u304c\u3001LDL-C\u306f\u95a2\u9023\u3057\u306a\u3044\u3002<\/span><\/p>\n

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\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u7dcf\u8ca0\u62c5\u3092\u6e1b\u5c11\u3055\u305b\u305f<\/span><\/h3>\n
McGuire DK, Zinman B, Inzucchi SE, et al. 2\u578b\u7cd6\u5c3f\u75c5\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u521d\u56de\u304a\u3088\u3073\u518d\u767a\u81e8\u5e8a\u30a4\u30d9\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306e\u52b9\u679c\uff1aEMPA-REG OUTCOME\u8a66\u9a13\u306e\u4e8c\u6b21\u89e3\u6790\u3002Lancet Diabetes Endocrinol 2020;8:949-59. <\/span><\/h6>\n

\u3053\u306eEMPA-REG OUTCOME\u8a66\u9a13\u306e\u6700\u65b0\u5831\u544a\u3067\u306f\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f53-2\uff08SGLT2\uff09\u963b\u5bb3\u85ac\u30a8\u30f3\u30d1\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u304c\u3001\u73fe\u5728\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u52a0\u3048\u3066\u3001\u6700\u521d\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u8d85\u3048\u3066\u3082\u5f15\u304d\u7d9a\u304d\u6709\u76ca\u6027\u3092\u793a\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTc1MCIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”15px” header_2_text_color=”gcid-primary-color” header_2_font_size=”32px” custom_margin=”||-13px|||” custom_padding=”9px|||27px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22header_2_text_color%22%93}”]<\/p>\n

2020 <\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

N-\u30a2\u30bb\u30c1\u30eb\u30ac\u30e9\u30af\u30c8\u30b5\u30df\u30f3\u7d50\u5408\u578bANGPTL3\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u85acVupanorsen\u306b\u6709\u671b\u6027<\/span><\/h3>\n
Vupanorsen, an N-acetyl galactosamine-conjugated antisense drug to ANGPTL3 mRNA, lowers triglycerides and atherogenic lipoproteins in patients with diabetes, hepatic steatosis, and hypertriglyceridaemia.Eur Heart J 2020 ; doi:10.1093\/eurheartj\/ehaa689 <\/span><\/h6>\n

2\u578b\u7cd6\u5c3f\u75c5\u3001\u809d\u8102\u80aa\u75c7\u3001\u304a\u3088\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4e0a\u6607\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u809d\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d83\uff08ANGPTL3\uff09\u86cb\u767d\u5408\u6210\u3092\u6a19\u7684\u3068\u3057\u305fvupanorsen\uff08AKCEA-ANGPTL3-L Rx\uff09\u306f\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u542b\u6709\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjI1MTg1MyIsImVuYWJsZV9odG1sIjoib2ZmIn19@” url_new_window=”on” button_text=”\u7d9a\u304d\u3092\u8aad\u3080” button_alignment=”right” _builder_version=”4.27.4″ _dynamic_attributes=”button_url” _module_preset=”9bc3f405-43a0-4056-a483-11952257355c” button_bg_color=”RGBA(255,255,255,0)” button_icon=”$||divi||400″ button_icon_color=”gcid-primary-color” button_on_hover=”off” custom_margin=”|44px|||false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22button_text_color%22,%22button_icon_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”40px|auto||auto||” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30ea\u30dd\u86cb\u767d(a)\uff1a\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u30de\u30fc\u30ab\u30fc<\/span><\/h3>\n
\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u969b\u306b\u4e88\u5f8c\u4e88\u6e2c\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u3001\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3053\u306e\u5b9f\u81e8\u5e8a\u89e3\u6790\u3067\u793a\u3055\u308c\u305f\u3002<\/span><\/h6>\n

Liu HH, Cao YX, Jin JL et al. \u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u5024\u3068\u30a4\u30d9\u30f3\u30c8\u518d\u767a\u3068\u306e\u95a2\u9023\u3002Heart 2020; doi:10.1136\/heartjnl-2020-316586.<\/span><\/p>\n

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Women’s Health Study\u304b\u3089\u306e\u6d1e\u5bdf\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u3068\u5f37\u304f\u95a2\u9023\u3059\u308b<\/span><\/h3>\n
Women’s Health Study\u5185\u306e\u524d\u5411\u304d\u75c7\u4f8b\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u7d50\u679c\u304b\u3089\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\uff08TRL\uff09\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u542b\u91cf\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u306f\u7121\u95a2\u4fc2\u306b\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span><\/h6>\n

Duran EK, Aday AW, Cook NR et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u5c0f\u6fc3\u5ea6LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u3002J Am Coll Cardiol 2020; 75:2122-35. <\/span><\/p>\n

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\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\uff1a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023<\/span><\/h3>\n
\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4f4e\u4e0b\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u4f4e\u4e0b\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3067\u3082\u3001\u4e3b\u8981\u306a\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/span><\/h6>\n

Marston NA, Giugliano RP, Im KA, et al.\u8907\u6570\u306e\u8102\u8cea\u4f4e\u4e0b\u85ac\u6cbb\u7642\u30af\u30e9\u30b9\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023\u3002\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u3068\u30e1\u30bf\u56de\u5e30\u5206\u6790\u3002Circulation 2019;140:1308-17. <\/span><\/p>\n

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\u5b9f\u969b\u306e\u30c7\u30fc\u30bf\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u3088\u304f\u307f\u3089\u308c\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3002<\/span><\/h3>\n
\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\u306e4\u4eba\u306b1\u4eba\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\uff08135\u301c499mg\/dL\u30011.52\u301c5.63mmol\/L\uff09\u304c\u9ad8\u3044\u3002\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u4e0a\u6607\u3059\u308b\u306b\u3064\u308c\u3066\u5897\u52a0\u3059\u308b\u3002 <\/span><\/h6>\n

Lawler PR, Kotrri G, Koh M et al.\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u95a2\u9023\u3059\u308b\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u5b9f\u4e16\u754c\u30ea\u30b9\u30af\u3068\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u6f5c\u5728\u7684\u9069\u683c\u6027\u3002Eur Heart J 2019; doi:10.1093\/eurheartj\/ehz767 <\/span><\/p>\n

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2019 <\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” link_option_url_new_window=”on” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3051\u308bANGPTL3\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53<\/span><\/h3>\n
ANGPTL3\uff08\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u86cb\u767d\u8cea3\uff09\u306b\u5bfe\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308bEvinacumab\u306f\u3001\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2cI\u76f8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u5b9f\u8cea\u7684\u304b\u3064\u6301\u7d9a\u7684\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/span><\/h6>\n

Ahmad Z\u3001Baneljee P\u3001Hamon S\u3089\uff1a\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306b\u3088\u308b\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea3\u306e\u963b\u5bb3\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3002Circulation 2019; DOI: 10.1161\/CIRCULATIONAHA.118.039107 <\/span><\/p>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af<\/span><\/h3>\n
Copenhagen General Population Study\u306e\u5831\u544a\u306b\u3088\u308b\u3068\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u9ad8\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/span><\/h6>\n

Varbo A, Nordestgaard BG.\u4e00\u822c\u96c6\u56e3112,512\u4eba\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3002Ann Neurol 2019;85:550-9. <\/span><\/p>\n

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2018 <\/span><\/h2>\n

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\u30ec\u30e0\u30ca\u30f3\u30c8\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u95a2\u9023\u6027\u3092\u793a\u3059\u8a3c\u62e0\u304c\u5897\u3048\u305f<\/span><\/h3>\n
ARIC\uff08Atherosclerosis Risk in Communities\uff09\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u6b8b\u5b58\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08RLP-C\uff09\u3068\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08LDL-TG\uff09\u306e\u4e21\u5024\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308a\u3001APOE\u306e\u5909\u7570\u4f53\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/span><\/h6>\n

Saeed A\u3001Feofanova EV\u3001Yu B\u3089\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u69d8\u7c92\u5b50\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u3002J Am Coll Cardiol 2018;72:156-69. <\/span><\/p>\n

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