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2026 <\/span><\/h2>\n

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Watts GF, Scott R, Sullivan D, et al. Zodasiran for cholesterol and triglyceride lowering in patients with hyperlipidemia: final report of phase 1 basket trial. Clinical Trial Nat Med 2026;32:1432-1443. <\/span><\/em><\/p>\n

Raal FJ, Bergeron J, Gaudet D, et al. Zodasiran, an RNAi therapeutic targeting ANGPTL3, for treating patients with homozygous familial hypercholesterolaemia (GATEWAY): an open-label, randomised, phase 2 trial. Lancet Diabetes Endocrinol 2026;14(2):123-136. <\/span><\/em><\/p>\n

Key words: Zodasiran; angiopoietin-like protein 3 (ANGPTL3); RNA therapeutic; familial hypercholesterolemia; hypertriglyceridemia<\/span><\/em><\/p>\n

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ANGPTL3\u963b\u5bb3\u85ac\u306e\u30e1\u30bf\u89e3\u6790<\/span><\/strong><\/p>\n

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\u672c\u30e1\u30bf\u89e3\u6790\u306fPRISMA\uff08\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u304a\u3088\u3073\u30e1\u30bf\u89e3\u6790\u306e\u305f\u3081\u306e\u512a\u5148\u5831\u544a\u9805\u76ee\uff09\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u5f93\u3063\u3066\u5b9f\u65bd\u3055\u308c\u305f\u3002ANGPTL3\u963b\u5bb3\u85ac\uff08\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u3001\u30d6\u30d1\u30ce\u30eb\u30bb\u30f3\u3001\u30be\u30c0\u30b7\u30e9\u30f3\u3001\u30bd\u30eb\u30d3\u30f3\u30b7\u30e9\u30f3\uff09\u306e\u8102\u8cea\u5024\u3078\u306e\u5f71\u97ff\u3092\u6bd4\u8f03\u3057\u305f\u3001\u82f1\u8a9e\u3067\u767a\u8868\u3055\u308c\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u304c\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002 <\/span><\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u3001ANGPTL3\u963b\u5bb3\u306f\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u307b\u307c\u534a\u6e1b\u3055\u305b\uff0847.1%\u4f4e\u4e0b\uff09\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u309272.7%\u4f4e\u4e0b\u3055\u305b\u3001\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0821.6%\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30afB\uff0819.9%\uff09\u3001\u975e\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0831.5%\uff09\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0832.8%\uff09\u306b\u304a\u3044\u3066\u4e00\u8cab\u3057\u305f\u4f4e\u4e0b\u3092\u793a\u3057\u305f\u3002\u30ea\u30dd\u30bf\u30f3\u30d1\u30af(a)\u306b\u3064\u3044\u3066\u3082\u8efd\u5ea6\u306e\u4f4e\u4e0b\uff0811.5%\uff09\u304c\u307f\u3089\u308c\u305f\u3002 <\/span><\/p>\n

\u7d50\u679c\u306f\u6709\u671b\u3067\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u8a66\u9a13\u6570\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u6bd4\u8f03\u7684\u5c0f\u3055\u3044\u3053\u3068\u3001\u8ffd\u8de1\u671f\u9593\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u63a2\u7d22\u7684\u306a\u3082\u306e\u3068\u307f\u306a\u3059\u3079\u304d\u3067\u3042\u308b\u3002ANGPTL3\u963b\u5bb3\u306b\u4f34\u3046\u826f\u597d\u306a\u8102\u8cea\u4f4e\u4e0b\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u6539\u5584\u306b\u3064\u306a\u304c\u308b\u304b\u3069\u3046\u304b\u3092\u8a55\u4fa1\u3059\u308b\u306b\u306f\u3001\u9577\u671f\u8ffd\u8de1\u3092\u4f34\u3046\u5927\u898f\u6a21\u306a\u524d\u5411\u304d\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/span><\/p>\n

Xie S, Galimberti F, Olmastroni E, et al. Effect of angiopoietin-like protein 3 inhibitors on lipid profile and other biomarkers: a meta-analysis of randomized controlled trials. Eur J Prev Cardiol 2026; doi: 10.1093\/eurjpc\/zwag230. <\/span><\/em><\/p>\n

Key words: Angiopoietin-like protein 3 (ANGPTL3) inhibitors; meta-analysis; triglycerides; lipids<\/span><\/em><\/p>\n

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https:\/\/academic.oup.com\/eurjpc\/advance-article-abstract\/doi\/10.1093\/eurjpc\/zwag106\/8494640<\/a><\/span><\/strong><\/p>\n

\u30ea\u30dd\u30bf\u30f3\u30d1\u30af(a)\u3014Lp(a)\u3015\u306f\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u56e0\u679c\u7684\u304b\u3064\u72ec\u7acb\u3057\u305f\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u3001\u305d\u306e\u5024\u306f\u4e3b\u306b\uff0890%>\uff09\u907a\u4f1d\u7684\u306b\u6c7a\u5b9a\u3055\u308c\u308b\u3002\u307e\u305f\u3001\u4eba\u7a2e\uff0f\u6c11\u65cf\u306b\u3088\u3063\u3066\u5024\u304c\u5909\u52d5\u3059\u308b\u3068\u3044\u3046\u8a3c\u62e0\u3082\u3042\u308b\u304c\u3001\u3053\u308c\u304c\u7570\u306a\u308b\u30ea\u30b9\u30af\u95be\u5024\u306e\u8a2d\u5b9a\u306b\u3064\u306a\u304c\u308b\u3079\u304d\u304b\u3069\u3046\u304b\u306f\u7d50\u8ad6\u304c\u51fa\u3066\u3044\u306a\u3044\u3002\u672c\u5831\u544a\u3067\u306f\u3001NHANES III\u306e\u7c73\u56fd\u6210\u4eba\u3092\u4ee3\u8868\u3059\u308b\u591a\u6c11\u65cf\u30b3\u30db\u30fc\u30c8\uff08\u8abf\u67fb\u91cd\u307f\u4ed8\u3051\u30ec\u30b3\u30fc\u30c950,519,751\u4ef6\u3001\u5e73\u5747\u8ffd\u8de1\u671f\u959322.6\u5e74\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u4eba\u7a2e\uff0f\u6c11\u65cf\u5225\u306eLp(a)\u3068\u6b7b\u4ea1\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u305f\u3002\u5bfe\u8c61\u8005\u306f\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u767d\u4eba\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u9ed2\u4eba\u3001\u30e1\u30ad\u30b7\u30b3\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306b\u5206\u985e\u3055\u308c\u305f\u3002Lp(a)\u6fc3\u5ea6\u30c7\u30fc\u30bf\u306f\u5bfe\u6570\u5909\u63db\u3055\u308c\u30013\u7fa4\uff08<50 mg\/dL\u300150\uff5e75 mg\/dL\u3001>75 mg\/dL\uff09\u306b\u5206\u3051\u3089\u308c\u305f\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u3001Lp(a)\u6fc3\u5ea6\u306e\u4e2d\u592e\u5024\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\uff09\u306f\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u767d\u4eba\u3084\u30e1\u30ad\u30b7\u30b3\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u3088\u308a\u3082\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u9ed2\u4eba\u306e\u53c2\u52a0\u8005\u3067\u9ad8\u304b\u3063\u305f\uff0836 mg\/dL\u301422-66\u3015\u5bfe 12 mg\/dL\u30143-30\u3015\u5bfe 8 mg\/dL\u30142-22\u3015\uff09\u3002\u3055\u3089\u306b\u3001Lp(a>75 mg\/dL\u306e\u30e1\u30ad\u30b7\u30b3\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u306f\u3001\u4ed6\u306e2\u7fa4\u3068\u6bd4\u3079\u3066\u5fc3\u8840\u7ba1\u6b7b\u30ea\u30b9\u30af\u304c\u7d043\u500d\u9ad8\u304f\u3001\u3053\u308c\u306f\u591a\u5909\u91cf\u8abf\u6574\u5f8c\u3082\u6301\u7d9a\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd42.93\u300195%\u4fe1\u983c\u533a\u95931.01-8.56\u3001p\uff1d0.049\uff09\u3002\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u9ed2\u4eba\u3067\u306f\u3001Lp(a)\u304c\u9ad8\u3044\u3053\u3068\u304c\u672a\u8abf\u6574\u30e2\u30c7\u30eb\u3067\u306f\u5168\u6b7b\u4ea1\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001\u8abf\u6574\u5f8c\u306f\u95a2\u9023\u304c\u307f\u3089\u308c\u305a\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u767d\u4eba\u3067\u306f\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/span><\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u5c64\u5225\u5316\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u4eba\u7a2e\uff0f\u6c11\u65cf\u5225\u306eLp(a)\u95be\u5024\u3092\u5b9a\u7fa9\u30fb\u691c\u8a3c\u3059\u308b\u5fc5\u8981\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

Lim LC, Al-Jarshawi M, Chew NW, et al. Lipoprotein(a) distribution across race\/ethnicity and association with mortality outcomes in NHANES III (1988-1994) with follow <\/span><\/em>\u2011up to 2019. Am J Cardiol 2026; doi: 10.1016\/j.amjcard.2026.04.063. <\/span><\/em><\/p>\n

Key words: Lipoprotein(a); NHANES; risk stratification; race; ethnicity; thresholds<\/span><\/em><\/p>\n

<\/span><\/p>\n

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HDL\u306e\u6297\u708e\u75c7\u80fd\u3068\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af<\/span><\/strong><\/p>\n

\u8102\u8cea\u7814\u7a76\u306e\u7126\u70b9\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8c4a\u5bcc\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3078\u3068\u79fb\u884c\u3057\u3066\u3044\u308b\u304c\u3001\u672c\u5831\u544a\u306f\u3001\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\uff08HDL\uff09\u306e\u6a5f\u80fd\u304c\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u306f\u3001\u4e2d\u56fd\u5357\u90e8\u306e\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005\uff08n\uff1d466\u3001\u5e73\u5747\u5e74\u9f6264\u6b73\u300178%\u304c\u7537\u6027\uff09\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\uff08MACE\uff1a\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u30fb\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u30fb\u5fc3\u8840\u7ba1\u6b7b\u306e\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\uff09\u306b\u5bfe\u3059\u308bHDL\u6297\u708e\u75c7\u80fd\u306e\u4e88\u6e2c\u4fa1\u5024\u3092\u8a55\u4fa1\u3057\u305f\u3002HDL\u306e\u6297\u708e\u75c7\u6d3b\u6027\u306f\u3001\u5185\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066\u816b\u760d\u58ca\u6b7b\u56e0\u5b50\u03b1\u306b\u3088\u308a\u523a\u6fc0\u3055\u308c\u305f\u8840\u7ba1\u7d30\u80de\u63a5\u7740\u5206\u5b501\u306emRNA\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u80fd\u529b\u306b\u3088\u3063\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002 <\/span><\/p>\n

\u4e2d\u592e\u50242.3\u5e74\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u300112.7%\u306e\u60a3\u8005\u304cMACE\u3092\u518d\u767a\u3057\u305f\u3002HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304a\u3088\u3073\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u542b\u3080\u591a\u5909\u91cf\u8abf\u6574\u5f8c\u3001HDL\u6297\u708e\u75c7\u80fd\u304c\u9ad8\u3044\u3053\u3068\u306f\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u3055\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\uff08p\uff1d0.022\uff09\u3002\u4e09\u5206\u4f4d\u3067\u5206\u985e\u3057\u305f\u5834\u5408\u3001HDL\u6297\u708e\u75c7\u80fd\u304c\u6700\u3082\u9ad8\u3044\u60a3\u8005\u306f\u3001\u5bfe\u7167\u7fa4\u3068\u6bd4\u3079\u3066MACE\u30ea\u30b9\u30af\u304c\u534a\u6e1b\u3057\u305f\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd40.48\u300195%\u4fe1\u983c\u533a\u95930.24-0.97\u3001p\uff1d0.040\uff09\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001HDL\u306e\u6297\u708e\u75c7\u6a5f\u80fd\u80fd\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u304c\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u4e8c\u6b21\u5fc3\u8840\u7ba1\u4e88\u9632\u306b\u304a\u3051\u308bHDL\u6a5f\u80fd\u8a55\u4fa1\u306e\u5f79\u5272\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

Jia C, Wu W, Xu X, et al. HDL anti-inflammatory capacity and residual cardiovascular risk: A prospective cohort study. J Clin Lipidol 2026; doi: 10.1016\/j.jacl.2026.03.015. <\/span><\/em><\/p>\n

Key words: HDL function; anti-inflammatory capacity; residual cardiovascular risk<\/span><\/em><\/p>\n

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\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\uff08gemilukast\uff09\uff1a\u8102\u8cea\u4f4e\u4e0b\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u306e\u4f75\u5b58<\/span><\/strong><\/p>\n

\u8102\u8cea\u4f4e\u4e0b\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u3092\u4f75\u305b\u6301\u3064\u85ac\u5264\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u7ba1\u7406\u306e\u3088\u308a\u5305\u62ec\u7684\u306a\u6226\u7565\u306e\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3059\u308b\u3002\u3053\u306e\u6982\u5ff5\u5b9f\u8a3c\uff08proof-of-concept\uff09\u306e\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u5f53\u521d\u306f\u5598\u606f\u6cbb\u7642\u306e\u305f\u3081\u306b\u958b\u767a\u3055\u308c\u305f\u30b7\u30b9\u30c6\u30a4\u30cb\u30eb\u30ed\u30a4\u30b3\u30c8\u30ea\u30a8\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u3067\u3042\u308b\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\u304c\u3001\u8102\u8cea\u4f4e\u4e0b\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u306e\u4e21\u65b9\u3092\u793a\u3057\u3001\u6cbb\u7642\u4e0a\u306e\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u305f <\/span><\/p>\n

\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\u306e\u4f5c\u7528\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u3001\u672c\u7814\u7a76\u3067\u306f\u3001Caco-2\u7d30\u80de\u306b\u304a\u3051\u308b\u8178\u7ba1\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u53d6\u308a\u8fbc\u307f\u3078\u306e\u5f71\u97ff\u3001\u306a\u3089\u3073\u306bRAW 264.7\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3051\u308b\u6297\u708e\u75c7\u6d3b\u6027\u304a\u3088\u3073\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u5206\u6975\u3078\u306e\u5f71\u97ff\u3092\u8a55\u4fa1\u3057\u3001\u4e21\u4f5c\u7528\u306e\u57fa\u76e4\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306e\u6a5f\u5e8f\u7814\u7a76\u3092\u884c\u3063\u305f\u3002\u307e\u305f\u3001\u6025\u6027\u304a\u3088\u3073\u6162\u6027\u306e\u9ad8\u8102\u8840\u75c7\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\u306e\u8102\u8cea\u4f4e\u4e0b\u4f5c\u7528\u3082\u8a55\u4fa1\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\u306f\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u53d6\u308a\u8fbc\u307f\u3092\u963b\u5bb3\u3057\u3001\u30df\u30bb\u30eb\u4e2d\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6eb6\u89e3\u5ea6\u309240%\u8d85\u4f4e\u4e0b\u3055\u305b\u3066\u8178\u7ba1\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u53d6\u308a\u8fbc\u307f\u306e\u969c\u5bb3\u3092\u88cf\u4ed8\u3051\u3001\u30ea\u30dd\u591a\u7cd6\u523a\u6fc0RAW 264.7\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3044\u3066\u6297\u708e\u75c7\u6d3b\u6027\u3092\u793a\u3057\u3001TNF-\u03b1\u30fbIL-1\u03b2\u30fbIL-6\u3092\u6e1b\u5c11\u3055\u305b\u3001M1\u304b\u3089M2\u3078\u306e\u518d\u5206\u6975\u3092\u4fc3\u9032\u3057\u3001PI3K\/AKT\u306e\u6d3b\u6027\u5316\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3002\u751f\u4f53\u5185\u3067\u306f\u3001\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\uff0810 mg\/kg\uff09\u306f\u6025\u6027\u304a\u3088\u3073\u6162\u6027\u306e\u9ad8\u8102\u8840\u75c7\u30e2\u30c7\u30eb\u306e\u4e21\u65b9\u3067\u8840\u6f3f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u5f8c\u8005\u306e\u30e2\u30c7\u30eb\u3067\u306f\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u4f4e\u4e0b\u3082\u307f\u3089\u308c\u305f\u3002\u8102\u8cea\u4f4e\u4e0b\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u3092\u4f75\u305b\u6301\u3064\u3053\u306e\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u8e0f\u307e\u3048\u3001\u30b2\u30df\u30eb\u30ab\u30b9\u30c8\u306f\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u7ba1\u7406\u306b\u304a\u3051\u308b\u6cbb\u7642\u4e0a\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3055\u3089\u306a\u308b\u7814\u7a76\u306b\u5024\u3059\u308b\u3002 <\/span><\/p>\n

Liu Y, Wang Y, Zhang R Wang R, et al. Identification of gemilukast as a bifunctional molecule with lipid-lowering and anti-inflammatory activities. Front Immunol 2026; doi: 10.3389\/fimmu.2026.1738104<\/span><\/em><\/p>\n

Key words: Gemilukast; anti-inflammatory; lipid-lowering; residual cardiovascular risk<\/span><\/em><\/p>\n

<\/span><\/p>\n

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\u305d\u306e\u4ed6\u306e\u51fa\u7248\u7269<\/h2>\n

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2026 <\/span><\/h2>\n

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American College of Cardiology Scientific Sessions\uff08New Orleans\u30012026\u5e743\u670828\u201330\u65e5\uff09\u304b\u3089\u306e\u30cb\u30e5\u30fc\u30b9<\/strong><\/p>\n

<\/strong><\/p>\n

Ez\u2011PAVE\u306f\u3001\u3088\u308a\u4f4e\u3044LDL\u2011C\u76ee\u6a19\u306e\u5fc3\u8840\u7ba1\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u793a\u3057\u305f<\/strong><\/p>\n

\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u81e8\u5e8a\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u9650\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u60a3\u8005\u306e\u4e8c\u6b21\u4e88\u9632\u306b\u304a\u3044\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u76ee\u6a19\u5024\u3068\u3057\u3066<55 mg\/dL\uff08<1.4 mmol\/L\uff09\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002 ASCVD\u3092\u6709\u3059\u308b\u97d3\u56fd\u4eba\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u975e\u76f2\u691c\u512a\u8d8a\u6027\u8a66\u9a13\u3067\u3042\u308bEz-PAVE\uff08\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u5bfe\u3059\u308b\u30a8\u30bc\u30c1\u30df\u30d6\u4f75\u7528\u7642\u6cd5\u306e\u52b9\u679c \u2014 LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u76ee\u6a19\u5024<70 mg\/dL\u5bfe<55 mg\/dL\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\uff09\u306e\u7d50\u679c\u3067\u306f\u3001\u3053\u306e\u76ee\u6a19\u5024\u307e\u3067\u6cbb\u7642\u3059\u308b\u3053\u3068\u3067\u3001\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u304c\u7d043\u5206\u306e1\u3001\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 <\/p>\n

Ez\u2011PAVE\u3067\u306f\u3001ASCVD\u60a3\u80053,048\u4f8b\u304c\u3001LDL\u2011C <55 mg\/dL\u3092\u76ee\u6a19\u3068\u3059\u308b\u5f37\u5316\u6cbb\u7642\u7fa4\uff08n=1,526\uff09\u307e\u305f\u306f<70 mg\/dL\u3092\u76ee\u6a19\u3068\u3059\u308b\u5f93\u6765\u6cbb\u7642\u7fa4\uff08n=1,522\uff09\u306b\u7121\u4f5c\u70ba\u5316\u3055\u308c\u305f\u3002\u4e21\u7fa4\u306f\u5747\u8861\u3057\u3066\u304a\u308a\u3001\u5e73\u5747\u5e74\u9f62\u306f64.4\u6b73\u3001\u5973\u6027\u306f20.9%\u3001\u904e\u53bb\u306e\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u306f55.6%\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u306e\u65e2\u5f80\u306f67.2%\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u306f\u3001LDL\u2011C\u4e2d\u592e\u5024\u306f76 mg\/dL\uff08\u56db\u5206\u4f4d\u7bc4\u56f2 61\u201396 mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u30013\u5e74\u6642\u70b9\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u3001\u4efb\u610f\u306e\u8840\u884c\u518d\u5efa\u3001\u307e\u305f\u306f\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u306b\u3088\u308b\u5165\u9662\u306e\u8907\u5408\u3067\u3042\u3063\u305f\u3002 <\/p>\n

1\u304b\u6708\u6642\u70b9\u3067\u3001\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u305f\u5272\u5408\u306f\u3001\u5f37\u5316\u76ee\u6a19\u7fa4\u306753.5%\u3001\u5f93\u6765\u76ee\u6a19\u7fa4\u306735.9%\u3067\u3042\u308a\u3001\u3053\u306e\u5dee\u306f\u8a66\u9a13\u671f\u9593\u4e2d\u6301\u7d9a\u3057\u305f\u3002\u8a66\u9a13\u671f\u9593\u4e2d\u306eLDL\u2011C\u4e2d\u592e\u5024\u306f\u3001\u5f37\u5316\u76ee\u6a19\u7fa4\u306756 mg\/dL\uff08\u56db\u5206\u4f4d\u7bc4\u56f2 48\u201367 mg\/dL\uff09\u3001\u5f93\u6765\u76ee\u6a19\u7fa4\u306766 mg\/dL\uff08\u56db\u5206\u4f4d\u7bc4\u56f2 58\u201376 mg\/dL\uff09\u3067\u3042\u3063\u305f\u30023\u5e74\u6642\u70b9\u3067\u3001\u5f37\u5316\u76ee\u6a19\u7fa4\u306e60.8%\u304cLDL\u2011C<55 mg\/dL\u3092\u9054\u6210\u3057\u300185.2%\u304c<70 mg\/dL\u3092\u9054\u6210\u3057\u305f\u3002\u60a3\u8005\u306e\u307b\u307c\u534a\u6570\uff0848.4%\uff09\u304c\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u30013\u5206\u306e2\uff0866.6%\uff09\u304cezetimibe\u3092\u6295\u4e0e\u3055\u308c\u3001PCSK9\u963b\u5bb3\u85ac\u3092\u6295\u4e0e\u3055\u308c\u305f\u306e\u306f2.3%\u306e\u307f\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50243.0\u5e74\u5f8c\u3001\u5f37\u529b\u306aLDL\u2011C\u4f4e\u4e0b\u306f\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e33%\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.67\u300195%\u4fe1\u983c\u533a\u95930.52\u20130.86\u3001p=0.002\uff09\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u518d\u767a\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u3044ASCVD\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u63a8\u5968LDL\u2011C\u76ee\u6a19 <55 mg\/dL\u3092\u9054\u6210\u3059\u308b\u305f\u3081\u306e\u5f37\u529b\u306aLDL\u2011C\u4f4e\u4e0b\u4f75\u7528\u7642\u6cd5\u306e\u91cd\u8981\u6027\u3092\u518d\u78ba\u8a8d\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/p>\n

Lee YJ, Lee SJ, Kim JW, et al. Intensive LDL cholesterol targeting in atherosclerotic cardiovascular disease. N Engl J Med 2026; DOI: 10.1056\/NEJMoa2600283.<\/a> <\/em><\/p>\n

Key words: Intensive lipid lowering; low-density lipoprotein cholesterol target; guidelines<\/em><\/p>\n

CORALreef AddOn\uff1a\u7d4c\u53e3PCSK9\u963b\u5bb3\u85acenlicitide\u3068\u7d4c\u53e3\u975e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306e\u6bd4\u8f03<\/strong><\/p>\n

\u30b9\u30bf\u30c1\u30f3\u5358\u5264\u7642\u6cd5\u3067\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u308b\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL\u2011C\uff09\u76ee\u6a19\u3092\u9054\u6210\u3059\u308b\u306b\u306f\u4e0d\u5341\u5206\u306a\u3053\u3068\u304c\u591a\u3044\u3002\u65b0\u898f\u7d4c\u53e3PCSK9\u963b\u5bb3\u85ac\u3067\u3042\u308benlicitide\u306f\u3001CORALreef AddOn\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u4e2d\u3067LDL\u2011C\u76ee\u6a19\u672a\u9054\u306e\u60a3\u8005\u306eLDL\u2011C\u3092\u6709\u52b9\u306b\u4f4e\u4e0b\u3055\u305b\u3001\u8ffd\u52a0\u7d4c\u53e3\u6cbb\u7642\u3068\u3057\u3066\u306e\u6f5c\u5728\u7684\u5f79\u5272\u3092\u793a\u5506\u3057\u305f\u3002 <\/p>\n

\u3053\u306e\u7b2c3\u76f8\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u306f\u3001\u6210\u4eba301\u4f8b\uff08\u5e73\u5747\u5e74\u9f6264.4\u6b73\u3001\u5973\u602737%\u300198%\u304c\u4e2d\u7b49\u5ea6\u307e\u305f\u306f\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\uff09\u3067\u3001LDL\u2011C \u226555 mg\/dL\uff08\u4e8c\u6b21\u4e88\u9632\uff09\u307e\u305f\u306f\u226570 mg\/dL\uff08\u4e2d\u7b49\u5ea6\u301c\u9ad8\u30ea\u30b9\u30af\uff09\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u3001enlicitide 20 mg\uff08n=101\uff09\u3001bempedoic acid 180 mg\uff08n=50\uff09\u3001ezetimibe 10 mg\uff08n=50\uff09\u3001\u307e\u305f\u306fbempedoic acid 180 mg\uff0bezetimibe 10 mg\uff08n=100\uff09\u306b\u7121\u4f5c\u70ba\u5316\u3057\u30011\u65e51\u56de56\u65e5\u9593\u6295\u4e0e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308956\u65e5\u76ee\u307e\u3067\u306eLDL\u2011C\u5e73\u5747\u5909\u5316\u7387\u3067\u3042\u3063\u305f\u3002 <\/p>\n

56\u65e5\u76ee\u306b\u3001enlicitide\u306f\u6bd4\u8f03\u5bfe\u7167\u6cbb\u7642\u3068\u6bd4\u3079\u3066\u512a\u308c\u305fLDL\u2011C\u4f4e\u4e0b\u3092\u3082\u305f\u3089\u3057\u305f\u3002LDL\u2011C\u5e73\u5747\u5909\u5316\u7387\u306f\u3001enlicitide\u3067-64.6%\uff0895%\u4fe1\u983c\u533a\u9593\uff3bCI\uff3d-68.3\u301c-60.9\uff09\u3001bempedoic acid\u3067-6.3%\uff0895% CI -13.5\u301c0.8\uff09\u3001ezetimibe\u3067-27.8%\uff0895% CI -32.3\u301c-23.4\uff09\u3001bempedoic acid\uff0bezetimibe\u3067-36.5%\uff0895% CI -40.8\u301c-32.2\uff09\u3067\u3042\u3063\u305f\uff08\u3044\u305a\u308c\u3082p<0.001\uff09\u3002 <\/p>\n

Catapano AL, Mikhailova E, Navar AM, et al. <\/span><\/em>Oral PCSK9 inhibitor enlicitide versus oral non-statin therapies: a phase 3 randomized clinical trial. J Am Coll Cardiol 2026 <\/em>; DOI: 10.1016\/j.jacc.2026.03.036<\/a><\/p>\n

Key words: Oral PCSK9 inhibitor; enlicitide; CORALreef AddOn trial<\/em><\/p>\n

2\u3064\u306e\u72ec\u7acb\u3057\u305f\u4e8b\u5f8c\u89e3\u6790\u304b\u3089\u306e\u8ffd\u52a0\u30c7\u30fc\u30bf\u306f\u3001enlicitide\u306b\u5bfe\u3059\u308bLDL\u2011C\u4f4e\u4e0b\u53cd\u5fdc\u306e\u6301\u7d9a\u6027\u3092\u793a\u3057\u305f\u3002CORALreef Lipids\u3067\u306f\u3001enlicitide\u3092\u6295\u4e0e\u3055\u308c\u305f1,935\u4f8b\u304a\u3088\u3073\u30d7\u30e9\u30bb\u30dc969\u4f8b\u3092\u542b\u307f\u3001\u6cbb\u7642\u4e2d\u306e\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5f8cLDL\u2011C\u5e73\u5747\u4f4e\u4e0b\u7387\u306f24\u9031\u6642\u70b9\u306e-62.9%\u304b\u308952\u9031\u6642\u70b9\u306e-58.0%\u307e\u3067\u6301\u7d9a\u3057\u305f\u3002CORALreef HeFH\u3067\u3082\u540c\u69d8\u306e\u6240\u898b\u304c\u5831\u544a\u3055\u308c\u3001\u6cbb\u7642\u4e2d\u306e\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5f8cLDL\u2011C\u5e73\u5747\u4f4e\u4e0b\u7387\u306f24\u9031\u6642\u70b9\u3067-62.2%\u300152\u9031\u6642\u70b9\u3067-65.3%\u3067\u3042\u3063\u305f\u3002enlicitide\u306f\u6982\u306d\u5fcd\u5bb9\u6027\u826f\u597d\u3067\u3042\u308a\u3001\u6709\u5bb3\u4e8b\u8c61\u306e\u767a\u73fe\u7387\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002 <\/p>\n

Lp(a)\u304a\u3088\u3073CAC\u306f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b<\/strong><\/p>\n

\u7d71\u5408\u591a\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u3088\u308a\u3001Lp(a)\u9ad8\u5024\uff08Lp(a)>50 mg\/dL\uff09\u304a\u3088\u3073\u51a0\u52d5\u8108\u77f3\u7070\u5316\uff08CAC\uff09\u30b9\u30b3\u30a2>0\u304c\u300115\u5e74\u8ffd\u8de1\u306b\u304a\u3051\u308b\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u30ea\u30b9\u30af\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002Lp(a)\u9ad8\u5024\u306f\u3001CAC=0\u3092\u542b\u3080CAC\u5c64\u5225\u5168\u4f53\u3067\u3001ASCVD\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u305f\u3002 <\/p>\n

\u672c\u7814\u7a76\u306b\u306f\u300111,319\u4f8b\uff08\u5e73\u5747\u5e74\u9f6256\u6b73\u3001\u5973\u602754%\uff09\u304c\u542b\u307e\u308c\u3001\u5e73\u5747\u8ffd\u8de1\u671f\u959314.8\u5e74\u30671,569\u4ef6\u306eASCVD\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f\u3002\u500b\u5225\u306b\u306f\u3001Lp(a)>50 mg\/dL\u304a\u3088\u3073CAC>0\u306f\u3001\u305d\u308c\u305e\u308cASCVD\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.24\u300195%\u4fe1\u983c\u533a\u95931.09\u20131.41\uff09\u304a\u3088\u3073\uff082.44\u30012.14\u20132.77\uff09\uff08\u4ea4\u4e92\u4f5c\u7528P=0.80\uff09\u3002CAC\u5c64\u5225\u5168\u4f53\u3067\u3001Lp(a)\u9ad8\u5024\u306f\u3001CAC=0\u306e\u500b\u4eba\u306b\u304a\u3044\u3066\u3082ASCVD\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u305f\u3002\u3057\u304b\u3057\u3001CAC=0\u306e\u500b\u4eba\u3067\u306f\u3001Lp(a)\u304c\u9ad8\u5024\u3067\u3042\u3063\u3066\u3082\u7d76\u5bfe\u30a4\u30d9\u30f3\u30c8\u7387\u306f\u4f4e\u304b\u3063\u305f\u3002\u8981\u7d04\u3059\u308b\u3068\u3001Lp(a)\u306f\u907a\u4f1d\u7684\u3067\u5927\u304d\u306a\u500b\u4eba\u5dee\u3092\u6709\u3059\u308b\u304c\u3001CAC\u30b9\u30ad\u30e3\u30f3\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u306e\u307f\u3088\u308a\u3082\u826f\u597d\u306a\u30ea\u30b9\u30af\u5c64\u5225\u5316\u304c\u53ef\u80fd\u3068\u306a\u308b\u3002 <\/p>\n

Bhatia HS, Fan Y, Dharmavaram G, et al. Use of coronary artery calcium scoring in individuals with elevated lipoprotein(a). J Am Coll Cardiol 2026; DOI: doi.org\/10.1016\/j.jacc.2026.02.5067<\/a> <\/em><\/p>\n

Key words: Lipoprotein(a); coronary artery calcium; risk stratification<\/em><\/p>\n

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BMI\u3092\u4f4e\u4e0b\u3055\u305b\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u65b0\u898f\u85ac\u7269\u7642\u6cd5\u306f\u3001\u73fe\u5728\u3001BMI\u304c27\u301c30 kg\/m\u00b2\u306e\u500b\u4eba\u3067\u306f\u3001\u4ed6\u306e\u5371\u967a\u56e0\u5b50\u3092\u6709\u3059\u308b\u5834\u5408\u306b\u306e\u307f\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u6cbb\u7642\u3092\u691c\u8a0e\u3059\u308b\u969b\u306bLp(a)\u3092\u8003\u616e\u3059\u3079\u304d\u6839\u62e0\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u4e00\u6b21\u4e88\u9632\u304a\u3088\u3073\u4e8c\u6b21\u4e88\u9632\u306e\u53cc\u65b9\u306b\u304a\u3044\u3066\u3001\u9ad8Lp(a)\u3068\u9ad8BMI\u3092\u4f75\u305b\u6301\u3064\u500b\u4eba\u304cASCVD\u30ea\u30b9\u30af\u6700\u9ad8\u3067\u3042\u3063\u305f\u3002 <\/p>\n

>\u672c\u7814\u7a76\u3067\u306f\u3001Copenhagen General Population Study\u304a\u3088\u3073UK Biobank\u304b\u3089\u3001ASCVD\u3092\u6709\u3057\u306a\u3044512,687\u4eba\u306a\u3089\u3073\u306bASCVD\u3092\u6709\u3059\u308b14,161\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u8a55\u4fa1\u3057\u305f\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u3001\u4e00\u6b21\u4e88\u9632\u3067\u306f39,255\u4eba\u3001\u4e8c\u6b21\u4e88\u9632\u3067\u306f3,501\u4eba\u304cASCVD\u3092\u767a\u75c7\u3057\u305f\u3002\u4e00\u6b21\u4e88\u9632\u306e\u72b6\u6cc1\u3067\u306f\u3001\u9ad8Lp(a)\uff0895\u301c100\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff09\u304b\u3064BMI>30 kg\/m\u00b2\u306e\u500b\u4eba\u306f\u3001Lp(a)<50\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u304b\u3064BMI 18.5\u301c26.9 kg\/m\u00b2\u306e\u500b\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001ASCVD\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u304c\u7d042\u500d\u9ad8\u304b\u3063\u305f\uff08Copenhagen General Population Study\u3067\u306f\u30cf\u30b6\u30fc\u30c9\u6bd41.97\u300195%\u4fe1\u983c\u533a\u95931.61\u20132.40\u3001UK Biobank\u3067\u306f2.19\u30012.01\u20132.37\uff09\u3002\u7d76\u5bfeASCVD\u30ea\u30b9\u30af\u3082\u3001\u9ad8Lp(a)\u3068\u9ad8BMI\u3092\u4f75\u305b\u6301\u3064\u500b\u4eba\u3067\u306f\u3001BMI >30 kg\/m\u00b2\u3067\u4f4eLp(a)\u306e\u500b\u4eba\u3088\u308a\u3082\u9ad8\u304b\u3063\u305f\u3002\u4e8c\u6b21\u4e88\u9632\u306e\u72b6\u6cc1\u3067\u3082\u540c\u69d8\u306e\u6240\u898b\u304c\u5831\u544a\u3055\u308c\u3001\u9ad8Lp(a)\u304b\u3064BMI 18.5\u301c26.9 kg\/m\u00b2\u306e\u500b\u4eba\u306f\u3001BMI \u226527 kg\/m\u00b2\u304b\u3064\u4f4eLp(a)\u306e\u500b\u4eba\u3088\u308a\u3082\u30ea\u30b9\u30af\u304c\u9ad8\u304b\u3063\u305f\u3002 <\/p>\n

\u7dcf\u5408\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001BMI\u304c27\u301c30 kg\/m\u00b2\u306e\u500b\u4eba\u306b\u5bfe\u3059\u308b\u4f53\u91cd\u4f4e\u4e0b\u7642\u6cd5\u306b\u95a2\u3059\u308b\u6cbb\u7642\u5224\u65ad\u306b\u304a\u3044\u3066\u3001Lp(a)\u3092\u7d44\u307f\u5165\u308c\u308b\u3053\u3068\u304c\u6709\u7528\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3002\u73fe\u5728\u3001\u904e\u4f53\u91cd\u307e\u305f\u306f\u80a5\u6e80\u306e\u500b\u4eba\u3092\u7ba1\u7406\u3059\u308b\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u306fLp(a)\u306f\u542b\u307e\u308c\u3066\u3044\u306a\u3044\u3002 <\/p>\n

Thomas PE, Nielsen SF, Nordestgaard BG, Kamstrup PR. High lipoprotein(a) and high BMI jointly confer the highest risk of ASCVD in both primary and secondary prevention. <\/strong> <\/em>Eur J Prevent Cardiol 2026<\/em>; https:\/\/doi.org\/10.1093\/eurjpc\/zwag106<\/a><\/em><\/p>\n

Key words: Lipoprotein(a); overweight treatment guidelines; atherosclerotic cardiovascular disease<\/em><\/p>\n

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\u5fc3\u623f\u7d30\u52d5\u306b\u304a\u3051\u308b\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u6b8b\u4f59\u8133\u5352\u4e2d\u30ea\u30b9\u30af<\/strong><\/p>\n

Atherosclerosis Risk in Communities\u7814\u7a76\u304b\u3089\u306e\u672c\u5831\u544a\u306b\u3088\u308b\u3068\u3001\u5fc3\u623f\u7d30\u52d5\uff08AF\uff09\u60a3\u8005\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u304c\u865a\u8840\u6027\u8133\u5352\u4e2d\u304a\u3088\u3073\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u306e\u767a\u751f\u7387\u4e0a\u6607\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n

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\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3092\u6709\u3059\u308bAF\u60a3\u80052,154\u4f8b\u306e\u30c7\u30fc\u30bf\u304c\u8a55\u4fa1\u3055\u308c\u305f\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304b\u3089\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073\u9ad8\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u5dee\u3057\u5f15\u3044\u305f\u5024\u3068\u3057\u3066\u7b97\u51fa\u3055\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306f\u3001\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u309240%\u4ee5\u4e0a\u5897\u52a0\u3055\u305b\u305f\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd41.41\u300195%\u4fe1\u983c\u533a\u95931.02\u20131.94\u3001p=0.039\uff09\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c1\u6a19\u6e96\u504f\u5dee\u5897\u52a0\u3059\u308b\u3054\u3068\u306b\u3001\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306f11%\u9ad8\u304b\u3063\u305f\u3002\u3053\u306e\u9ad8\u30ea\u30b9\u30af\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u5834\u5408\u3067\u3082\u6301\u7d9a\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u6a19\u6e96\u7684\u306a\u6297\u51dd\u56fa\u7642\u6cd5\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u30ea\u30b9\u30af\u304c\u6301\u7d9a\u3057\u305f\u3053\u3068\u304b\u3089\u3001AF\u3092\u6709\u3059\u308b\u500b\u4eba\u306e\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u306b\u306f\u3001\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306e\u7ba1\u7406\u3001\u7279\u306b\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u304c\u91cd\u8981\u3067\u3042\u308b\u3002 <\/p>\n

Li Y, Ling Y, Wu H, et al. Association between remnant cholesterol and stroke among patients with atrial fibrillation: A population-based cohort study. J Clin Lipidol 2026; doi: 10.1016\/j.jacl.2026.02.020. <\/span><\/em><\/p>\n

Keywords: ARIC; atrial fibrillation; remnant cholesterol; stroke<\/span><\/em><\/p>\n

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\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff1aASCVD\u30ea\u30b9\u30af\u306e\u65e9\u671f\u30de\u30fc\u30ab\u30fc\u304b\uff1f<\/strong><\/p>\n

\u3053\u306e\u5927\u898f\u6a21\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u7d50\u679c\u306f\u3001\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09\u304c\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u65e9\u671f\u30de\u30fc\u30ab\u30fc\u304a\u3088\u3073\u4e88\u9632\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u3001Korean NHIS-HEALS\u30b3\u30db\u30fc\u30c8\u306e\u6210\u4eba211,881\u4f8b\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u8102\u80aa\u809d\u6307\u6570\uff08FLI \u226530\uff09\u3068\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u5b9a\u7fa9\u3055\u308c\u305fMASLD\u3068\u3001\u8840\u884c\u518d\u5efa\u3092\u4f34\u3046\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u304a\u3088\u3073\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001ACS\u304a\u3088\u3073\u8840\u884c\u518d\u5efa\u3092\u4f34\u3046MI\u3067\u3042\u3063\u305f\u3002 <\/p>\n

MASLD\u3092\u6709\u3059\u308b\u7537\u6027\u304a\u3088\u3073\u5973\u6027\u306f\u3044\u305a\u308c\u3082\u3001MASLD\u3092\u6709\u3057\u306a\u3044\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001ACS\u304a\u3088\u3073MI\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u304c\u9ad8\u304b\u3063\u305f\u3002\u8840\u884c\u518d\u5efa\u3092\u4f34\u3046ACS\u306e\u30cf\u30b6\u30fc\u30c9\u6bd4\uff0895%\u4fe1\u983c\u533a\u9593\uff09\u306f\u3001\u4e2d\u7b49\u5ea6\u30ea\u30b9\u30afMASLD\u304a\u3088\u3073\u9ad8\u30ea\u30b9\u30afMASLD\u3092\u6709\u3059\u308b\u7537\u6027\u3067\u305d\u308c\u305e\u308c1.34\uff081.16\u20131.55\uff09\u304a\u3088\u30731.35\uff081.08\u20131.68\uff09\u3067\u3042\u308a\u3001\u5973\u6027\u306e\u540c\u69d8\u306e\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u3067\u306f1.44\uff081.16\u20131.79\uff09\u304a\u3088\u30731.16\uff080.76\u20131.77\uff09\u3067\u3042\u3063\u305f\u3002\u8840\u884c\u518d\u5efa\u3092\u4f34\u3046MI\u3068\u3044\u3046\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u6240\u898b\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u95a2\u9023\u306f\u3001\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u3001\u751f\u6d3b\u7fd2\u6163\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u56e0\u5b50\u3067\u8abf\u6574\u5f8c\u3082\u6301\u7d9a\u3057\u305f\u3002\u8457\u8005\u3089\u306f\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u304cASCVD\u306e\u65e9\u671f\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306eMASLD\u3092\u652f\u6301\u3059\u308b\u3068\u8ff0\u3079\u3066\u3044\u308b\u3002 <\/p>\n

Kim M, Lee H-A, Kim J, Kang HT. Metabolic dysfunction\u2013associated steatotic liver disease and incident coronary events with revascularization: A nationwide cohort study. Atherosclerosis 2026; DOI: 10.1016\/j.atherosclerosis.2026.120698<\/em><\/p>\n

Key words: Metabolic dysfunction\u2013associated steatotic liver disease; MASLD; acute coronary syndrome<\/em><\/p>\n

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\u30a2\u30e9\u30d3\u30a2\u6e7e\u5cb8\u5730\u57df\u306b\u304a\u3051\u308b\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u77e5\u898b<\/strong><\/p>\n

Gulf Triglyceride and Residual Cardiovascular Risk\uff08Gulf CALLS\uff09\u30b3\u30db\u30fc\u30c8\u306b\u3088\u308b\u3068\u3001LDL\u2011C\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u3066\u3082\u3001non-HDL\u2011C\u76ee\u6a19\u672a\u9054\u306f\u6709\u610f\u306b\u9ad8\u3044\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n

Gulf CALLS\u30b3\u30db\u30fc\u30c8\u306f\u3001\u6e7e\u5cb85\u304b\u56fd\uff08Oman\u3001United Arab Emirates\u3001Kuwait\u3001Bahrain\u3001Qatar\uff09\u306b\u307e\u305f\u304c\u308b\u5f8c\u308d\u5411\u304d\u7814\u7a76\u3067\u3042\u308a\u300145>\u8d85\u3067\u7cd6\u5c3f\u75c5\u307e\u305f\u306f\u65e2\u5b58\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u4e2d\u306bLDL\u2011C\u5024 <1.8 mmol\/L\u304a\u3088\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024 <4.5 mmol\/L\u3067\u3042\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u5168\u4f53\u306722%\uff08521\/2344\uff09\u306e\u60a3\u8005\u304cnon-HDL\u2011C\u76ee\u6a19\uff08<2.6 mmol\/L\uff09\u3092\u9054\u6210\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002LDL\u2011C\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u60a3\u8005\uff08<1.8 mmol\/L\uff09\u306e\u3046\u3061\u300155%\u304cnon-HDL\u2011C\u76ee\u6a19\u3092\u9054\u6210\u3067\u304d\u3066\u304a\u3089\u305a\u3001\u3088\u308a\u9ad8\u3044\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6709\u3057\u3066\u3044\u305f\u3002\u5bfe\u7167\u7684\u306b\u3001non-HDL\u2011C\u76ee\u6a19\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u3067\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u304c25%\u4f4e\u304b\u3063\u305f\uff08p=0.028\uff09\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u4e0b\u3067LDL\u2011C\u5024\u304c\u826f\u597d\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u3066\u3082\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u304a\u3088\u3073non-HDL\u2011C\u304c\u91cd\u8981\u306a\u30ea\u30b9\u30af\u3068\u3057\u3066\u6b8b\u308b\u3053\u3068\u3092\u88dc\u5f37\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u3053\u306e\u5730\u57df\u306b\u304a\u3051\u308b\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u306b\u306f\u3001LDL\u2011C\u3092\u8d85\u3048\u305f\u3088\u308a\u5f37\u529b\u306a\u8102\u8cea\u7ba1\u7406\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002<\/p>\n

Al Mahmeed W, Al Kindi M, Al-Sarraf A, et al. Residual cardiovascular risk associated with non-HDL-C in statin-treated patients: data from the Gulf Triglyceride and Residual Cardiovascular Risk (Gulf CALLS) Cohort. Angiology 2026; doi: 10.1177\/00033197261422789.<\/em><\/p>\n

Keywords: Arabian Gulf; LDL-cholesterol; cardiovascular diseases; diabetes mellitus; residual risk; triglycerides.<\/em><\/p>\n

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\u6b8b\u4f59\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u30ea\u30dd\u86cb\u767d(a)\u3068\u708e\u75c7\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3059\u308b<\/strong><\/p>\n

\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\uff3bLp(a)\uff3d\u304a\u3088\u3073\u708e\u75c7\u306f\u3001\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\u3002Lp(a)\u9ad8\u5024\u306f\u8840\u7ba1\u708e\u75c7\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u30892\u3064\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u540c\u6642\u306b\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u8ffd\u52a0\u7684\u306a\u81e8\u5e8a\u7684\u6709\u76ca\u6027\u304c\u5f97\u3089\u308c\u308b\u304b\u3069\u3046\u304b\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u672c\u7814\u7a76\u306f\u3001Lp(a)\u304a\u3088\u3073IL-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u306e\u52b9\u679c\u3092\u6a21\u5023\u3059\u308b\u305f\u3081\u306b\u3001LPA\u304a\u3088\u3073\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff08IL-6\uff09\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306b\u95a2\u3059\u308b\u907a\u4f1d\u7684\u30b9\u30b3\u30a2\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u306b\u306f\u3001UK Biobank\u304b\u3089408,687\u4eba\u306e\u500b\u4eba\uff08\u5e73\u5747\u5e74\u9f6257\u6b73\u3001\u5973\u602754%\uff09\u304c\u542b\u307e\u308c\u305f\u3002\u907a\u4f1d\u7684\u306b\u4e88\u6e2c\u3055\u308c\u305fLp(a)\u306e\u4f4e\u5024\u306f\u3001\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u304a\u3088\u3073\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002Lp(a)\u304c50mg\/dL\u4f4e\u3044\u3054\u3068\u306b\u3001CHD\u30ea\u30b9\u30af\u306e32%\u4f4e\u4e0b\uff08\u30aa\u30c3\u30ba\u6bd40.68\u300195%\u4fe1\u983c\u533a\u9593[CI] 0.65-0.71\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306e11%\u4f4e\u4e0b\uff08\u30aa\u30c3\u30ba\u6bd40.89\u300195%CI 0.80-0.98\uff09\u3001\u304a\u3088\u3073PAD\u30ea\u30b9\u30af\u306e32%\u4f4e\u4e0b\uff08\u30aa\u30c3\u30ba\u6bd40.68\u300195%CI 0.62-0.76\uff09\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u307e\u305f\u3001\u4e88\u6e2c\u3055\u308c\u308bIL-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u306e\u4f4e\u5024\u3082\u3001CHD\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u5bfe\u6570\u5909\u63db\u3057\u305fC\u53cd\u5fdc\u6027\u86cb\u767d\u5024\u306e0.5log mg\/L\u4f4e\u4e0b\u3042\u305f\u308a\u306e\u30aa\u30c3\u30ba\u6bd40.67\u300195%CI 0.55-0.82\uff09\u3002\u907a\u4f1d\u7684\u306b\u4e88\u6e2c\u3055\u308c\u305f\u4f4eLp(a)\u304a\u3088\u3073\u4f4eIL-6\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u3078\u306e\u8907\u5408\u7684\u306a\u66dd\u9732\u306f\u3001CHD\u30ea\u30b9\u30af\u306e\u76f8\u52a0\u7684\u306a\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u89b3\u5bdf\u30c7\u30fc\u30bf\u306b\u57fa\u3065\u304f\u500b\u5225\u306e\u89e3\u6790\u3082\u3053\u308c\u3092\u652f\u6301\u3057\u3066\u304a\u308a\u3001\u4e2d\u592e\u5024\u672a\u6e80\u306eIL-6\u5024\u306850mg\/dL\u672a\u6e80\u306eLp(a)\u6fc3\u5ea6\u304c\u3001\u72ec\u7acb\u3057\u3066\u76f8\u52a0\u7684\u306b\u4f4e\u3044CHD\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002 <\/span><\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001\u672c\u7814\u7a76\u304b\u3089\u306e\u91cd\u8981\u306a\u30e1\u30c3\u30bb\u30fc\u30b8\u306f\u3001\u4e0a\u6607\u3057\u305fLp(a)\u3068\u708e\u75c7\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u76f8\u52a0\u7684\u306b\u6e1b\u5c11\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306e\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6226\u7565\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u305f\u3060\u3057\u3001\u907a\u4f1d\u7684\u306b\u6c7a\u5b9a\u3055\u308c\u305fLp(a)\u304a\u3088\u3073IL-6\u306e\u4f4e\u3044\u968e\u5c64\u306f\u751f\u6daf\u306b\u308f\u305f\u308b\u66dd\u9732\u3092\u53cd\u6620\u3057\u3066\u304a\u308a\u3001\u305d\u306e\u5f8c\u306e\u4eba\u751f\u306b\u304a\u3051\u308b\u6cbb\u7642\u7684\u8abf\u7bc0\u3092\u53cd\u6620\u3059\u308b\u3082\u306e\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u6761\u4ef6\u304c\u3064\u304f\u3002<\/span><\/p>\n

Xiang B, Zhang R, Zhou Y, et al. Genetic variants lowering lipoprotein(a) and downregulating interleukin-6 signalling are additively associated with a decreased risk of cardiovascular disease. Eur J Prev Cardiol 2026; doi: 10.1093\/eurjpc\/zwag090. <\/span><\/em><\/p>\n

Key words: Lipoprotein(a); interleukin-6; inflammation; residual cardiovascular risk; UK Biobank<\/span><\/em><\/p>\n

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PCI\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u3044\u6b8b\u4f59\u708e\u75c7\u30ea\u30b9\u30af<\/strong><\/p>\n

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Romeo FJ, Golino M, Morello M, et al. Residual inflammatory risk and clinical outcomes after contemporary percutaneous coronary intervention: a systematic review and meta-analysis. Sci Rep 2026; doi.org\/10.1038\/s41598-026-39691-1. <\/span><\/em><\/p>\n

Key words: Residual inflammatory risk; percutaneous coronary intervention; MACE<\/span><\/em><\/p>\n

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\u672b\u68a2\u52d5\u8108\u75be\u60a3\u306b\u304a\u3051\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9<\/strong><\/p>\n

\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u8840\u7ba1\u75be\u60a3\u306e\u4e00\u822c\u7684\u3067\u8870\u5f31\u6027\u306e\u9ad8\u3044\u30bf\u30a4\u30d7\u3067\u3042\u308b\u3002\u73fe\u5728\u3001\u4e16\u754c\u4e2d\u30672\u51043\u5343\u4e07\u4eba\u4ee5\u4e0a\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u304a\u308a\u3001\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u3084\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u75be\u60a3\u306e\u8ca0\u62c5\u5897\u5927\u306b\u3088\u308a\u3001PAD\u306e\u6709\u75c5\u7387\u306f\u5897\u52a0\u3059\u308b\u3068\u4e88\u60f3\u3055\u308c\u3066\u3044\u308b\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306a\u3069\u306e\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u5229\u70b9\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001STRIDE\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306b\u3088\u308b\u6cbb\u7642\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306e\u6b69\u884c\u80fd\u529b\u304a\u3088\u3073\u8840\u884c\u52d5\u614b\u30d1\u30e9\u30e1\u30fc\u30bf\u30fc\u3092\u6539\u5584\u3057\u3001PAD\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u305f\u3002 <\/p>\n

\u3053\u306e\u7cfb\u7d71\u7684\u30ec\u30d3\u30e5\u30fc\u304a\u3088\u3073\u30e1\u30bf\u89e3\u6790\u306f\u300119\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u5bfe\u7167\u8a66\u9a13\u306b\u542b\u307e\u308c\u305f2\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\/\u307e\u305f\u306f\u904e\u4f53\u91cd\u3082\u3057\u304f\u306f\u80a5\u6e80\u306e51,557\u4eba\u306e\u500b\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u56db\u80a2\u306e\u6709\u5bb3\u4e8b\u8c61\u306b\u5bfe\u3059\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3057\u305f\u3002\u4e8b\u524d\u306b\u6307\u5b9a\u3055\u308c\u305f\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u8840\u884c\u518d\u5efa\u8853\u3001\u5207\u65ad\u3001\u304a\u3088\u3073PAD\u306e\u9032\u884c\u3068\u3057\u3066\u5b9a\u7fa9\u3055\u308c\u308b\u56db\u80a2\u306e\u4e3b\u8981\u4e8b\u8c61\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u5bfe\u7167\u4ecb\u5165\u3068\u6bd4\u8f03\u3057\u3066\u3001\u56db\u80a2\u306e\u4e3b\u8981\u4e8b\u8c61\u306e\u30ea\u30b9\u30af\u306e30%\u306e\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u30aa\u30c3\u30ba\u6bd40.70\u300195%\u4fe1\u983c\u533a\u9593[CI] 0.60-0.82\u3001p < 0.0001\uff09\u3002\u7cd6\u5c3f\u75c5\u60a3\u8005\uff080.70\u300195%CI 0.57-0.87\u3001p = 0.001\uff09\u307e\u305f\u306f\u80a5\u6e80\u60a3\u8005\uff080.71\u300195%CI 0.56-0.89\u3001p = 0.003\uff09\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u5229\u76ca\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306e\u65e2\u77e5\u306e\u5fc3\u8840\u7ba1\u304a\u3088\u3073\u814e\u81d3\u3078\u306e\u5229\u76ca\u3092\u3001\u56db\u80a2\u3092\u8105\u304b\u3059\u5408\u4f75\u75c7\u306e\u4e88\u9632\u306b\u307e\u3067\u62e1\u5927\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u3001\u591a\u69d8\u306a\u96c6\u56e3\u304a\u3088\u3073\u6cbb\u7642\u74b0\u5883\u306b\u308f\u305f\u3063\u3066\u56db\u80a2\u306e\u4e3b\u8981\u4e8b\u8c61\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u56db\u80a2\u306b\u95a2\u9023\u3059\u308b\u8840\u7ba1\u306e\u5b89\u5168\u6027\u306b\u5bfe\u3059\u308b\u6f5c\u5728\u7684\u306a\u4fdd\u8b77\u52b9\u679c\u3092\u652f\u6301\u3057\u3066\u3044\u308b\u3002 <\/p>\n

Cesaro A, Acerbo V , Longo M, et al. Impact of semaglutide on limb events: a meta-analysis of randomized controlled trials. Eur J Prevent Cardiol 2026; doi: 10.1093\/eurjpc\/zwag077. <\/em><\/p>\n

Key words: Semaglutide; glucagon-like peptide-1 receptor agonists; peripheral artery disease-<\/em><\/p>\n

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\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\u306b\u304a\u3051\u308b\u30d9\u30f3\u30da\u30c9\u9178<\/strong><\/p>\n

\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff09\u3092\u6709\u3059\u308b\u500b\u4eba\u306f\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u809d\u8102\u80aa\u75c7\u3001\u809d\u81d3\u306e\u708e\u75c7\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u809d\u708e\uff1bMASH\uff09\u304a\u3088\u3073\u809d\u7dda\u7dad\u5316\u306f\u3001\u75be\u60a3\u306e\u9032\u884c\u3092\u793a\u3059\u6307\u6a19\u3067\u3059\u3002
\u3057\u305f\u304c\u3063\u3066\u3001\u975e\u4fb5\u8972\u7684\u691c\u67fb\u3092\u7528\u3044\u3066\u809d\u8102\u80aa\u75c7\u307e\u305f\u306f\u7dda\u7dad\u5316\u3092\u65e9\u671f\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u306f\u3001\u809d\u81d3\u95a2\u9023\u306e\u81e8\u5e8a\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u4e88\u6e2c\u3001\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u304a\u3044\u3066\u610f\u7fa9\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u306f\u3001CLEAR Outcomes\u8a66\u9a13\uff08Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen\uff09\u306e\u4e8b\u5f8c\u89e3\u6790\u3067\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u8a55\u4fa1\u3055\u308c\u305f\u691c\u67fb\u306f\u3001Framingham Steatosis Index\uff08FSI\uff09\u3001Fibrosis-4 index\uff08FIB-4\uff09\u3001\u304a\u3088\u3073NAFLD fibrosis score\uff08NFS\uff09\u3067\u3042\u3063\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3001\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u6b7b\u3092\u542b\u30804\u8981\u7d20\u304b\u3089\u306a\u308b\u4e3b\u8981\u5fc3\u8840\u7ba1\u6709\u5bb3\u4e8b\u8c61\uff08MACE\uff09\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u4ed6\u306e\u5371\u967a\u56e0\u5b50\u3067\u8abf\u6574\u3057\u305f\u5834\u5408\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u304a\u3044\u3066\u809d\u8102\u80aa\u5316\u306fMACE\u306e\u767a\u751f\u7387\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001FSI\u304c1\u5358\u4f4d\u5897\u52a0\u3059\u308b\u3054\u3068\u306b\u30ea\u30b9\u30af\u304c13%\u5897\u52a0\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.13\u300195%\u4fe1\u983c\u533a\u9593[CI] 1.08-1.18\uff09\u3002\u3055\u3089\u306b\u3001\u809d\u7dda\u7dad\u5316\u306fMACE\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\uff08FIB-4\u30b9\u30b3\u30a2\u306e1\u5358\u4f4d\u5897\u52a0\u3042\u305f\u308a\u30cf\u30b6\u30fc\u30c9\u6bd41.21\u300195%CI 1.09-1.34\u3001\u304a\u3088\u3073NFS\u30b9\u30b3\u30a2\u306e1\u5358\u4f4d\u5897\u52a0\u3042\u305f\u308a1.16\u300195%CI 1.10-1.23\uff09\u3002 <\/span><\/p>\n

\u30d9\u30f3\u30da\u30c9\u9178\u306b\u3088\u308b\u6cbb\u7642\u306fMACE\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u809d\u8102\u80aa\u5316\u30b9\u30b3\u30a2\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u6700\u5927\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002\u8457\u8005\u3089\u306f\u3001\u3053\u306e\u89e3\u6790\u306e\u63a2\u7d22\u7684\u306a\u4e8b\u5f8c\u30c7\u30b6\u30a4\u30f3\u3001\u304a\u3088\u3073\u75be\u60a3\u306e\u6bb5\u968e\u3092\u78ba\u7acb\u3059\u308b\u305f\u3081\u306e\u753b\u50cf\u307e\u305f\u306f\u7d44\u7e54\u5b66\u7684\u30c7\u30fc\u30bf\u306e\u6b20\u5982\u306b\u3088\u308b\u9650\u754c\u3092\u8a8d\u3081\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5f7c\u3089\u306e\u77e5\u898b\u306f\u3001\u8102\u80aa\u5316\u304a\u3088\u3073\u7dda\u7dad\u5316\u306e\u975e\u4fb5\u8972\u7684\u691c\u67fb\u304c\u3001\u4e88\u9632\u7684\u6cbb\u7642\u306e\u5f37\u5316\u3092\u5fc5\u8981\u3068\u3059\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u6700\u3082\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

de Jong VD, Nissen SE, Sasiela WJ, et al. Effect of bempedoic acid on cardiovascular risk in patients with metabolic dysfunction-associated steatotic liver disease. Eur J Prev Cardiol 2026; doi: 10.1093\/eurjpc\/zwag102. <\/span><\/em><\/p>\n

Key words: Metabolic dysfunction-associated steatotic liver disease; MASLD; steatosis; fibrosis; cardiovascular risk; CLEAR-Outcomes trial<\/span><\/em><\/p>\n

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\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u60a3\u8005\u306b\u304a\u3044\u3066\u6709\u52b9\u6027\u3092\u793a\u3059<\/span><\/strong><\/p>\n

\u3053\u306e\u7b2c3\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3092\u4f34\u3046\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u60a3\u8005\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u6cbb\u7642\u4e0a\u306e\u9078\u629e\u80a2\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u306b\u306f\u3001\u5408\u8a0871\u4f8b\u306e\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u60a3\u8005\uff08\u5e74\u9f62\u4e2d\u592e\u502464\u6b73\u3001\u5973\u602771.8%\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u6295\u4e0e\u4e2d22.5%\uff09\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u30ea\u30b9\u30af\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u5fdc\u3058\u305f\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u3066\u304a\u3089\u305a\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306f\u6b63\u5e38\u57fa\u6e96\u7bc4\u56f2\u5185\u3067\u3057\u305f\uff08\u7a7a\u8179\u6642<1.67 mmol\/L\u3001\u307e\u305f\u306f\u975e\u7a7a\u8179\u6642<1.98 mmol\/L\uff09\u3002
\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u306f\u3001\u5c11\u306a\u304f\u3068\u30821\u7a2e\u985e\u306e\u30b9\u30bf\u30c1\u30f3\u3067\u5b89\u5168\u6027\u4e0a\u306e\u554f\u984c\u304c\u767a\u751f\u3057\u3001\u6cbb\u7642\u4e2d\u6b62\u307e\u305f\u306f\u7528\u91cf\u6e1b\u91cf\u306b\u81f3\u3063\u305f\u5834\u5408\u3068\u5b9a\u7fa9\u3055\u308c\u307e\u3057\u305f\u3002
\u60a3\u8005\u306f\u3001\u5f90\u653e\u6027\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c80.2 mg\/\u65e5\u7fa4\uff08n=23\uff09\u30010.4 mg\/\u65e5\u7fa4\uff08n=24\uff09\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n=24\uff09\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002 \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308912\u9031\u6642\u70b9\uff08\u6cbb\u7642\u7d42\u4e86\u6642\uff09\u307e\u3067\u306e\u7b97\u51faLDL-C\u306e\u5909\u5316\u7387\u3067\u3057\u305f\u3002 <\/span><\/p>\n

12\u9031\u5f8c\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089LDL-C\u5024\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u307e\u3057\u305f\uff08\u6700\u5c0f\u4e8c\u4e57\u5e73\u5747\uff3b95%\u4fe1\u983c\u533a\u9593\uff3d\uff1a0.2 mg\/\u65e5\u7fa4\u3067\u221220.0%\uff3b\u221224.1\u301c\u221215.9\uff3d\u30010.4 mg\/\u65e5\u7fa4\u3067\u221224.8%\uff3b\u221228.8\u301c\u221220.9\uff3d\uff09\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u22120.4%\uff3b\u22124.2\u301c3.5\uff3d\u3067\u3057\u305f\u3002
\u307e\u305f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6cbb\u7642\u306b\u3088\u308a\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaB\u5024\u3082\u4f4e\u4e0b\u3057\u30010.2 mg\/\u65e5\u7fa4\u3067\u221218.2%\u30010.4 mg\/\u65e5\u7fa4\u3067\u221220.6%\u3067\u3057\u305f\uff08\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u3066p<0.001\uff09\u3002 \u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u4f75\u7528\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u540c\u69d8\u306b\u6709\u52b9\u3067\u3042\u308a\u3001\u6982\u3057\u3066\u5fcd\u5bb9\u6027\u306f\u826f\u597d\u3067\u3057\u305f\u3002 <\/span><\/p>\n

\u8981\u7d04\u3059\u308b\u3068\u3001\u3053\u306e\u5c0f\u898f\u6a21\u306a\u7b2c3\u76f8\u8a66\u9a13\u306e\u77e5\u898b\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u5bb9\u306b\u95a2\u9023\u3059\u308b\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306b\u304a\u3044\u3066\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u7ba1\u7406\u304c\u56f0\u96e3\u306a\u60a3\u8005\u30b0\u30eb\u30fc\u30d7\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

Yamashita S, ArakiE, Arai H, et al. Efficacy for LDL-C\u2013lowering and safety of pemafibrate extended-release formulation in patients with statin-intolerant hypercholesterolemia: a Phase 3 multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. J Clin Lipidol 2026; doi.org\/10.1016\/j.jacl.2026.01.008 <\/span><\/em><\/p>\n

Key words: Pemafibrate; statin-intolerance; selective PPAR\u03b1 modulator<\/span><\/em><\/p>\n

<\/span><\/p>\n

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[\/et_pb_text][et_pb_button button_url=”https:\/\/www.lipidjournal.com\/article\/S1933-2874(26)00014-0\/fulltext&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”10px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_padding=”||0px|||” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)<\/span><\/strong><\/p>\n

\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\uff3bLp(a)\uff3d\u306f\u3001\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u72ec\u7acb\u3057\u305f\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u5e83\u304f\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u3057\u304b\u3057\u3001Lp(a)\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3067\u3001\u73fe\u5728\u306e\u4e88\u6e2c\u30e2\u30c7\u30eb\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u5f93\u6765\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u8d85\u3048\u3066\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u5c64\u5225\u5316\u304c\u6539\u5584\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u3001\u307e\u305f\u305d\u306e\u4e88\u5f8c\u7684\u4fa1\u5024\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u7a0b\u5ea6\u306b\u3088\u3063\u3066\u7570\u306a\u308b\u304b\u3069\u3046\u304b\u306f\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u3053\u306e\u89e3\u6790\u3067\u306f\u3001\u6b7b\u4ea1\u8ffd\u8de1\u30c7\u30fc\u30bf\u304c2019\u5e74\u307e\u3067\u5229\u7528\u53ef\u80fd\u306a\u7b2c3\u56de\u7c73\u56fd\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08NHANES III\u30011988\u301c1994\u5e74\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u3053\u308c\u3089\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u300155,050,155\u4ef6\uff08\u91cd\u307f\u4ed8\u3051\u306a\u30574,707\u4ef6\uff09\u306e\u8abf\u67fb\u8a18\u9332\u306e\u30c7\u30fc\u30bf\u304c\u8a55\u4fa1\u3055\u308c\u3001\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u4f4e\u30ea\u30b9\u30af\u7fa4\uff08N=4,052,849\uff09\u3001\u5883\u754c\u57df\u4e2d\u9593\u7fa4\uff08N=22,670,568\uff09\u3001\u9ad8\u30ea\u30b9\u30af\u7fa4\uff08N=28,326,737\uff09\u306b\u5c64\u5225\u5316\u3057\u305f\u6210\u4eba\u3092\u8868\u3057\u3066\u3044\u305f\u3002\u5e73\u5747\u8ffd\u8de1\u671f\u959322.4\u5e74\u306e\u9593\u306b\u300117,301,805\u4eba\u306e\u5168\u6b7b\u56e0\u6b7b\u4ea1\u30684,965,456\u4eba\u306e\u5fc3\u8840\u7ba1\u6b7b\u304c\u3042\u3063\u305f\u3002Lp(a)\u9ad8\u5024\u306f\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3001\u7279\u306b\u9ad8\u30ea\u30b9\u30af\u8005\u306b\u304a\u3044\u3066\u3001\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u6b7b\u4ea1\u7387\u306e\u5897\u52a0\u3068\u6709\u610f\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001Lp(a)>75mg\/dL\u306e\u4eba\u306f\u3001\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c25\uff05\u9ad8\u304f\u3001\u5fc3\u8840\u7ba1\u6b7b\u306e\u30ea\u30b9\u30af\u304c21\uff05\u9ad8\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u95a2\u9023\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u30ec\u30d9\u30eb\u306b\u95a2\u4fc2\u306a\u304f\u8a8d\u3081\u3089\u308c\u305f\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001Lp(a)\u6e2c\u5b9a\u3092\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u3001\u7279\u306b\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306b\u5bfe\u3057\u3066\u884c\u3046\u3053\u3068\u304c\u652f\u6301\u3055\u308c\u308b\u3002<\/span><\/p>\n

Al-jarshawi M, Chew N, Bonaca MP, et al. \u4f1d\u7d71\u7684\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9023\u7d9a\u4f53\u306b\u308f\u305f\u308b\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u306b\u5bfe\u3059\u308b\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u4ed8\u52a0\u7684\u4e88\u5f8c\u4e88\u6e2c\u5024\uff1aNHANES III\uff081988-1994\uff09\u306e\u89e3\u6790\u30682019\u5e74\u307e\u3067\u306e\u8ffd\u8de1\u3002Eur J Prev Cardiol 2026; doi: 10.1093\/eurjpc\/zwag037. <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff1b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u8a55\u4fa1\uff1b\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\uff1b\u5168\u6b7b\u4ea1\u7387<\/span><\/em><\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/academic.oup.com\/eurjpc\/advance-article\/doi\/10.1093\/eurjpc\/zwag037\/8426533&#8243<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”10px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_padding=”||0px|||” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

DA VINCI\uff1a\u8102\u8cea\u76ee\u6a19\u9054\u6210\u6539\u5584\u306e\u305f\u3081\u306b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u6a19\u7684\u3068\u3059\u308b<\/span><\/strong><\/p>\n

DA VINCI\u7814\u7a76\u306e\u65b0\u305f\u306a\u89e3\u6790\u306f\u3001\u975e\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb(non-HDL-C)\u76ee\u6a19\u306e\u9054\u6210\u7387\u3092\u5411\u4e0a\u3055\u305b\u308b\u305f\u3081\u306e\u512a\u5148\u4e8b\u9805\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9(TG)\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306b\u6539\u3081\u3066\u91cd\u70b9\u3092\u7f6e\u304f\u3053\u3068\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u3002Non-HDL-C\u306f\u3001TG\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3084\u30ea\u30dd\u86cb\u767d(a)\u3092\u542b\u3080\u3059\u3079\u3066\u306e\u52d5\u8108\u786c\u5316\u60f9\u8d77\u6027\u30ea\u30dd\u86cb\u767d\u306b\u3088\u3063\u3066\u904b\u3070\u308c\u308b\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u53cd\u6620\u3057\u3001\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb(LDL-C)\u3088\u308a\u3082\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u5f37\u529b\u306a\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002 <\/span><\/p>\n

\u305d\u306e\u7d50\u679c\u3001non-HDL-C\u306f\u3001LDL-C\u30ec\u30d9\u30eb\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u500b\u4eba\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u4e8c\u6b21\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u3002 <\/span><\/p>\n

DA VINCI\u306f\u3001\u6b27\u5dde18\u304b\u56fd\u3067\u5b9f\u65bd\u3055\u308c\u305f\u6a2a\u65ad\u7684\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308a\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u6210\u4eba5,888\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u3001\u4e00\u6b21\u4e88\u9632\u304a\u3088\u3073\u4e8c\u6b21\u4e88\u9632\u306e\u60a3\u8005\u6570\u306f\u307b\u307c\u540c\u7a0b\u5ea6\u3067\u3057\u305f\u3002
\u4eca\u56de\u306e\u6700\u65b0\u89e3\u6790\u3067\u306f\u3001\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\uff08ESC\uff09\u306e\u30ea\u30b9\u30af\u306b\u57fa\u3065\u304f2016\u5e74\u304a\u3088\u30732019\u5e74\u306e\u76ee\u6a19\u5024\u306b\u5f93\u3044\u3001non-HDL-C\u76ee\u6a19\u9054\u6210\u7387\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002
\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e59%\u304c2016\u5e74\u306e\u30ea\u30b9\u30af\u306b\u57fa\u3065\u304fnon-HDL-C\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u30012019\u5e74\u306e\u30ea\u30b9\u30af\u306b\u57fa\u3065\u304f\u76ee\u6a19\u5024\u3092\u5f8c\u308d\u5411\u304d\u306b\u9069\u7528\u3059\u308b\u3068\u9054\u6210\u7387\u306f\u3055\u3089\u306b\u4f4e\u304f\u3001non-HDL-C\u76ee\u6a19\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u306f\u308f\u305a\u304b40%\u3067\u3057\u305f\u3002
\u3055\u3089\u306b\u3001non-HDL-C\u76ee\u6a19\u9054\u6210\u7387\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3067\u3088\u308a\u4f4e\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002 non-HDL-C\u76ee\u6a19\u9054\u6210\u7387\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306e\u4e3b\u306a\u512a\u5148\u4e8b\u9805\u3068\u3057\u3066\u3001\u8457\u8005\u3089\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3088\u308a\u9069\u5207\u306b\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3001\u304a\u3088\u3073\u8102\u8cea\u4f4e\u4e0b\u4f75\u7528\u7642\u6cd5\u3092\u3088\u308a\u5e83\u304f\u4f7f\u7528\u3059\u308b\u3053\u3068\u3092\u63a8\u5968\u3057\u307e\u3057\u305f\u3002 <\/span><\/p>\n

Arif A, Karungi I, Stevens CAT, et al. Attainment of non-high-density lipoprotein cholesterol targets in secondary and primary care: A secondary-analysis of the DA VINCI study. Atherosclerosis 2026; doi.org\/10.1016\/j.atherosclerosis.2026.120644<\/span><\/em><\/p>\n

Key words: Goal attainment; non-HDL-C; Triglyceride-rich lipoproteins; DA VINCI<\/span><\/em><\/p>\n

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2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u52d5\u8108\u786c\u5316\u3068ANGPTL8\u306e\u95a2\u9023<\/span><\/strong><\/p>\n

\u65b0\u305f\u306a\u30c7\u30fc\u30bf\u306f\u3001ANGPTL8\uff08\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea8\uff09\u304c\u8102\u8cea\u4ee3\u8b1d\u3068\u708e\u75c7\u306e\u65b0\u898f\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u308a\u3001\u4ee3\u8b1d\u8abf\u7bc0\u7570\u5e38\u3068\u8840\u7ba1\u75c5\u7406\u306b\u304a\u3044\u3066\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u4e2d\u56fd\u306e\u7814\u7a76\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u5faa\u74b0ANGPTL8\u30ec\u30d9\u30eb\u3068\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u3068\u306e\u72ec\u7acb\u3057\u305f\u95a2\u9023\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002\u3053\u306e\u30de\u30c3\u30c1\u30c9\u30b1\u30fc\u30b9\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7814\u7a76\u306b\u306f\u3001202\u540d\u306e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\uff08\u52d5\u8108\u786c\u5316\u3042\u308a\u304a\u3088\u3073\u306a\u3057\uff09\u304c\u542b\u307e\u308c\u305f\u3002 <\/span><\/p>\n

\u52d5\u8108\u786c\u5316\u306f\u9838\u52d5\u8108\u5185\u819c\u4e2d\u819c\u8907\u5408\u4f53\u539a\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3055\u308c\u3001\u91cd\u75c7\u5ea6\u306f\u7dcf\u30d7\u30e9\u30fc\u30af\u30b9\u30b3\u30a2\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3055\u308c\u305f\u3002\u52d5\u8108\u786c\u5316\u3092\u6709\u3059\u308b\u60a3\u8005\u306f\u3001\u5faa\u74b0ANGPTL8\u30ec\u30d9\u30eb\u304c\u6709\u610f\u306b\u9ad8\u304f(p=0.027)\u3001ANGPTL8\u306e\u6700\u9ad8\u56db\u5206\u4f4d\u7fa4\u306e\u60a3\u8005\u306f\u3001\u6700\u4f4e\u56db\u5206\u4f4d\u7fa4\u306e\u500b\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u304c3.71\u500d\u5897\u52a0\u3057\u305f(p=0.004)\u3002\u3053\u306e\u95a2\u9023\u306f\u3001\u5f93\u6765\u306e\u8102\u8cea\u4ee3\u8b1d\u7d4c\u8def\u3067\u306f\u306a\u304f\u3001\u30b7\u30b9\u30bf\u30c1\u30f3C\u95a2\u9023\u708e\u75c7\u7d4c\u8def\u3092\u4ecb\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u8457\u8005\u3089\u306f\u3053\u308c\u3089\u306e\u77e5\u898b\u306b\u57fa\u3065\u304d\u3001ANGPTL8\u30922\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u5c64\u5225\u5316\u306e\u305f\u3081\u306e\u65b0\u898f\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u5f37\u8abf\u3057\u3001\u8102\u8cea\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u6226\u7565\u3092\u8d85\u3048\u3066\u9ad8\u3044\u5fc3\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u6a19\u7684\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

Ye H, Zhu Q, Zong Q, et al. Elevated ANGPTL8 (Angiopoietin-\u00ad Like Protein 8) levels as a novel predictor of atherosclerosis in type 2 diabetes: Beyond lipid metabolism. J Am Heart Assoc 2026;15:e044806.<\/span><\/em><\/p>\n

Key words: ANGPTL8; Angiopoietin-Like Protein 8; Type 2 diabetes; Residual cardiovascular risk<\/span><\/em><\/p>\n

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\u30cb\u30e5\u30fc\u30b9\u306b\u306a\u3063\u305f\u65b0\u898f\u6cbb\u7642\u6cd5<\/span><\/strong><\/p>\n

TLC-2716\uff1a\u7d4c\u53e3\u809d\u81d3\u7279\u7570\u7684LXR\u30a4\u30f3\u30d0\u30fc\u30b9\u30a2\u30b4\u30cb\u30b9\u30c8 <\/span><\/em><\/p>\n

\u521d\u671f\u306e\u81e8\u5e8a\u6240\u898b\u306f\u3001\u8102\u8cea\u7570\u5e38\u75c7\u7ba1\u7406\u306e\u305f\u3081\u306e\u7d4c\u53e3\u6295\u4e0e\u53ef\u80fd\u306a\u8178\u304a\u3088\u3073\u809d\u81d3\u7279\u7570\u7684\u809dX\u53d7\u5bb9\u4f53(LXR)\u30a4\u30f3\u30d0\u30fc\u30b9\u30a2\u30b4\u30cb\u30b9\u30c8\u3067\u3042\u308bTLC-2716\u306e\u6709\u671b\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002LXR\u306e\u6291\u5236\u306f\u3001de novo\u8102\u80aa\u751f\u6210\u304a\u3088\u3073\u8178\u7ba1\u8102\u8cea\u5438\u53ce\u3092\u6291\u5236\u3057\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9(TG)\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u4fc3\u9032\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3057\u304b\u3057\u3001\u5168\u8eab\u6027\u306eLXR\u6291\u5236\u304c\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9006\u8ee2\u9001\u3092\u640d\u306a\u3046\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u61f8\u5ff5\u304b\u3089\u3001\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u8ffd\u6c42\u306f\u63a7\u3048\u3089\u308c\u3066\u304d\u305f\u3002TLC-2716\u306e\u958b\u767a\u306f\u3053\u306e\u554f\u984c\u3092\u56de\u907f\u3057\u305f\u3002\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3067\u306f\u3001TLC-2716\u306e14\u65e5\u9593\u306e\u6295\u4e0e\u306f\u5fcd\u5bb9\u6027\u304c\u826f\u597d\u3067\u3042\u308a\u3001\u8840\u6f3fTG\u3092\u6700\u592738.5%\u3001\u98df\u5f8c\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6700\u592761%\u4f4e\u4e0b\u3055\u305b\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u306e\u85ac\u5264\u306e\u3055\u3089\u306a\u308b\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u308b(ClinicalTrials.gov identifier: NCT05483998)\u3002 <\/span><\/p>\n

Li X, Benegiamo G, Vijayakumar A, et al. An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial. Nat Med 2026; doi: 10.1038\/s41591-025-04169-6. <\/span><\/em><\/p>\n

Key words: Residual risk; Liver X receptor; Phase I trial; Triglycerides; Remnant cholesterol<\/span><\/em><\/p>\n

<\/span><\/span><\/em><\/p>\n

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SHR-1918\uff1a\u30db\u30e2\u63a5\u5408\u4f53\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306b\u5bfe\u3059\u308b\u3082\u3046\u4e00\u3064\u306eANGPTL3\u6297\u4f53<\/span><\/em><\/p>\n

ANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306f\u3001\u30db\u30e2\u63a5\u5408\u4f53\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7(HoFH)\u3092\u7279\u5fb4\u3065\u3051\u308b\u975e\u5e38\u306b\u9ad8\u3044\u30ec\u30d9\u30eb\u306e\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb(LDL-C)\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u5831\u544a\u3067\u306f\u3001\u4e2d\u56fd\u306e8\u65bd\u8a2d\u306726\u540d\u306eHoFH\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u591a\u65bd\u8a2d\u5358\u7fa4\u7b2c2\u76f8\u975e\u7121\u4f5c\u70ba\u5316\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u8ad6\u3058\u3066\u3044\u308b\u3002\u65b0\u898fANGPTL3\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308bSHR-1918\u304c\u3001600 mg\u306e\u7528\u91cf\u30674\u9031\u9593\u3054\u3068\u306b12\u9031\u9593\u76ae\u4e0b\u6295\u4e0e\u3055\u308c\u3001\u305d\u306e\u5f8c8\u9031\u9593\u306e\u8ffd\u8de1\u8abf\u67fb\u304c\u884c\u308f\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306b\u304a\u3044\u3066\u3001\u5b89\u5b9a\u3057\u305f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u4e0b\u3067\u306e\u5e73\u5747\uff08\u6a19\u6e96\u504f\u5dee\u3001SD\uff09LDL-C\u306f433.59 (173.74) mg\/dL\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u3001\u5b89\u5b9a\u3057\u305f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u4e0b\u3067\u306e\u5e73\u5747LDL-C\uff08\u6a19\u6e96\u504f\u5dee\u3001SD\uff09\u306f433.59\uff08173.74\uff09mg\/dL\u3067\u3057\u305f\u3002SHR-1918\u306b\u3088\u308b12\u9031\u9593\u306e\u6cbb\u7642\u306b\u3088\u308a\u3001LDL-C\u306f\u5e73\u574759%\u4f4e\u4e0b\u3057\u3001\u305d\u306e\u52b9\u679c\u306f\u8ffd\u8de1\u671f\u9593\u3092\u901a\u3058\u3066\u6301\u7d9a\u3057\u307e\u3057\u305f\u3002 SHR-1918\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u826f\u597d\u3067\u3042\u308a\u3001HoFH\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3055\u3089\u306a\u308b\u691c\u8a0e\u3092\u652f\u6301\u3059\u308b\u7d50\u679c\u3067\u3057\u305f\u3002 <\/span><\/p>\n

Peng D, Wang L, Pin L, et al. Anti-ANGPTL3 antibody SHR-1918 for homozygous familial hypercholesterolemia: A nonrandomized clinical trial. JAMA Cardiol 2026; doi: 10.1001\/jamacardio.2025.4878. <\/span><\/em><\/p>\n

Key words: Homozygous familial hypercholesterolemia; ANGPTL3; Monoclonal antibody<\/span><\/em><\/p>\n

<\/span><\/em><\/span><\/em><\/p>\n

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Neratinib\uff1a\u708e\u75c7\u3068\u52d5\u8108\u786c\u5316\u3078\u306e\u8ee2\u7528\uff1f<\/span><\/em><\/p>\n

\u4e73\u304c\u3093\u306e\u78ba\u7acb\u3055\u308c\u305f\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30cd\u30e9\u30c1\u30cb\u30d6\u306f\u3001\u672c\u5831\u544a\u306b\u3088\u308b\u3068\u3001\u8840\u7ba1\u708e\u75c7\u306b\u5bfe\u3057\u3066\u6f5c\u5728\u7684\u306a\u4fdd\u8b77\u52b9\u679c\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u627f\u8a8d\u85ac\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b3\u30cd\u30af\u30c6\u30a3\u30d3\u30c6\u30a3\u30de\u30c3\u30d7\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u7528\u3044\u3066\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u5185\u76ae\u7d30\u80de\u306b\u304a\u3044\u3066\u5e83\u7bc4\u306a\u6297\u708e\u75c7\u4f5c\u7528\u3092\u793a\u3059\u30d2\u30c3\u30c8\u5316\u5408\u7269\u3068\u3057\u3066\u30cd\u30e9\u30c1\u30cb\u30d6\u3092\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002
\u8ffd\u52a0\u7814\u7a76\u3067\u306f\u3001\u30cd\u30e9\u30c1\u30cb\u30d6\u304c\u5f93\u6765\u306e\u6a19\u7684\u3067\u3042\u308bHER2\uff08\u30d2\u30c8\u4e0a\u76ae\u6210\u9577\u56e0\u5b50\u53d7\u5bb9\u4f532\uff09\/ERBB2\u963b\u5bb3\u3068\u306f\u72ec\u7acb\u3057\u3066\u5185\u76ae\u7d30\u80de\u306e\u708e\u75c7\u3092\u6291\u5236\u3057\u3001ASK1\uff08\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u30b7\u30b0\u30ca\u30eb\u8abf\u7bc0\u30ad\u30ca\u30fc\u30bc1\uff09\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002
\u30de\u30a6\u30b9\u3067\u306f\u3001\u30cd\u30e9\u30c1\u30cb\u30d6\u306f\u30d7\u30e9\u30fc\u30af\u8ca0\u8377\u3092\u6e1b\u5c11\u3055\u305b\u3001\u58ca\u6b7b\u6027\u30b3\u30a2\u306e\u30b5\u30a4\u30ba\u3092\u7e2e\u5c0f\u3057\u3001\u75c5\u5909\u90e8\u3078\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u6d78\u6f64\u3092\u8efd\u6e1b\u3057\u307e\u3057\u305f\u3002\u30ed\u30b9\u30d0\u30b9\u30bf\u30c1\u30f3\u3068\u4f75\u7528\u3057\u305f\u5834\u5408\u3001\u6297\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u4f5c\u7528\u306f\u30b9\u30bf\u30c1\u30f3\u5358\u72ec\u7642\u6cd5\u3067\u8a8d\u3081\u3089\u308c\u305f\u52b9\u679c\u3092\u4e0a\u56de\u308a\u307e\u3057\u305f\u3002 \u3053\u308c\u3089\u306e\u8208\u5473\u6df1\u3044\u7d50\u679c\u306f\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u306b\u5024\u3057\u307e\u3059\u3002 <\/span><\/p>\n

Zhang F-S , He C, Yin Y, et al. Neratinib, a clinical drug against breast cancer, protects against vascular inflammation and atherosclerosis. Circ Res 2026; doi: 10.1161\/CIRCRESAHA.125.326508. <\/span><\/em><\/p>\n

Key words: Neratinib; Inflammation; Atherosclerosis<\/span><\/em><\/p>\n

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2025 <\/span><\/h2>\n

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\u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306b\u304a\u3051\u308b\u30be\u30b8\u30b7\u30e9\u30f3<\/strong><\/h5>\n

GATEWAY\u8a66\u9a13\u306e\u7d50\u679c\u3001ANGPTL3\u3092\u6a19\u7684\u3068\u3059\u308bRNA\u5e72\u6e09\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30be\u30c0\u30b7\u30e9\u30f3\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u3067\u8102\u8cea\u4f4e\u4e0b\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u30db\u30e2\u63a5\u5408\u578b\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff08HoFH\uff09\u60a3\u8005\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c\u307b\u307c\u534a\u6e1b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002
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\u30026\u30f5\u6708\u5f8c\u3001\u30be\u30b8\u30b7\u30e9\u30f3\u6295\u4e0e\u306f\u7a7a\u8179\u6642LDL-C\u306e\u5927\u5e45\u306a\u4f4e\u4e0b\uff08\u5e73\u5747\u4f4e\u4e0b\u738735.7\uff05\uff1b95\uff05\u4fe1\u983c\u533a\u959357.6\u301c13.7\uff1b200mg\u6295\u4e0e\u7fa4\u304a\u3088\u307339.9\uff05\uff1b300mg\u6295\u4e0e\u7fa4\u306753.9\u301c-26.0\uff09\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u5404\u7fa4\u3067LDL-C\u5024\u304c40\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3057\u305f\u3068\u3044\u3046\u4e2d\u9593\u89e3\u6790\u7d50\u679c\u3068\u4e00\u81f4\u3057\u3066\u3044\u305f\u3002\u6709\u52b9\u6027\u306f\u9577\u671f\u8ffd\u8de1\u671f\u9593\u4e2d\u3082\u6301\u7d9a\u3057\u3001\u3055\u3089\u306b12\u30f5\u6708\u6295\u4e0e\u3057\u305f\u5f8c\u306e\u30d7\u30fc\u30eb\u7528\u91cf\u3067\u306e\u5e73\u5747LDL-C\u4f4e\u4e0b\u7387\u306f40.7\uff05\u3067\u3042\u3063\u305f\u3002\u30be\u30b8\u30b7\u30e9\u30f3\u306e\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u826f\u597d\u3067\u3042\u3063\u305f\u3002\u3053\u308c\u3089\u306eGATEWAY\u306e\u7d50\u679c\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001HoFH\u60a3\u8005\u306b\u304a\u3051\u308b\u6700\u5927\u9650\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u80cc\u666f\u306b\u3057\u305f\u30be\u30b8\u30b7\u30e9\u30f3\u6cbb\u7642\u306e\u81e8\u5e8a\u7684\u6709\u7528\u6027\u304c\u793a\u3055\u308c\u3001\u3053\u306e\u3088\u3046\u306a\u975e\u5e38\u306b\u6cbb\u7642\u56f0\u96e3\u306a\u60a3\u8005\u306b\u304a\u3051\u308bLDL-C\u76ee\u6a19\u5024\u9054\u6210\u306e\u5177\u4f53\u7684\u306a\u898b\u901a\u3057\u304c\u5f97\u3089\u308c\u305f\u3002
Raal FJ, Bergeron J, Gaudet D, et al. \u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308bANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305fRNAi\u6cbb\u7642\u85acZodasiran\uff08GATEWAY\uff09\uff1a\u975e\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u7b2c2\u76f8\u8a66\u9a13\u3002Lancet Diabetes Endocrinol 2025\uff1a10.1016\/S2213-8587(25)00290-6.
\u30ad\u30fc\u30ef\u30fc\u30c9\u30be\u30b8\u30b7\u30e9\u30f3\uff1bANGPTL3\uff1b\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d83\u86cb\u767d\uff1b\u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7 <\/p>\n

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\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u308b\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\u8ceaB\u306e\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3059\u308b\u6a5f\u4f1a\u3092\u9003\u3059<\/strong><\/h5>\n

\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08apo\uff09B\u306f\u3001LDL-C\u304a\u3088\u3073\/\u307e\u305f\u306f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u3092\u4f34\u3046\u3002\u3057\u304b\u3057\u3001Copenhagen General Population Study\u306e\u3053\u306e\u5831\u544a\u3067\u306f\u3001LDL-C\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068apoB\u5024\u304c\u9ad8\u3044\u4eba\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001LDL-C\u3068apoB\u5024\u306f\u9ad8\u3044\u304c\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u3044\u4eba\u3088\u308a\u3082\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304b\u3063\u305f\u3002 <\/span><\/p>\n

\u7814\u7a76\u8005\u3089\u306f\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u304a\u3089\u305a\u3001ASCVD\u306e\u65e2\u5f80\u3082\u306a\u3044\u6210\u4eba94,299\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u8a55\u4fa1\u3057\u307e\u3057\u305f\u3002\u5bfe\u8c61\u8005\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001LDL-C\u304a\u3088\u3073apoB\u306e\u4e2d\u592e\u5024\u306b\u57fa\u3065\u3044\u3066\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002
\u4e2d\u592e\u502412\u5e74\u9593\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u30019,269\u4eba\u304cASCVD\u3092\u767a\u75c7\u3057\u307e\u3057\u305f\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001apoB\u304a\u3088\u3073LDL-C\u304c\u3044\u305a\u308c\u3082\u4f4e\u5024\u3067\u4e00\u81f4\u3057\u3066\u3044\u305f\u500b\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073apoB\u304c\u9ad8\u5024\u3067\u3042\u308b\u4e00\u65b9\u3001LDL-C\u304c\u4f4e\u5024\u3067\u3042\u3063\u305f\u500b\u4eba\u3067\u306f\u3001ASCVD\u30ea\u30b9\u30af\u304c45%\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.45\u300195%\u4fe1\u983c\u533a\u95931.34\u20131.56\uff09\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u5024\u3067\u3001apoB\u304a\u3088\u3073LDL-C\u304c\u9ad8\u5024\u3067\u3042\u3063\u305f\u5bfe\u8c61\u8005\u3067\u306f\u3001ASCVD\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306f20%\u3067\u3057\u305f\u3002
\u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001LDL-C\u304a\u3088\u3073apoB\u304c\u9ad8\u5024\u3067\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u5024\u3067\u3042\u3063\u305f\u5bfe\u8c61\u8005\u306e\u65b9\u304c\u3001LDL-C\u304c\u4e0d\u4e00\u81f4\u306b\u4f4e\u5024\u3067\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304a\u3088\u3073apoB\u304c\u9ad8\u5024\u3067\u3042\u3063\u305f\u5bfe\u8c61\u8005\u3088\u308a\u3082\u3001\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u958b\u59cb\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\uff08\u30aa\u30c3\u30ba\u6bd45.1\u30014.3\u20135.9 \u5bfe \u30aa\u30c3\u30ba\u6bd43.0\u30012.5\u20133.6\uff09\u3002 \u8981\u7d04\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001apoB\u9ad8\u5024\u306b\u5bfe\u3059\u308b\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u958b\u59cb\u306e\u6a5f\u4f1a\u304c\u898b\u9003\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u3066\u3044\u307e\u3059\u3002 <\/span><\/p>\n

Hvid K, Balling M, Nordestgaard BG, Afzal S. \u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u308b\u30a2\u30ddB\u4e0a\u6607\u306f\u3001\u5341\u5206\u306a\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u4fc3\u3059\u3053\u3068\u306a\u304fASCVD\u306e\u9ad8\u30ea\u30b9\u30af\u3092\u3082\u305f\u3089\u3059\uff1a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u57fa\u3065\u304f\u9650\u754c\u3068\u30a2\u30f3\u30e1\u30c3\u30c8\u30fb\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30cb\u30fc\u30ba\u3002Eur J Prev Cardiol 2025; doi: 10.1093\/eurjpc\/zwaf735. <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u96c6\u56e3\u7814\u7a76\uff1b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1b\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\uff1b\u4e0d\u4e00\u81f4\u5206\u6790\uff1b\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5<\/em><\/p>\n

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ZEUS\uff1a\u6162\u6027\u814e\u81d3\u75c5\u306b\u304a\u3051\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\u306e\u6a19\u7684\u5316<\/strong><\/h5>\n

\u708e\u75c7\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u57fa\u790e\u3067\u3042\u308a\u3001\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u306b\u3082\u95a2\u9023\u3057\u3001ASCVD\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u306e\u4e00\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308b\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f36\uff08IL-6\uff09\u306f\u52d5\u8108\u786c\u5316\u306b\u304a\u3051\u308b\u708e\u75c7\u53cd\u5fdc\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u304a\u308a\u3001CKD\u3067\u306f\u4e0a\u6607\u3059\u308b\u3053\u3068\u304b\u3089\u3001\u6cbb\u7642\u4ecb\u5165\u306e\u6709\u671b\u306a\u6a19\u7684\u3067\u3042\u308b\u3002\u5b9f\u969b\u3001\u7b2cII\u76f8RESCUE\u8a66\u9a13\u3067\u306f\u3001IL-6\u306b\u5bfe\u3059\u308b\u5b8c\u5168\u30d2\u30c8\u578b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308b\u30b8\u30eb\u30c1\u30d9\u30ad\u30de\u30d6\u306b\u3088\u308b\u6cbb\u7642\u304c\u3001\u9ad8\u611f\u5ea6CRP\uff08hsCRP\uff09\u4e0a\u6607\u3092\u4f34\u3046CKD\u60a3\u8005\u306b\u304a\u3044\u3066\u5b89\u5168\u304b\u3064\u6709\u52b9\u3067\u3042\u308a\u300115mg\u306e\u6295\u4e0e\u3067hsCRP\u309288\uff05\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001ASCVD\u3001CKD\u3001\u708e\u75c7\uff08hsCRP\u50242mg\/L\u4ee5\u4e0a\uff09\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fZiltivekimab Cardiovascular Outcomes Trial\uff08ZEUS\uff1bNCT05021835\uff09\u3078\u306e\u9053\u3092\u958b\u3044\u305f\u3002
\u3053\u306e\u591a\u56fd\u7c4d\u3001\u4e8c\u91cd\u76f2\u691c\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u30a4\u30d9\u30f3\u30c8\u99c6\u52d5\u578b\u8a66\u9a13\u3067\u306f\u30016,376\u4f8b\u306e\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f6269.5\u6b73\u3001\u5973\u602727.5%\uff09\u304c\u3001\u30b8\u30eb\u30c1\u30d9\u30ad\u30de\u30d615 mg\u3092\u6bce\u6708\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u7fa4\u3001\u307e\u305f\u306f\u5bfe\u5fdc\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002
\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u3001\u8a66\u9a13\u96c6\u56e3\u306e\u7279\u5fb4\u3068\u3057\u3066\u3001\u5e73\u5747\u63a8\u7b97\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff08eGFR\uff09\u306f44.5 mL\/min\/1.73 m\u00b2\u3001\u5e73\u5747\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u306f77.7 mg\/dL\u3001hsCRP\u4e2d\u592e\u5024\u306f4.5 mg\/L\u3001IL-6\u4e2d\u592e\u5024\u306f4.9 pg\/mL\u3067\u3057\u305f\u3002 \u672c\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u307e\u305f\u306f\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u304b\u3089\u306a\u308b3\u9805\u76ee\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3059\u3002
ZEUS\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3057\u3001\u5fc3\u8840\u7ba1\u7cfb\u3084\u814e\u81d3\u306e\u8ee2\u5e30\u306e\u60aa\u5316\u3092\u9632\u3050\u65b9\u6cd5\u3092\u7406\u89e3\u3059\u308b\u4e0a\u3067\u3001\u6b21\u306e\u5927\u304d\u306a\u4e00\u6b69\u3068\u306a\u308b\u3002<\/p>\n

Ridker PM, Baeres FMM, Hveplund A, et al. Rationale, design, and baseline clinical characteristics of the Ziltivekimab Cardiovascular Outcomes Trial: Interleukin-6 inhibition and atherosclerotic event rate reduction. JAMA Cardiol 2025; doi: 10.1001\/jamacardio.2025.4491.
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\u8133\u5352\u4e2d\u4e88\u9632\u306e\u305f\u3081\u306e\u708e\u75c7\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30ea\u30dd\u86cb\u767d(a)\u306e\u65e9\u671f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0<\/strong><\/span><\/em><\/h5>\n

Women’s Health Study\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u8133\u5352\u4e2d\u306e\u4e00\u6b21\u4e88\u9632\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\uff08hsCRP\uff09\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u65e9\u671f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n

Women’s Health Study\u306f\u300145\u6b73\u4ee5\u4e0a\u3067\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u764c\u306e\u306a\u3044\u5973\u6027\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3001\u30a2\u30b9\u30d4\u30ea\u30f3\u3068\u30d3\u30bf\u30df\u30f3E\u306b\u95a2\u3059\u308b\u7c73\u56fd\u306e\u524d\u5411\u304d\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3067\u30012004\u5e74\u306b\u7d42\u4e86\u3057\u305f\u3002\u4eca\u56de\u306e\u89e3\u6790\u3067\u306f\u3001hsCRP\u3068LDL-C\u306e\u6e2c\u5b9a\u304c\u53ef\u80fd\u3067\u3042\u3063\u305f27,939\u4eba\uff08\u5e74\u9f62\u4e2d\u592e\u502453\u6b73\u3001\u80a5\u6e80\u5ea6\u4e2d\u592e\u502425kg\/<\/sup>m2\uff09\u306e\u8ffd\u8de1\u30c7\u30fc\u30bf\u304c\u8a55\u4fa1\u3055\u308c\u305f\uff08\u307b\u3068\u3093\u3069\u306e\u88ab\u9a13\u8005\u3067\u306f\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u306e\u30c7\u30fc\u30bf\u3082\uff09\u3002 <\/span><\/p>\n

\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502427.7\u5e74\u9593\u3067\u30011345\u4ef6\u306e\u8133\u5352\u4e2d\u30a4\u30d9\u30f3\u30c8\u304c\u767a\u751f\u3057\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306ehsCRP\u304c\u6700\u4f4e5\u5206\u4f4d\uff08<0.7mg\/L\uff09\u304b\u3089\u6700\u9ad85\u5206\u4f4d\uff08\u22675.2mg\/L\uff09\u307e\u3067\u6bb5\u968e\u7684\u306b\u5897\u52a0\u3059\u308b\u3053\u3068\u306f\u3001\u8133\u5352\u4e2d\u7dcf\u767a\u751f\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002LDL-C\uff08\u22673.4mmol\/L\uff09\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\uff08a\uff09\uff08\u226744.1mg\/dL\uff09\u306e\u6700\u9ad8\u4e94\u5206\u4f4d\u7fa4\u3067\u306f\u3001\u6700\u4f4e\u4e94\u5206\u4f4d\u7fa4\uff08\u305d\u308c\u305e\u308c<2.5mmol\/L\u304a\u3088\u3073<3.6mg\/dL\uff09\u3088\u308a\u3082\u5168\u8133\u5352\u4e2d\u306e\u7d2f\u7a4d\u767a\u751f\u7387\u304c\u9ad8\u304b\u3063\u305f\u3002\u591a\u5909\u91cf\u8abf\u6574\u89e3\u6790\u306b\u3088\u308b\u3068\u30013\u3064\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u3059\u3079\u3066\u4e0a\u6607\u3057\u305f\u5973\u6027\u304c5\u5206\u4f4d\u7fa4\u306b\u5c5e\u3059\u308b\u3068\u3001\u5168\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c60\uff05\u4e0a\u6607\u3057\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.60\u300195\uff05\u4fe1\u983c\u533a\u95931,10-2.34\uff09\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u304c79\uff05\u4e0a\u6607\u3057\u305f\uff081.79\u30011.23-2.61\uff09\u3002\u3044\u305a\u308c\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3082\u51fa\u8840\u6027\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u3068\u306f\u76f8\u95a2\u3057\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u5973\u6027\u306b\u304a\u3051\u308b\u8133\u5352\u4e2d\u306e\u4e00\u6b21\u4e88\u9632\u306e\u305f\u3081\u306b\u3001LDL-C\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3068\u5171\u306bhsCRP\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u542b\u3081\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n

\u5065\u5eb7\u306a\u5973\u6027\u306b\u304a\u3051\u308b\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3068\u8133\u5352\u4e2d30\u5e74\u30ea\u30b9\u30af\uff1a\u524d\u5411\u304d\u7e26\u65ad\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002Lancet Neurol 2025;24:920-30. <\/span><\/em><\/p>\n

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CORE\u8a66\u9a13\u306e\u6700\u7d42\u7d50\u679c\u306f\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC-III\uff08APOC3\uff09\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fcRNA\u3092\u6a19\u7684\u3068\u3059\u308b\u30a2\u30f3\u30c1\u30bb\u30f3\u30b9\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3067\u3042\u308b\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u6025\u6027\u81b5\u708e\u306e\u767a\u751f\u7387\u3092\u6e1b\u5c11\u3055\u305b\u305f\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u7ba1\u7406\u304c\u56f0\u96e3\u306a\u60a3\u8005\u306b\u5bfe\u3059\u308b\u65b0\u3057\u3044\u6cbb\u7642\u6cd5\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n

CORE\u8a66\u9a13\u306f\u30012\u3064\u306e\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\uff08CORE-TIMI 72a\u8a66\u9a13\u304a\u3088\u3073CORE2-TIMI 72b\u8a66\u9a13\uff09\u3067\u3042\u308a\u3001\u5730\u57df\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u5f93\u3063\u3066\u5b89\u5b9a\u3057\u305f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u306a\u304c\u3089\u3001\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9> 500mg\/dL\u30922\u56de\u793a\u3057\u305f\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u60a3\u8005\u306f\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\uff0850mg\u307e\u305f\u306f80mg\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u306b\u3088\u308b\u6cbb\u7642\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u300112\u30f5\u6708\u9593\u6bce\u6708\u6295\u4e0e\u3055\u308c\u305f\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f6\u30f5\u6708\u5f8c\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u3067\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u6295\u4e0e\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa4\u3067\u6bd4\u8f03\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u6025\u6027\u81b5\u708e\u30a4\u30d9\u30f3\u30c8\u3082\u4e21\u8a66\u9a13\u3067\u8a55\u4fa1\u3055\u308c\u305f\u3002 <\/span><\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u30011061\u4f8b\u306e\u60a3\u8005\u304c\u4e00\u6b21\u89e3\u6790\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\uff08CORE-TIMI 72a\u8a66\u9a13\u3067\u306f617\u4f8b\u3001CORE2-TIMI 72b\u8a66\u9a13\u3067\u306f444\u4f8b\uff09\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e\u5e74\u9f62\u4e2d\u592e\u5024\u306f54\u6b73\u3001\u5973\u6027\u306f23.6\uff05\u3001\u7cd6\u5c3f\u75c5\u306f63.4\uff05\u3067\u3042\u3063\u305f\u3002\u307b\u307c\u5168\u4f8b\u304c\u5c11\u306a\u304f\u3068\u30821\u7a2e\u985e\u306e\u8102\u8cea\u4f4e\u4e0b\u85ac\u3092\u670d\u7528\u3057\u3066\u304a\u308a\u300163.5\uff05\u304c\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7cfb\u85ac\u5264\u3092\u670d\u7528\u3057\u3066\u3044\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u4e2d\u592e\u5024\u306f793mg\/dL\uff088.96mmol\/L\uff09\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

6\u304b\u6708\u6642\u70b9\u3067\u3001CORE-TIMI 72a\u8a66\u9a13\u3067\u306f\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f350 mg\u306b\u3088\u308a\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u221262.9%\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff0895%\u4fe1\u983c\u533a\u9593 \u221272.2\u301c\u221253.6\u3001p<0.001\u3001\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5f8c\uff09\u3002\u307e\u305f\u300180 mg\u6295\u4e0e\u7fa4\u3067\u306f\u221272.2%\u4f4e\u4e0b\u3057\u307e\u3057\u305f\uff0895%\u4fe1\u983c\u533a\u9593 \u221281.4\u301c\u221263.1\u3001p<0.001\u3001\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5f8c\uff09\u3002
CORE2-TIMI 72b\u8a66\u9a13\u3067\u306f\u3001\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5f8c\u306e\u4f4e\u4e0b\u7387\u306f\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f350 mg\u7fa4\u3067\u221249.2%\u300180 mg\u7fa4\u3067\u221254.5%\u3067\u3057\u305f\uff08\u3044\u305a\u308c\u3082\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u3066p<0.001\uff09\u3002
\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\u6cbb\u7642\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u6025\u6027\u81b5\u708e\u306e\u767a\u751f\u7387\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\uff08\u5e73\u5747\u7387\u6bd40.15\u300195%\u4fe1\u983c\u533a\u95930.05\u301c0.40\u3001p<0.001\uff09\u3002\u6709\u5bb3\u4e8b\u8c61\u5168\u4f53\u306e\u767a\u751f\u7387\u306f\u3001\u5404\u8a66\u9a13\u306b\u304a\u3044\u30663\u7fa4\u9593\u3067\u540c\u7a0b\u5ea6\u3067\u3057\u305f\u3002 \u3057\u304b\u3057\u3001\u809d\u9175\u7d20\u5024\u306e\u4e0a\u6607\u304a\u3088\u3073\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff08\u8840\u5c0f\u677f\u6570<100,000\/\u00b5L\uff09\u306f\u3001\u30aa\u30ec\u30b6\u30eb\u30bb\u30f380 mg\u7fa4\u3067\u3088\u308a\u591a\u304f\u8a8d\u3081\u3089\u308c\u3001\u809d\u8102\u80aa\u5206\u753b\u306e\u7528\u91cf\u4f9d\u5b58\u7684\u306a\u5897\u52a0\u3082\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u3053\u306e\u8a66\u9a13\u306b\u306f\u3001\u7279\u306b\u5973\u6027\u306e\u5272\u5408\u304c\u4f4e\u3044\u3053\u3068\u3001\u6cbb\u7642\u671f\u9593\u304c1\u5e74\u9593\u3068\u77ed\u3044\u3053\u3068\u306a\u3069\u306e\u9650\u754c\u304c\u3042\u308b\u304c\u3001\u3053\u306e\u77e5\u898b\u306f\u3001\u3053\u306e\u60a3\u8005\u7fa4\u306b\u304a\u3051\u308b\u30aa\u30ec\u30b6\u30eb\u30c4\u30bb\u30f3\u306e\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u308b\u30021\u5e74\u3092\u8d85\u3048\u308b\u7d99\u7d9a\u7684\u306a\u8ffd\u8de1\u8abf\u67fb\u306f\u3001\u975e\u76f2\u691c\u5ef6\u9577\u8a66\u9a13\uff08ClinicalTrials.gov\u756a\u53f7\u3001NCT05681351\uff09\u306e\u7126\u70b9\u3067\u3042\u308b\u3002<\/span><\/p>\n

Marston NA, Bergmark BA, Alexander VJ, et al. Olezarsen for managing severe hypertriglyceridemia and pancreatitis risk. N Engl J Med 2025; DOI: 10.1056\/NEJMoa2512761<\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\u30aa\u30ec\u30b6\u30eb\u30bb\u30f3\uff1bApoC3\uff1b\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\uff1b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff1b\u81b5\u708e<\/span><\/em><\/p>\n

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DR10624\uff1a\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u5bfe\u3059\u308b\u65b0\u898f\u85ac\u5264<\/strong><\/h5>\n

DR10624\u306f\u3001\u4e2d\u6027\u8102\u80aa\u4ee3\u8b1d\u306b\u95a2\u9023\u3059\u308b3\u3064\u306e\u7570\u306a\u308b\u53d7\u5bb9\u4f53\u3092\u540c\u6642\u306b\u6d3b\u6027\u5316\u3059\u308b\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30af\u30e9\u30b9\u306e\u85ac\u5264\u3067 <\/span>\u3042\u308b\u3001 FGF21\uff08\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b5021\uff09\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u304a\u3088\u3073\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff08GLP-1\uff09\u53d7\u5bb9\u4f53\u306f\u3001\u91cd\u75c7\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3053\u306e\u8102\u8cea\u7570\u5e38\u75c7\u306e\u60a3\u8005\u306f <\/span> \u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08MASLD\uff1b\u4ee5\u524d\u306f\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u307e\u305f\u306fNAFLD\u3068\u547c\u3070\u308c\u3066\u3044\u305f\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3002\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\u3001MASLD\u306b\u5bfe\u3059\u308b\u7279\u7570\u7684\u306a\u85ac\u7406\u5b66\u7684\u6cbb\u7642\u6cd5\u306f\u306a\u3044\u3002\u73fe\u5728\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7cfb\u85ac\u5264\u3001\u9ad8\u7528\u91cf\u306e\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u307e\u305f\u306f\u30b9\u30bf\u30c1\u30f3\u7cfb\u85ac\u5264\u304c\u91cd\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u6cbb\u7642\u306e\u4e3b\u6d41\u3067\u3042\u308b\u304c\u3001\u3053\u308c\u3089\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u4f4e\u4e0b\u3084\u809d\u8102\u80aa\u306e\u6e1b\u5c11\u306b\u306f\u4e0d\u5341\u5206\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/span><\/p>\n

\u3053\u306e\u7b2c2\u76f8\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u306b\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c500\u301c2000mg\/dL\u306e\u30a2\u30b8\u30a2\u306e\u6210\u4eba79\u4eba\uff08\u5e73\u5747\u5e74\u9f6246\u6b73\u300189\uff05\u304c\u7537\u6027\u3001\u307b\u307c\u5168\u54e1\u304c\u6f22\u6c11\u65cf\uff09\u304c\u767b\u9332\u3055\u308c\u305f\u3002\u60a3\u8005\u306fDR10624\uff0812.5mg\u300125mg\u300150mg\uff09\u3092\u90311\u56de\u76ae\u4e0b\u6ce8\u5c04\u3059\u308b\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u309212\u9031\u9593\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u8a66\u9a13\u7fa4\u306e\u7d0430\uff05\u304c\u8a66\u9a13\u4e2d\u306b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u85ac\u7269\u7642\u6cd5\u3092\u4f75\u7528\u3057\u305f\u3002 <\/span><\/p>\n

12\u9031\u5f8c\u3001DR10624 12.5 mg\u7fa4\u3067\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c74.5%\u4f4e\u4e0b\u3057\u3001\u3088\u308a\u9ad8\u7528\u91cf\u306e2\u7fa4\u3067\u306f\u3084\u3084\u4f4e\u3044\u53cd\u5fdc\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff0825 mg\u7fa4\u306766.2%\u4f4e\u4e0b\u300150 mg\u7fa4\u306768.9%\u4f4e\u4e0b\uff09\u3002\u3053\u308c\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306e\u4f4e\u4e0b\u306f8.0%\u3067\u3057\u305f\u3002
\u5168\u4f53\u3068\u3057\u3066\u3001DR10624\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u306e89.5%\u304c\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024<500 mg\/dL\u3092\u9054\u6210\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f25.0%\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001DR10624\u6295\u4e0e\u60a3\u8005\u306e78.5%\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024>50%\u4ee5\u4e0a\u4f4e\u4e0b\u3057\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f5%\u3067\u3057\u305f\u3002
\u52a0\u3048\u3066\u3001DR10624\u6cbb\u7642\u306b\u3088\u308a\u809d\u8102\u80aa\u306f63.5%\u6e1b\u5c11\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f8.4%\u306e\u6e1b\u5c11\u3067\u3057\u305f\u3002 \u6700\u3082\u591a\u304f\u8a8d\u3081\u3089\u308c\u305f\u526f\u4f5c\u7528\u306f\u3001\u60aa\u5fc3\u306a\u3069\u306e\u6d88\u5316\u5668\u75c7\u72b6\u3067\u3042\u308a\u3001\u6982\u3057\u3066\u8efd\u5ea6\u3067\u3057\u305f\u3002 <\/span><\/p>\n

\u6cbb\u7642\u671f\u9593\u304c\u77ed\u3044\u3053\u3068\uff0812\u9031\u9593\uff09\u3001\u60a3\u8005\u30b5\u30f3\u30d7\u30eb\u6570\u304c\u9650\u3089\u308c\u3066\u3044\u308b\u3053\u3068\u3001\u60a3\u8005\u96c6\u56e3\u306e\u591a\u69d8\u6027\u304c\u4e0d\u8db3\u3057\u3066\u3044\u308b\u3053\u3068\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u3092\u5ff5\u982d\u306b\u7f6e\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u307b\u307c\u3059\u3079\u3066\u306e\u60a3\u8005\u304c\u6f22\u6c11\u65cf\u3067\u3042\u3063\u305f\u305f\u3081\u3001\u672c\u7814\u7a76\u306e\u7d50\u679c\u306f\u4ed6\u306e\u6c11\u65cf\u96c6\u56e3\u306b\u306f\u4e00\u822c\u5316\u3067\u304d\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u7559\u610f\u70b9\u306f\u3042\u308b\u3082\u306e\u306e\u3001\u672c\u7d50\u679c\u306f\u3001DR10624\u304c\u91cd\u5ea6\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u7ba1\u7406\u306b\u304a\u3044\u3066\u6cbb\u7642\u7684\u53ef\u80fd\u6027\u3092\u6709\u3059\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 <\/span><\/p>\n

Li J et al. American Heart Association Scientific Sessions 2025, Abstract 4392939.<\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9DR10624\u3001\u91cd\u75c7\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u3001\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u95a2\u9023\u8102\u80aa\u6027\u809d\u75be\u60a3<\/span><\/em><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”10px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_padding=”||0px|||” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30a8\u30f3\u30ea\u30b7\u30bf\u30a4\u30c9\uff1a\u65b0\u898f\u7d4c\u53e3PCSK9\u963b\u5bb3\u5264<\/strong><\/h5>\n

CORALreef Lipids\u8a66\u9a13\u3067\u306f\u3001\u7d4c\u53e3PCSK9\u963b\u5bb3\u85ac\u30a8\u30f3\u30ea\u30b7\u30c1\u30c9\u306e1\u65e51\u56de\u6295\u4e0e\u306b\u3088\u308a\u300124\u9031\u6642\u70b9\u3067\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3001\u305d\u308c\u304c52\u9031\u9593\u6301\u7d9a\u3057\u305f\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u307e\u305f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u5fcd\u5bb9\u6027\u3082\u826f\u597d\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

PCSK9\u3092\u6a19\u7684\u3068\u3059\u308b\u6cbb\u7642\u85ac\uff08\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u307e\u305f\u306fRNA\u6cbb\u7642\u85ac\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\uff09\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308bLDL-C\u4f4e\u4e0b\u7642\u6cd5\u306e\u9078\u629e\u80a2\u3068\u3057\u3066\u3059\u3067\u306b\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u3053\u308c\u3089\u306e\u6cbb\u7642\u85ac\u306f\u975e\u5e38\u306b\u6709\u52b9\u3067\u3042\u308b\u3082\u306e\u306e\u3001\u76ae\u4e0b\u6ce8\u5c04\u306b\u3088\u3063\u3066\u6295\u4e0e\u3055\u308c\u307e\u3059\u3002 \u7d4c\u53e3PCSK9\u963b\u5bb3\u85ac\u306f\u3001\u60a3\u8005\u304a\u3088\u3073\u533b\u7642\u5f93\u4e8b\u8005\u306b\u3068\u3063\u3066\u5b9f\u7528\u4e0a\u306e\u5229\u70b9\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 <\/span><\/p>\n

\u30a8\u30f3\u30ea\u30b7\u30c1\u30c9\u306f\u3001PCSK9\u3068LDL\u53d7\u5bb9\u4f53\u3068\u306e\u7d50\u5408\u3092\u963b\u5bb3\u3059\u308b\u7d4c\u53e3\u4f4e\u5206\u5b50\u5927\u74b0\u72b6\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002
\u3053\u306e\u7b2c3\u76f8\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u306b\u306f\u3001\u5fc3\u7b4b\u6897\u585e\u307e\u305f\u306f\u8133\u5352\u4e2d\u306e\u65e2\u5f80\u3092\u6709\u3059\u308b\u3001\u307e\u305f\u306f\u3053\u308c\u3089\u306e\u30a4\u30d9\u30f3\u30c8\u306e10\u5e74\u30ea\u30b9\u30af\u304c\u4e2d\u7b49\u5ea6\u3082\u3057\u304f\u306f\u9ad8\u30ea\u30b9\u30af\u3067\u3042\u308b\u6210\u4eba2,912\u4f8b\uff08\u5e73\u5747\u5e74\u9f6263\u6b73\u3001\u5973\u602739%\uff09\u304c\u767b\u9332\u3055\u308c\u307e\u3057\u305f\u3002\u3059\u3079\u3066\u306e\u60a3\u8005\u306f\u3001\u5c11\u306a\u304f\u3068\u308230\u65e5\u9593\u306e\u5b89\u5b9a\u3057\u305f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\uff08\u5c11\u306a\u304f\u3068\u3082\u4e2d\u7b49\u5ea6\u307e\u305f\u306f\u9ad8\u5f37\u5ea6\u30b9\u30bf\u30c1\u30f3\uff09\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001LDL-C\u5024\u304c\u63a8\u5968\u76ee\u6a19\u3092\u4e0a\u56de\u3063\u3066\u3044\u307e\u3057\u305f\u3002
\u60a3\u8005\u306f\u3001\u30a8\u30f3\u30ea\u30b7\u30c1\u30c920 mg\u30921\u65e51\u56de\u6295\u4e0e\u3059\u308b\u7fa4\uff08n=1,935\uff09\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n=969\uff09\u306b2:1\u306e\u5272\u5408\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u30025\u4f8b\u306f\u6cbb\u9a13\u85ac\u3092\u6295\u4e0e\u3055\u308c\u305a\u30013\u4f8b\u306f\u4ed6\u306e\u8a66\u9a13\u3078\u306e\u53c2\u52a0\u306b\u3088\u308a\u9664\u5916\u3055\u308c\u307e\u3057\u305f\u3002
\u6cbb\u7642\u7fa4\u9593\u306f\u540c\u7b49\u3067\u3042\u308a\u3001\u5168\u4f53\u306e\u5e73\u5747\u5e74\u9f62\u306f62.8\u6b73\u3001\u5973\u6027\u306f39%\u3001\u767d\u4eba\u306f54%\u3001\u904e\u53bb\u306b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u30a4\u30d9\u30f3\u30c8\u3092\u6709\u3059\u308b\u60a3\u8005\u306f58%\u3067\u3057\u305f\u3002 \u307b\u307c\u3059\u3079\u3066\u306e\u60a3\u8005\uff0895%\uff09\u304c\u3001\u4e2d\u7b49\u5ea6\u304b\u3089\u9ad8\u5f37\u5ea6\u306e\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u307e\u3057\u305f\u3002 <\/span><\/p>\n

24\u9031\u5f8c\u3001\u30a8\u30f3\u30ea\u30b7\u30c1\u30c9\u6cbb\u7642\u306b\u3088\u308aLDL-C\u306f\u6700\u592760%\u4f4e\u4e0b\u3057\u3001\u305d\u306e\u4f4e\u4e0b\u52b9\u679c\u306f52\u9031\u6642\u70b9\u307e\u3067\u6301\u7d9a\u3057\u307e\u3057\u305f\u3002
\u3055\u3089\u306b\u3001non-HDL-C\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaB\u306f\u5c11\u306a\u304f\u3068\u308250%\u4f4e\u4e0b\u3057\u3001\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\u308228%\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002
\u5168\u4f53\u3068\u3057\u3066\u3001\u30a8\u30f3\u30ea\u30b7\u30c1\u30c9\u7fa4\u306e70.3%\u306e\u60a3\u8005\u304cLDL-C\u3092\u5c11\u306a\u304f\u3068\u308250%\u4f4e\u4e0b\u3055\u305b\u3001\u304b\u3064LDL-C\u502470 mg\/dL\u672a\u6e80\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u300167.5%\u306e\u60a3\u8005\u304cLDL-C\u3092\u5c11\u306a\u304f\u3068\u308250%\u4f4e\u4e0b\u3055\u305b\u300155 mg\/dL\u672a\u6e80\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002 \u672c\u7814\u7a76\u306f\u73fe\u5728\u3082\u9032\u884c\u4e2d\u3067\u3042\u308a\u3001\u5b8c\u5168\u306a\u8ad6\u6587\u767a\u8868\u304c\u5f85\u305f\u308c\u307e\u3059\u3002 <\/span><\/p>\n

Navar AM, et al. Efficacy and safety of enlicitide, an oral PCSK9 inhibitor, for lowering LDL cholesterol in adults with or at-risk for ASCVD: the Phase 3 CORALreef Lipids Trial. American Heart Association Scientific Sessions 2025, Late-Breaking Science Abstract 4391578. <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\u30a8\u30f3\u30ea\u30b7\u30bf\u30a4\u30c9\uff1b\u7d4c\u53e3PCSK9\u963b\u5bb3\u85ac\uff1bCORALreef\u8102\u8cea\u8a66\u9a13<\/span><\/em><\/p>\n

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APOC3\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u6e1b\u3092\u907a\u4f1d\u5b50\u30e2\u30c7\u30ea\u30f3\u30b0\u304c\u652f\u6301<\/strong><\/h5>\n

UK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u306e8,000\u4eba\u3092\u8d85\u3048\u308b\u88ab\u9a13\u8005\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u3053\u306e\u907a\u4f1d\u5b50\u30e2\u30c7\u30ea\u30f3\u30b0\u7814\u7a76\u3067\u306f\u3001APOC3\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u7642\u6cd5\u306b\u3088\u308a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\uff08TRL\uff09\/\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u309216\uff5e23mg\/dL\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u30925\u5e74\u9593\u3067\u7d0425\uff05\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u4e88\u6e2c\u3055\u308c\u3001\u3053\u306e\u6a19\u7684\u6cbb\u7642\u306e\u6709\u52b9\u6027\u304c\u5f37\u5316\u3055\u308c\u305f\u3002 <\/span><\/p>\n

APOC3\u907a\u4f1d\u5b50\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u85ac\u306f\u3001TRL\uff0f\u30ec\u30e0\u30ca\u30f3\u30c8\u5024\u306e\u4f4e\u4e0b\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u308c\u306b\u4f34\u3046\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\uff08CHD\uff09\u30ea\u30b9\u30af\u3078\u306e\u5f71\u97ff\u306f\u307e\u3060\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002
\u672c\u7814\u7a76\u3067\u306f\u3001\u591a\u907a\u4f1d\u5b50\u30b9\u30b3\u30a2\uff08PGS\uff09\u306b\u57fa\u3065\u304f\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001APOC3\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u85ac\u306e\u8a66\u9a13\u3067\u8a8d\u3081\u3089\u308c\u305f\u7a0b\u5ea6\u306eTRL\uff0f\u30ec\u30e0\u30ca\u30f3\u30c8\u4f4e\u4e0b\u304c\u3001CHD\u30ea\u30b9\u30af\u306e\u6709\u610f\u306a\u4f4e\u4e0b\u306b\u3064\u306a\u304c\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002
\u6700\u3082\u9ad8\u3044PGS\u3092\u6709\u3057\u3001\u907a\u4f1d\u7684\u306bTRL\uff0f\u30ec\u30e0\u30ca\u30f3\u30c8\u5024\u304c\u9ad8\u3044\u500b\u4eba\uff08\u30d7\u30e9\u30bb\u30dc\u3092\u6a21\u5023\uff09\u306b\u304a\u3051\u308bCHD\u30a4\u30d9\u30f3\u30c8\u7387\u3092\u3001\u6700\u3082\u4f4e\u3044PGS\u3092\u6709\u3057\u3001TRL\uff0f\u30ec\u30e0\u30ca\u30f3\u30c8\u5024\u304c\u4f4e\u3044\u500b\u4eba\uff08APOC3\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3092\u6a21\u5023\uff09\u3068\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002 \u5404\u7fa4\u306b\u306f4,000\u4eba\u3092\u8d85\u3048\u308b\u5bfe\u8c61\u8005\u306e\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u9ad8PGS\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4f4ePGS\u7fa4\u3067\u306f\u3001\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c34%\u4f4e\u304f\u3001TRL\uff0f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c22.5%\u4f4e\u304f\u3001\u3055\u3089\u306bnon-HDL-C\u3001LDL-C\u304a\u3088\u3073\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaB\u306b\u3082\u3088\u308a\u5c0f\u3055\u3044\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5dee\u306f\u3001APOC3\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u85ac\u306e\u8a66\u9a13\u3067\u5831\u544a\u3055\u308c\u305f\u3082\u306e\u3068\u540c\u7a0b\u5ea6\u3067\u3057\u305f\u3002
\u307e\u305f\u3001\u4f4ePGS\u7fa4\u3067\u306f\u3001\u751f\u6daf\u306b\u308f\u305f\u308bCHD\u30a4\u30d9\u30f3\u30c8\u7387\u304c28%\u4f4e\u3044\u3053\u3068\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002
\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u30925\u5e74\u9593\u306e\u8a66\u9a13\u306b\u5916\u633f\u3059\u308b\u3068\u3001APOC3\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u85ac\u306b\u3088\u308bTRL\uff0f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e16\u301c23 mg\/dL\u306e\u4f4e\u4e0b\u306f\u3001CHD\u30ea\u30b9\u30af\u3092\u7d0425%\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u4e88\u6e2c\u3055\u308c\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u306b\u304a\u3044\u3066\u3053\u308c\u3089\u306e\u6a19\u7684\u6cbb\u7642\u3092\u691c\u8a3c\u3059\u308b\u6839\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3059\u3002 <\/span><\/p>\n

Bj\u00f6rnson E, Packard C, Adiels M, et al. Genetic modelling of triglyceride-rich lipoprotein\/remnant lowering mimics APOC3-silencing and predicts clinically relevant coronary heart disease event reductions. Eur J Prev Cardiol 2025 Oct 14:zwaf657. doi: 10.1093\/eurjpc\/zwaf657. <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9APOC3\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3001\u907a\u4f1d\u5b50\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u3001\u907a\u4f1d\u5b50\u30e2\u30c7\u30ea\u30f3\u30b0\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u3001UK\u30d0\u30a4\u30aa\u30d0\u30f3\u30af\u3002<\/span><\/em><\/p>\n

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\u60a3\u8005\u306f\u3001\u7b97\u51fa\u3055\u308c\u305f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u306b\u57fa\u3065\u304d\u3001<50\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\uff08\u57fa\u6e96\u7fa4\uff09\u300150\u301c<75\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u300175\u301c<90\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u300190\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u4ee5\u4e0a\u306b\u5206\u985e\u3055\u308c\u307e\u3057\u305f\u3002
\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001PCI\u5f8c1\u5e74\u6642\u70b9\u306b\u304a\u3051\u308b\u5168\u6b7b\u4ea1\u3001\u81ea\u7136\u767a\u75c7\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u304a\u3088\u3073\u8133\u5352\u4e2d\u306e\u8907\u5408\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u3067\u3057\u305f\u3002
\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c90\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u4ee5\u4e0a\u306e\u7fa4\u3067\u306f\u3001<50\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u65b0\u898fMI\u306e\u30ea\u30b9\u30af\u304c54%\u5897\u52a0\u3057\u3066\u3044\u307e\u3057\u305f\uff08p\u5024=0.010\uff09\u3002\u3057\u304b\u3057\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306b\u3064\u3044\u3066\u306f\u7fa4\u9593\u5dee\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002 \u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u672c\u7814\u7a76\u306f\u3001\u51a0\u52d5\u8108\u30b9\u30c6\u30f3\u30c8\u7559\u7f6e\u5f8c1\u5e74\u4ee5\u5185\u306eMI\u30ea\u30b9\u30af\u4e0a\u6607\u3092\u793a\u3059\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u3001\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u652f\u6301\u3057\u3066\u3044\u307e\u3059\u3002 <\/span><\/p>\n

Pitaro N, Bay B, Sartori S, et al. \u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\u3092\u53d7\u3051\u305f\u975e\u5fc3\u7b4b\u6897\u585e\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u306b\u5bfe\u3059\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5f71\u97ff\u3002Eur J Prevent Cardiol 2025; doi.org\/10.1093\/eurjpc\/zwaf683 <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1bPCI\uff1b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u8ee2\u5e30\uff1b\u865a\u8840\u30a4\u30d9\u30f3\u30c8<\/span><\/em><\/p>\n

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\u6297\u708e\u75c7\u7642\u6cd5\u304c\u6709\u52b9\u306a\u306e\u306f\u3069\u306e\u3088\u3046\u306a\u4eba\u3067\u3059\u304b\uff1f<\/strong><\/h5>\n

\u9ad8\u611f\u5ea6CRP\uff08hs-CRP\uff09\u4e0a\u6607\u306b\u95a2\u9023\u3059\u308b\u56e0\u5b50\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306f\u3001\u6297\u708e\u75c7\u7642\u6cd5\u304c\u6700\u3082\u6709\u52b9\u306a\u60a3\u8005\u306e\u540c\u5b9a\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3053\u306e\u6a2a\u65ad\u7814\u7a76\u3067\u306f\u3001UK Biobank\uff082006\uff5e2010\u5e74\u3001n\uff1d23,045\uff09\u3068US National Health and Nutrition Examination Survey\uff08NHANES\u30011999\uff5e2010\u5e74\u304a\u3088\u30732015\uff5e2018\u5e74\u3001n\uff1d3,415\uff09\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u75be\u60a3\u60a3\u8005\u306e\u5b9f\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u554f\u984c\u3092\u691c\u8a0e\u3057\u305f\u3002 <\/span><\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u30016\u3064\u306e\u56e0\u5b50\uff08\u3059\u3079\u3066p<0.05\uff09\u304c\u4e21\u30b3\u30db\u30fc\u30c8\u306b\u304a\u3044\u3066hsCRP\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u80a5\u6e80\u304c\u6700\u3082\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u3063\u305f\uff08\u30aa\u30c3\u30ba\u6bd4\uff3b95\uff05\u4fe1\u983c\u533a\u9593\uff3d\uff1a\u82f1\u56fd\u30b3\u30db\u30fc\u30c8\u3067\u306f3.48 [3.18-3.80]\u3001\u7c73\u56fd\u30b3\u30db\u30fc\u30c8\u3067\u306f4.11 [2.66-6.34]\uff09\u3002hs-CRP\u306e\u4e0a\u6607\u306b\u95a2\u9023\u3059\u308b\u4ed6\u306e\u56e0\u5b50\u306f\u3001\u305d\u308c\u305e\u308c\u3001\u4f53\u91cd\u904e\u591a\uff081.56\uff3b1.44-1.70\uff3d\u30012.26\uff3b1.51-3.38\uff3d\uff09\u3001\u55ab\u7159\u8005\uff082.47\uff3b2.27-2.69\uff3d\u30011.96\uff3b1.23-3.10\uff3d\uff09\u3001\u5973\u6027\uff081.69\uff3b1.59-1.80\uff3d\u30011.69\uff3b1.24-2.31\uff3d\uff09\u3067\u3042\u3063\u305f\u3002\u8102\u8cea\u56e0\u5b50\u306e\u4e2d\u3067\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5897\u52a0\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u5897\u52a0\u304c\u3068\u3082\u306bhs-CRP\u5024\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002 <\/span><\/p>\n

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\u3053\u308c\u3089\u306e\u56e0\u5b50\u306e\u6570\u304c\u5897\u3048\u308b\u307b\u3069hs-CRP\u5024\u306f\u9ad8\u304f\u306a\u308a\u30017\u3064\u306e\u56e0\u5b50\u3059\u3079\u3066\u3092\u6709\u3059\u308b\u4eba\u306ehs-CRP\u4e2d\u592e\u5024\u306f\u3001UK Biobank\u30b3\u30db\u30fc\u30c8\u3067\u306f5.39mg\/L\u3001NHANES\u30b3\u30db\u30fc\u30c8\u3067\u306f6.99mg\/L\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u6297\u708e\u75c7\u7642\u6cd5\u304c\u6700\u3082\u6709\u52b9\u306a\u60a3\u8005\u3092\u540c\u5b9a\u3059\u308b\u305f\u3081\u306bhs-CRP\u5024\u3092\u3069\u306e\u3088\u3046\u306a\u60a3\u8005\u306b\u691c\u67fb\u3059\u3079\u304d\u304b\u306b\u3064\u3044\u3066\u3001\u81e8\u5e8a\u7684\u5224\u65ad\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/span><\/p>\n

Ray KK, Reuter SB, Dalbeler A et al. \u7c73\u56fd\u3068\u82f1\u56fd\u306b\u304a\u3051\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\u5024\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\u56e0\u5b50\u3002doi: 10.1093\/eurjpc\/zwaf609. <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9ASCVD; NHANES; UK Biobank; hsCRP; \u5b9f\u4e16\u754c\u306e\u30a8\u30d3\u30c7\u30f3\u30b9; \u5168\u8eab\u6027\u708e\u75c7\u3002<\/span><\/em><\/p>\n

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REDUCE-IT\u306b\u3088\u308b\u305d\u306e\u4ed6\u306e\u6d1e\u5bdf<\/strong><\/h5>\n

\u3053\u306eREDUCE-IT\u306e\u6700\u65b0\u89e3\u6790\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u4e2d\u7b49\u5ea6\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4e0a\u6607\u3092\u6709\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u6295\u4e0e\u306b\u3088\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u3001\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u306e\u307b\u3068\u3093\u3069\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u62e1\u5927\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u306e\u6cbb\u7642\u306b\u3088\u308b\u51fa\u8840\u30ea\u30b9\u30af\u306e\u5897\u52a0\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002
REDUCE-IT\uff08Reduction of Cardiovascular Events with Icosapent Ethyl Intervention Trial\uff09\u3067\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\uff084 g\/\u65e5\uff09\u306b\u3088\u308b\u6cbb\u7642\u304c\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u975e\u81f4\u6b7b\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u6027\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u3001\u307e\u305f\u306f\u5165\u9662\u3092\u8981\u3059\u308b\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u304b\u3089\u306a\u308b\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3092\u6709\u610f\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u3059\u3067\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u6cbb\u7642\u306f\u5fc3\u7b4b\u6897\u585e\uff08MI\uff09\u306e\u767a\u751f\u7387\u308231%\u4f4e\u4e0b\u3055\u305b\u307e\u3057\u305f\u3002
\u672c\u89e3\u6790\u3067\u306f\u3001\u3053\u306e\u52b9\u679c\u304c\u3001\u81f4\u6b7b\u6027MI\u304a\u3088\u3073\u975e\u81f4\u6b7b\u6027MI\u3068\u3044\u3046\u500b\u5225\u8a55\u4fa1\u9805\u76ee\uff08\u4e8b\u524d\u898f\u5b9a\uff09\u3001\u306a\u3089\u3073\u306bST\u4e0a\u6607\u578b\u5fc3\u7b4b\u6897\u585e\uff08STEMI\uff09\u3001\u975eST\u4e0a\u6607\u578b\u5fc3\u7b4b\u6897\u585e\uff08NSTEMI\uff09\u3001\u6897\u585e\u30b5\u30a4\u30ba\u5225\u306a\u3069\u306eMI\u30b5\u30d6\u30bf\u30a4\u30d7\uff08\u4e8b\u5f8c\u89e3\u6790\uff09\u306b\u304a\u3044\u3066\u4e00\u8cab\u3057\u3066\u8a8d\u3081\u3089\u308c\u308b\u304b\u3069\u3046\u304b\u304c\u691c\u8a0e\u3055\u308c\u307e\u3057\u305f\u3002
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REDUCE-IT\u306b\u304a\u3051\u308b\u5fc3\u7b4b\u6897\u585e\u306e\u7a2e\u985e\u3068\u898f\u6a21\u3092\u8d85\u3048\u305f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u6709\u76ca\u6027\u3002doi: 10.1093\/eurjpc\/zwaf602. <\/span><\/em><\/p>\n

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\u672c\u30ec\u30d3\u30e5\u30fc\u3067\u8b70\u8ad6\u3055\u308c\u3066\u3044\u308b\u3053\u308c\u3089\u306e\u70b9\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u8ab2\u984c\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u4e0b\u304cASCVD\u4e88\u9632\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u6587\u8108\u306b\u304a\u3051\u308b\u4e3b\u306a\u554f\u3044\u306b\u306f\u3001\u4ee5\u4e0b\u304c\u542b\u307e\u308c\u307e\u3059\u3002
\u2022 \u8907\u5408\u578b\u9ad8\u8102\u8840\u75c7\u3092\u6709\u3059\u308b\u500b\u4eba\u3067\u306f\u3001\u8840\u6f3f\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaB\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3092\u4e3b\u8981\u76ee\u6a19\u3068\u3059\u3079\u304d\u304b\u3002
\u2022 \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068HDL\u306e\u5f71\u97ff\u3092\u5207\u308a\u5206\u3051\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u305f\u3081\u3001\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff08HDL\uff09\u304a\u3088\u3073\u305d\u306e\u30b5\u30d6\u30d5\u30e9\u30af\u30b7\u30e7\u30f3\u5206\u5e03\u306e\u5909\u5316\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u610f\u7fa9\u304c\u3042\u308b\u306e\u304b\u3002
\u2022 REDUCE-IT\u3067\u8a8d\u3081\u3089\u308c\u305f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u9178\u30a8\u30c1\u30eb\u306e\u6709\u76ca\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u304a\u3044\u3066\u3001TRL\u306b\u542b\u307e\u308c\u308b\u5fae\u91cf\u8102\u8cea\u306e\u5909\u5316\u306f\u91cd\u8981\u306a\u306e\u304b\u3002
LDL\u306b\u3064\u3044\u3066\u306f\u300cone-size fits all\uff08\u4e00\u5f8b\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\uff09\u300d\u3068\u3044\u3046\u8003\u3048\u65b9\u304c\u9069\u5207\u3067\u3042\u308b\u4e00\u65b9\u3001TRL\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u306f\u8907\u96d1\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u3088\u3046\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u9069\u5207\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 TRL\u5236\u5fa1\u306b\u91cd\u8981\u306a\u500b\u5225\u306e\u6a19\u7684\u306b\u4f5c\u7528\u3059\u308b\u7279\u7570\u7684\u306a\u907a\u4f1d\u5b50\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u85ac\u306e\u958b\u767a\u306f\u3001\u3053\u308c\u3089\u306e\u8907\u96d1\u306a\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u3044\u3046\u300c\u30d1\u30f3\u30c9\u30e9\u306e\u7bb1\u300d\u304b\u3089\u751f\u3058\u308b\u591a\u304f\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u53ef\u80fd\u6027\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002 <\/p>\n

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Chapman MJ, Packard CJ, Bj\u00f6rnson E, et al. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff1a\u6211\u3005\u304c\u77e5\u3063\u3066\u3044\u308b\u3053\u3068\u3068\u77e5\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u3002\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c72025;https:\/\/doi.org\/10.1016\/j.atherosclerosis.2025.120529<\/a> <\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\uff1b\u30ec\u30e0\u30ca\u30f3\u30c8\uff1b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\uff1b\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\uff1b\u30e1\u30ab\u30cb\u30ba\u30e0\uff1b\u7dcf\u8aac<\/span><\/em><\/p>\n

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1\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306e\u6b8b\u5b58\uff1aREC1TE\u8a66\u9a13<\/strong><\/h5>\n

\u6162\u6027\u7684\u306a\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u307f\u3089\u308c\u3001\u5927\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u708e\u75c7\u306f1\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u306b\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002\u5faa\u74b0\u4e2d\u306e\u708e\u75c7\u6027\u86cb\u767d\u6fc3\u5ea6\u306e\u5897\u52a0\u306f2\u578b\u7cd6\u5c3f\u75c5\u3088\u308a\u3082\u9855\u8457\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u30011\u578b\u7cd6\u5c3f\u75c5\u3067\u306f\u6b8b\u5b58\u3059\u308b\u708e\u75c7\u6027\u30ea\u30b9\u30af\u304c\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u6297\u708e\u75c7\u85ac\u3067\u3042\u308b\u30b3\u30eb\u30d2\u30c1\u30f3\u306f\uff0c\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3084\u4f4e\u8840\u7cd6\uff0c\u30b1\u30c8\u30a2\u30b7\u30c9\u30fc\u30b7\u30b9\u306a\u3069\u306e\u6025\u6027\u5408\u4f75\u75c7\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u3068\u6bd4\u8f03\u691c\u8a0e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u304c\uff0c\u708e\u75c7\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u306b\u3088\u308a1\u578b\u7cd6\u5c3f\u75c5\u306e\u6cbb\u7642\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes (REC1TE, ClinicalTrials.gov ID NCT05949281)\u306e\u76ee\u7684\u306f\u30011\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f3\u306e\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002<\/span><\/p>\n

REC1TE\u306f\u30011\u578b\u7cd6\u5c3f\u75c5\u3092\u6709\u3057\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u3001\u307e\u305f\u306f\u305d\u306e\u9ad8\u30ea\u30b9\u30af\u3067\u3042\u308a\u3001\u6b8b\u4f59\u708e\u75c7\u30ea\u30b9\u30af\uff08\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\u8cea\uff3bhsCRP\uff3d\u22652 mg\/L\u304c2\u56de\u9023\u7d9a\u3057\u3066\u6e2c\u5b9a\u3055\u308c\u308b\u3053\u3068\u3068\u5b9a\u7fa9\uff09\u3092\u6709\u3059\u308b\u500b\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u4f4e\u7528\u91cf\u30b3\u30eb\u30d2\u30c1\u30f3\uff080.5 mg\/\u65e5\uff09\u3092\u8a55\u4fa1\u3059\u308b\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7b2c2\u76f8\u8a66\u9a13\u3067\u3059\u3002
\u9069\u683c\u60a3\u8005\u306f\u3001\u6a19\u6e96\u6cbb\u7642\u306b\u52a0\u3048\u3066\u3001\u30b3\u30eb\u30d2\u30c1\u30f3\u7fa4\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b1:1\u306e\u5272\u5408\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u3001\u6700\u957752\u9031\u9593\u6cbb\u7642\u3092\u53d7\u3051\u307e\u3059\u3002
\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u300126\u9031\u6642\u70b9\u306b\u304a\u3051\u308b2\u7fa4\u9593\u306ehsCRP\u306e\u5dee\u3067\u3059\u3002 \u73fe\u5728\u307e\u3067\u306b102\u4f8b\u306e\u60a3\u8005\u304c\u767b\u9332\u3055\u308c\u3066\u304a\u308a\u3001\u6700\u7d42\u60a3\u8005\u306e\u6765\u9662\u306f2026\u5e74\u521d\u982d\u306b\u4e88\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/span><\/p>\n

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Mathiesen DS, Hansen JV, H\u00f8ck A, et al. Repurposing colchicine for reduction of residual inflammatory risk in type 1 diabetes: Design and rationale of the REC1TE trial. Diabetes Obes Metab 2025 Oct 6. doi: 10.1111\/dom.70139. <\/span><\/em><\/p>\n

\u30ad\u30fc\u30ef\u30fc\u30c9\uff1a\u5fc3\u8840\u7ba1\u3001\u30b3\u30eb\u30d2\u30c1\u30f3\u3001\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u30011\u578b\u7cd6\u5c3f\u75c5<\/span><\/em><\/p>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306fLDL-C\u4f4e\u4e0b\u7642\u6cd5\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u306b\u5bc4\u4e0e\u3059\u308b<\/strong><\/h5>\n

\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u30e1\u30bf\u56de\u5e30\u5206\u6790\u306b\u3088\u308b\u3068\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3001PCSK9\uff08prorotein convertase subtilisin\/kexin type 9\uff09\u963b\u5bb3\u85ac\u306b\u3088\u308b\u6cbb\u7642\u3067\u89b3\u5bdf\u3055\u308c\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u6e1b\u5c11\u306e\u4e00\u56e0\u3067\u3042\u308b\u3002 <\/span><\/p>\n

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\u3057\u304b\u3057\u3001LDL\u4ee5\u5916\u306e\u8102\u8cea\u3082\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u672c\u7814\u7a76\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3001\u304a\u3088\u3073PCSK9\u963b\u5bb3\u85ac\u306e\u8a66\u9a13\u3067\u8a8d\u3081\u3089\u308c\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u306b\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u304c\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u304c\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u672c\u89e3\u6790\u306b\u306f\u300143\u8a66\u9a13\u306b\u53c2\u52a0\u3057\u305f327,264\u4f8b\u306e\u60a3\u8005\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u3001\u305d\u306e\u3046\u306142,016\u4ef6\u306e\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u304c\u767a\u751f\u3057\u307e\u3057\u305f\u3002
\u5168\u4f53\u3068\u3057\u3066\u3001LDL-C\u304c1 mmol\/L\u4f4e\u4e0b\u3059\u308b\u3054\u3068\u306b\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f0.19 mmol\/L\u4f4e\u4e0b\u3057\u3001LDL-C\u304c20%\u4f4e\u4e0b\u3059\u308b\u3054\u3068\u306b11%\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002
1 mmol\/L\u4f4e\u4e0b\u3042\u305f\u308a\u306e\u56fa\u5b9a\u52b9\u679c\uff0f\u30e9\u30f3\u30c0\u30e0\u52b9\u679c\u30ea\u30b9\u30af\u6bd4\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u3067\u8abf\u6574\u3057\u305fLDL-C\u306b\u3064\u3044\u3066\u306f0.88\uff0895%\u4fe1\u983c\u533a\u95930.85\u20130.91\uff09\uff0f0.82\uff080.74\u20130.91\uff09\u3067\u3042\u308a\u3001LDL-C\u4f4e\u4e0b\u3067\u8abf\u6574\u3057\u305f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3064\u3044\u3066\u306f0.74\uff080.60\u20130.92\uff09\uff0f0.92\uff080.45\u20131.187\uff09\u3067\u3057\u305f\u3002 \u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3001\u304a\u3088\u3073PCSK9\u963b\u5bb3\u85ac\u306e\u8a66\u9a13\u3067\u8a8d\u3081\u3089\u308c\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4f4e\u4e0b\u306e\u4e00\u90e8\u304c\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u306b\u3088\u3063\u3066\u8aac\u660e\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002
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Tybj\u00e6rg Nordestgaard A, Nordestgaard BG. Remnant cholesterol lowering in cardiovascular disease risk reduction in statin, ezetimibe, and PCSK9 inhibitor trials: meta-regression analyses. Eur J Prev Cardiol 2025: doi: 10.1093\/eurjpc\/zwaf337. <\/span><\/em><\/p>\n

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NHANES\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6709\u75c5\u7387\u304c\u6e1b\u5c11\u50be\u5411\u3092\u793a\u3059<\/strong><\/h5>\n

\u5168\u7c73\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08NHANES\uff09\u306f\u3001\u7c73\u56fd\u306e\u6210\u4eba\u304a\u3088\u3073\u5c0f\u5150\u306e\u5065\u5eb7\u3068\u6804\u990a\u72b6\u614b\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u306b\u8a08\u753b\u3055\u308c\u305f\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u30011999\uff5e2020\u5e74\u306e\u671f\u9593\u306b\u8abf\u67fb\u3055\u308c\u305f\u6210\u4eba24,658\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3001\u7a7a\u8179\u6642\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08TC\uff09\u3001\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u3002\u4e3b\u306a\u76ee\u7684\u306f\u3001\u7c73\u56fd\u306b\u304a\u3051\u308b\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6709\u75c5\u7387\u306e\u9577\u671f\u7684\u50be\u5411\u3092\u8abf\u67fb\u3059\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306fTC-HDL-C-LDL-C\u3068\u3057\u3066\u8a08\u7b97\u3055\u308c\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f0.78mmol\/L\u4ee5\u4e0a\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002 <\/span><\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6709\u75c5\u7387\u306f26.6\uff05\uff081999-2002\u5e74\uff09\u304b\u308913.7\uff05\uff082015-2020\u5e74\uff09\u3078\u3068\u6e1b\u5c11\u50be\u5411\u3092\u793a\u3057\u3001\u5e74\u95935.4\uff05\u6e1b\u5c11\u3057\u305f\uff08\u7dda\u5f62\u50be\u5411\u306ep<0.001\uff09\u300260\u6b73\u4ee5\u4e0a\u3068\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u9ed2\u4eba\u3067\u3088\u308a\u9855\u8457\u306a\u6e1b\u5c11\u304c\u307f\u3089\u308c\u305f\u3002\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6709\u75c5\u7387\u304c\u5168\u4f53\u7684\u306b\u6e1b\u5c11\u3057\u305f\u306e\u306f\u3001\u540c\u671f\u9593\u4e2d\u306b\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u308b\u4eba\u304c\u5897\u52a0\u3057\u305f\u3053\u3068\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\uff088.3\uff05\u304b\u308919.9\uff05\u3078\uff09\u3002\u4ed6\u306e\u7814\u7a76\u3067\u3082\u3001\u7c73\u56fd\u306b\u304a\u3051\u308b\u540c\u69d8\u306e\u671f\u9593\u306b\u304a\u3051\u308b\u8102\u8cea\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6539\u5584\u50be\u5411\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u652f\u6301\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

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\u80a5\u6e80\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u304c\u5897\u52a0\u3059\u308b\u4e2d\u3067\u3001\u6210\u4eba\u96c6\u56e3\u306e\u76f8\u5f53\u306a\u5272\u5408\u304c\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u30ea\u30b9\u30af\u306b\u3055\u3089\u3055\u308c\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002 \u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u95a2\u9023\u3059\u308b\u3053\u308c\u3089\u306e\u4e3b\u8981\u306a\u4fee\u6b63\u53ef\u80fd\u30ea\u30b9\u30af\u56e0\u5b50\u306b\u5bfe\u51e6\u3059\u308b\u3053\u3068\u306f\u3001\u98df\u4e8b\u3001\u751f\u6d3b\u7fd2\u6163\u304a\u3088\u3073\u4f53\u91cd\u3092\u5bfe\u8c61\u3068\u3057\u305f\u516c\u8846\u885b\u751f\u4ecb\u5165\u306b\u304a\u3051\u308b\u55ab\u7dca\u306e\u512a\u5148\u8ab2\u984c\u3067\u3059\u3002 <\/span><\/p>\n

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1999\u5e74\u304b\u30892020\u5e74\u307e\u3067\u306eNHANES\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u7c73\u56fd\u6210\u4eba\u306b\u304a\u3051\u308b\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068\u305d\u306e\u5371\u967a\u56e0\u5b50\u306e\u50be\u5411\uff1a\u9023\u7d9a\u6a2a\u65ad\u7814\u7a76\u3002BMJ Open 2025; 15:e095079.<\/em><\/p>\n

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\u814e\u6a5f\u80fd\u969c\u5bb3\u306b\u304a\u3051\u308b\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607<\/strong><\/h5>\n

\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002
CKD\u306e\u767a\u75c7\u304a\u3088\u3073\u9032\u884c\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u308b\u708e\u75c7\u3068\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3044\u305a\u308c\u3082\u3001CKD\u306b\u304a\u3051\u308bASCVD\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u4eba\u53e3\u7814\u7a76\u304b\u3089\u306e\u672c\u5831\u544a\u3067\u306f\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u3092\u6709\u3057\u3001\u304b\u3064\u4f4e\u30b0\u30ec\u30fc\u30c9\u708e\u75c7\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306e\u4e21\u65b9\u3092\u8a8d\u3081\u308b\u500b\u4eba\u3067\u3001\u5fc3\u7b4b\u6897\u585e\u3001ASCVD\u3001\u304a\u3088\u3073\u5168\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u6700\u3082\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u3053\u306e\u7814\u7a76\u306f\u3001Copenhagen General Population Study\u306e102,906\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u5bfe\u8c61\u3068\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u3046\u30619,935\u4eba\u306f\u814e\u6a5f\u80fd\u969c\u5bb3\uff08\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf<60 mL\/\u5206\/1.73m<\/sup>2\uff09\u3092\u6709\u3057\u3066\u3044\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u6a19\u6e96\u7684\u306a\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304b\u3089\u7b97\u51fa\u3057\u3001\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306fC\u53cd\u5fdc\u6027\u86cb\u767d\uff08C-reactive protein\uff09\u3068\u5b9a\u7fa9\u3057\u305f\u3002 <\/span>\u22651.3 mg\/L &<10 mg\/L\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306fASCVD\u3067\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002 <\/span><\/p>\n

\u4e2d\u592e\u50249\u5e74\u9593\u306e\u8ffd\u8de1\u3067\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u8005\u3067\u306f\u5fc3\u7b4b\u6897\u585e\u304c566\u4f8b\u3001ASCVD\u304c1,122\u4f8b\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u304c583\u4f8b\u3001\u4f55\u3089\u304b\u306e\u539f\u56e0\u3067\u6b7b\u4ea1\u3057\u305f\u8005\u304c3,139\u4f8b\u3067\u3042\u3063\u305f\u3002C\u53cd\u5fdc\u6027\u86cb\u767d\uff08<1.3mg\/L\uff09\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4f4e\u3044\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001C\u53cd\u5fdc\u6027\u86cb\u767d\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u3068\u3082\u306b\u9ad8\u3044\u4eba\u306f\u5fc3\u7b4b\u6897\u585e\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.39\u300195\uff05\u4fe1\u983c\u533a\u9593[CI]1.10-1.76\uff09\u3001ASCVD\uff081.33\u300195\uff05CI1.13-1.57\uff09\u3001\u5168\u6b7b\u4ea1\uff081.20\u300195\uff05CI1.09-1.33\uff09\u306e\u30ea\u30b9\u30af\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3002\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u3068\u9577\u3044\u8ffd\u8de1\u671f\u9593\u306b\u3088\u308a\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306e\u9811\u5065\u6027\u306f\u5f37\u5316\u3055\u308c\u305f\u304c\u3001\u8457\u8005\u3089\u306f\u3001\u89b3\u5bdf\u30c7\u30b6\u30a4\u30f3\u3001\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u306e1\u56de\u9650\u308a\u306e\u8a55\u4fa1\u3001\u30b5\u30f3\u30d7\u30eb\u306e\u5927\u90e8\u5206\u304c\u767d\u4eba\u6c11\u65cf\u3067\u3042\u308b\u3053\u3068\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u3092\u8a8d\u3081\u3066\u3044\u308b\u3002\u3053\u308c\u3089\u306e\u9650\u754c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u672c\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u3053\u306e\u9ad8\u30ea\u30b9\u30af\u96c6\u56e3\u306b\u304a\u3051\u308bASCVD\u4e88\u9632\u306e\u305f\u3081\u306e\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\u306e\u6307\u91dd\u3068\u306a\u308b\u3067\u3042\u308d\u3046\u3002 <\/p>\n

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El\u00edas-Lopez D, Kobyleckia CJ, Vedel-Krogh S, et al.\u814e\u6a5f\u80fd\u969c\u5bb3\u306b\u304a\u3051\u308b\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u3068\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u3068ASCVD\u304a\u3088\u3073\u6b7b\u4ea1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3002Atherosclerosis 2025; doi.org\/10.1016\/j.atherosclerosis.2025.119241.<\/span><\/em><\/p>\n

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\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u30fb\u30a6\u30a7\u30b9\u30c8\u5468\u56f2\u5f84\u6307\u6570\u306f\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u306e\u30ea\u30b9\u30af\u3092\u4e88\u6e2c\u3059\u308b\u3002<\/strong><\/h5>\n

\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\uff08OSA\uff09\u306f\u3001\u53cd\u5fa9\u6027\u306e\u4e0a\u6c17\u9053\u9589\u585e\u3068\u6c17\u6d41\u6e1b\u5c11\u3092\u4f34\u3046\u7761\u7720\u969c\u5bb3\u3067\u3042\u308a\u3001\u9593\u6b20\u7684\u306a\u4f4e\u9178\u7d20\u3068\u7761\u7720\u306e\u65ad\u7247\u5316\u3092\u4f34\u3046\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u306f\u3001OSA\u306e\u6709\u75c5\u7387\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u6307\u6a19\u3067\u3042\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u6307\u6570\u3068\u306e\u9593\u306b\u6b63\u306e\u76f8\u95a2\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u4f53\u7d44\u6210\u306e\u6e2c\u5b9a\u5024\u3092\u7d44\u307f\u8fbc\u3093\u3060\u4fee\u6b63\u7248\u304c\u3001\u3053\u306e\u6307\u6a19\u306e\u4e88\u6e2c\u80fd\u529b\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u8a3c\u62e0\u3082\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u306e\u3088\u3046\u306a\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u6307\u6a19\u3068OSA\u3068\u306e\u95a2\u9023\u3092\u88cf\u4ed8\u3051\u308b\u5927\u898f\u6a21\u306a\u8abf\u67fb\u306f\u3053\u308c\u307e\u3067\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002\u3053\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u30ae\u30e3\u30c3\u30d7\u306f\u3001NHANES\u306e4\u30b5\u30a4\u30af\u30eb\uff082005\uff5e2008\u5e74\u30012015\uff5e2018\u5e74\uff09\u306e7,789\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u672c\u7814\u7a76\u306b\u3088\u3063\u3066\u89e3\u6c7a\u3055\u308c\u305f\u3002 <\/span><\/p>\n

\u591a\u5909\u91cf\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u3067\u306f\u3001\u80a5\u6e80\u5ea6\u3092\u7d44\u307f\u8fbc\u3093\u3060\u4fee\u6b63\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u6307\u6570\uff08\u30aa\u30c3\u30ba\u6bd41.55\u300195\uff05\u4fe1\u983c\u533a\u9593[CI]1.20-2.00\u3001p<\/span> <<\/span> 0.05\uff09\u307e\u305f\u306f\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\uff08\u30aa\u30c3\u30ba\u6bd41.13\u300195\uff05CI 1.04-1.23\u3001p<\/span> <<\/span>\u20090.05\uff09\u304cOSA\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u305f\u3002ROC\uff08\u9762\u7a4d-\u66f2\u7dda\u4e0b\u53d7\u4fe1\u8005\u52d5\u4f5c\u7279\u6027\uff09\u89e3\u6790\u3067\u306f\u3001\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u3092\u7d44\u307f\u8fbc\u3093\u3060\u6307\u6570\u304cOSA\u306e\u4e88\u6e2c\u80fd\u304c\u6700\u3082\u9ad8\u304f\u3001773.86\u3092\u8d85\u3048\u308b\u3068\u30ea\u30b9\u30af\u304c\u6709\u610f\u306b\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u307e\u305f\u3001OSA\u60a3\u8005\u3067\u306f\u3001\u4e2d\u6027\u8102\u80aa-\u30d6\u30c9\u30a6\u7cd6-\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u306e\u6307\u6a19\u3068\u6b7b\u4ea1\u7387\u306e\u9593\u306b\u975e\u7dda\u5f62\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u3082\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u3092\u7d44\u307f\u8fbc\u3093\u3060\u3053\u306e\u4fee\u6b63\u6307\u6570\u306f\u3001OSA\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u4eba\u3092\u691c\u51fa\u3059\u308b\u6709\u7528\u306a\u30c4\u30fc\u30eb\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3002 <\/span><\/p>\n

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Zhang Y, Li T, Yu H.\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u30fb\u30a6\u30a8\u30b9\u30c8\u5468\u56f2\u5f84\u6307\u6570\u306f\u3001\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u306e\u30ea\u30b9\u30af\u3068\u5168\u6b7b\u56e0\u6b7b\u4ea1\u7387\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u6b7b\u4ea1\u7387\u306e\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u308b\u3002Sci Rep 2025; doi: 10.1038\/s41598-025-11246-w. <\/span><\/em><\/p>\n

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\u6b27\u5dde\u52d5\u8108\u786c\u5316\u5b66\u4f1a\uff082025\u5e745\u67084\uff5e7\u65e5\u3001\u82f1\u56fd\u30b0\u30e9\u30b9\u30b4\u30fc\uff09\u3088\u308a<\/strong><\/h5>\n
\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d6\u306e\u826f\u597d\u306a\u7d50\u679c<\/h5>\n

BROADWAY\u8a66\u9a13\uff08\u6700\u5927\u8010\u7528\u91cf\u306e\u8102\u8cea\u4fee\u98fe\u7642\u6cd5\u306b\u4e0a\u4e57\u305b\u3057\u305fobicetrapib\u306e\u52b9\u679c\u3092\u8a55\u4fa1\u3059\u308b\u7121\u4f5c\u70ba\u5316\u8a66\u9a13\u3001ClinicalTrials.gov\/NCT05142722\uff09\u306e\u7d50\u679c\u306f\u3001\u9ad8\u5ea6\u306b\u9078\u629e\u7684\u306a\u30b3\u30ec\u30b9\u30c6\u30ea\u30eb\u30a8\u30b9\u30c6\u30eb\u8ee2\u9001\u30bf\u30f3\u30d1\u30af\uff08CETP\uff09\u963b\u5bb3\u85ac\u3067\u3042\u308bobicetrapib\u304c\u3001\u6700\u5927\u8010\u7528\u91cf\u306e\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u9ad8\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3092\u7d043\u5206\u306e1\uff08\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\uff09\u4f4e\u4e0b\u3055\u305b\u305f\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u5b66\u4f1a\u3067\u30ec\u30a4\u30c8\u30d6\u30ec\u30a4\u30ab\u30fc\u3068\u3057\u3066\u767a\u8868\u3055\u308c\u3001\u540c\u6642\u306bNew England Journal of Medicine\u306b\u63b2\u8f09\u3055\u308c\u305f\u3002
BROADWAY\u8a66\u9a13\u3067\u306f\u3001\u30d8\u30c6\u30ed\u63a5\u5408\u4f53\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u307e\u305f\u306f\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u3092\u6709\u3057\u3001LDL-C\u304a\u3088\u3073\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u30ea\u30b9\u30af\u306b\u57fa\u3065\u304f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u76ee\u6a19\u3092\u4e0a\u56de\u308b2,530\u4f8b\uff08\u5e73\u5747\u5e74\u9f6265\u6b73\u3001\u5973\u602734%\uff09\u3092\u3001obicetrapib 10 mg\u7fa4\uff08n=1,686\uff09\u307e\u305f\u306f\u5bfe\u5fdc\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u7fa4\uff08n=844\uff09\u306b\u7121\u4f5c\u70ba\u5316\u3057\u3001365\u65e5\u9593\u6295\u4e0e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b84\u65e5\u76ee\u306b\u304a\u3044\u3066\u3001obicetrapib\u306fLDL-C\u309229.9%\u4f4e\u4e0b\u3055\u305b\u305f\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u306f2.7%\u5897\u52a0\u3057\u305f\uff08\u7fa4\u9593\u5dee \u221232.6%\u300195%\u4fe1\u983c\u533a\u9593 \u221235.8\uff5e\u221229.5\uff1bp\u2026\uff09\u3002 <0.001).
\u3055\u3089\u306b\u3001\u8ffd\u52a0\u306e\u5b89\u5168\u6027\u89e3\u6790\u306b\u304a\u3044\u3066\u3001\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d6\u6295\u4e0e\u306f\u3001\u51a0\u52d5\u8108\u75be\u60a3\u6b7b\u4ea1\u3001\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3001\u975e\u81f4\u6b7b\u7684\u8133\u5352\u4e2d\u3001\u51a0\u52d5\u8108\u8840\u884c\u518d\u5efa\u8853\u306e\u8907\u5408\u3068\u5b9a\u7fa9\u3055\u308c\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u63a2\u7d22\u7684\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306b\u304a\u3044\u3066\u300121\uff05\u306e\u76f8\u5bfe\u7684\u6e1b\u5c11\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.79\u300195\uff05\u4fe1\u983c\u533a\u95930.54-1.15\uff09\u3068\u95a2\u9023\u3057\u305f\u3002
\u7d50\u8ad6\u3068\u3057\u3066\u3001BROADWAY\u8a66\u9a13\u306e\u7d50\u679c\u306f\u3001\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d6\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u62e1\u5927\u3057\u3001\u65e2\u5b58\u306e\u6cbb\u7642\u6cd5\u3067\u306f\u5341\u5206\u306a\u52b9\u679c\u304c\u5f97\u3089\u308c\u306a\u3044\u304b\u3001\u5fcd\u5bb9\u6027\u304c\u5341\u5206\u3067\u306a\u3044\u3053\u306e\u6cbb\u7642\u56f0\u96e3\u306a\u60a3\u8005\u7fa4\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u3092\u5b9f\u8a3c\u3057\u305f\u3002<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d6\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3002N Engl J Med 2025 doi: 10.1056\/NEJMoa2415820.<\/span><\/i><\/p>\n

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<\/h5>\n

\u3082\u3046\u4e00\u3064\u306e\u5f8c\u671f\u30d6\u30ec\u30fc\u30ab\u30fc\u767a\u8868\u3067\u306f\u3001TANDEM\u8a66\u9a13\uff08Study of Obicetrapib & Ezetimibe Fixed Dose Combination on Top of Maximum Tolerated Lipid-Modifying Therapies\uff09\u306e\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u305f\u3001 <\/span>NCT06005597<\/span>)\u3068\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d610mg\u3068\u30a8\u30bc\u30c1\u30df\u30d610mg\u306e\u56fa\u5b9a\u7528\u91cf\u914d\u5408\u5264(FDC)\u3092\u6bd4\u8f03\u3057\u305f\u3002TANDEM\u8a66\u9a13\u306f\u3001\u6700\u5927\u8010\u7528\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u3082\u304b\u304b\u308f\u3089\u305aLDL-C\u5024\u304c1.8mmol\/lL\uff0870mg\/dL\uff09\u4ee5\u4e0a\u306e\u9ad8\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u60a3\u8005407\u4f8b\u3092\u3001\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d6\uff0b\u30a8\u30bc\u30c1\u30df\u30d6\u306eFDC\u7642\u6cd5\u3001\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d610mg\u5358\u5264\u7642\u6cd5\u3001\u30a8\u30bc\u30c1\u30df\u30d610mg\u5358\u5264\u7642\u6cd5\u3001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u7642\u6cd5\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002 <\/span><\/p>\n

84\u65e5\u76ee\u6642\u70b9\u3067\u3001FDC\u306f\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066LDL-C\u309248.6%\u4f4e\u4e0b\u3055\u305b\u307e\u3057\u305f\uff08p<0.001\uff09\u3002\u4e00\u65b9\u3001\u30aa\u30d3\u30bb\u30c8\u30e9\u30d4\u30d6\u5358\u5264\u7642\u6cd5\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066LDL-C\u304c31.9%\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002
\u91cd\u8981\u306a\u70b9\u3068\u3057\u3066\u3001\u60a3\u8005\u306e70%\u4ee5\u4e0a\u304cLDL-C\u50241.4 mmol\/L\u672a\u6e80\uff08<55 mg\/dL\uff09\u3092\u9054\u6210\u3057\u307e\u3057\u305f\u3002 \u3053\u308c\u3089\u306e\u77e5\u898b\u306b\u57fa\u3065\u304d\u3001\u3053\u306e\u7d4c\u53e3\u5358\u5264\u306e\u56fa\u5b9a\u7528\u91cf\u914d\u5408\u5264\uff08FDC\uff09\u6cbb\u7642\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3059\u308b\u3001\u307e\u305f\u306f\u305d\u306e\u9ad8\u30ea\u30b9\u30af\u3067\u3042\u308b\u60a3\u8005\u306b\u304a\u3051\u308bLDL-C\u7ba1\u7406\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 <\/span><\/p>\n

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Sarraju A, Brennan D, Hayden K, et al. Fixed-dose combination of obicetrapib and ezetimibe for LDL cholesterol reduction (TANDEM): a phase 3, randomised, double-blind, placebo-controlled trial. The Lancet 2025; DOI: 10.1016\/S0140-6736(25)00721-4. <\/span><\/i><\/p>\n

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<\/h5>\n
\u65b0\u898fANGPTL4\u963b\u5bb3\u5264\u306e\u521d\u306e\u30d2\u30c8\u8a66\u9a13\u30c7\u30fc\u30bf<\/h5>\n

\u3082\u3046\u3072\u3068\u3064\u306e\u30a8\u30ad\u30b5\u30a4\u30c6\u30a3\u30f3\u30b0\u306a\u5f8c\u767a\u533b\u85ac\u54c1\u306f\u3001ANGPTL4\uff08\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea4\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30af\u30e9\u30b9\u306e\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53MAR001\u306e\u6700\u521d\u306e\u81e8\u5e8a\u7d50\u679c\u3092\u767a\u8868\u3057\u305f\u3002 <\/span><\/p>\n

ANGPTL4\u306f\u3001\u8102\u80aa\u7d44\u7e54\u304a\u3088\u3073\u809d\u81d3\u3067\u9ad8\u767a\u73fe\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308a\u3001\u4e3b\u306b\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30d1\u30fc\u30bc\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u8102\u8cea\u4ee3\u8b1d\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u3092\u3082\u305f\u3089\u3057\u307e\u3059\u3002
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\u3057\u304b\u3057\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u6700\u826f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u6b8b\u4f59\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306b\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u7279\u7570\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u6cbb\u7642\u6cd5\u306f\u4e0d\u8db3\u3057\u3066\u3044\u307e\u3059\u3002 \u30d2\u30c8\u907a\u4f1d\u5b66\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306bANGPTL4\u3092\u6cbb\u7642\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u306e\u6839\u62e0\u3092\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002 <\/span><\/p>\n

ANGPTL4\u3092\u6a19\u7684\u3068\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308bMAR001\u306e\u53cd\u5fa9\u6295\u4e0e\u304c\u3001\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c1.7 mmol\/L\u4ee5\u4e0a5.6 mmol\/L\u4ee5\u4e0b\u306e55\u4f8b\u3092\u5bfe\u8c61\u306b\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002
\u5bfe\u8c61\u8005\u306f\u3001MAR001\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u30922\u9031\u9593\u3054\u3068\u306b\u6295\u4e0e\u3055\u308c\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u30b3\u30db\u30fc\u30c8\u3067\u306f\u300110\u4f8b\u304cMAR001 150 mg\u7fa4\u30019\u4f8b\u304cMAR001 300 mg\u7fa4\u300117\u4f8b\u304cMAR001 450 mg\u7fa4\u300119\u4f8b\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u3002
12\u9031\u6642\u70b9\u3067\u3001MAR001\u306e\u6700\u9ad8\u7528\u91cf\u306f\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u309252.5%\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u309252.7%\u4f4e\u4e0b\u3055\u305b\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u4f4e\u4e0b\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c200 mg\/dL\u4ee5\u4e0a\u306e\u5bfe\u8c61\u8005\u3067\u3088\u308a\u5927\u304d\u304f\u3001\u305d\u308c\u305e\u308c66.0%\u304a\u3088\u307364.0%\u3067\u3057\u305f\u3002 \u91cd\u8981\u306a\u70b9\u3068\u3057\u3066\u3001MAR001\u306f\u5fcd\u5bb9\u6027\u304c\u826f\u597d\u3067\u3042\u308a\u3001\u5168\u8eab\u6027\u708e\u75c7\u3001\u7e26\u9694\u30ea\u30f3\u30d1\u7bc0\u816b\u5927\u3001\u307e\u305f\u306f\u5c40\u6240\u708e\u75c7\u6027\u5909\u5316\u306e\u6240\u898b\u3092\u542b\u3081\u3001\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u6240\u898b\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002 <\/span><\/p>\n

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Cummings B, et al. A novel ANGPTL4 inhibitory antibody safely lowers plasma triglycerides and remnant cholesterol in humans. Abstract 1320. <\/span><\/i>2025\u5e745\u670817\u65e5\u30aa\u30f3\u30e9\u30a4\u30f3\u516c\u958b\uff1a <\/span><\/i>\u8102\u8cea\u4f4e\u4e0b\u306b\u5bfe\u3059\u308b\u65b0\u898fANGPTL4\u963b\u5bb3\u6297\u4f53\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\uff1a\u7b2c1\u76f8\u304a\u3088\u3073\u7b2c1b\/2a\u76f8\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u3002Lancet 2025; doi: 10.1016\/S0140-6736(25)00825-6 <\/span><\/i><\/p>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u52d5\u8108\u786c\u5316\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u65e9\u671f\u30de\u30fc\u30ab\u30fc\uff1f<\/b><\/h5>\n

\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u4ee3\u7528\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u52d5\u8108\u786c\u5316\u5ea6\u306e\u4e0a\u6607\u306f\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3001NHANES\uff08National Health and Nutrition Examination Survey\uff09\u306e\u89e3\u6790\u304b\u3089\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u30011999\u5e74\u304b\u30892018\u5e74\u307e\u3067NHANES\u306b\u767b\u9332\u3055\u308c\u305f20\u6b73\u4ee5\u4e0a\u306e12,505\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u8a55\u4fa1\u3057\u305f\u3002\u52d5\u8108\u786c\u5316\u306f\u3001\u52d5\u8108\u58c1\u306e\u5f3e\u529b\u6027\u306e\u30b4\u30fc\u30eb\u30c9\u30b9\u30bf\u30f3\u30c0\u30fc\u30c9\u6307\u6a19\u3067\u3042\u308b\u9838\u52d5\u8108-\u5927\u817f\u8108\u6ce2\u4f1d\u64ad\u901f\u5ea6\u3088\u308a\u3082\u5358\u7d14\u3067\u3001\u975e\u4fb5\u8972\u7684\u3067\u3001\u3088\u308a\u5229\u7528\u3057\u3084\u3059\u3044\u6307\u6a19\u3067\u3042\u308b\u63a8\u5b9a\u8108\u6ce2\u4f1d\u64ad\u901f\u5ea6\uff08ePWV\uff09\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3057\u305f\u3002 <\/span><\/p>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u306f\u3001\u4e00\u8cab\u3057\u3066ePWV\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e94\u5206\u4f4d\u3067\u89e3\u6790\u3057\u305f\u5834\u5408\u3001\u6700\u9ad8\u4e94\u5206\u4f4d\u306e\u5bfe\u8c61\u8005\u3067\u306f\u3001\u6700\u4f4e\u4e94\u5206\u4f4d\u306e\u5bfe\u8c61\u8005\u3068\u6bd4\u8f03\u3057\u3066ePWV\u304c\u5927\u304d\u304f\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002
\u3053\u306e\u95a2\u9023\u306f\u300140<\u672a\u6e80\u306e\u500b\u4eba\u3001\u5973\u6027\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u767d\u4eba\u3001\u304a\u3088\u3073\u8ca7\u56f0\u72b6\u614b\u306b\u306a\u3044\u500b\u4eba\u3067\u3088\u308a\u9855\u8457\u3067\u3057\u305f\u3002 \u975e\u5e38\u306b\u9ad8\u3044\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u3067\u306f\u3001\u3053\u306e\u95a2\u9023\u306b\u6f5c\u5728\u7684\u306a\u98fd\u548c\u52b9\u679c\u304c\u8a8d\u3081\u3089\u308c\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u52d5\u8108\u786c\u5316\u306b\u5bfe\u3057\u3066\u975e\u7dda\u5f62\u306e\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u6240\u898b\u304b\u3089\u3001\u8457\u8005\u3089\u306f\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306fASCVD\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u96c6\u56e3\u3092\u7279\u5b9a\u3059\u308b\u305f\u3081\u306e\u81e8\u5e8a\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308a\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u305f\u3002<\/span><\/p>\n

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Lai T, Liang Y, Guan F, et al. \u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u52d5\u8108\u786c\u5316\u3068\u306e\u95a2\u9023\uff1aNHANES 1999-2018\u304b\u3089\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3002Nutrition, Metabolism and Cardiovascular Diseases 2025; doi.org\/10.1016\/j.numecd.2025.104013<\/span><\/i><\/p>\n

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Copenhagen General Population Study\u306b\u57fa\u3065\u304f\u3053\u306e\u30e2\u30c7\u30ea\u30f3\u30b0\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u7a4d\u6975\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u5927\u5e45\u306b\u6e1b\u5c11\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002\u3055\u3089\u306b\u3001\u63a8\u5b9a\u3055\u308c\u305f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u7d76\u5bfe\u7684\u6e1b\u5c11\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u672a\u6295\u4e0e\u306e\u88ab\u9a13\u8005\u3068\u6bd4\u8f03\u3057\u3066\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u88ab\u9a13\u8005\u3067\u3088\u308a\u5927\u304d\u304b\u3063\u305f\u3002 <\/span><\/p>\n

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\u3057\u304b\u3057\u73fe\u5728\u307e\u3067\u306e\u3068\u3053\u308d\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4f4e\u4e0b\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u3092\u793a\u3059\u81e8\u5e8a\u8a66\u9a13\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u3053\u306e\u30b3\u30db\u30fc\u30c8\u30e2\u30c7\u30ea\u30f3\u30b0\u89e3\u6790\u306f\u3001\u3053\u306e\u7591\u554f\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u89e3\u6790\u306e\u5bfe\u8c61\u3068\u306a\u3063\u305f\u306e\u306f\u3001Copenhagen General Population Study\u306eASCVD\u65e2\u5f80\u306e\u306a\u3044\u5973\u602756,422\u4eba\u3001\u7537\u602743,952\u4eba\u306e\u30c7\u30fc\u30bf\u3067\u3042\u308b\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502412\u5e74\u306e\u9593\u306b\u3001\u5973\u60274,946\u4eba\u3001\u7537\u60276,043\u4eba\u304cASCVD\u3092\u767a\u75c7\u3057\u305f\u3002\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u975e\u5e38\u306b\u9ad8\u3044\u5973\u6027\u306b\u304a\u3044\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u304c1mmol\/L\uff0839mg\/dL\uff09\u4f4e\u4e0b\u3059\u308b\u3068\u3001ASCVD\u306e10\u5e74\u7d76\u5bfe\u30ea\u30b9\u30af\u306f\u30b9\u30bf\u30c1\u30f3\u4f7f\u7528\u8005\u306710\uff05\u3001\u975e\u4f7f\u7528\u8005\u30677\uff05\u4f4e\u4e0b\u3057\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u4eba\u3067\u306f\u30012mmol\/lL\uff0877mg\/dL\uff09\u306e\u6e1b\u5c11\u3067\u7d76\u5bfe\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u304c\u307b\u307c2\u500d\u306b\u306a\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u30e2\u30c7\u30eb\u5316\u3055\u308c\u305f\u30c7\u30fc\u30bf\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u7279\u306b\u9ad8\u30ea\u30b9\u30af\u8005\u306b\u304a\u3044\u3066\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7a4d\u6975\u7684\u306a\u4f4e\u4e0b\u304c\u53ca\u307c\u3059\u5f71\u97ff\u3092\u691c\u8a0e\u3059\u308b\u7814\u7a76\u306e\u6839\u62e0\u3068\u306a\u308b\u3002 <\/span><\/p>\n

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Hvid K, Balling M, Afzal S, Nordestgaard BG.ASCVD\u4e88\u9632\u306e\u305f\u3081\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\uff1a\u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u4eba\u53e3\u7814\u7a76\u306b\u304a\u3051\u308b\u30e2\u30c7\u30eb\u5316\u3002Eur J Prev Cardiol 2025; doi: 10.1093\/eurjpc\/zwaf203. <\/span><\/i><\/p>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u4ee3\u8b1d\u969c\u5bb3\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u969c\u5bb3\u306e\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u591a\u304f\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u3002\u3053\u306eChina Health and Retirement Longitudinal Study\u306e\u5831\u544a\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u30fb\u814e\u81d3\u30fb\u4ee3\u8b1d\u75c7\u5019\u7fa4\uff08CKM\uff09\u306e\u9032\u884c\u3068\u306e\u95a2\u9023\u3092\u8abf\u3079\u305f\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n

China Health and Retirement Longitudinal Study\uff08CHARLS\uff09\u306f\u300128\u7701\u306b\u307e\u305f\u304c\u308b150\u306e\u5730\u533a\u3068450\u306e\u6751\u307e\u305f\u306f\u90fd\u5e02\u30b3\u30df\u30e5\u30cb\u30c6\u30a3\u306b\u4f4f\u308045\u6b73\u4ee5\u4e0a\u306e\u4e2d\u56fd\u4eba\u4f4f\u6c11\u306e\u5065\u5eb7\u30c7\u30fc\u30bf\u3092\u53ce\u96c6\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u308b\u30022011\u5e74\u304b\u30892020\u5e74\u306b\u304b\u3051\u3066\u3001\u5408\u8a0889,031\u4eba\u304c\u8abf\u67fb\u306b\u53c2\u52a0\u3057\u3001\u305d\u306e\u3046\u306146,619\u4eba\u304c\u8abf\u67fb\u5bfe\u8c61\u3068\u306a\u3063\u305f\u3002 <\/span><\/p>\n

Cox\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u4eba\u307b\u3069\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u6700\u3082\u4f4e\u3044\u56db\u5206\u4f4d\u306e\u4eba\u306b\u6bd4\u3079\u3066\u3001CKM\u75c5\u671f\u304c\u9032\u884c\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u305f\uff08\u50be\u5411\u306eP< 0.001\uff09\u3002\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50249.0\u5e74\u306e\u9593\u306b\u3001CKM\u75c5\u671f0\u301c3\u306e1,498\u4eba\uff0821.8\uff05\uff09\u304c\u5fc3\u8840\u7ba1\u75be\u60a3\u3092\u767a\u75c7\u3057\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u307b\u3069\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306f\u9ad8\u304f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u304c\u56db\u5206\u4f4d\u50243\u307e\u305f\u306f4\u306e\u60a3\u8005\u3067\u306f\u3001\u6700\u3082\u4f4e\u3044\u56db\u5206\u4f4d\u5024\u306e\u4eba\u306b\u6bd4\u3079\u3066\u30ea\u30b9\u30af\u304c20\uff05\u8fd1\u304f\u4e0a\u6607\u3057\u305f\uff08\u56db\u5206\u4f4d\u50243\uff1a\u30cf\u30b6\u30fc\u30c9\u6bd41.181\u300195\uff05\u4fe1\u983c\u533a\u9593[CI]1.02-1.36\u3001\u56db\u5206\u4f4d\u50244\uff1a\u30cf\u30b6\u30fc\u30c9\u6bd41.195\u300195\uff05CI1.03-1.38\uff09\u3002\u8457\u8005\u3089\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u65e9\u671f\u767a\u898b\u3068\u7ba1\u7406\u306fCKM\u306e\u9032\u884c\u4e88\u9632\u306b\u81e8\u5e8a\u7684\u5229\u76ca\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u305f\u3002 <\/span><\/p>\n

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\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u30fb\u814e\u81d3\u30fb\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u9032\u884c\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\uff1a\u4e2d\u56fd\u5065\u5eb7\u30fb\u9000\u8077\u7e26\u65ad\u7814\u7a76\u304b\u3089\u306e\u8003\u5bdf\u3002Eur J Prev Cardiol 2025; doi: 10.1093\/eurjpc\/zwaf248. <\/span><\/i><\/p>\n

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\u65b0\u3057\u3044\u30ec\u30d3\u30e5\u30fc\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u907a\u4f1d\u5b66<\/b><\/h5>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u907a\u4f1d\u7684\u6c7a\u5b9a\u56e0\u5b50\u3092\u7279\u5b9a\u3057\u3001\u305d\u308c\u3089\u3092\u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3068\u95a2\u9023\u4ed8\u3051\u308b\u3053\u3068\u306f\u3001\u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u7ba1\u7406\u306b\u5411\u3051\u305f\u65b0\u305f\u306a\u6cbb\u7642\u9078\u629e\u80a2\u306e\u63a2\u7d22\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u63a8\u9032\u529b\u3068\u306a\u3063\u3066\u304d\u307e\u3057\u305f\u3002
\u3053\u306e\u30bf\u30a4\u30e0\u30ea\u30fc\u306a\u65b0\u898f\u8ad6\u6587\u3067\u306f\u3001\u8457\u8005\u3089\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u4ee3\u8b1d\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u306b\u3064\u3044\u3066\u3001\u30d2\u30c8\u907a\u4f1d\u75ab\u5b66\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u306b\u306f\u3001 <\/span>APOC3<\/span><\/i>, <\/span>ANGPTL3<\/span><\/i>\u304a\u3088\u3073 <\/span>ANGPTL4<\/span><\/i> \u907a\u4f1d\u5b50\u306f\u3001\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u306e\u6d3b\u6027\u3092\u5236\u5fa1\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u305d\u306e\u7d50\u679c\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3002\u65b0\u3057\u3044RNA\u6cbb\u7642\u85ac\u306f\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u3068\u305d\u306e\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7279\u7570\u7684\u306b\u6a19\u7684\u3068\u3059\u308b\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3059\u308b\u3002 <\/span><\/p>\n

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Wulff AB\u3001Nordestgaard BG\u3002\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u907a\u4f1d\u5b66\u3002Curr Opin Lipidol 2025; doi: 10.1097\/MOL.000000000991. <\/span><\/i><\/p>\n

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Kraaijenhof JM, Kerkvliet MJ, Nurmohamed NS, et al.
\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u95a2\u9023\u3059\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u304a\u3051\u308b\u5168\u8eab\u6027\u708e\u75c7\u306e\u5f79\u5272\uff1aEPIC-Norfolk\u7814\u7a76\u304b\u3089\u306e\u8003\u5bdf\u3002Eur J Prev Cardiol 2025; doi: 10.1093\/eurjpc\/zwaf037. <\/p>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304c\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306b\u5bc4\u4e0e\u3059\u308b<\/strong><\/h5>\n

Copenhagen General Population Study\u3067\u5f97\u3089\u308c\u305f\u77e5\u898b\u306b\u3088\u308b\u3068\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e5\u4ef6\u306b1\u4ef6\u306f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306b\u8d77\u56e0\u3057\u3066\u3044\u308b\u3002\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3067\u3042\u308a\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306eASCVD\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3002Copenhagen General Population Study\u306e\u3053\u306e\u89e3\u6790\u306f\u3001\u3053\u306e\u60a3\u8005\u7fa4\u306b\u304a\u3051\u308bASCVD\u306b\u5bfe\u3059\u308b\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08
\uff09\u306e\u5bc4\u4e0e\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002Copenhagen General Population Study\u306f\u5927\u898f\u6a21\u306a\u96c6\u56e3\u7814\u7a76\u3067\u3042\u308a\u3001\u5f53\u521d\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u5371\u967a\u56e0\u5b50\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u8a08\u753b\u3055\u308c\u305f\u304c\u3001\u305d\u306e\u5f8c\u3001\u4ed6\u306e\u5065\u5eb7\u72b6\u614b\u3084\u907a\u4f1d\u7684\u30fb\u5fc3\u7406\u793e\u4f1a\u7684\u56e0\u5b50\u306a\u3069\u3001\u3088\u308a\u5e83\u7bc4\u306a\u5bfe\u8c61\u3092\u542b\u3080\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u4eca\u56de\u306e\u89e3\u6790\u306f107,243\u4eba\u306e\u30b3\u30db\u30fc\u30c8\u304b\u3089\u5f97\u3089\u308c\u305f\u3082\u306e\u3067\u3001\u305d\u306e\u3046\u30613,806\u4eba\u304c\u7cd6\u5c3f\u75c5\u3068\u540c\u5b9a\u3055\u308c\u305f\u3002\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u3001\u6b27\u5dde\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306e\u76ee\u6a19\u5024\u306b\u5f93\u3063\u3066\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08non-HDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1c2.6mmol\/L\uff08100mg\/dL\uff09\u306e\u500b\u4eba\u3067\u89b3\u5bdf\u3055\u308c\u308b\u5024\uff08
\uff09\u3088\u308a\u3082\u9ad8\u3044\u5024\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u300215\u5e74\u9593\u306e\u8ffd\u8de1\u3067498\u4f8b\u306e\u60a3\u8005\u304cASCVD\u30a4\u30d9\u30f3\u30c8\u3092\u7d4c\u9a13\u3057\u3001172\u4f8b\u304c\u672b\u68a2\u52d5\u8108\u75be\u60a3\u3001185\u4f8b\u304c\u5fc3\u7b4b\u6897\u585e\u3001195\u4f8b\u304c\u865a\u8840\u6027\u8133\u5352\u4e2d\u3067\u3042\u3063\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e2d\u592e\u5024\u306f\u3001\u975eHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c2.6mmol\/L\u672a\u6e80\u306e\u60a3\u8005\u3067\u306f0.5mmol\/L\uff0820mg\/dL\uff09\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u306f0.8mmol\/L\uff0831mg\/dL\uff09\u3067\u3042\u3063\u305f\u3002\u591a\u5909\u91cf\u8abf\u6574\u30dd\u30a2\u30bd\u30f3\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304cASCVD\u30a4\u30d9\u30f3\u30c8\u306e19\uff05\uff0895\uff05\u4fe1\u983c\u533a\u959310\u301c28\uff05\uff09\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u3053\u306e\u5024\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304cASCVD\u30a4\u30d9\u30f3\u30c8\u306e16\uff05\uff089\uff05\u301c22\uff05\uff09\u306b\u95a2\u4e0e\u3057\u3066\u3044\u305fUK Biobank\u306e\u7d50\u679c\u3068\u4e00\u81f4\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308bASCVD\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4e0a\u6607\u306e\u91cd\u8981\u6027\u304c\u652f\u6301\u3055\u308c\u3001\u3053\u306e\u5371\u967a\u56e0\u5b50\u3092\u6a19\u7684\u3068\u3059\u308b\u3053\u3068\u3067\u3053\u306e\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u7fa4\u306b\u304a\u3051\u308bASCVD\u3092\u4e88\u9632\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306e\u3055\u3089\u306a\u308b\u7814\u7a76\u306e\u6839\u62e0\u3068\u306a\u308b\u3002 <\/p>\n

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Wadstr\u00f6m BN, Pedersen KM, Wulff AB, Nordestgaard BG.\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u30a4\u30d9\u30f3\u30c8\u306e5\u4ef6\u306b1\u4ef6\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306b\u8d77\u56e0\u3059\u308b\u3002Diabetes Metab Res Rev 2024;40(8): e70005. <\/span><\/i><\/p>\n

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\u9ad8\u9f62\u8005\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/strong><\/h5>\n

\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u306e\u30ea\u30b9\u30af\u56e0\u5b50\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\u3057\u304b\u3057\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u591a\u304f\u306f\u82e5\u5e74\u6210\u4eba\u306b\u7531\u6765\u3057\u3066\u304a\u308a\u3001\u9ad8\u9f62\u8005\uff0870>\u8d85\uff09\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u4eba\u53e3\u306e\u9ad8\u9f62\u5316\u3092\u8e0f\u307e\u3048\u308b\u3068\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\u3002 \u30b3\u30da\u30f3\u30cf\u30fc\u30b2\u30f3\u4e00\u822c\u4eba\u53e3\u7814\u7a76\u304b\u3089\u306e\u672c\u89e3\u6790\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u9ad8\u5024\u306f\u3001\u9ad8\u9f62\u8005\uff0870\u301c100\u6b73\uff09\u306b\u304a\u3044\u3066\u3082\u3001\u82e5\u5e74\u6210\u4eba\u3068\u5c11\u306a\u304f\u3068\u3082\u540c\u7a0b\u5ea6\u306b\u91cd\u8981\u306a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u306b\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306bASCVD\u3001\u7cd6\u5c3f\u75c5\u3001\u307e\u305f\u306f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3092\u6709\u3057\u3066\u3044\u306a\u304420\u301c100\u6b73\u306e\u7537\u597390,875\u4eba\u306e\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502412.8\u5e74\u306e\u9593\u306b\u30017,352\u4eba\u304cASCVD\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u300270\u301c100\u6b73\u3067\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c1.0 mmol\/L>\uff0839 mg\/dL>\uff09\u306e\u500b\u4eba\u3067\u306f\u3001ASCVD\u306e\u767a\u751f\u7387\u304c\u6700\u3082\u9ad8\u304f\u306a\u308a\u307e\u3057\u305f\uff081,000\u4eba\u5e74\u3042\u305f\u308a23\u4ef6\u300195%\u4fe1\u983c\u533a\u9593\uff3bCI\uff3d21\u301c25\uff09\u3002
70\u301c100\u6b73\u306e\u5e74\u9f62\u7fa4\u3067\u306f\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c1.0 mmol\/L\uff0839 mg\/dL\uff09\u5897\u52a0\u3059\u308b\u3054\u3068\u306b\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c31%\u9ad8\u304f\u306a\u308b\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u304a\u308a\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.31\u300195% CI\uff1a1.20\u301c1.44\uff09\u3001\u3053\u308c\u306f\u82e5\u5e74\u5e74\u9f62\u7fa4\u3067\u8a8d\u3081\u3089\u308c\u305f\u95a2\u9023\u3068\u540c\u7a0b\u5ea6\u3067\u3057\u305f\u3002 \u9ad8\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3088\u308bASCVD\u306e\u5bc4\u4e0e\u5272\u5408\u306f\u300170\u6b73\u306712%\u3001100\u6b73\u30679%\u3067\u3057\u305f\u3002 <\/span><\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001\u9ad8\u5e74\u9f62\u7fa4\u3067\u306f\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304cASCVD\u306e\u9ad8\u767a\u751f\u7387\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u5e74\u9f62\u3092\u554f\u308f\u305a\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3092\u6a19\u7684\u3068\u3057\u305f\u4ecb\u5165\u306e\u91cd\u8981\u6027\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n

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Riis J, Nordestgaard BG, Afzal S. 70-100\u6b73\u306e\u5065\u5eb7\u306a\u5973\u6027\u304a\u3088\u3073\u7537\u6027\u306b\u304a\u3051\u308b\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Eur J Prev Cardiol 2025; doi: 10.1093\/eurjpc\/zwaf092. <\/span><\/i><\/p>\n

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\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u3092\u7528\u3044\u305fOCEAN(a)-DOSE\u8a66\u9a13\u306e\u6700\u65b0\u30cb\u30e5\u30fc\u30b9<\/b><\/h5>\n

\u3053\u306e\u6700\u65b0\u306e\u89e3\u6790\u306f <\/span>\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u6e1b\u5c11-DOSE\u6240\u898b\u8a66\u9a13\uff08OCEAN(a)-DOSE\uff09\u306e\u6700\u65b0\u89e3\u6790\u7d50\u679c <\/span>\u306e\u6700\u65b0\u306e\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u306f\u30ea\u30dd\u86cb\u767d(a)[L(a)]\u309295\uff05\u4ee5\u4e0a\u4f4e\u4e0b\u3055\u305b\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u306e\u4fc3\u9032\u306b\u95a2\u4e0e\u3059\u308b\u9178\u5316\u30ea\u30f3\u8102\u8cea\u306e\u30ec\u30d9\u30eb\u3082\u4f4e\u4e0b\u3055\u305b\u305f\u3002 <\/span> <\/p>\n

OCEAN(a)-DOSE\u306f\u3001ASCVD\u304c\u78ba\u7acb\u3057Lp(a)> 150nmol\/L\u306e\u60a3\u8005281\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u591a\u65bd\u8a2d\u5171\u540c\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u7528\u91cf\u8a2d\u5b9a\u8a66\u9a13\u3067\u3042\u308b\u3002\u4eca\u56de\u306e\u4e8b\u524d\u898f\u5b9a\u89e3\u6790\u3067\u306f\u3001272\u4eba\u306e\u60a3\u8005\uff08\u5e74\u9f62\u4e2d\u592e\u502462\u6b73\u3001\u5973\u602731.6\uff05\uff09\u306e\u30c7\u30fc\u30bf\u304c\u5bfe\u8c61\u3068\u306a\u3063\u305f\u3002\u60a3\u8005\u306f\u3001\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u306e\u76ae\u4e0b\u6295\u4e0e\uff0810mg\u300175mg\u3001225mg\u309212\u9031\u3054\u3068\u3001225mg\u309224\u9031\u3054\u3068\uff09\u306e\u3044\u305a\u308c\u304b\u3092\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u7121\u4f5c\u70ba\u306b\u6295\u4e0e\u3055\u308c\u305f\u3002\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u4e0a\u306e\u9178\u5316\u30ea\u30f3\u8102\u8cea\uff08Ox-PL-apoB\uff09\u3001\u9ad8\u611f\u5ea6CRP\uff08hs-CRP\uff09\u3001\u9ad8\u611f\u5ea6\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3-6\uff08hs-IL-6\uff09\u3092\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u300136\u9031\u76ee\u300148\u9031\u76ee\u306b\u6e2c\u5b9a\u3057\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308936\u9031\u76ee\u307e\u3067\u306eOx-PL-apoB\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5f8c\u306e\u5909\u5316\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306eLp(a)\u6fc3\u5ea6\u306e\u4e2d\u592e\u5024\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\uff3bIQR\uff3d\uff09\u306f260.3nmol\/L\uff08198.1-352.4\uff09\u3001Ox-PL-apoB\u6fc3\u5ea6\u306e\u4e2d\u592e\u5024\uff08IQR\uff09\u306f26.5nmol\/L\uff0819.7-33.9\uff09\u3067\u3042\u3063\u305f\u300236\u9031\u6642\u70b9\u3067\u3001\u30aa\u30eb\u30d1\u30b7\u30e9\u30f375mg\u4ee5\u4e0a\u309212\u9031\u3054\u3068\u306b\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u3068\u6bd4\u8f03\u3057\u3066Lp(a)\u304c\u5c11\u306a\u304f\u3068\u308295\uff05\u6e1b\u5c11\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308936\u9031\u76ee\u307e\u3067\u306eOx-PL-apoB\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5e73\u5747\u5909\u5316\u7387\u306f\u300110mg\u309212\u9031\u6bce\u306b\u6295\u4e0e\u3057\u305f\u7fa4\u306751.6\uff05\u3001225mg\u309224\u9031\u6bce\u306b\u6295\u4e0e\u3057\u305f\u7fa4\u306793.7\uff05\u3067\u3042\u3063\u305f\u3002\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u306e\u52b9\u679c\u306f48\u9031\u9593\u6301\u7d9a\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u306f36\u9031\u76ee\u300148\u9031\u76ee\u3068\u3082\u306b\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066hs-CRP\u3001hs-IL-6\u306b\u6709\u610f\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u304b\u3063\u305f\u3002 <\/span><\/p>\n

\u3053\u308c\u3089\u306e\u6240\u898b\u304b\u3089\u3001Lp(a)\u3068Ox-PL-apoB\u306e\u6e1b\u5c11\u304c\u3001\u30aa\u30eb\u30d1\u30b7\u30e9\u30f3\u306b\u3088\u308b\u6f5c\u5728\u7684\u306a\u81e8\u5e8a\u7684\u6709\u7528\u6027\u306e\u4e3b\u306a\u8981\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002<\/span><\/p>\n

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Rosenson RS, L\u00f3pez JAG, Gaudet D, et al. Olpasiran, oxidized phospholipids, and systemic inflammatory biomarkers: Results from the OCEAN(a)-DOSE Trial. JAMA Cardiol 2025:e245433. doi: 10.1001\/jamacardio.2024.5433<\/span><\/i>.<\/span><\/i><\/p>\n

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\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u75c7\u5019\u7fa4\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/b><\/h5>\n

\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\uff08OSA\uff09\u306f\u3001\u6025\u6027\u51a0\u75c7\u5019\u7fa4\uff08ACS\uff09\u60a3\u8005\u306b\u591a\u304f\u8a8d\u3081\u3089\u308c\u3001\u3053\u306e\u96c6\u56e3\u306e\u6700\u59273\u5206\u306e2\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002
\u7814\u7a76\u3067\u306f\u3001OSA\u306e\u5b58\u5728\u304cACS\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 OSA\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306f\u3001\u5171\u901a\u3059\u308b\u30ea\u30b9\u30af\u56e0\u5b50\u304a\u3088\u3073\u75c5\u614b\u751f\u7406\u5b66\u7684\u80cc\u666f\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u3053\u306e\u95a2\u9023\u3092\u81e8\u5e8a\u7684\u306b\u91cd\u8981\u306a\u3082\u306e\u3068\u3057\u3066\u3044\u307e\u3059\u3002 <\/span>\u7814\u7a76\u306b\u3088\u308b\u3068\u3001OSA\u306f\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u304c\u3001\u9593\u6b20\u7684\u4f4e\u9178\u7d20\u75c7\u3001\u7761\u7720\u306e\u65ad\u7247\u5316\u3001\u4ea4\u611f\u795e\u7d4c\u6d3b\u52d5\u306e\u4ea2\u9032\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/span>.<\/span> <\/span><\/p>\n

OSA-ACS\u8a66\u9a13\u306f\u3001ACS\u60a3\u8005\u306b\u304a\u3051\u308bOSA\u3068\u9577\u671f\u7684\u306a\u5fc3\u8840\u7ba1\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306b\u30c7\u30b6\u30a4\u30f3\u3055\u308c\u305f\u5927\u898f\u6a21\u306a\u524d\u5411\u304d\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308b\u3002\u4eca\u56de\u306e\u89e3\u6790\u3067\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068\u9ad8\u611f\u5ea6CRP\uff08high-sensitivity C-reactive protein\uff1ahs-CRP\uff09\u3067\u793a\u3055\u308c\u308b\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306e\u4e21\u65b9\u3092\u6709\u3059\u308bACS\u60a3\u80051,833\u4eba\u3092\u5bfe\u8c61\u306b\u3001OSA\u3068\u5fc3\u8840\u7ba1\u8ee2\u5e30\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u305f\u3002\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306f\u3001\u5fc3\u8840\u7ba1\u6b7b\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u3001\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u307e\u305f\u306f\u5fc3\u4e0d\u5168\u306b\u3088\u308b\u5165\u9662\u3001\u865a\u8840\u306b\u3088\u308b\u8840\u884c\u518d\u5efa\u8853\u306e\u8907\u5408\u3067\u3042\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30fb\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACCE\uff09\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u4e2d\u592e\u502435.1\u30f5\u6708\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u3001OSA\u306e\u5b58\u5728\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u3001\u4f4e\u60aa\u6027\u5ea6\u306e\u708e\u75c7\u3092\u6709\u3059\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001MACCE\uff08\u8abf\u6574\u30cf\u30b6\u30fc\u30c9\u6bd4[HR]1.58\u300195\uff05\u4fe1\u983c\u533a\u9593[CI]1.01-2.47\u3001p\uff1d0.045\uff09\u304a\u3088\u3073\u8133\u5352\u4e2d\uff08\u8abf\u6574HR5.23\u300195\uff05CI1.19-22.99\u3001p\uff1d0.027\uff09\u306e\u30ea\u30b9\u30af\u3092\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001OSA\u3092\u6709\u3059\u308bACS\u60a3\u8005\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u4e21\u5909\u6570\u306e\u30eb\u30fc\u30c1\u30f3\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3068\u5305\u62ec\u7684\u306a\u7ba1\u7406\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n

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Xu D, Zhang Y, Zhen L, et al. \u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u4f4e\u60aa\u6027\u5ea6\u708e\u75c7\u306e\u4e8c\u91cd\u30ea\u30b9\u30af\u3092\u6709\u3059\u308b\u6025\u6027\u51a0\u75c7\u5019\u7fa4\u60a3\u8005\u306b\u304a\u3051\u308b\u9589\u585e\u6027\u7761\u7720\u6642\u7121\u547c\u5438\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3068\u306e\u95a2\u9023\uff1aOSA-ACS\u7814\u7a76\u306e\u4e8b\u5f8c\u89e3\u6790\u3002Sleep Breath 2025;29(1):119. <\/span><\/i><\/p>\n

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2024 <\/span><\/h2>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f2\u578b\u7cd6\u5c3f\u75c5\u306e\u672b\u671f\u7cd6\u5c3f\u75c5\u6027\u814e\u81d3\u75c5\u306e\u975e\u4fb5\u8972\u7684\u30de\u30fc\u30ab\u30fc\u304b\uff1f<\/b><\/h5>\n

\u3053\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u7d50\u679c\u30012\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u60a3\u8005\u3067\u306f\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u304c\u9ad8\u3044\u307b\u3069\u672b\u671f\u814e\u81d3\u75c5\uff08ESKD\uff09\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u7cd6\u5c3f\u75c5\u6027ESKD\u306e\u65b0\u305f\u306a\u975e\u4fb5\u8972\u7684\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

\u672c\u7814\u7a76\u3067\u306f\u30012010\uff5e2019\u5e74\u306e\u897f\u4e2d\u56fd\u75c5\u9662\u30b3\u30db\u30fc\u30c8\u306e2\u578b\u7cd6\u5c3f\u75c5\u30fb\u751f\u691c\u78ba\u5b9a\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\uff08T2DM-DN\uff09\u60a3\u8005334\u4f8b\uff08\u5e73\u5747\u5e74\u9f6251.1\u6b73\u3001\u7537\u602770\uff05\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u814e\u81d3\u306e\u8ee2\u5e30\u3068\u306e\u7e26\u65ad\u7684\u95a2\u4fc2\u3092\u8a55\u4fa1\u3057\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306fMartin-Hopkins\u5f0f\u3092\u7528\u3044\u3066\u7b97\u51fa\u3057\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306fESKD\u3068\u3057\u3001\u6162\u6027\u814e\u4ee3\u66ff\u7642\u6cd5\u306e\u5fc5\u8981\u6027\u307e\u305f\u306f\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf<15 mL\/min\/1.73 m <\/span>2<\/span>. <\/span> <\/p>\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u304c\u6700\u3082\u4f4e\u3044\u56db\u5206\u4f4d\u7fa4\u306e\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6700\u3082\u9ad8\u3044\u56db\u5206\u4f4d\u7fa4\u306e\u60a3\u8005\u306f\u7d2f\u7a4d\u814e\u751f\u5b58\u671f\u9593\u304c\u77ed\u304f\u3001\u814e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u3082\u77ed\u304b\u3063\u305f\uff08\u4e2d\u592e\u5024\uff3b\u56db\u5206\u4f4d\u7bc4\u56f2\uff3d34.0\uff3b26.4-41.6\uff3d\u5bfe55.0\uff3b29.8-80.2\uff3d\u30f5\u6708\uff09\u3002\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7fa4\u306fESKD\u3078\u306e\u9032\u884c\u30ea\u30b9\u30af\u3082\u9ad8\u304f\u3001\u6700\u3082\u4f4e\u3044\u56db\u5206\u4f4d\u7fa4\u306b\u6bd4\u3079\u30663\u500d\u8fd1\u304f\u9ad8\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd42.857\u300195\uff05\u4fe1\u983c\u533a\u95931.305-6.257\u3001p = 0.009\uff09\u3002\u4ea4\u7d61\u56e0\u5b50\u3092\u88dc\u6b63\u3057\u305f\u5f8c\u3067\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c1\u6a19\u6e96\u504f\u5dee\u4e0a\u6607\u3059\u308b\u3068\u3001ESKD\u3078\u306e\u9032\u884c\u30ea\u30b9\u30af\u304c42\uff05\u4e0a\u6607\u3057\u305f\u3002 \u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u306b\u5024\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u672b\u671f\u814e\u4e0d\u5168\uff08ESKD\uff09\u306e\u65b0\u305f\u306a\u975e\u4fb5\u8972\u7684\u4e88\u6e2c\u56e0\u5b50\u3068\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306e\u672b\u671f\u814e\u81d3\u75c5\u3078\u306e\u9032\u5c55\u30ea\u30b9\u30af\uff1a\u7e26\u65ad\u7684\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u3002\u5185\u5206\u6ccc 2024;doi: 10.1007\/s12020-024-03948-4 <\/span><\/i><\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11554765\/pdf\/12020_2024_Article_3948.pdf&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u7814\u7a76<\/b><\/h5>\n

\u97d3\u56fd\u3067\u884c\u308f\u308c\u305f\u3053\u306e\u5168\u56fd\u898f\u6a21\u306e\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u306f\u3001\u5168\u6b7b\u56e0\u6027\u75f4\u5446\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3001\u8840\u7ba1\u6027\u75f4\u5446\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u305f\u3002 <\/span><\/p>\n

\u8102\u8cea\u7570\u5e38\u75c7\u306f\u3001\u8840\u7ba1\u6027\u75f4\u5446\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u542b\u3080\u69d8\u3005\u306a\u75f4\u5446\u306e\u7f79\u60a3\u7387\u306e\u4e0a\u6607\u3068\u4e00\u8cab\u3057\u3066\u5f37\u3044\u95a2\u9023\u3092\u793a\u3057\u3066\u304d\u305f\u3002\u3053\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8a8d\u77e5\u75c7\u767a\u75c7\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002 <\/span><\/p>\n

\u97d3\u56fd\u56fd\u6c11\u306e\u5927\u591a\u6570\uff08\u7d0498\uff05\uff09\u304c\u52a0\u5165\u3057\u3066\u3044\u308b\u5f37\u5236\u5065\u5eb7\u4fdd\u967a\u5236\u5ea6\u3067\u3042\u308b\u97d3\u56fd\u306e\u56fd\u6c11\u5065\u5eb7\u4fdd\u967a\u30b5\u30fc\u30d3\u30b9\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u8a8d\u77e5\u75c7\u89e3\u6790\u3067\u3042\u308b\u3002\u3053\u306e\u5206\u6790\u306b\u306f\u30012009\u5e74\u306b\u56fd\u6c11\u5065\u5eb7\u8a3a\u67fb\u3092\u53d7\u3051\u305f40\u6b73\u4ee5\u4e0a\u306e\u88ab\u9a13\u8005\u306e\u30c7\u30fc\u30bf\u304c\u542b\u307e\u308c\u308b\u3002 \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c 400 mg\/dL\u4ee5\u4e0a \u306e\u4eba\u306f\u3001\u8a08\u7b97\u306b\u3088\u308b LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u6fc3\u5ea6\u306e\u6b63\u78ba\u6027\u306b\u61f8\u5ff5\u304c\u3042\u308b\u305f\u3081\u9664\u5916 \u3055\u308c\u3001\u307e\u305f \u8a8d\u77e5\u75c7\u306e\u65e2\u5f80\u8a3a\u65ad\u304c\u3042\u308b\u4eba \u3082\u9664\u5916\u3055\u308c\u305f\u3002 <\/span><\/p>\n

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Zhang X, Zhao S, Huang Y, et al. \u7cd6\u5c3f\u75c5\u95a2\u9023\u5927\u8840\u7ba1\u5408\u4f75\u75c7\u306f\u7cd6\u5c3f\u75c5\u6027\u7d30\u5c0f\u8840\u7ba1\u5408\u4f75\u75c7\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3059\u308b\uff1aUK Biobank\u306e1\u578b\u7cd6\u5c3f\u75c5\u60a3\u80051518\u4eba\u30682\u578b\u7cd6\u5c3f\u75c5\u60a3\u800520802\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u524d\u5411\u304d\u7814\u7a76\u3002J Am Heart Assoc 2024;13(11):e032626.<\/span><\/i><\/p>\n

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\u6025\u6027\u5fc3\u7b4b\u6897\u585e\uff08AMI\uff09\u5f8c\u306e\u9ad8\u5f37\u5ea6\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u51e6\u65b9\u306b\u95a2\u3057\u3066\u3001\u5973\u6027\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u5229\u3067\u3042\u308a\u3001\u3053\u308c\u306f\u751f\u5b58\u3068\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002\u3053\u308c\u306f\u30d5\u30e9\u30f3\u30b9\u306e\u5168\u56fd\u7684\u767b\u9332\u3067\u3042\u308bFAST-MI\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u89e3\u6790\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u3067\u3042\u308b\u3002 <\/span><\/p>\n

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[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

Weizman O, Hauguel-Moreau M, Tea V, et al. \u5973\u6027\u306b\u304a\u3051\u308b\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u5f8c\u306e\u9ad8\u5f37\u5ea6\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306e\u51e6\u65b9\u4e0d\u8db3\u304c\u4e88\u5f8c\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3002 Eur J Prevent Cardiol 2024; <\/span><\/i>doi.org\/10.1093\/eurjpc\/zwae255<\/span><\/i><\/a><\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/academic.oup.com\/eurjpc\/article-abstract\/31\/15\/1850\/7727541?redirectedFrom=fulltext&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

PALISADE\u304c\u5bb6\u65cf\u6027\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u8840\u75c7\u75c7\u5019\u7fa4\u306b\u304a\u3051\u308b\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\u306e\u6709\u52b9\u6027\u3092\u5b9f\u8a3c<\/b><\/h5>\n

\u809d\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u30d5\u30a1\u30fc\u30b9\u30c8\u30fb\u30a4\u30f3\u30fb\u30af\u30e9\u30b9\u306eAPOC3\uff08small interfering RNA\uff09\u6cbb\u7642\u85ac\u3067\u3042\u308b\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\u306f\u3001\u907a\u4f1d\u5b66\u7684\u306b\u78ba\u8a8d\u3055\u308c\u305f\u3001\u307e\u305f\u306f\u81e8\u5e8a\u7684\u306b\u8a3a\u65ad\u3055\u308c\u305f\u5bb6\u65cf\u6027\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u8840\u75c7\u75c7\u5019\u7fa4\uff08FCS\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3067\u3042\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u4f4e\u4e0b\u4f5c\u7528\u306b\u6210\u529f\u3057\u305f\u3002 <\/span><\/p>\n

FCS\u306f\u3001TG\u5024\u304c\u6975\u3081\u3066\u9ad8\u304f\u3001\u901a\u5e38880mg\/dL\u3092\u8d85\u3048\u308b\u91cd\u7be4\u306a\u8d85\u5e0c\u5c11\u907a\u4f1d\u75c5\u3067\u3042\u308b\u3002FCS\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u7684\u539f\u56e0\u304c\u95a2\u9023\u3057\u3066\u3044\u308b\u304c\u3001FCS\u60a3\u8005\u306e\u7d0480\uff05\u306b\u306f\u30ea\u30dd\u86cb\u767d\u30ea\u30d1\u30fc\u30bc\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002\u6025\u6027\u81b5\u708e\u306fFCS\u306e\u6700\u3082\u91cd\u7be4\u306a\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001\u7e70\u308a\u8fd4\u3057\u767a\u75c7\u3057\u3001\u9577\u671f\u7684\u306a\u81b5\u6a5f\u80fd\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u672a\u6cbb\u7642\u306e\u5834\u5408\u306f\u81f4\u6b7b\u7684\u3068\u306a\u308b\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u6cbb\u7642\u306e\u4e3b\u306a\u76ee\u7684\u306e\u4e00\u3064\u306f\u3001\u3053\u306e\u30ea\u30b9\u30af\u3092\u53ef\u80fd\u306a\u9650\u308a\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002 <\/span><\/p>\n

PALISADE\u8a66\u9a13\u306f18\u30f5\u56fd39\u65bd\u8a2d\u3067\u5b9f\u65bd\u3055\u308c\u305f\u3002\u5168\u4f53\u306775\u4eba\u306e\u60a3\u8005\u304c\u30013\u30f5\u6708\u306b1\u56de\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f325mg\u307e\u305f\u306f50mg\u3092\u6295\u4e0e\u3055\u308c\u308b\u7fa4\u3068\u3001\u305d\u308c\u306b\u30de\u30c3\u30c1\u3059\u308b\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3055\u308c\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u7121\u4f5c\u70ba\u5316\u671f\u9593\u3092\u7d42\u4e86\u3057\u305f\u60a3\u8005\u306f\u3001\u5168\u53c2\u52a0\u8005\u304c\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\u3092\u6295\u4e0e\u3055\u308c\u308b2\u90e8\u69cb\u6210\u306e\u5ef6\u9577\u671f\u9593\u306b\u5165\u308b\u8cc7\u683c\u3092\u5f97\u305f\u3002 \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u300110\u304b\u6708\u6642\u70b9\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u5024\u306e\u30d7\u30e9\u30bb\u30dc\u8abf\u6574\u5f8c\u306e\u4e2d\u592e\u5024\u5909\u5316\u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u5168\u4f53\u3068\u3057\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u308910\u30f5\u6708\u76ee\u307e\u3067\u306e\u5e73\u5747TG\u4f4e\u4e0b\u7387\u306f\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f325mg\u6295\u4e0e\u7fa4\u306780\uff05\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f350mg\u6295\u4e0e\u7fa4\u306778\uff05\uff08\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa417\uff05\u3001p<0.001\uff09\u3001\u6700\u5927\u4f4e\u4e0b\u7387\u306f98\uff05\u3067\u3042\u3063\u305f\u300212\u30f5\u6708\u5f8c\u306eTG\u4f4e\u4e0b\u7387\u306f\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f325mg\u6295\u4e0e\u7fa4\u306778\uff05\u300150mg\u6295\u4e0e\u7fa4\u306773\uff05\uff08\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa47\uff05\uff09\u3067\u3042\u308a\u3001\u6700\u5927\u4f4e\u4e0b\u7387\u306f99\uff05\u3067\u3042\u3063\u305f\u3002 10\u304b\u6708\u6642\u70b9\u306b\u304a\u3051\u308b APOC3\u306e\u4f4e\u4e0b\u7387 \u306f\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f325 mg\u306788%\u300150 mg\u306794% \u3067\u3042\u3063\u305f\u3002 <\/span><\/p>\n

\u3059\u3079\u3066\u306e\u4e3b\u8981\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u3066\u7d71\u8a08\u5b66\u7684\u6709\u610f\u5dee\u3092\u3082\u3063\u3066\u9054\u6210\u3055\u308c\u305f\u3002\u591a\u65bd\u8a2d\u7ba1\u7406\u306b\u3088\u308b\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u306b\u306f\u300110\u30f5\u6708\u76ee\u304a\u3088\u307312\u30f5\u6708\u76ee\u306e\u7a7a\u8179\u6642TG\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u300110\u30f5\u6708\u76ee\u306e\u7a7a\u8179\u6642APOC3\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u300112\u30f5\u6708\u76ee\u306e\u7a7a\u8179\u6642APOC3\u306e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306e\u5909\u5316\u7387\u3001\u304a\u3088\u3073\u7121\u4f5c\u70ba\u5316\u671f\u9593\u4e2d\u306e\u6025\u6027\u81b5\u708e\u306e\u80af\u5b9a\u7684\u5224\u5b9a\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u304c\u542b\u307e\u308c\u305f\u3002\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\u306b\u3088\u308b\u6cbb\u7642\u306f\u826f\u597d\u306a\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u306e\u8a66\u9a13\u306e\u5b8c\u5168\u306a\u767a\u8868\u306f\u5f85\u305f\u308c\u308b\u3002 \u3053\u308c\u3089\u306e\u7d50\u679c\u306b\u57fa\u3065\u304d\u3001\u30d7\u30ed\u30b6\u30b7\u30e9\u30f3\uff08plozasiran\uff09 \u306f\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09 \u306b\u3088\u308a \u30aa\u30fc\u30d5\u30a1\u30f3\u30c9\u30e9\u30c3\u30b0\u6307\u5b9a \u304a\u3088\u3073 \u30d5\u30a1\u30b9\u30c8\u30c8\u30e9\u30c3\u30af\u6307\u5b9a \u3092\u53d7\u3051\u3001\u3055\u3089\u306b \u6b27\u5dde\u533b\u85ac\u54c1\u5e81\uff08EMA\uff09 \u306b\u3088\u308a \u30aa\u30fc\u30d5\u30a1\u30f3\u30c9\u30e9\u30c3\u30b0\u6307\u5b9a \u3092\u53d7\u3051\u3066\u3044\u308b\u3002 <\/span><\/p>\n

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Arrowhead Pharmaceuticals \u793e\u3001\u5bb6\u65cf\u6027\u30ab\u30a4\u30ed\u30df\u30af\u30ed\u30f3\u8840\u75c7\u75c7\u5019\u7fa4\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4e3b\u8981\u306a\u7b2c 3 \u76f8 Palisade \u8a66\u9a13\u3067 plozasiran \u306e\u826f\u597d\u306a\u30c8\u30c3\u30d7\u30e9\u30a4\u30f3\u7d50\u679c\u3092\u5831\u544a\u3002\u30a2\u30ed\u30fc\u30d8\u30c3\u30c9\u793eJune 3, 2024.2024\u5e746\u67083\u65e5\u30a2\u30af\u30bb\u30b9\u3002 https:\/\/ir.arrowheadpharma.com\/news-releases\/news-release-details\/arrowhead-pharmaceuticals-reports-successful-topline-results<\/a>.<\/span><\/i>
<\/span><\/i>\u30a2\u30ed\u30fc\u30d8\u30c3\u30c9\u793e\u3001aro-APOC3\u306eFDA\u30d5\u30a1\u30b9\u30c8\u30c8\u30e9\u30c3\u30af\u6307\u5b9a\u3092\u53d7\u3051\u308b\u3002\u30a2\u30ed\u30fc\u30d8\u30c3\u30c9\u793e2023\u5e743\u670820\u65e5\u30022024\u5e745\u670828\u65e5\u30a2\u30af\u30bb\u30b9\u3002 https:\/\/ir.arrowheadpharma.com\/news-releases\/news-release-details\/arrowhead-receives-fda-fast-track-designation-aro-apoc3<\/a>.<\/span><\/i><\/p>\n

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\u6df7\u5408\u578b\u9ad8\u8102\u8840\u75c7\u306b\u304a\u3051\u308bANGPTL3 siRNA\u30be\u30c0\u30b7\u30e9\u30f3<\/b><\/h5>\n

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Rosenson RS, Gaudet D, Hegele RA<\/span>, et al. Zodasiran, an RNAi therapeutic targeting ANGPTL3, for mixed hyperlipidemia. N Engl J Med 2024; doi: 10.1056\/NEJMoa2404147<\/span><\/i><\/p>\n

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[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

\u809d\u81d3\u306b\u304a\u3051\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u30aa\u30e1\u30ac3\u9178\u30a8\u30c1\u30eb\u30a8\u30b9\u30c6\u30eb\u306e\u6709\u52b9\u6027\u306e\u6bd4\u8f03\uff1aPORTRAIT\u8a66\u9a13\u3002J Atheroscler Thromb 2024; doi: 10.5551\/jat.64896. <\/span><\/i><\/p>\n

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\u591a\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u708e\u75c7\u6027\u30ea\u30b9\u30af<\/strong><\/h5>\n

\u591a\u8840\u7ba1\u75be\u60a3\u306e\u60a3\u8005\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3002\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u3068\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u304c\u540c\u6642\u306b\u9ad8\u5024\u3092\u793a\u3057\u3001\u3053\u306e\u30ea\u30b9\u30af\u3092\u60aa\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u7814\u7a76\u3067\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u3002 \u708e\u75c7\u304c\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\u5f8c\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u8e0f\u307e\u3048\u3001\u672c\u7814\u7a76\u306fPCI\u3092\u53d7\u3051\u308b\u591a\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\u3092\u691c\u8a0e\u3059\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u3002 <\/span><\/p>\n

\n

\u5168\u4f53\u3068\u3057\u3066\u3001\u6162\u6027\u51a0\u52d5\u8108\u75be\u60a3\u306b\u5bfe\u3057\u3066PCI\u3092\u53d7\u3051\u305f10,359\u4eba\u306e\u60a3\u8005\u304c\u5bfe\u8c61\u3068\u306a\u308a\u3001\u305d\u306e\u3046\u30611801\u4eba\uff0817.4\uff05\uff09\u304c\u591a\u8840\u7ba1\u75be\u60a3\u3092\u6709\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306f\u3001\u591a\u8840\u7ba1\u75be\u60a3\u306e\u306a\u3044\u60a3\u8005\u306b\u6bd4\u3079\u3066\u9ad8\u611f\u5ea6CRP\uff08high-sensitivity Creactive protein\uff1ahsCRP\uff09\u5024\u304c\u9ad8\u304b\u3063\u305f\u3002hsCRP\u5024>3mg\/L\u306f33.6\uff05\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u591a\u8840\u7ba1\u75be\u60a3\u306e\u306a\u3044\u60a3\u8005\u3067\u306f24.7\uff05\u3067\u3042\u3063\u305f\u3002hsCRP\u306e\u4e0a\u6607\u3068\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u30ea\u30b9\u30af\u3068\u306e\u9593\u306b\u306f\u3001\u591a\u8840\u7ba1\u75be\u60a3\u306e\u3042\u308b\u60a3\u8005\u3067\u306f\u72ec\u7acb\u3057\u305f\u95a2\u9023\u304c\u8a8d\u3081\u3089\u308c\u305f\u304c\u3001\u591a\u8840\u7ba1\u75be\u60a3\u306e\u306a\u3044\u60a3\u8005\u3067\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002 \u591a\u8840\u7ba1\u75be\u60a3\u3068 hsCRP\u9ad8\u5024 \u306e\u4e21\u65b9\u3092\u6709\u3059\u308b\u60a3\u8005\u306f\u30011\u5e74\u5f8c\u306e\u8ffd\u8de1\u8abf\u67fb\u306b\u304a\u3044\u3066\u3001\u4ed6\u306e\u3059\u3079\u3066\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u6709\u610f\u306b\u9ad8\u3044MACE\u767a\u751f\u7387\u3092\u793a\u3057\u305f\u3002 <\/span><\/p>\n

\n

\u3053\u308c\u3089\u306e\u77e5\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001PCI\u5f8c\u306e\u81e8\u5e8a\u8ee2\u5e30\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u3092\u540c\u5b9a\u3057\u3001\u305d\u306e\u60a3\u8005\u306b\u5408\u3063\u305f\u6cbb\u7642\u3092\u884c\u3046\u306e\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span><\/p>\n

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Bay\u6c0f\u3001Vogel B\u6c0f\u3001Sharma R\u6c0f\u3001\u4ed6\uff1aPCI\u3092\u53d7\u3051\u305f\u60a3\u8005\u306b\u304a\u3051\u308b\u591a\u8840\u7ba1\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u306e\u72b6\u614b\u306b\u3088\u308b\u708e\u75c7\u6027\u30ea\u30b9\u30af\u3068\u81e8\u5e8a\u8ee2\u5e30\u3002Clin Res Cardiol 2024; doi: 10.1007\/s00392-024-02471-w <\/span><\/i><\/p>\n

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2\u578b\u7cd6\u5c3f\u75c5\u3068\u6162\u6027\u814e\u81d3\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u6295\u4e0e<\/strong><\/h5>\n

\u3053\u306e\u5927\u898f\u6a21\u8a66\u9a13\u306e\u7d50\u679c\u304b\u3089\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f2\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u814e\u81d3\u306e\u8ee2\u5e30\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u672c\u8a66\u9a13\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u3068CKD\uff08\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\uff3beGFR\uff3d\u304c50\uff5e75ml\/\u5206\/\u4f53\u8868\u9762\u7a4d1.73m<\/sup>2\u3001\u5c3f\u4e2d\u30a2\u30eb\u30d6\u30df\u30f3\uff0f\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u304c>300\u304a\u3088\u3073<5000\u3001\u307e\u305f\u306feGFR\u304c25\uff5e<50ml\/\u5206\/\u4f53\u8868\u9762\u7a4d1.73m<\/sup>2\u3001\u5c3f\u4e2d\u30a2\u30eb\u30d6\u30df\u30f3\uff0f\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u304c>100\u304a\u3088\u3073<5000\uff09\u3092\u6709\u3059\u308b\u60a3\u80053533\u4f8b\u3092\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c91.0mg\u3092\u90311\u56de\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u3092\u90311\u56de\u76ae\u4e0b\u6295\u4e0e\u3059\u308b\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u4e3b\u8981\u814e\u75be\u60a3\u30a4\u30d9\u30f3\u30c8\u3068\u3057\u3001\u814e\u4e0d\u5168\u306e\u767a\u75c7\uff08\u900f\u6790\u3001\u79fb\u690d\u3001\u307e\u305f\u306feGFR\u304c<15 ml\/min\/1.73m<\/sup>2\uff09\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u306eeGFR\u306e\u5c11\u306a\u304f\u3068\u308250\uff05\u4f4e\u4e0b\u3001\u307e\u305f\u306f\u814e\u81d3\u95a2\u9023\u307e\u305f\u306f\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u8907\u5408\u3068\u3057\u305f\u3002 <\/span><\/p>\n

\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u50243.4\u5e74\u3067\u3001\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f\u4e2d\u9593\u89e3\u6790\u306b\u304a\u3044\u3066\u65e9\u671f\u306e\u8a66\u9a13\u4e2d\u6b62\u304c\u63a8\u5968\u3055\u308c\u305f\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u3001\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u309224\uff05\u4f4e\u4e0b\u3055\u305b\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\u30010.76\uff1b95\uff05\u4fe1\u983c\u533a\u9593[CI]\u30010.66\u301c0.88\uff1bp\uff1d0.0003\uff09\u3001\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306e\u814e\u81d3\u7279\u7570\u7684\u8981\u7d20\u306e\u30ea\u30b9\u30af\u309221\uff05\u4f4e\u4e0b\u3055\u305b\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\u30010.79\uff1b95\uff05CI\u30010.66\u301c0.94\uff09\u3001\u5fc3\u8840\u7ba1\u6b7b\u30ea\u30b9\u30af\u309229\uff05\u4f4e\u4e0b\u3055\u305b\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4\u30010.71\uff1b95\uff05CI\u30010.56\u301c0.89\uff09\u3002\u4e3b\u8981\u5fc3\u8840\u7ba1\u7cfb\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u306f18\uff05\u4f4e\u304f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.82\u300195\uff05CI\u30010.68\u301c0.98\u3001p\uff1d0.029\uff09\u3001\u3042\u3089\u3086\u308b\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u306f20\uff05\u4f4e\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.80\u300195\uff05CI\u30010.67\u301c0.95\u3001p\uff1d0.01\uff09\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u814e\u4e0d\u5168\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304a\u3088\u3073\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u306e\u60a3\u8005\u96c6\u56e3\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u81e8\u5e8a\u7684\u6709\u7528\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 <\/span><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u6162\u6027\u814e\u81d3\u75c5\u306b\u5bfe\u3059\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306e\u52b9\u679c\u3002N Engl J Med 2024; DOI: 10.1056\/NEJMoa2403347<\/p>\n

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\u6025\u6027\u865a\u8840\u6027\u8133\u5352\u4e2d\u306f\u4e2d\u56fd\u306b\u304a\u3051\u308b\u7d4c\u6e08\u7684\u8ca0\u62c5\u306e\u5927\u304d\u306a\u539f\u56e0\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u708e\u75c7\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u5f62\u6210\u3068\u30d7\u30e9\u30fc\u30af\u7834\u88c2\u306e\u91cd\u8981\u306a\u4fc3\u9032\u56e0\u5b50\u3067\u3042\u308a\u3001\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u518d\u767a\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u4e2d\u56fd\u4eba\u306e\u6025\u6027\u865a\u8840\u6027\u8133\u5352\u4e2d\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u9ad8\u3044\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\u3068\u9838\u52d5\u8108\u306e\u8106\u5f31\u6027\u30d7\u30e9\u30fc\u30af\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3057\u305f\u3002
\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u60a3\u8005468\u4eba\uff08\u5e73\u5747\u5e74\u9f6264\u6b73\u3001\u7537\u602765\uff05\uff09\u3092\u767b\u9332\u3057\u3001\u8106\u5f31\u6027\u30d7\u30e9\u30fc\u30af\u304c\u8a8d\u3081\u3089\u308c\u305f157\u4eba\uff0833.5\uff05\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u300128.6\uff05\u306b\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306e\u307f\u304c\u6b8b\u5b58\u3057\uff08\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff3bLDL-C\uff3d\uff1c2.6mmol\/L\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\uff3bhsCRP\uff3d\u22672mg\/L\uff09\u300118.8\uff05\u306b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u30ea\u30b9\u30af\u306e\u307f\u304c\u6b8b\u5b58\u3057\u305f\uff08LDL-C\u22672.6mmol\/L\u3001hsCRP\uff1c2mg\/L\uff09\u300119.7\uff05\u306f\u30ea\u30b9\u30af\u307e\u305f\u306f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306e\u4e21\u65b9\uff08LDL-C\u22672.6mmol\/L\u3001hsCRP\u22672mg\/L\uff09\u3092\u6709\u3057\u300132.9\uff05\u306f\u3069\u3061\u3089\u306e\u30ea\u30b9\u30af\u3082\u6709\u3055\u306a\u304b\u3063\u305f\uff08LDL-C\uff1c2.6mmol\/L\u3001hsCRP\uff1c2mg\/L\uff09\u3002\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306f\u3001\u4e3b\u8981\u4ea4\u7d61\u56e0\u5b50\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3001\u8106\u5f31\u30d7\u30e9\u30fc\u30af\u3068\u95a2\u9023\u3057\uff08\u30aa\u30c3\u30ba\u6bd41.98\u300195\uff05\u4fe1\u983c\u533a\u95931.13-3.45\u3001p =0.016\uff09\u3001\u7279\u306b\u5927\u52d5\u8108\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u30b5\u30d6\u30bf\u30a4\u30d7\u3067\u9855\u8457\u3067\u3042\u3063\u305f\uff08\u30aa\u30c3\u30ba\u6bd42.71\u300195\uff05\u4fe1\u983c\u533a\u95931.08-6.77\u3001p = 0.034\uff09\u3002
\u865a\u8840\u6027\u8133\u5352\u4e2d\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u3068\u9838\u52d5\u8108\u306e\u8106\u5f31\u30d7\u30e9\u30fc\u30af\u3001\u7279\u306b\u5927\u898f\u6a21\u52d5\u8108\u786c\u5316\u30b5\u30d6\u30bf\u30a4\u30d7\u306b\u304a\u3051\u308b\u6709\u610f\u306a\u6b63\u306e\u95a2\u9023\u306f\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u304c\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u52a0\u3048\u3066\u6297\u708e\u75c7\u7642\u6cd5\u3092\u884c\u3046\u3053\u3068\u3067\u3055\u3089\u306b\u5229\u76ca\u3092\u5f97\u3089\u308c\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u6297\u708e\u75c7\u4ecb\u5165\u3092\u691c\u8a0e\u3059\u308b\u305f\u3081\u306b\u524d\u5411\u304d\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n

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\u865a\u8840\u6027\u8133\u5352\u4e2d\u60a3\u8005\u306b\u304a\u3051\u308b\u9838\u52d5\u8108\u306e\u6b8b\u5b58\u708e\u75c7\u30ea\u30b9\u30af\u3068\u8106\u5f31\u6027\u30d7\u30e9\u30fc\u30af\u3002Front Neurol 2024; DOI 10.3389\/fneur.2024.1325960<\/p>\n

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\u7cd6\u5c3f\u75c5\u307e\u305f\u306f\u80a5\u6e80\u75c7\u306e\u60a3\u8005\u306b\u304a\u3051\u308b\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3<\/strong><\/h5>\n

ORION-9\u3001ORION-10\u304a\u3088\u3073ORION-11\u8a66\u9a13\u306e\u30d7\u30fc\u30eb\u89e3\u6790\u3067\u306f\u3001\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306f\u3001\u8840\u7cd6\u5024\uff0f\u80a5\u6e80\u5ea6\uff08BMI\uff09\u30ec\u30d9\u30eb\u3092\u8d85\u3048\u3066\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5b9f\u8cea\u7684\u304b\u3064\u6301\u7d9a\u7684\u306a\u4f4e\u4e0b\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u60a3\u8005\u306f1\u5bfe1\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u3001\u521d\u56de\u6295\u4e0e\u30683\u30f5\u6708\u6295\u4e0e\u5f8c\u3001\u5e742\u56de\u3001\u6700\u592718\u30f5\u6708\u307e\u3067\u3001\u30d0\u30c3\u30af\u30b0\u30e9\u30a6\u30f3\u30c9\u306e\u7d4c\u53e3\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u3068\u3068\u3082\u306b\u3001300mg\u306e\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u6295\u4e0e\u3055\u308c\u305f\u3002\u89e3\u6790\u306f\u3001\u8840\u7cd6\u72b6\u614b\uff08\u6b63\u5e38\u8840\u7cd6\u3001\u7cd6\u5c3f\u75c5\u524d\u75c7\u3001\u7cd6\u5c3f\u75c5\uff09\u307e\u305f\u306fBMI\uff0825\u672a\u6e80\u300125\u4ee5\u4e0a30\u672a\u6e80\u300130\u4ee5\u4e0a35\u672a\u6e80\u300135kg\/m 2\u4ee5\u4e0a\uff09\u3067\u5c64\u5225\u5316\u3055\u308c\u305f\u3002
\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089510\u65e5\u76ee\u307e\u3067\u306eLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5909\u5316\u7387\uff08\u30d7\u30e9\u30bb\u30dc\u88dc\u6b63\u5024\uff09\u306f\u3001\u8840\u7cd6\u5024\u5c64\u3067-47.6\uff05\u304b\u3089-51.9\uff05\u3001BMI\u5c64\u3067-48.8\uff05\u304b\u3089-54.4\uff05\u3067\u3042\u3063\u305f\u300290\u65e5\u76ee\u4ee5\u964d540\u65e5\u76ee\u307e\u3067\u306e\u6642\u9593\u8abf\u6574\u5f8c\u306e\u5909\u5316\u7387\u306f\u3001\u8840\u7cd6\u5024\uff0fBMI\u5c64\u3067\u305d\u308c\u305e\u308c-46.8\uff05\u304b\u3089-52.0\uff05\u300148.6\uff05\u304b\u3089-53.3\uff05\u3067\u3042\u3063\u305f\u3002\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u6295\u4e0e\u306f\u3001\u4ed6\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u304a\u3088\u3073\u30ea\u30dd\u86cb\u767d\u306e\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3059\u308b\u6709\u610f\u306a\u4f4e\u4e0b\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u6295\u4e0e\u306b\u3088\u308bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95be\u5024\uff1c1.8mmol\/L\u304a\u3088\u3073\uff1c1.4mmol\/L\u306e\u9054\u6210\u7387\u306f\u3001\u8840\u7cd6\u5024\u304a\u3088\u3073BMI\u5c64\u304c\u5897\u52a0\u3059\u308b\u306b\u3064\u308c\u3066\u5897\u52a0\u3057\u305f\u3053\u3068\u3067\u3042\u308b\u3002
\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u6b63\u5e38\u304a\u3088\u3073\u9ad8\u8840\u7cd6\/BMI\u30ec\u30d9\u30eb\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306e\u4fa1\u5024\u304c\u652f\u6301\u3055\u308c\u308b\u3002 <\/p>\n

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Leiter LA, Raal FJ, Schwartz GG, et al.\u7cd6\u5c3f\u75c5\u307e\u305f\u306f\u80a5\u6e80\u75c7\u60a3\u8005\u306b\u304a\u3051\u308b\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\uff1aORION-9\u3001ORION-10\u3001ORION-11\u7b2c3\u76f8\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a13\u306e\u4e8b\u5f8c\u30d7\u30fc\u30eb\u89e3\u6790\u3002Diabetes Obes Metab 2024; doi: 10.1111\/dom.15650. <\/p>\n

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\u305d\u308c\u306b\u3088\u308b\u3068\u3001\u30e1\u30ad\u30b7\u30b3\u4eba\u306e\u7d041,000\u4e07\u4eba\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u4e0a\u6607\u306e\u7d20\u56e0\u3068\u306a\u308b\u9ad8\u30ea\u30b9\u30af\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u4e2d\u6fc3\u5ea6\uff0838mg\/dL\u8d85\uff09\u3092\u6709\u3057\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u6162\u6027\u75be\u60a3\u3068\u8840\u4e2d\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u3068\u306e\u95a2\u9023\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001\u5168\u56fd\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08ENSANUT\uff092018\u306e\u6210\u4eba9,591\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u305f\u3002\u6bcd\u96c6\u56e3\u53c2\u7167\u3068\u3057\u3066NHANES\uff082005\uff5e2014\u5e74\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\u3002\u3059\u3079\u3066\u306e\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u306b\u304a\u3044\u3066\u3001\u30e1\u30ad\u30b7\u30b3\u4eba\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u306f\u4ed6\u306e\u6c11\u65cf\u3088\u308a\u3082\u9ad8\u304b\u3063\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3001\u7cd6\u5c3f\u75c5\u3001\u9ad8\u8840\u5727\u3001\u80a5\u6e80\u3001\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3059\u3079\u3066\u306e\u8ee2\u5e30\u306b\u304a\u3044\u3066\u3001\u8840\u4e2d\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6fc3\u5ea6\u306f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3088\u308a\u3082\u5f37\u3044\u30ea\u30b9\u30af\u4e88\u6e2c\u56e0\u5b50\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u304c\u3001\u30e1\u30ad\u30b7\u30b3\u4eba\u96c6\u56e3\u306b\u304a\u3051\u308b\u5fc3\u8840\u7ba1\u75be\u60a3\u3084\u305d\u306e\u4ed6\u306e\u6162\u6027\u75be\u60a3\u306e\u5f37\u529b\u306a\u72ec\u7acb\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u3001\u305d\u308c\u306b\u5408\u308f\u305b\u305f\u4ecb\u5165\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002<\/p>\n

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Cruz-\u30d0\u30a6\u30c6\u30a3\u30b9\u30bfI\u3001Escamilla-N\u00fa\u00f1ez\u3001Yuscely F\u3001\u4ed6\u3002\u30e1\u30ad\u30b7\u30b3\u4eba\u96c6\u56e3\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3068\u305d\u306e\u6b8b\u6e23\u306e\u5206\u5e03\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3078\u306e\u5bc4\u4e0e\u3002J Clin Lipidol 2024; DOI:https:\/\/doi.org\/10.1016\/j.jacl.2024.05.002<\/a>. <\/p>\n

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\u7c73\u56fd\u306b\u304a\u3051\u308b\u30ea\u30b9\u30af\u8981\u56e0\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u505c\u6ede<\/h5>\n

\u3053\u306e\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08NHANES\uff09\u306e\u6700\u65b0\u5831\u544a\u306f\u3001\u8840\u5727\u3068\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u975eHDL-C\uff09\u306e\u7ba1\u7406\u306b\u304a\u3051\u308b\u3053\u308c\u307e\u3067\u306e\u6539\u5584\u304c\u505c\u6ede\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u30021999\u5e74\u304b\u30892018\u5e74\u306b\u304b\u3051\u3066\u306e\u5371\u967a\u56e0\u5b50\u7ba1\u7406\u3092\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u60a3\u80055717\u4eba\u3092\u542b\u3080\u6210\u4eba55,021\u4eba\uff08\u5e73\u5747\u5e74\u9f6247\u6b73\u3001\u7537\u602748.0\uff05\uff09\u3067\u8a55\u4fa1\u3057\u305f\u3002\u5371\u967a\u56e0\u5b50\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306f\u3001\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3A1c<7%, \u8840\u5727<140\/90mmHg, \u975eHDL-C<100mg\/dL\u3068\u5b9a\u7fa9\u3057\u305f\u3002 <\/span>
<\/span>
ASCVD\u6709\u75c5\u7387\u306f\u3053\u306e\u671f\u9593\u4e2d\u5b89\u5b9a\u3057\u3066\u3044\u305f\uff087.3\uff05\u304b\u30898.9\uff05\uff09\u304c\u3001\u3053\u308c\u3089\u306e\u60a3\u8005\u306e\u3046\u3061\u7cd6\u5c3f\u75c5\u6709\u75c5\u7387\u306f\u307b\u307c\u500d\u5897\u3057\u305f\uff0821.4\uff05\u304b\u308938.0\uff05\uff09\u3002\u3055\u3089\u306b\u3001\u5371\u967a\u56e0\u5b50\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6539\u5584\u7387\u306f\u505c\u6ede\u3057\u305f\u3002\u7279\u306b\u3001\u975eHDL-C\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u6709\u75c5\u7387\u306f1999\u5e74\u304b\u30892006\u5e74\u306e\u9593\u306b2\u500d\u4ee5\u4e0a\uff087.1\uff05\u304b\u308915.7\uff05\uff09\u306b\u5897\u52a0\u3057\u305f\u304c\u3001\u305d\u306e\u5f8c\u6a2a\u3070\u3044\u3068\u306a\u308a\u30012007\u5e74\u304b\u30892010\u5e74\u306f22.5\uff05\u30012011\u5e74\u304b\u30892014\u5e74\u306f27.3\uff05\u30012015\u5e74\u304b\u30892018\u5e74\u306f30.9\uff05\u304c\u975eHDL-C<100mg\/dL\u3092\u9054\u6210\u3057\u3066\u3044\u308b\u3002\u8840\u5727\u3068\u8840\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u3064\u3044\u3066\u3082\u540c\u69d8\u306e\u50be\u5411\u304c\u898b\u3089\u308c\u305f\u3002\u3053\u306e\u5371\u967a\u56e0\u5b50\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u306f\u3001\u80a5\u6e80\u3068\u591a\u91cf\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306e\u5897\u52a0\u306b\u3088\u3063\u3066\u60aa\u5316\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u7537\u5973\u9593\u3001\u6c11\u65cf\u9593\u3001\u793e\u4f1a\u7d4c\u6e08\u7684\u30b0\u30eb\u30fc\u30d7\u9593\u3067\u5371\u967a\u56e0\u5b50\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306b\u683c\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002\u7279\u306b\u3001\u5973\u6027\u306eASCVD\u60a3\u8005\u306f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304f\u3001\u3059\u3079\u3066\u306e\u5371\u967a\u56e0\u5b50\u304c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u4f4e\u304b\u3063\u305f\u3002\u3053\u306e\u6700\u65b0\u306eNHANES\u8abf\u67fb\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u3059\u3079\u3066\u306e\u4eba\u53e3\u7d71\u8a08\u5b66\u7684\u96c6\u56e3\u306b\u304a\u3044\u3066\u5fc3\u8840\u7ba1\u7cfb\u306e\u5065\u5eb7\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u3001\u305d\u308c\u305e\u308c\u306b\u5408\u3063\u305f\u4ecb\u5165\u3092\u884c\u3046\u5fc5\u8981\u6027\u304c\u5f37\u8abf\u3055\u308c\u308b\u3002 <\/span><\/p>\n

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\u7c73\u56fd\u6210\u4eba\u306b\u304a\u3051\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u6cbb\u7642\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u50be\u5411\u3068\u683c\u5dee\u30011999\u5e74\u304b\u30892018\u5e74\u307e\u3067\u3002<\/div>\n
Li J, Zhang J, Somers VK, et al.<\/div>\n

 <\/p>\n

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AEGIS-II\u8a66\u9a13\u306f\u4e0d\u6210\u529f\u306b\u7d42\u308f\u308b<\/h5>\n
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CSL-112\u306e\u6295\u4e0e\u306f90\u65e5\u76ee\u306b\u304a\u3051\u308b\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3068\u306f\u95a2\u9023\u305b\u305a\uff08CSL 112\u7fa44.9\uff05\u3001\u30d7\u30e9\u30bb\u30dc\u7fa45.2\uff05\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4\uff3bHR\uff3d0.93\u300195\uff05\u4fe1\u983c\u533a\u9593\uff3bCI\uff3d0.81-1.05\u3001p\uff1d0.24\uff09\u3001180\u65e5\u76ee\u304a\u3088\u3073365\u65e5\u76ee\u306b\u304a\u3044\u3066\u3082\u540c\u69d8\u306e\u6240\u898b\u3067\u3042\u3063\u305f\uff08\u305d\u308c\u305e\u308cHR 0.91\u300195\uff05CI\uff1a0.81-1.01\u3001HR 0.93\u300195\uff05CI\uff1a0.85-1.02\uff09\u30021\u578bMI\u30684b\u578bMI\uff08\u30b9\u30c6\u30f3\u30c8\u8840\u6813\u75c7\u306b\u3088\u308bMI\uff09\u3067\u306fCSL-112\u306eMI\u306b\u5bfe\u3059\u308b\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u305f\u3002\u7c73\u56fd\u5fc3\u81d3\u75c5\u5b66\u4f1a2024\u5e74\u5b66\u8853\u96c6\u4f1a\u3067\u5831\u544a\u3055\u308c\u305f\u63a2\u7d22\u7684\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u5024\u304c100mg\/dL\u4ee5\u4e0a\u306e\u60a3\u8005\u3067\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u6bd4\u3057\u306690\u65e5\u5f8c\u306eCSL-112\u6295\u4e0e\u7fa4\u3067\u4e3b\u8981\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u306e\u767a\u751f\u7387\u304c\u4f4e\u304b\u3063\u305f\uff08HR 0.69\u300195\uff05CI 0.53-0.90\u3001p=0.007\uff09\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLDL-C\u304c<100mg\/dL\u306e\u60a3\u8005\u306e\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001CSL-112\u70b9\u6ef4\u306e\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u30a2\u30ddA-I\u8f38\u6ce8\u304c\u9ad8\u8102\u8840\u75c7\u60a3\u8005\u306b\u6709\u76ca\u3067\u3042\u308b\u3068\u3044\u3046\u3082\u3063\u3068\u3082\u3089\u3057\u3044\u751f\u7269\u5b66\u7684\u6839\u62e0\u306f\u3042\u308b\u304c\u3001\u3053\u308c\u306b\u306f\u524d\u5411\u304d\u306a\u691c\u8a3c\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p><\/div>\n

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\u5fc3\u7b4b\u6897\u585e\u518d\u767a\u3068\u5fc3\u8840\u7ba1\u6b7b\u306b\u5bfe\u3059\u308bCSL112\u306e\u52b9\u679c\uff1aAEGIS-II\u8a66\u9a13\u304b\u3089\u306e\u77e5\u898b<\/div>\n
Povsic TJ, Korjian S, Bahit MC, et al. J Am Coll Cardiol 2024; doi: 10.1016\/j.jacc.2024.03.396 <\/div>\n<\/div>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u4ee3\u8b1d\u75be\u60a3\u30ea\u30b9\u30af<\/h5>\n
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2\u578b\u7cd6\u5c3f\u75c5\u3001\u865a\u8840\u6027\u5fc3\u75be\u60a3\u3001\u8133\u5352\u4e2d\u306a\u3069\u3092\u542b\u3080\u5fc3\u4ee3\u8b1d\u6027\u75be\u60a3\u306f\u3001\u4e16\u754c\u7684\u306b\u65e9\u671f\u6b7b\u4ea1\u306e\u4e3b\u306a\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u5fc3\u4ee3\u8b1d\u6027\u75be\u60a3\u306e\u5408\u4f75\u306f\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u60aa\u5316\u3055\u305b\u3001\u60a3\u8005\u306eQOL\u306b\u5927\u304d\u306a\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3002\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u30ea\u30dd\u86cb\u767d\u306e\u9ad8\u5024\u306f\u3001\u3053\u306e\u591a\u75be\u60a3\u5408\u4f75\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u672c\u7814\u7a76\u3067\u306f\u30e1\u30f3\u30c7\u30eb\u30e9\u30f3\u30c0\u30e0\u6cd5\u3092\u7528\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b\u5fc3\u4ee3\u8b1d\u6027\u75be\u60a3\u306e\u306a\u3044UK Biobank\u306e30\u4e07\u4eba\u4ee5\u4e0a\u306e\u6210\u4eba\u3092\u5bfe\u8c61\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001TG\u3068\u5fc3\u4ee3\u8b1d\u6027\u591a\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u305f\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u751f\u7269\u5b66\u7684\u306b\u95a2\u9023\u3059\u308b13\u306e\u4e00\u5869\u57fa\u591a\u578b\u3092\u907a\u4f1d\u5b66\u7684\u6307\u6a19\u3068\u3057\u3066\u7528\u3044\u3001\u52a0\u91cd\u907a\u4f1d\u5b66\u7684\u30ea\u30b9\u30af\u30b9\u30b3\u30a2\u3092\u5c0e\u304d\u51fa\u3057\u305f\u3002 <\/span>
<\/span>
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<\/span>
\u3057\u305f\u304c\u3063\u3066\u3001\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u5fc3\u4ee3\u8b1d\u6027\u75be\u60a3\u306e\u4e88\u9632\u3068\u6cbb\u7642\u306e\u305f\u3081\u306e\u6cbb\u7642\u6a19\u7684\u3068\u3057\u3066\u306eTG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u8cea\u306e\u5f79\u5272\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/span><\/p>\n<\/div>\n

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Zhao Y, Zhuang Z, Li Y, et al.<\/div>\n

Nature Communications 2024;15:2451\u3002<\/p><\/div>\n<\/div>\n

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\u539f\u7530-\u67f4M\u3001Davdison MH\u3001Ditmarsch M\u3001\u4ed6<\/div>\n

J Atheroscler Thromb 2024; 31\uff1a<\/p><\/div>\n<\/div>\n

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\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea(a)\u3092\u6a19\u7684\u3068\u3059\u308b\u5225\u306esiRNA<\/h5>\n
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\u30ea\u30dd\u86cb\u767d(a) [Lp(a)]\u306e\u4e0a\u6607\u306f\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3(ASCVD)\u3084\u77f3\u7070\u6c88\u7740\u6027\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u306e\u539f\u56e0\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u306e\u4e00\u56e0\u3067\u3042\u308b\u3053\u3068\u3092\u88cf\u4ed8\u3051\u308b\u8a3c\u62e0\u304c\u3042\u308b\u3002\u305d\u306e\u305f\u3081\u3001\u4e0a\u6607\u3057\u305fLp(a)\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u52b9\u679c\u306e\u3042\u308b\u65b0\u898f\u6cbb\u7642\u6cd5\u304c\u81e8\u5e8a\u958b\u767a\u306e\u7126\u70b9\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u3053\u306e\u7b2cII\u76f8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001siRNA\u3067\u3042\u308bzerlasiran\u306f\u3001\u5065\u5e38\u4eba\u3068\u78ba\u7acb\u3057\u305fASCVD\u60a3\u8005\u306b\u304a\u3044\u3066Lp(a)\u5024\u3092\u6301\u7d9a\u7684\u306b\u4f4e\u4e0b\u3055\u305b\u3001\u5fcd\u5bb9\u6027\u3082\u826f\u597d\u3067\u3042\u3063\u305f\u3002 <\/p>\n

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Lipoprotein(a)\u3092\u6a19\u7684\u3068\u3059\u308b\u77ed\u9396\u5e72\u6e09RNA\u3001zerlasiran\u306e\u5358\u56de\u4e0a\u884c\u304a\u3088\u3073\u53cd\u5fa9\u6295\u4e0e\u8a66\u9a13<\/div>\n
Nissen SE, Wolski K, Watts GF et al.<\/div>\n

).<\/a> JAMA 2024; doi:10.1001\/jama.2024.4504<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/38587822\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

NHANES\uff1a\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u7570\u5e38\u75c7\u306e\u4e0d\u5747\u4e00\u6027<\/h5>\n
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\u7cd6\u5c3f\u75c5\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306f\u3001\u5178\u578b\u7684\u306b\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306e\u4e0a\u6607\u3068\u8840\u6f3f\u4e2d\u306e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08HDL-C\uff09\u306e\u4f4e\u5024\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u7279\u5fb4\u3065\u3051\u3089\u308c\u308b\u304c\u3001\u305f\u3068\u3048\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u826f\u597d\u3067\u3042\u3063\u305f\u3068\u3057\u3066\u3082\u3001\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4e3b\u8981\u306a\u8981\u56e0\u3067\u3042\u308b\u3002\u3053\u306eNational Health and Nutrition Examination Survey\uff08NHANES\uff09\u306e\u5831\u544a\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u7570\u5e38\u75c7\u306e\u4e0d\u5747\u4e00\u306a\u30d7\u30ed\u30d5\u30a3\u30fc\u30eb\u304c\u5f37\u8abf\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

\u672c\u7814\u7a76\u306f\u3001\u7cd6\u5c3f\u75c5\u306e\u6709\u7121\u306b\u304b\u304b\u308f\u3089\u305a\u6210\u4eba\uff08>18\u6b73\uff09\u3092\u5bfe\u8c61\u3068\u3057\u305fNHANES 2011-2016\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u305f\u3002\u4f4eHDL-C\u306f\u7537\u6027<40mg\/dL\u3001\u5973\u6027<50mg\/dL\u3001\u9ad8TG\u306f>150mg\/dL\u3068\u5b9a\u7fa9\u3057\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u7814\u7a76\u96c6\u56e3\u306f7574\u4eba\u3001\u7537\u60273679\u4eba\u3001\u5973\u60273895\u4eba\u3067\u69cb\u6210\u3055\u308c\u3001\u3053\u306e\u3046\u30612048\u4eba\uff0827\uff05\uff09\u304c\u7cd6\u5c3f\u75c5\u3068\u8a3a\u65ad\u3055\u308c\u305f\u3002TG\u4e0a\u6607\u3068HDL-C\u4f4e\u4e0b\u306e\u5408\u4f75\u306f\u7cd6\u5c3f\u75c5\u7fa4\u306e19.3\uff05\u306b\u307f\u3089\u308c\u305f\uff08\u7cd6\u5c3f\u75c5\u3067\u306a\u3044\u7fa4\u3067\u306f8.8\uff05\uff09\u3002\u3057\u304b\u3057\u3001\u7cd6\u5c3f\u75c5\u7fa4\u306e\u8102\u8cea\u7570\u5e38\u75c7\u306b\u306f\u7570\u8cea\u6027\u304c\u3042\u308a\u300114.1\uff05\u306bTG\u4e0a\u6607\u306e\u307f\u300116.8\uff05\u306bHDL-C\u4f4e\u4e0b\u306e\u307f\u3001\u307b\u307c\u534a\u6570\u306b\u8102\u8cea\u7570\u5e38\u306e\u3044\u305a\u308c\u3082\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u7cd6\u5c3f\u75c5\u6027\u8102\u8cea\u7570\u5e38\u75c7\uff08TG\u4e0a\u6607\u3001HDL-C\u4f4e\u4e0b\uff09\u306e\u6709\u75c5\u7387\u3092\u5e74\u9f62\u968e\u7d1a\u5225\u306b\u307f\u308b\u3068\u300130\u6b73\u4ee5\u4e0a\u3067\u306f\u6709\u75c5\u7387\u304c\u4f4e\u4e0b\u3059\u308b\u50be\u5411\u304c\u307f\u3089\u308c\u305f\u304c\u3001\u6700\u3082\u6709\u75c5\u7387\u304c\u9ad8\u304b\u3063\u305f\u306e\u306f30\u301c40\u6b73\u306e\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u3042\u3063\u305f\uff0826.9\uff05\uff09\u3002\u4e00\u65b9\u3001\u7cd6\u5c3f\u75c5\u306e\u306a\u3044\u7fa4\u3067\u306f\u3001TG\u4e0a\u6607\u3001HDL-C\u4f4e\u4e0b\u3001\u4e21\u8102\u8cea\u7570\u5e38\u306e\u5272\u5408\u306f\u3001\u5e74\u9f62\u5c64\u5225\u306b\u307f\u3066\u3082\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002 <\/p>\n

\u3053\u306e\u5831\u544a\u304b\u3089\u5f97\u3089\u308c\u308b\u30e1\u30c3\u30bb\u30fc\u30b8\u306f\u3001\u9ad8TG\u8840\u75c7\u3068\u4f4eHDL-C\u8840\u75c7\u306e\u5408\u4f75\u306f\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u3088\u304f\u307f\u3089\u308c\u3001\u3053\u306e\u60a3\u8005\u7fa4\u306e\u7d045\u4eba\u306b1\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u306e\u8102\u8cea\u7570\u5e38\u75c7\u306e\u6709\u75c5\u7387\u306f\u82e5\u5e74\u8005\uff0830\u301c40\u6b73\uff09\u3067\u6700\u3082\u9ad8\u304f\u3001\u82e5\u5e74\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u7570\u5e38\u75c7\u306e\u7ba1\u7406\u306b\u518d\u3073\u7126\u70b9\u3092\u5f53\u3066\u308b\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002 <\/p><\/div>\n

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\u7cd6\u5c3f\u75c5\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306e\u4e0d\u5747\u4e00\u6027\u3001NHANES\u306e\u30c7\u30fc\u30bf\uff082011-2016\u5e74\uff09\u3002<\/div>\n
Li Y, Liu J, Huang N, et al. Medicine 2024;103:6\u3002 <\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/38335399\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30ea\u30dd\u86cb\u767d(a)\u3068\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af<\/h5>\n
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BiomarCaRE\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u304c\u30ea\u30dd\u86cb\u767d(a)[Lp(a)]\u3068\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3(CHD)\u518d\u767a\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u4e2d\u592e\u5024\u306713.8\u5e74\u307e\u3067\u306e\u8ffd\u8de1\u3092\u884c\u3063\u305f8\u3064\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u524d\u5411\u304d\u96c6\u56e3\u30d9\u30fc\u30b9\u306e\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306b\u542b\u307e\u308c\u308b71,678\u4eba\u306e\u60a3\u8005\uff08\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306bCHD\u304c\u78ba\u7acb\u3057\u3066\u3044\u305f6,017\u4eba\uff09\u306e\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3002\u305d\u306e\u76ee\u7684\u306f\u3001\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u86cb\u767d\uff08hsCRP\uff09\u304c\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308bLp(a)\u3068CHD\u306e\u95a2\u9023\u3092\u8abf\u7bc0\u3059\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306bCHD\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u4eba\u3067\u306f\u3001Lp(a)\u306fCHD\u30a4\u30d9\u30f3\u30c8\u30ea\u30b9\u30af\u3068\u6b63\u306e\u76f8\u95a2\u3092\u793a\u3057\u3001\u3053\u306e\u76f8\u95a2\u306fhsCRP\u30ec\u30d9\u30eb\u306b\u306f\u5f71\u97ff\u3055\u308c\u306a\u304b\u3063\u305f\u3002Lp(a)\u306e\u6700\u9ad8\u5024\u3068\u6700\u4f4e\u5024\u306e\u4e94\u5206\u4f4d\u7fa4\u306e\u30aa\u30c3\u30ba\u6bd4\uff0895\uff05\u4fe1\u983c\u533a\u9593\uff09\u306f\u3001hsCRP<2mg\/L\u306e\u4eba\u30671.45\uff081.23-1.72\uff09\u3001hsCRP\u30ec\u30d9\u30eb\u22672mg\/L\u306e\u4eba\u30671.48\uff081.23-1.78\uff09\u3067\u3042\u3063\u305f\u3002\u4e00\u65b9\u3001CHD\u306e\u65e2\u5f80\u306e\u3042\u308b\u4eba\u3067\u306f\u3001Lp(a)\u3068CHD\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023\u306fhsCRP\u5024\u304c2mg\/L\u4ee5\u4e0a\u306e\u5834\u5408\u306b\u306e\u307f\u660e\u3089\u304b\u3067\u3042\u308a\uff08\u30aa\u30c3\u30ba\u6bd41.34\u300195\uff05CI 1.03-1.76\uff09\u3001hsCRP\u5024\u306e\u4f4e\u3044\u4eba\u3067\u306f\u660e\u78ba\u306a\u95a2\u9023\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/p>\n

\u7d50\u8ad6\u3068\u3057\u3066\u3001\u3053\u306e\u5831\u544a\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u304cLp(a)\u306b\u95a2\u9023\u3057\u305fCHD\u518d\u767a\u30ea\u30b9\u30af\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u304a\u308a\u3001\u65b0\u898f\u306eLp(a)\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306e\u9069\u5fdc\u60a3\u8005\u3092\u9078\u629e\u3059\u308b\u969b\u306b\u8003\u616e\u3059\u3079\u304d\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/p><\/div>\n

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[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

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C\u53cd\u5fdc\u6027\u86cb\u767d\u8cea\u306f\u30ea\u30dd\u86cb\u767d(a)\u95a2\u9023\u306e\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u30ea\u30b9\u30af\u3092\u4fee\u98fe\u3059\u308b\uff1aBiomarCaRE\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3002<\/div>\n
\u30a2\u30fc\u30ce\u30eb\u30c9N\u3001\u30d6\u30e9\u30a6\u30e0C\u3001\u30b4\u30fc\u30b9\u30ea\u30f3\u30b0A\u3001\u4ed6<\/div>\n

Eur Heart J 2024:ehad867.<\/p><\/div>\n

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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff1a\u5927\u52d5\u8108\u5f01\u30ab\u30eb\u30b7\u30a6\u30e0\u9032\u884c\u306e\u6b8b\u5b58\u5371\u967a\u56e0\u5b50<\/h5>\n
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MESA\uff08Multi-Ethnic Study of Atherosclerosis\uff09\u7814\u7a76\u306e\u7d50\u679c\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u3001\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\u306b\u95a2\u4fc2\u306a\u304f\u3001\u5927\u52d5\u8108\u5f01\u30ab\u30eb\u30b7\u30a6\u30e0\uff08AVC\uff09\u306e\u9032\u884c\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u306e\u95a2\u9023\u306f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u304c\u81f3\u9069\u30ec\u30d9\u30eb\u306e\u4eba\u3067\u3082\u660e\u3089\u304b\u3067\u3042\u3063\u305f\u3002 <\/span>
<\/span>
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<\/span>
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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5927\u52d5\u8108\u5f01\u30ab\u30eb\u30b7\u30a6\u30e0\u306e\u9032\u884c\u30ea\u30b9\u30af\uff1aMESA\u7814\u7a76\u304b\u3089\u306e\u8003\u5bdf\u3002<\/div>\n
Li ZH, Hao QY, Zeng YH, et al.<\/div>\n

Cardiovasc Diabetol 2024; 23:20.<\/p><\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-023-02081-2&#8243<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”15px” header_2_text_color=”gcid-primary-color” header_2_font_size=”32px” custom_margin=”||-13px|||” custom_padding=”9px|||27px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22header_2_text_color%22%93}”]<\/p>\n

2023 <\/span><\/h2>\n

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\u9577\u671f\u6b8b\u5b58\u30ea\u30b9\u30af\u304c\u9ad8\u3044\uff1a\u65e9\u3081\u306e\u5bfe\u5fdc<\/h5>\n
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\u3053\u306e\u6700\u8fd1\u306e\u7dcf\u8aac\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u3067\u6cbb\u7642\u3055\u308c\u305f\u4e8c\u6b21\u4e88\u9632\u60a3\u8005\u306b\u304a\u3044\u3066\u9577\u671f\u7684\u306b\u6b8b\u5b58\u3059\u308b\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u5f37\u8abf\u3057\u3001\u3053\u308c\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u8fc5\u901f\u3067\u52b9\u679c\u7684\u306a\u6cbb\u7642\u306e\u5fc5\u8981\u6027\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u3067\u306f\u300140\uff05\u4ee5\u4e0a\u306e\u60a3\u8005\u304c10\u5e74\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u3092\u7d4c\u9a13\u3057\u3001\u8133\u8840\u7ba1\u969c\u5bb3\u3092\u6709\u3059\u308b\u60a3\u8005\u306e\u307b\u307c5\u4eba\u306b1\u4eba\u304c\u3053\u306e\u671f\u9593\u306b\u8133\u5352\u4e2d\u306e\u518d\u767a\u3092\u7d4c\u9a13\u3057\u3066\u3044\u308b\u3002\u3053\u308c\u306f\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5341\u5206\u306b\u7ba1\u7406\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3067\u3042\u308b\u3002\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001\u3053\u306e\u9ad8\u3044\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u8102\u8cea\u3068\u8102\u8cea\u4ee5\u5916\u306e\u5371\u967a\u56e0\u5b50\u306e\u4e21\u65b9\u3092\u6a19\u7684\u3068\u3057\u305f\u8ffd\u52a0\u6cbb\u7642\u306b\u3088\u308b\u65e9\u6025\u306a\u5bfe\u5fdc\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u7d50\u8ad6\u306f\u3001Residual Risk Reduction Initiative\uff08R3i\uff09\u306e\u4f7f\u547d\u3068\u975e\u5e38\u306b\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002 <\/div>\n
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[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

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\u30b9\u30bf\u30c1\u30f3\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u78ba\u7acb\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u60a3\u8005\u306b\u304a\u3051\u308b\u4e2d\u9593\u304a\u3088\u3073\u9577\u671f\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af Vijayaraghavan K, Baum S, Desai NR, Voyce SJ.<\/div>\n

Front Cardiovasc Med 2024; DOI 10.3389\/fcvm.2023.1308173<\/p><\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10822878\/#:~:text=CV%20event%20rates%20among%20patients,approximately%2040%25%20over%2010%20years.&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30a2\u30b8\u30a2\u3067\u5897\u52a0\u3059\u308b\u8133\u5352\u4e2d<\/h5>\n
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\u8133\u5352\u4e2d\u306f\u3001\u4e16\u754c\u4e2d\u3067\u8eab\u4f53\u969c\u5bb3\u3084\u8840\u7ba1\u6b7b\u306e\u4e3b\u306a\u539f\u56e0\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u9ad8\u3044\u7d4c\u6e08\u7684\u8ca0\u62c5\u3092\u4e0e\u3048\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001Global Burden of Disease 2019\u8abf\u67fb\u306e\u7d50\u679c\u306f\u3001\u30a2\u30b8\u30a2\u306b\u304a\u3051\u308b\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u5c06\u6765\u7684\u306a\u8ca0\u62c5\u306e\u5897\u52a0\u3092\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002 <\/span>
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\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u5e74\u9f62\u6a19\u6e96\u5316\u7f79\u60a3\u7387\u306f\u30011990\u5e74\u304b\u30892019\u5e74\u306b\u304b\u3051\u3066\u7de9\u3084\u304b\u306a\u4e0a\u6607\u50be\u5411\u3092\u793a\u3057\u3001\u75be\u75c5\u8ca0\u62c5\u306f\u9ad8\u9f62\u8005\u3001\u7279\u306b65\u6b73\u4ee5\u4e0a\u306b\u96c6\u4e2d\u3057\u3066\u3044\u308b\u3002\u6ce8\u76ee\u3059\u3079\u304d\u306f\u3001\u30a2\u30b8\u30a2\u306e\u4ed6\u306e\u5730\u57df\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6771\u30a2\u30b8\u30a2\u304c\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u8ca0\u62c5\u304c\u6700\u3082\u9ad8\u304b\u3063\u305f\u3053\u3068\u3067\u3042\u308b\u3002\u4e16\u754c\u4eba\u53e3\u306e\u534a\u5206\u4ee5\u4e0a\u304c\u30a2\u30b8\u30a2\u306b\u5c45\u4f4f\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u672c\u7814\u7a76\u306f\u5065\u5eb7\u304a\u3088\u3073\u793e\u4f1a\u7d4c\u6e08\u7684\u306b\u91cd\u8981\u306a\u610f\u5473\u3092\u6301\u3064\u3002\u4f4f\u6c11\u5168\u4f53\u3092\u5bfe\u8c61\u3068\u3057\u305f\u4e00\u6b21\u4e88\u9632\u6226\u7565\u3092\u5b9f\u65bd\u3057\u306a\u3051\u308c\u3070\u3001\u865a\u8840\u6027\u8133\u5352\u4e2d\u306e\u8ca0\u62c5\u306f\u5c06\u6765\u7684\u306b\u5897\u5927\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3002 <\/span><\/div>\n
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Zhang X\u3001Lv H\u3001Chen X\u3001\u4ed6<\/div>\n

Front Neurol 2023:14:1309931.<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u7cd6\u5c3f\u75c5\u524d\u75c7\u3001MACE\u3001\u56db\u80a2\u306e\u6709\u5bb3\u4e8b\u8c61<\/h5>\n
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\u53f0\u6e7e\u3067\u884c\u308f\u308c\u305f\u3053\u306e\u7814\u7a76\u306e\u7d50\u679c\u3001\u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd\u306f\u3001\u6b63\u5e38\u8840\u7cd6\u306e\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u3001\u56db\u80a2\u306e\u4e3b\u8981\u6709\u5bb3\u4e8b\u8c61\uff08MALE\uff09\u304a\u3088\u3073\u4e3b\u8981\u5fc3\u8840\u7ba1\u7cfb\u6709\u5bb3\u4e8b\u8c61\uff08MACE\uff09\u3001\u7279\u306b\u672b\u68a2\u52d5\u8108\u75be\u60a3\uff08PAD\uff09\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/span>
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\u3053\u308c\u306f\u30012014\u5e74\u304b\u30892019\u5e74\u306e\u9593\u306b\u53f0\u6e7e\u306e3\u6b21\u533b\u7642\u65bd\u8a2d\u3067\u6cbb\u7642\u3092\u53d7\u3051\u305f45\u6b73\u4ee5\u4e0a\u306e\u60a3\u800536,950\u4eba\u306e\u96fb\u5b50\u30ab\u30eb\u30c6\u306e\u7e26\u65ad\u7684\u30ec\u30c8\u30ed\u30b9\u30da\u30af\u30c6\u30a3\u30d6\u30b3\u30db\u30fc\u30c8\u89e3\u6790\u3067\u3042\u308b\u3002\u7cd6\u5c3f\u75c5\u3001\u307e\u305f\u306fPAD\u3001\u91cd\u75c7\u865a\u8840\u80a2\u3001\u5207\u65ad\u3001\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u3001\u8133\u5352\u4e2d\u306e\u65e2\u5f80\u6b74\u306e\u3042\u308b\u60a3\u8005\u306f\u9664\u5916\u3057\u305f\u3002\u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd\u304a\u3088\u3073\u6b63\u5e38\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u8abf\u7bc0\u306f\u30012023\u5e74\u7c73\u56fd\u7cd6\u5c3f\u75c5\u5b66\u4f1a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u5f93\u3063\u3066\u5b9a\u7fa9\u3057\u305f\uff08\u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd\uff1a\u7a7a\u8179\u6642\u8840\u7cd6\u5024100\uff5e125mg\/dL\uff085.6\uff5e6.9mmol\/L\uff09\u300175g\u7d4c\u53e3\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u8a66\u9a13\u4e2d\u306e2\u6642\u9593\u8840\u7cd6\u5024140\uff5e199mg\/dL\uff087.8\uff5e11.0mmol\/L\uff09\u3001\u307e\u305f\u306fHbA1c\u5024\u304c5.7\uff5e6.4\uff05\uff0839\uff5e47mmol\/mol\uff09\u4ee5\u5185\uff09\u3002\u7dcf\u8a0836,950\u4eba\u300119,196\u4eba\u304c\u6b63\u5e38\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u8abf\u7bc0\u300117,754\u4eba\u304c\u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd\u3067\u3042\u3063\u305f\u3002\u7cd6\u5c3f\u75c5\u4e88\u5099\u8ecd\u60a3\u8005\u306f\u3001\u6b63\u5e38\u306a\u8840\u7cd6\u8abf\u7bc0\u306e\u60a3\u8005\u306b\u6bd4\u3079\u3066\u3001\u5e74\u9f62\u304c\u9ad8\u304f\uff0865.2\u00b110.7\u6b73\u5bfe62.9\u00b110.2\u6b73\u3001p<0.001\uff09\u3001\u7537\u6027\u304c\u591a\u304f\uff0848.9\uff05\u5bfe40.7\uff05\u3001p<0.001\uff09\u3001\u80a5\u6e80\u5ea6\u304c\u9ad8\u304f\u3001\u4f75\u5b58\u75be\u60a3\uff08\u9ad8\u8840\u5727\u3001\u9ad8\u8102\u8840\u75c7\u3001\u5fc3\u4e0d\u5168\u3001\u5fc3\u623f\u7d30\u52d5\u3001\u51a0\u52d5\u8108\u75be\u60a3\u3001\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\uff09\u304c\u591a\u304b\u3063\u305f\u3002 <\/span>
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\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u502446.4\u30f5\u6708\u306e\u9593\u306b\u3001MALE\u304c1324\u4f8b\u3001MACE\u304c1276\u4f8b\u3067\u3042\u3063\u305f\u3002\u4e21\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\uff081,000\u4eba\u5e74\u5f53\u305f\u308a\uff09\u306f\u3001\u7cd6\u5c3f\u75c5\u524d\u75c7\u306e\u30b3\u30db\u30fc\u30c8\u3067\u306f\u6b63\u5e38\u306e\u30b0\u30eb\u30b3\u30fc\u30b9\u8abf\u7bc0\u3088\u308a\u3082\u9ad8\u304b\u3063\u305f\uff08MALE\uff1a10.8\u5bfe9.53\u3001MACE\uff1a11.99\u5bfe7.56\uff09\u3002Kaplan-Meier\u89e3\u6790\u306e\u7d50\u679c\u3001\u7cd6\u5c3f\u75c5\u524d\u75c7\u7fa4\u3067\u306f\u6b63\u5e38\u7fa4\u306b\u6bd4\u3079MALE\uff08p=0.024\uff09\u3068MACE\uff08p<0.001\uff09\u304c\u6709\u610f\u306b\u5897\u52a0\u3057\u305f\u3002\u307e\u305f\u3001\u5408\u4f75\u75c7\u306e\u767a\u75c7\u3082\u7cd6\u5c3f\u75c5\u4e88\u5099\u7fa4\u306e\u65b9\u304c\u65e9\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u7cd6\u5c3f\u75c5\u524d\u75c7\u60a3\u8005\u306e\u4e88\u5f8c\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u3092\u96c6\u4e2d\u7684\u306b\u6539\u5584\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u304c\u5f37\u8abf\u3055\u308c\u308b\u3002 <\/span><\/div>\n
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Hsu J-C\u3001Yang Y-Y\u3001Chuang S-L\u3001\u4ed6<\/div>\n

Cardiovasc Diabetol 2023;22:348\u3002<\/p><\/div>\n<\/div>\n

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RICO\u767b\u9332\uff1a\u4e2d\u6027\u8102\u80aa\u306e\u4e0a\u6607\u3068\u865a\u8840\u518d\u767a\u306e\u6b8b\u5b58\u30ea\u30b9\u30af<\/h5>\n
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C\u00f4te d’Or MI observatory\uff08RICO\uff09\u767b\u9332\u304b\u3089\u306e\u3053\u306e\u5831\u544a\u3067\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607\u306f\u4e00\u822c\u7684\u3067\u3042\u308a\u3001\u5f93\u6765\u306e\u4e88\u5f8c\u56e0\u5b50\u3092\u8d85\u3048\u3066\u6025\u6027\u5fc3\u7b4b\u6897\u585e\uff08AMI\uff09\u306e\u518d\u767a\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/span>
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\u3053\u306e\u5927\u898f\u6a21\u5730\u57df\u767b\u9332\u306f\u3001AMI\u3067\u5165\u9662\u3057\u305f10,667\u4f8b\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u305f\u3082\u306e\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08200mg\/dL\u4ee5\u4e0b\u307e\u305f\u306f>200mg\/dL\uff09\u306b\u3088\u3063\u3066\u5206\u985e\u3055\u308c\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u300117.7\uff05\uff08n=1886\uff09\u304c\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u3067\u3042\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u60a3\u8005\u306f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4f4e\u5024\u306e\u60a3\u8005\u306b\u6bd4\u3079\u3066\u5e73\u5747\u5e74\u9f62\u304c10\u6b73\u82e5\u304f\u3001\u80a5\u6e80\u3068\u7cd6\u5c3f\u75c5\u306e\u6709\u75c5\u7387\u304c\u9ad8\u304f\u3001\u55ab\u7159\u50be\u5411\u304c\u5f37\u304b\u3063\u305f\u3002 <\/span>
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1\u5e74\u5f8c\u306e\u8ffd\u8de1\u3067\u306f\u3001\u865a\u8840\u30a4\u30d9\u30f3\u30c8\uff08\u4e0d\u5b89\u5b9a\u72ed\u5fc3\u75c7\u3001MI\u518d\u767a\uff09\u304a\u3088\u3073\u8133\u5352\u4e2d\u3092\u542b\u3080\u8907\u5408\u865a\u8840\u30a4\u30d9\u30f3\u30c8\uff08\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\u3001\u51a0\u52d5\u8108\u30d0\u30a4\u30d1\u30b9\u8853\uff09\u306e\u767a\u751f\u7387\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u7fa4\u3067\u9ad8\u304b\u3063\u305f\uff0811.2\uff05 vs \u4f4e\u5024\u7fa49.1\uff05\u3001p\u22660.004\uff09\u3002\u591a\u5909\u91cf\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u9ad8\u5024\u306f\u8907\u5408\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u6700\u3082\u5f37\u3044\u4e88\u6e2c\u56e0\u5b50\u306e1\u3064\u3067\u3042\u308a\uff08\u30aa\u30c3\u30ba\u6bd41.356\u300195\uff05\u4fe1\u983c\u533a\u95931.095-1.679\uff09\u3001p=0.005\uff09\u3001\u7cd6\u5c3f\u75c5\u306b\u95a2\u9023\u3059\u308b\u30ea\u30b9\u30af\u3068\u540c\u7b49\u3067\u3042\u3063\u305f\u3002 <\/span>
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\u7d50\u8ad6\u3068\u3057\u3066\u3001\u3053\u306e\u73fe\u5b9f\u306e\u5927\u898f\u6a21\u30ec\u30b8\u30b9\u30c8\u30ea\u306e\u7d50\u679c\u306f\u3001AMI\u60a3\u8005\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u4e0a\u6607\u306e\u9ad8\u3044\u6709\u75c5\u7387\uff08\u307b\u307c5\u4eba\u306b1\u4eba\uff09\u3092\u793a\u3057\u3001\u3053\u308c\u306f\u865a\u8840\u30a4\u30d9\u30f3\u30c8\u306e\u518d\u767a\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/span><\/div>\n
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\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u3067\u4e2d\u6027\u8102\u80aa\u304c\u4e0a\u6607\u3057\u305f\u60a3\u8005\u306e\u7279\u5fb4\u3068\u4e88\u5f8c\uff1a17\u5e74\u9593\u306e\u5927\u898f\u6a21\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304b\u3089\u306e\u89b3\u5bdf\u30c7\u30fc\u30bf\u3002<\/div>\n
Zeller M, Chague F, Maza M, et al.<\/div>\n

J Clin Lipidol 2023;13:54.<\/p><\/div>\n<\/div>\n

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[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/37985275\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u65e9\u671f\u6b7b\u4ea1\u30ea\u30b9\u30af<\/h5>\n
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UK Biobank\u304b\u3089\u306e\u5831\u544a\u306b\u3088\u308b\u3068\u3001\u8840\u6e05\u4e2d\u306e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u5024\u3067\u3042\u308b\u3053\u3068\u306f\u3001\u65e9\u671f\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u5897\u52a0\u304a\u3088\u3073\u5e73\u5747\u4f59\u547d\u306e\u77ed\u7e2e\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u4e88\u9632\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u30ea\u30b9\u30af\u5c64\u5225\u5316\u306b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u7d44\u307f\u5165\u308c\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span>
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\u3053\u306e\u7814\u7a76\u306f\u3001UK Biobank\u306e428,804\u4eba\u306e\u30c7\u30fc\u30bf\u3092\u8a55\u4fa1\u3057\u305f\u3082\u306e\u3067\u3001\u8ffd\u8de1\u671f\u9593\u4e2d\u592e\u5024\u306f12.1\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f211.0\u301c13.0\u5e74\uff09\u3067\u3042\u3063\u305f\u3002\u5bfe\u8c61\u8005\u306f\u3001\u6bcd\u96c6\u56e3\u30d1\u30fc\u30bb\u30f3\u30bf\u30a4\u30eb\u6cd5\u3092\u7528\u3044\u3066\u3001\u4f4e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7fa4\uff08\u5e73\u57470.34mmol\/L\uff09\u3001\u4e2d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7fa4\uff080.53mmol\/L\uff09\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7fa4\uff081.02mmol\/L\uff09\u306e3\u7fa4\u306b\u5206\u985e\u3055\u308c\u305f\u3002\u591a\u5909\u91cfCox\u6bd4\u4f8b\u30cf\u30b6\u30fc\u30c9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u65e9\u671f\u6b7b\u4ea1\uff0875\u6b73\u4ee5\u524d\u306e\u6b7b\u4ea1\uff09\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u3001\u751f\u547d\u8868\u6cd5\u3092\u7528\u3044\u3066\u5e73\u5747\u4f59\u547d\u3092\u63a8\u5b9a\u3057\u305f\u3002 <\/span>
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\u8ffd\u8de1\u671f\u9593\u4e2d\u300123,693\u4f8b\u306e\u5168\u6b7b\u56e0\u6b7b\u4ea1\u304c\u3042\u3063\u305f\uff081,000\u4eba\u5e74\u5f53\u305f\u308a4.83\u4f8b\uff09\u3002\u4f4e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u4e2d\u7b49\u5ea6\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4eba\u306f\u5168\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c9\uff05\u9ad8\u304f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4[HR]1.09\u300195\uff05\u4fe1\u983c\u533a\u9593[CI]1.05\uff5e1.14\uff09\u3001\u9ad8\u5024\u306e\u4eba\u306f11\uff05\u9ad8\u304b\u3063\u305f\uff08HR1.11\u300195\uff05CI1.07\uff5e1.16\uff09\u300250\u6b73\u306e\u6642\u70b9\u3067\u3001\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u4f4e\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5973\u6027\u3067\u306f\u5e73\u57472.2\u5e74\u3001\u7537\u6027\u3067\u306f\u5e73\u57470.1\u5e74\u5bff\u547d\u304c\u77ed\u3044\u3053\u3068\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u4e88\u9632\u306b\u304a\u3051\u308b\u30ea\u30b9\u30af\u5c64\u5225\u5316\u306b\u304a\u3044\u3066\u3001\u5f93\u6765\u306e\u5371\u967a\u56e0\u5b50\u306b\u52a0\u3048\u3066\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u8003\u616e\u3059\u308b\u5fc5\u8981\u6027\u3092\u88dc\u5f37\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/div>\n
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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u65e9\u671f\u6b7b\u4ea1\u30ea\u30b9\u30af\uff1a\u5168\u56fd\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u304b\u3089\u306e\u89e3\u6790\u3002<\/div>\n
Li L, Lai J, Zhang J, et al.<\/div>\n

Eur Heart J Qual Care Clin Outcomes 2023:qcad071.<\/p><\/div>\n<\/div>\n

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[\/et_pb_text][et_pb_button button_url=”https:\/\/academic.oup.com\/ehjqcco\/advance-article-abstract\/doi\/10.1093\/ehjqcco\/qcad071\/7473717&#8243<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u4ee3\u8b1d\u7570\u5e38<\/h5>\n
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\u7c73\u56fd\u56fd\u6c11\u5065\u5eb7\u6804\u990a\u8abf\u67fb\uff08NHANES\uff09\u306e\u89e3\u6790\u306b\u3088\u308b\u3068\u3001\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u60a3\u8005\u306b\u304a\u3051\u308b\u809d\u786c\u5909\u306e\u4e88\u6e2c\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/span>
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Wang Y, Song W, Yuan Q, et al.<\/div>\n

Scand J Gastroenterol 2023 22:1-11.<\/p><\/div>\n<\/div>\n

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ACS\u306b\u304a\u3051\u308b\u30ea\u30dd\u86cb\u767d(a)\u3068\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\uff1a\u6e2c\u5b9a\u65b9\u6cd5\u306f\u91cd\u8981\u304b\uff1f<\/h5>\n
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\u7814\u7a76\u8005\u3089\u306f\u3001\u7570\u306a\u308b\u514d\u75ab\u6e2c\u5b9a\u6cd5\uff08Siemens n-latex nephelometric immunoassay\uff08\u8cea\u91cf\u3001mg\/dL\uff09\u307e\u305f\u306fRoche tina-quant\u00ae turbidimetric immunoassay\uff08\u30e2\u30eb\u3001nmol\/L\uff09\uff09\u304a\u3088\u3073\u975e\u5546\u7528\u8cea\u91cf\u5206\u6790\u30d9\u30fc\u30b9\u306e\u691c\u67fb\u6cd5\uff08nmol\/L\uff09\u3067\u6e2c\u5b9a\u3057\u305f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eLp(a)\u6fc3\u5ea6\u306b\u5fdc\u3058\u3066\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306e\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u30ea\u30b9\u30af\u3068\u30a2\u30ea\u30ed\u30af\u30de\u30d6\u306b\u3088\u308bMACE\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u3092\u6bd4\u8f03\u3057\u305f\u3002<\/span>
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Szarek M, Reijnders E, Jukema JW, et al.<\/div>\n

Circulation 2023; doi: 10.1161\/CIRCULATIONAHA.123.066398.\u30aa\u30f3\u30e9\u30a4\u30f3\u7248<\/p><\/div>\n<\/div>\n

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\u5408\u8a083,383\u4eba\u306eT2DM\u60a3\u8005\u304c\u3053\u306e\u6a2a\u65ad\u7814\u7a76\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002CKD\u306e\u91cd\u75c7\u5ea6\u306f\u3001\u5c3f\u4e2d\u30a2\u30eb\u30d6\u30df\u30f3\uff0f\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u6bd4\u3068\u63a8\u5b9a\u7cf8\u7403\u4f53\u6ffe\u904e\u91cf\u306b\u57fa\u3065\u3044\u3066\u3001\u306a\u3057\uff082,587\u4eba\u300176.5\uff05\uff09\u3001\u4e2d\u7b49\u5ea6\uff08520\u4eba\u300115.4\uff05\uff09\u3001\u91cd\u5ea6\uff08189\u4eba\u30015.6\uff05\uff09\u3001\u8d85\u91cd\u5ea6\uff0887\u4eba\u30012.5\uff05\uff09\u3068\u5b9a\u7fa9\u3055\u308c\u305f\u3002\u591a\u5909\u91cf\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u304a\u3088\u3073\u591a\u5909\u91cf\u9806\u5e8f\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u3092\u7528\u3044\u3066\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068CKD\u3068\u306e\u95a2\u9023\u3092\u691c\u8a0e\u3057\u305f\u3002 <\/p>\n

\u4ea4\u7d61\u56e0\u5b50\u3092\u88dc\u6b63\u3057\u305f\u5f8c\u3001CKD\u91cd\u75c7\u5ea6\u306f\u5bfe\u6570\u5909\u63db\u3057\u305f\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c1\u5358\u4f4d\u5897\u52a0\u3059\u308b\u3054\u3068\u306b\u5897\u52a0\u3057\u305f\uff08\u30aa\u30c3\u30ba\u6bd41.76\u300195\uff05\u4fe1\u983c\u533a\u95931.52-2.05\uff09\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068CKD\u91cd\u75c7\u5ea6\u3068\u306e\u95a2\u9023\u306f\u3001\u8102\u8cea\u5024\u304c\u6b63\u5e38\u7bc4\u56f2\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\u8a8d\u3081\u3089\u308c\u305f\u3002 <\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Yuan Y, Zhou X, Ji L.<\/div>\n

.J Diabetes Complications 2023;37(9):108585.<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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REDUCE-IT\u306b\u3088\u308b\u305d\u306e\u4ed6\u306e\u6d1e\u5bdf<\/h5>\n
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\u4e8b\u5f8c\u89e3\u6790\u3067\u306f\u3001REDUCE-IT\u8a66\u9a13\u3067\u5831\u544a\u3055\u308c\u305f\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308b\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u521d\u56de\u767a\u751f25\uff05\u6e1b\u5c11\u306e\u6700\u3082\u53ef\u80fd\u6027\u306e\u9ad8\u3044\u30e1\u30c7\u30a3\u30a8\u30fc\u30bf\u30fc\u3068\u3057\u3066\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\uff08EPA\uff09\u6fc3\u5ea6\u304a\u3088\u3073EPA\u3068\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\uff08AA\uff09\u306e\u6bd4\u306e\u5909\u5316\u304c\u540c\u5b9a\u3055\u308c\u305f\u3002<\/span>
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\u3053\u306e\u89e3\u6790\u3067\u306f\u3001REDUCE-IT\u3067\u89b3\u5bdf\u3055\u308c\u305fMACE\u6e1b\u5c11\u306e\u5a92\u4ecb\u56e0\u5b50\u3068\u306a\u308a\u3046\u308b20\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u8a55\u4fa1\u3055\u308c\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u305f\u5358\u5909\u91cf\u89e3\u6790\u3067\u306f\u3001\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306b\u3088\u308bMACE\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306e\u3046\u3061\u3001EPA\u306e\u5909\u5316\u3068EPA:AA\u306e\u6bd4\u304c\u305d\u308c\u305e\u308c57.0%\u306864.8%\u3092\u5a92\u4ecb\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3055\u3089\u306b\u591a\u5909\u91cf\u89e3\u6790\u3067\u306f\u3001EPA\u6fc3\u5ea6\u306e\u4e0a\u6607\u3068AA\u304a\u3088\u3073\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u6e1b\u5c11\u304c\u3001\u7a4d\u6975\u7684\u6cbb\u7642\u306eMACE\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306e77.1\uff5e78.9\uff05\u3092\u5a92\u4ecb\u3057\u305f\u3002\u3053\u306e\u6240\u898b\u306f\u3001\u4e8b\u5f8c\u7684\u306a\u3082\u306e\u3067\u306f\u3042\u308b\u304c\u3001REDUCE-IT\u3067\u89b3\u5bdf\u3055\u308c\u305ficosapent ethyl\u306e\u6709\u76ca\u306a\u52b9\u679c\u306b\u3064\u3044\u3066\u3055\u3089\u306a\u308b\u6d1e\u5bdf\u3092\u4e0e\u3048\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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REDUCE-IT\u306b\u304a\u3044\u3066\u3001\u30a8\u30a4\u30b3\u30b5\u30da\u30f3\u30bf\u30a8\u30f3\u9178\u3001\u30a2\u30e9\u30ad\u30c9\u30f3\u9178\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ec\u30d9\u30eb\u304c\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u306e\u6709\u76ca\u6027\u306e\u5927\u90e8\u5206\u3092\u5a92\u4ecb\u3059\u308b\u3002ESC Congress 2023\u3001\u30a2\u30e0\u30b9\u30c6\u30eb\u30c0\u30e0\u3001\u30bb\u30c3\u30b7\u30e7\u30f3\u306b\u3066\u767a\u8868\uff1a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u306e\u9032\u884c\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3002 <\/div>\n
Szarek M\u3001Bhatt DL\u3001Miller M\u3001\u4ed6<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u65b0\u898fAPOC3\u963b\u5bb3\u5264\u306e\u524d\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf<\/h5>\n
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\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30ea\u30dd\u86cb\u767d\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3082\u3046\u4e00\u3064\u306e\u6f5c\u5728\u7684\u6a19\u7684-\u30a2\u30dd\u30ea\u30dd\u86cb\u767dC3\uff08\u30a2\u30ddC3\uff09-\u306f\u3001\u6297APOC3 GalNAc-siRNA\u5264RBD5044\u306e\u524d\u81e8\u5e8a\u7814\u7a76\u306e\u7126\u70b9\u3067\u3042\u3063\u305f\u3002\u81ea\u7136\u767a\u75c7\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u30a2\u30ab\u30b2\u30b6\u30eb\u306b\u304a\u3044\u3066\u3001\u30a2\u30ddC3\u306f61.2\uff05\u6e1b\u5c11\u3057\u3001\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3082\u534a\u6e1b\u3057\u305f\u3002\u30d2\u30c8\u5316APOC3\u30c8\u30e9\u30f3\u30b9\u30b8\u30a7\u30cb\u30c3\u30af\u30de\u30a6\u30b9\u3092\u7528\u3044\u305fRBD5044\u306e2\u56de\u76ee\u306e\u8a66\u9a13\u3067\u306f\u3001\u30a2\u30ddC3\u306e\u6700\u5927\u963b\u5bb3\u7387\u306f90\uff05\u3001\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u7d0490\uff05\u306e\u6e1b\u5c11\u304c\u8a8d\u3081\u3089\u308c\u3001RBD5044 3mg\/kg\u306e\u6700\u7d42\u6295\u4e0e\u304b\u30899\u9031\u9593\u5f8c\u3082APOC3\u306e41.6\uff05\u3001\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e49.4\uff05\u306e\u6e1b\u5c11\u304c\u6301\u7d9a\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u524d\u81e8\u5e8a\u6240\u898b\u306f\u7b2c1\u76f8\u81e8\u5e8a\u958b\u767a\u306e\u57fa\u790e\u3068\u306a\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RBD5044-\u65b0\u898f\u6297APOC3 GalNAc-siRNA\u85ac\u5264\u306f\u30de\u30a6\u30b9\u3068\u30a2\u30ab\u30b2\u30b6\u30eb\u3067\u6301\u7d9a\u7684\u304b\u3064\u5927\u5e45\u306a\u4e2d\u6027\u8102\u80aa\u306e\u6e1b\u5c11\u3092\u3082\u305f\u3089\u3057\u305f\u3002ESC Congress 2023\u306b\u3066\u767a\u8868\uff1a\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u6cbb\u7642\uff1a\u30a4\u30b3\u30b5\u30da\u30f3\u30c8\u30a8\u30c1\u30eb\u3068\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7cfb\u85ac\u5264 <\/div>\n
Luo H, Guo Z, Zheng S et al.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/academic.oup.com\/eurheartj\/article\/44\/Supplement_2\/ehad655.2799\/7391110&#8243<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u65b0\u898fANGPTL3\u963b\u5bb3\u5264<\/h5>\n
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\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea3\uff08ANGPTL3\uff09\u3092\u6a19\u7684\u3068\u3059\u308b\u65b0\u898fRNA\u5e72\u6e09\uff08RNAi\uff09\u7642\u6cd5\u3067\u3042\u308bARO-ANG3\u306e\u7b2cI\u76f8\u30c7\u30fc\u30bf\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u3053\u306e\u30d2\u30c8\u521d\u306e\u7b2c1\u76f8\u7121\u4f5c\u70ba\u5316\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u975e\u76f2\u691c\u8a66\u9a13\u3067\u306f\u3001\u5065\u5eb7\u306a\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u3068\u809d\u6027\u8102\u80aa\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u672c\u5264\u306e\u5358\u56de\u6295\u4e0e\u3068\u53cd\u5fa9\u6295\u4e0e\u304c\u691c\u8a0e\u3055\u308c\u305f\u3002 <\/p>\n

\u5065\u5e38\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5358\u56de\u4e0a\u4e57\u305b\u6295\u4e0e\uff08SAD\u3001n=40\uff09\u304a\u3088\u3073\u53cd\u5fa9\u4e0a\u4e57\u305b\u6295\u4e0e\uff08MAD\u3001n=12\uff09\u306b\u3088\u308a\u3001ARO-ANG3\uff08100mg\u3001200mg\u3001300mg\uff09\u306e\u5fcd\u5bb9\u6027\u304c\u6982\u306d\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u6cbb\u7642\u4e0a\u767a\u73fe\u3059\u308b\u6709\u5bb3\u4e8b\u8c61\uff08TEAE\uff09\u306e\u983b\u5ea6\u306f\u6d3b\u6027\u7fa4\u3068\u30d7\u30e9\u30bb\u30dc\u7fa4\u3067\u540c\u7a0b\u5ea6\u3067\u3042\u3063\u305f\u3002\u6295\u4e0e\u91cf\u306b\u95a2\u9023\u3057\u305fANGPTL3\u306e\u6e1b\u5c11\u306f\u3001SAD\u30b3\u30db\u30fc\u30c8\u3067\u306f12\u9031\u9593\u3067\u6700\u592775\uff05\u3001MAD\u8a66\u9a13\u3067\u306f16\u9031\u9593\u3067\u6700\u592793\uff05\u3068\u5831\u544a\u3055\u308c\u305f\u3002\u63a2\u7d22\u7684\u89e3\u6790\u3067\u306f\u3001\u8840\u6f3f\u4e2d\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u305d\u308c\u305e\u308c\u6700\u592750\uff05\u306870\uff05\u6e1b\u5c11\u3057\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u6700\u592720\uff05\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u304c\u6700\u592740\uff05\u6e1b\u5c11\u3057\u305f\u3002 <\/p>\n

ARO-ANG3 200mg\u307e\u305f\u306f\u30d7\u30e9\u30bb\u30dc\u3092\u8907\u6570\u56de\u6295\u4e0e\u3055\u308c\u305f\u809d\u6027\u8102\u80aa\u75c7\u3092\u6709\u3059\u308b\u88ab\u9a13\u8005\u306b\u304a\u3044\u3066\u300122\u4ef6\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u5831\u544a\u3055\u308c\u3001ARO-ANG3\u6295\u4e0e\u7fa45\/6\u4eba\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30bb\u30dc\u6295\u4e0e\u7fa43\/3\u4eba\u3067\u3042\u3063\u305f\u3002\u3059\u3079\u3066\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u3082\u306e\u3067\u3001\u6cbb\u7642\u4e2d\u6b62\u306e\u5fc5\u8981\u6027\u306f\u306a\u304b\u3063\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001ARO-ANG3 200mg\u306f\u3001ANGPTL3\u3092\u5e73\u574785.3\uff05\uff08\u30d7\u30e9\u30bb\u30dc\u3067\u306f10.7\uff05\uff09\u6e1b\u5c11\u3055\u305b\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u4e2d\u592e\u502444.1\uff05\uff08\u30d7\u30e9\u30bb\u30dc\u3067\u306f47.1\uff05\uff09\u6e1b\u5c11\u3055\u305b\u305f\u3002 <\/p>\n

\u3053\u308c\u3089\u306e\u521d\u671f\u6bb5\u968e\u306e\u30c7\u30fc\u30bf\u306f\u3001ANGPTL3\u304c\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306e\u6b8b\u5b58\u5fc3\u8840\u7ba1\u7cfb\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6a19\u7684\u3067\u3042\u308b\u3053\u3068\u3092\u652f\u6301\u3057\u3001ARO-ANG3\u306e\u3055\u3089\u306a\u308b\u81e8\u5e8a\u958b\u767a\u306e\u57fa\u76e4\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002<\/p><\/div>\n

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ANGPTL3\u3092\u6a19\u7684\u3068\u3057\u305fRNA\u5e72\u6e09\u306b\u3088\u308b\u4e2d\u6027\u8102\u80aa\u304a\u3088\u3073\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\uff1a\u7b2c1\u76f8\u30d0\u30b9\u30b1\u30c3\u30c8\u30c8\u30e9\u30a4\u30a2\u30eb\u30b3\u30db\u30fc\u30c8\u3002<\/div>\n
Watts GF, Schwabe C, Scott R, et al.<\/div>\n

Nat Med 2023; doi: 10.1038\/s41591-023-02494-2<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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ORION-8\uff1aPCSK9\u3092\u6a19\u7684\u3068\u3057\u305f\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306b\u95a2\u3059\u308b\u904e\u53bb\u6700\u5927\u306e\u81e8\u5e8a\u8a66\u9a13<\/h5>\n
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ORION-8\u975e\u76f2\u691c\u5ef6\u9577\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\uff08ASCVD\uff09\u3001ASCVD\u30ea\u30b9\u30af\u5897\u52a0\u307e\u305f\u306f\u30d8\u30c6\u30ed\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\uff08HeFH\uff09\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306b\u88dc\u52a9\u7684\u306b\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u3092\u5e742\u56de\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u30016\u5e74\u4ee5\u4e0a\u306b\u308f\u305f\u3063\u3066\u4e00\u8cab\u3057\u305f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u305f\u3002<\/span>
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ORION-8\u306f\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u716718\u30f5\u6708\u9593\u306e\u7b2cIII\u76f8\u8a66\u9a13ORION-9\u3001ORION-10\u3001ORION-11\u304a\u3088\u30734\u5e74\u9593\u306e\u7b2cII\u76f8\u8a66\u9a13ORION-3\u306e3\u5e74\u9593\u306e\u975e\u76f2\u691c\u5ef6\u9577\u8a66\u9a13\u3067\u3042\u308a\u3001\u5408\u8a088,500\u4eba\u5e74\u4ee5\u4e0a\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u672c\u8a66\u9a13\u3067\u306f\u30013,274\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001\u30a4\u30f3\u30af\u30b7\u30e9\u30f3\u306e\u9577\u671f\u5b89\u5168\u6027\u3001\u6709\u52b9\u6027\u3001\u5fcd\u5bb9\u6027\u3092\u8a55\u4fa1\u3057\u30012,446\u4eba\u306e\u60a3\u8005\u304c1080\u65e5\u76ee\uff083\u5e74\u9593\uff09\u307e\u3067\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u305f\u3002\u672c\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001\u8a66\u9a13\u7d42\u4e86\u6642\uff081080\u65e5\u76ee\u307e\u305f\u306f\u6700\u7d42\u6ce8\u5c04\u304b\u308990\u65e5\u5f8c\uff09\u306b\u3001\u4e8b\u524d\u306b\u898f\u5b9a\u3055\u308c\u305f\u30ea\u30b9\u30af\u30d9\u30fc\u30b9\u306eLDL-C\u76ee\u6a19\u5024\u3092\u9054\u6210\u3057\u305f\u60a3\u8005\u306e\u5272\u5408\u3067\u3042\u3063\u305f\u3002 <\/span>
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\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e\u307b\u307c80\uff05\uff0878.4\uff05\u300195\uff05\u4fe1\u983c\u533a\u9593\uff3bCI\uff3d76.8\uff05\u301c80.0\uff05\uff09\u304c\u4e8b\u524d\u306b\u6307\u5b9a\u3055\u308c\u305fLDL-C\u76ee\u6a19\u5024\u306b\u5230\u9054\u3057\u3001LDL-C\u5024\u306f\u5e73\u5747\u7d0450\uff05\uff0849.4\uff05\u300195\uff05CI48.3\uff05\u301c50.4\uff05\uff09\u4f4e\u4e0b\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306b\u3088\u308bLDL-C\u4f4e\u4e0b\u306e\u6301\u7d9a\u6027\u306e\u3055\u3089\u306a\u308b\u8a3c\u62e0\u3068\u306a\u308b\u3002 <\/span>
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ORION-8\u306f\u300150\u30ab\u56fd\u4ee5\u4e0a\u300130\u4ee5\u4e0a\u306e\u81e8\u5e8a\u8a66\u9a13\u306760,000\u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u3092\u767b\u9332\u3057\u3066\u3044\u308b\u5927\u898f\u6a21\u306a\u4e16\u754c\u7684\u81e8\u5e8a\u8a66\u9a13\u30d7\u30ed\u30b0\u30e9\u30e0\u3067\u3042\u308bVictORION\u306e\u4e00\u90e8\u3067\u3042\u308b\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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ORION-8\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u60a3\u8005\u306b\u304a\u3051\u308b\u5e742\u56de\u6295\u4e0e\u306e\u30a4\u30f3\u30af\u30ea\u30b7\u30e9\u30f3\u306e\u9577\u671f\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u30022023\u5e74ESC\u3067\u767a\u8868\u3002 <\/div>\n
RS Wright, FJ Raal, W Koenig, et al.<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u3068\u8133\u5352\u4e2d\u518d\u767a\u30ea\u30b9\u30af<\/h5>\n
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\u81ea\u7136\u8133\u5185\u51fa\u8840\uff08ICH\uff09\u306e\u751f\u5b58\u8005\u306b\u304a\u3044\u3066\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u306f\u865a\u8840\u6027\u8133\u5352\u4e2d\u3092\u542b\u3080\u3042\u3089\u3086\u308b\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3001ICH\u306e\u518d\u767a\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u306a\u304b\u3063\u305f\u3002\u30c7\u30f3\u30de\u30fc\u30af\u8133\u5352\u4e2d\u767b\u9332\uff08Danish Stroke Registry\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u30012003\u5e741\u6708\u304b\u30892021\u5e7412\u6708\u307e\u3067\u306b\u30c7\u30f3\u30de\u30fc\u30af\u3067\u521d\u767aICH\u3067\u5165\u9662\u3057\u300130\u65e5\u4ee5\u4e0a\u751f\u5b58\u3057\u305f50\u6b73\u4ee5\u4e0a\u306e\u60a3\u8005\u3092\u540c\u5b9a\u3057\u305f\u30022022\u5e748\u6708\u307e\u3067\u306e\u8ffd\u8de1\u671f\u9593\u4e2d\u306b\u30011,959\u4eba\u306e\u60a3\u8005\u304c\u4f55\u3089\u304b\u306e\u8133\u5352\u4e2d\u3092\u767a\u75c7\u3057\u305f\uff081,073\u4eba\u304c\u865a\u8840\u6027\u8133\u5352\u4e2d\u3001984\u4eba\u304c\u518d\u767a\u6027ICH\uff09\u3002\u9069\u5207\u306a\u5bfe\u7167\u7fa4\u3068\u30de\u30c3\u30c1\u3055\u305b\u308b\u3068\u3001\u30b9\u30bf\u30c1\u30f3\u306e\u4f7f\u7528\u306f\u3042\u3089\u3086\u308b\u8133\u5352\u4e2d\uff08\u75c7\u4f8b38.6\uff05\u5bfe\u5bfe\u716741.1\uff05\u3001\u8abf\u6574\u30aa\u30c3\u30ba\u6bd40.88\u300195\uff05\u4fe1\u983c\u533a\u9593[CI]0.78-0.99\uff09\u3068\u865a\u8840\u6027\u8133\u5352\u4e2d\uff08\u75c7\u4f8b39.8\uff05\u5bfe\u5bfe\u716741.8\uff05\u3001\u8abf\u6574\u30aa\u30c3\u30ba\u6bd40.79\u300195\uff05CI0.67-0.92\uff09\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u304c\u3001ICH\u518d\u767a\u30ea\u30b9\u30af\uff08\u75c7\u4f8b39.1\uff05\u5bfe\u5bfe\u716740.8\uff05\u3001\u8abf\u6574\u30aa\u30c3\u30ba\u6bd41.05\u300195\uff05CI0.88-1.24\uff09\u3068\u306f\u95a2\u9023\u3057\u3066\u3044\u306a\u304b\u3063\u305f\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u3001\u8133\u5352\u4e2d\u518d\u767a\u4e88\u9632\u306e\u305f\u3081\u306bICH\u751f\u5b58\u8005\u306b\u30b9\u30bf\u30c1\u30f3\u3092\u4f7f\u7528\u3059\u308b\u3053\u3068\u306b\u5b89\u5fc3\u611f\u3092\u4e0e\u3048\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\u30ac\u30a4\u30b9\u30c8D\u3001\u30ed\u30c9\u30ea\u30b2\u30b9LAG\u3001\u30cf\u30e9\u30b9J\u3001\u4ed6<\/div>\n

Neurology 2023; DOI: https:\/\/doi.org\/10.1212\/WNL.0000000000207792<\/a><\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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ESC\u65b0\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3<\/h5>\n
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\u672c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3051\u308b\u81f4\u6b7b\u7684\u30fb\u975e\u81f4\u6b7b\u7684\u5fc3\u7b4b\u6897\u585e\u3068\u8133\u5352\u4e2d\u306e10\u5e74\u30ea\u30b9\u30af\u3092\u63a8\u5b9a\u3059\u308b\u305f\u3081\u306e\u65b0\u3057\u3044\u30b9\u30b3\u30a2SCORE2-Diabetes\u3092\u7d39\u4ecb\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u30b9\u30b3\u30a2\u306f\u3001\u5f93\u6765\u306e\u5fc3\u8840\u7ba1\u5371\u967a\u56e0\u5b50\uff08\u5e74\u9f62\u3001\u55ab\u7159\u3001\u8840\u5727\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u3068\u7cd6\u5c3f\u75c5\u7279\u6709\u306e\u60c5\u5831\uff08\u8a3a\u65ad\u6642\u5e74\u9f62\u3001\u8840\u7cd6\u5024\u3001\u814e\u6a5f\u80fd\uff09\u3092\u7d71\u5408\u3057\u3001\u60a3\u8005\u3092\u4f4e\u30ea\u30b9\u30af\u3001\u4e2d\u30ea\u30b9\u30af\u3001\u9ad8\u30ea\u30b9\u30af\u3001\u8d85\u9ad8\u30ea\u30b9\u30af\u306b\u5206\u985e\u3059\u308b\u3002 <\/span>
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.<\/div>\n

Eur Heart J 2023. https:\/\/doi\/10.1093\/eurheartj\/ehad192<\/a>.<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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2006\u5e74\u4ee5\u964d\u3067\u6700\u3082\u5305\u62ec\u7684\u306a\u5206\u6790\u306b\u3088\u308b\u3068\u3001\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\uff08CVD\uff09\u306f2021\u5e74\u306b\u6b27\u5dde\u9023\u5408\uff08EU\uff09\u306b\u63a8\u5b9a2820\u5104\u30e6\u30fc\u30ed\u306e\u8cbb\u7528\u3092\u3082\u305f\u3089\u3057\u3001\u3053\u308c\u306fEU\u5168\u4f53\u306e\u4e88\u7b97\u3092\u4e0a\u56de\u308b\u3002\u91cd\u8981\u306a\u3053\u3068\u306f\u3001\u3053\u306e\u8cbb\u7528\u306e\u534a\u5206\u4ee5\u4e0a\uff081,550\u5104\u30e6\u30fc\u30ed\uff09\u3092\u533b\u7642\u3068\u4ecb\u8b77\u304c\u5360\u3081\u3066\u3044\u308b\u3053\u3068\u3067\u3042\u308b\u3002\u3053\u306e\u5206\u6790\u306f\u3001\u6b27\u5dde\u5fc3\u81d3\u75c5\u5b66\u4f1a\u3068\u82f1\u56fd\u30aa\u30c3\u30af\u30b9\u30d5\u30a9\u30fc\u30c9\u5927\u5b66\u306e\u5171\u540c\u7814\u7a76\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/span>
\u8cbb\u7528\u306e\u5185\u8a33\u306f\u3001\u533b\u7642\u8cbb\u304c1300\u5104\u30e6\u30fc\u30ed\uff0846\uff05\uff09\u3001\u793e\u4f1a\u7684\u30b1\u30a2\u304c250\u5104\u30e6\u30fc\u30ed\uff089\uff05\uff09\u3001\u30a4\u30f3\u30d5\u30a9\u30fc\u30de\u30eb\u306a\u30b1\u30a2\u304c790\u5104\u30e6\u30fc\u30ed\uff0828\uff05\uff09\u3067\u3042\u3063\u305f\u3002\u75c5\u9662\u3067\u306e\u30b1\u30a2\u306f\u533b\u7642\u30fb\u793e\u4f1a\u7684\u30b1\u30a2\u8cbb\u7528\u306e\u4e3b\u306a\u8ca2\u732e\u8005\u3067\u3042\u308a\u3001CVD\u95a2\u9023\u30b1\u30a2\u8cbb\u7528\u306e51\uff05\u306b\u3042\u305f\u308b790\u5104\u30e6\u30fc\u30ed\u3092\u5360\u3081\u305f\u3002 <\/span>
\u3053\u306e\u6700\u65b0\u306e\u5206\u6790\u306f\u3001EU\u306b\u304a\u3051\u308bCVD\u306b\u95a2\u9023\u3059\u308b\u7d4c\u6e08\u7684\u8ca0\u62c5\u306e\u5897\u5927\u3060\u3051\u3067\u306a\u304f\u3001\u533b\u7642\u8cbb\u652f\u51fa\u306b\u304a\u3051\u308bEU\u8af8\u56fd\u9593\u306e\u683c\u5dee\u3082\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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EU\u306b\u304a\u3051\u308bCVD\u306e\u7d4c\u6e08\u7684\u8ca0\u62c5\u3002ESC 2023\u30bb\u30c3\u30b7\u30e7\u30f3\u3067\u767a\u8868\uff1a\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3068\u4e88\u9632\u306b\u95a2\u3059\u308b\u767b\u9332\u3002 <\/div>\n
\u30eb\u30a8\u30f3\u30b4\u30fb\u30d5\u30a7\u30eb\u30ca\u30f3\u30c7\u30b9R<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10691195\/pdf\/ehad583.pdf&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u751f\u4f53\u5f01\u306e\u5909\u6027\u3068\u9ad8\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u95a2\u4fc2<\/h5>\n
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\u5f01\u7f6e\u63db\u8853\u306f\u5fc3\u81d3\u5f01\u819c\u75c7\u60a3\u8005\u306b\u5bfe\u3059\u308b\u7b2c\u4e00\u9078\u629e\u306e\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3002\u751f\u4f53\u5f01\u306f\u6a5f\u68b0\u5f01\u306b\u6bd4\u3079\u3066\u8840\u6813\u5f62\u6210\u304c\u5c11\u306a\u304f\u3001\u8840\u884c\u52d5\u614b\u304c\u826f\u597d\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u307e\u3059\u307e\u3059\u9078\u629e\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u3063\u3066\u304d\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u5f01\u306e\u69cb\u9020\u7684\u5909\u6027\u306f\u751f\u4f53\u5f01\u306e\u5408\u4f75\u75c7\u3067\u3042\u308a\u3001\u305d\u306e\u6839\u672c\u7684\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u5b8c\u5168\u306b\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u3002 <\/span>
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\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3067\u3042\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068\u3001\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u3092\u542b\u3080\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u306e\u8ee2\u5e30\u3068\u306e\u9593\u306b\u306f\u3001\u89b3\u5bdf\u7684\u304a\u3088\u3073\u907a\u4f1d\u7684\u306a\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u3092\u652f\u6301\u3059\u308b\u5e83\u7bc4\u306a\u8a3c\u62e0\u304c\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\uff0c\u3053\u306e\u904e\u7a0b\u304c\u5927\u52d5\u8108\u5f01\u72ed\u7a84\u75c7\u3068\u540c\u69d8\u306e\u8102\u8cea\u3092\u4ecb\u3059\u308b\u7d4c\u8def\u3092\u5171\u6709\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u8003\u616e\u3057\uff0c\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u6607\u304c\u4eba\u5de5\u5f01\u306e\u5909\u6027\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u3002 <\/span>
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\u5916\u79d1\u7684\u5927\u52d5\u8108\u5f01\u7f6e\u63db\u8853\u5f8c\u3001\u4e2d\u592e\u50247.0\u5e74\uff08\u56db\u5206\u4f4d\u7bc4\u56f2\uff1a5.1-9.2\uff09\u306e\u60a3\u8005203\u4eba\u304c\u7814\u7a76\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e0a\u4f4d\u4e09\u5206\u4f4d\u5024\uff08>23.7 mg\/dL\uff09\u306e\u60a3\u8005\u3067\u306f\u3001\u4e0b\u4f4d\u4e09\u5206\u4f4d\u5024\u306e\u60a3\u8005\u3068\u6bd4\u8f03\u3057\u3066\u3001\u751f\u4f53\u4eba\u5de5\u5927\u52d5\u8108\u5f01\u5909\u6027\u306e\u9032\u884c\u7387\u304c\u9ad8\u304b\u3063\u305f\uff08p=0.008\uff09\u3002\u3055\u3089\u306b\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\uff08>23.7 mg\/dL\uff09\u306f\u3001\u6b7b\u4ea1\u7387\u307e\u305f\u306f\u518d\u4ecb\u5165\u306e\u5897\u52a0\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.98\uff1b95\uff05\u4fe1\u983c\u533a\u95931.31-2.99\uff1bp\uff1d0.001\uff09\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u751f\u4f53\u5f01\u306e\u5909\u6027\u306b\u95a2\u4e0e\u3059\u308b\u6839\u672c\u7684\u306a\u904e\u7a0b\u306b\u304a\u3051\u308b\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u5f79\u5272\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

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Li Z, Zhang B, Salaun E, et al.<\/div>\n

Eur Heart J Cardiovasc Imaging 2023; doi: 10.1093\/ehjci\/jead159.<\/p><\/div>\n<\/div>\n

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\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u306b\u304a\u3051\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8<\/h5>\n
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\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08NAFLD\uff09\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u30ca\u30c8\u30ea\u30a6\u30e0\u30b0\u30eb\u30b3\u30fc\u30b9\u5171\u8f38\u9001\u4f53-2\uff08SGLT2\uff09\u963b\u5bb3\u306e\u4e21\u65b9\u304c\u8840\u6e05\u30c8\u30e9\u30f3\u30b9\u30a2\u30df\u30ca\u30fc\u30bc\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u304c\u3001\u4f75\u7528\u6cbb\u7642\u306e\u52b9\u679c\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u3053\u306e\u30d1\u30a4\u30ed\u30c3\u30c8\u8a66\u9a13\u306e\u7d50\u679c\u304b\u3089\u3001SGLT2\u963b\u5bb3\u85ac\u306b\u3088\u308b\u9577\u671f\u6cbb\u7642\u3067\u30c8\u30e9\u30f3\u30b9\u30a2\u30df\u30ca\u30fc\u30bc\u5024\u306e\u6b63\u5e38\u5316\u304c\u4e0d\u5341\u5206\u3067\u3042\u3063\u305fNAFLD\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b1\u5e74\u9593\u306e\u6cbb\u7642\u304c\u809d\u708e\u3001\u6a5f\u80fd\u3001\u7dda\u7dad\u5316\u306e\u30de\u30fc\u30ab\u30fc\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002 <\/span>
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\u672c\u8a66\u9a13\u306f\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305fNAFLD\u60a3\u8005\u306e\u3046\u3061\u3001\u4ee5\u524d\u306eSGLT2\u963b\u5bb3\u85ac\u6cbb\u7642\u306b\u62b5\u6297\u6027\u3067\u3042\u3063\u305f9\u4f8b\u3001\u3059\u306a\u308f\u3061\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6295\u4e0e\u524d\u306b12\u30f5\u6708\u4ee5\u4e0a\u30a2\u30e9\u30cb\u30f3\u30c8\u30e9\u30f3\u30b9\u30a2\u30df\u30ca\u30fc\u30bc\uff08ALT\uff09\u4e0a\u6607\uff08> 30 U\/L\uff09\u304c\u6301\u7d9a\u3057\u3066\u3044\u305f9\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f2\u65bd\u8a2d\u5171\u540c\u306e\u5f8c\u65b9\u8996\u7684\u89b3\u5bdf\u7814\u7a76\u3067\u3042\u308b\u30022\u4f8b\u306f\u8ffd\u8de1\u4e0d\u80fd\u306e\u305f\u3081\u9664\u5916\u3055\u308c\u305f\u30027\u4f8b\u306e\u60a3\u8005\u306f\u3059\u3079\u3066\u7537\u6027\u3067\u3001\u5e74\u9f62\u306e\u4e2d\u592e\u5024\u306f49\u6b73\u3001SGLT2\u963b\u5bb3\u85ac\u6295\u4e0e\u958b\u59cb\u3068\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6295\u4e0e\u958b\u59cb\u306e\u9593\u9694\u306e\u4e2d\u592e\u5024\u306f845\u65e5\u3067\u3042\u3063\u305f\u30021\u5e74\u9593\u3067\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u30c8\u30e9\u30f3\u30b9\u30a2\u30df\u30ca\u30fc\u30bc\uff08AST\uff09\u3001ALT\u3001\u03b3-\u30b0\u30eb\u30bf\u30df\u30eb\u30c8\u30e9\u30f3\u30b9\u30da\u30d7\u30c1\u30c0\u30fc\u30bc\uff08\u03b3-GTP\uff09\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3001\u7dcf\u30d3\u30ea\u30eb\u30d3\u30f3\u3001\u8840\u6e05\u30a2\u30eb\u30d6\u30df\u30f3\u3092\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u304c\u3001\u4f53\u91cd\u306b\u6709\u610f\u306a\u5909\u5316\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u30023\u4f8b\u306e\u60a3\u8005\u3067\u306f\u3001ALT\u304c\u8a66\u9a13\u671f\u9593\u4e2d\u306b\u6b63\u5e38\u5316\u3057\u305f\uff08\u226630 IU\/L\uff09\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306f\u809d\u6a5f\u80fd\u3068\u7dda\u7dad\u5316\u306e\u30de\u30fc\u30ab\u30fc\u3082\u6709\u610f\u306b\u6539\u5584\u3057\u305f\u3002 <\/span>
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\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u7dcf\u5408\u3059\u308b\u3068\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068SGLT2\u963b\u5bb3\u85ac\u306e\u4f75\u7528\u306fNAFLD\u30012\u578b\u7cd6\u5c3f\u75c5\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306e\u60a3\u8005\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u7b2c2\u76f8\u8a66\u9a13\u3067\u3055\u3089\u306b\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u304c\u3042\u308b\u3002 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

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\u30ca\u30c8\u30ea\u30a6\u30e0\u30b0\u30eb\u30b3\u30fc\u30b9\u30b3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc-2\u963b\u5bb3\u85ac\u306b\u3088\u308b\u9577\u671f\u6cbb\u7642\u62b5\u6297\u6027\u306e\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\u306b\u5bfe\u3059\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c81\u5e74\u6295\u4e0e\u306e\u6709\u52b9\u6027\uff1a\u30d1\u30a4\u30ed\u30c3\u30c8\u8a66\u9a13\u3002<\/div>\n
\u7be0\u5d0e\u614e\u4e00\u90ce\u3001\u7530\u539f\u4fca\u4e00\u90ce\u3001\u4e09\u6d66\u5065\u4e00\u90ce\u3001\u4ed6\u3002<\/div>\n

\u30e9\u30a4\u30d52023;13:1327\u3002 https:\/\/doi.org\/10.3390\/life13061327<\/a><\/p><\/div>\n<\/div>\n

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\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3092\u7528\u3044\u305fSUSTAIN 6\u8a66\u9a13\u3068PIONEER 6\u8a66\u9a13\u306e\u30cb\u30e5\u30fc\u30b9<\/h5>\n
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SUSTAIN 6\u8a66\u9a13\u304a\u3088\u3073PIONEER 6\u8a66\u9a13\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u9023\u7d9a\u6027\u3092\u8d85\u3048\u3066\u3001\u30b0\u30eb\u30ab\u30b4\u30f3\u69d8\u30da\u30d7\u30c1\u30c9-1\uff08GLP-1\uff09\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u3067\u3042\u308b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306b\u3088\u308b\u5fc3\u8840\u7ba1\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u304c\u793a\u3055\u308c\u305f\u3002GLP-1\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u306f\u8840\u6f3f\u4e2d\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u306b\u5bfe\u3057\u3066\u7de9\u3084\u304b\u306a\u52b9\u679c\u3092\u793a\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u8a66\u9a13\u306epost hoc\u89e3\u6790\u3067\u306f\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u304c2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u30ec\u30d9\u30eb\u3092\u8d85\u3048\u3066\u4e3b\u8981\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08MACE\uff09\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u3001\u307e\u305f\u6cbb\u7642\u671f\u9593\u4e2d\u306e\u8840\u6f3f\u4e2dTG\u306e\u5909\u5316\u3092\u691c\u8a0e\u3057\u305f\u3002 <\/span>
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\u5408\u8a08\u3067\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3TG\u6e2c\u5b9a\u304c\u884c\u308f\u308c\u305f\u4e21\u8a66\u9a13\u306e\u60a3\u80056417\u4eba\u304c\u89e3\u6790\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u30023191\u4eba\uff0849.7\uff05\uff09\u304cTG\u5024\u2266151\uff08\u4f4e\u5024\uff09\u30011459\u4eba\uff0822.7\uff05\uff09\u304cTG\u5024> 151-\u2266205mg\/dL\uff08\u4e2d\u5024\uff09\u30011767\u4eba\uff0827.5\uff05\uff09\u304cTG\u5024> 205mg\/dL\uff08\u9ad8\u5024\uff09\u3067\u3042\u3063\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3TG\u5024\u306e\u4e2d\u592e\u5024\uff08\u7bc4\u56f2\uff09\u306f\u3001\u4f4e\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3TG\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3001\u4e2d\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3TG\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3001\u9ad8\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3TG\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3067\u305d\u308c\u305e\u308c108.6\uff0810.7-151.3\uff09\u3001175.3\uff08152.2-204.7\uff09\u3001272.3\uff08205.6-3378\uff09mg\/dL\u3067\u3042\u3063\u305f\u3002 <\/span>
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MACE\u306e\u767a\u751f\u7387\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306eTG\u304c\u5897\u52a0\u3059\u308b\u306b\u3064\u308c\u3066\u5897\u52a0\u3057\u305f\u3002\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306b\u3088\u308b\u6cbb\u7642\u306f\u3059\u3079\u3066\u306eTG\u7fa4\u3067\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3057\u3066MACE\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u305f\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u8840\u6f3f\u4e2dTG\u304c\u4f4e\u3044\u7fa4\u3067\u306e\u307f\u6709\u610f\u306a\u6e1b\u5c11\u304c\u307f\u3089\u308c\u305f\u3002\u4e21\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089104\u9031\u76ee\u307e\u3067\u306e\u8840\u6f3f\u4e2dTG\u3092\u6e1b\u5c11\u3055\u305b\u305f\uff08SUSTAIN-6\u3067\u306f14.8mg\/dL\u5bfe\u30d7\u30e9\u30bb\u30dc5.4mg\/dL\u3001p=0.024\u3001PIONEER-6\u3067\u306f16.4mg\/dL\u5bfe\u30d7\u30e9\u30bb\u30dc6.5mg\/dL\u3001p=0.005\uff09\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u8457\u8005\u3089\u306f\u3001post hoc\u89e3\u6790\u306e\u6ce8\u610f\u70b9\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u304b\u3089\u6709\u610f\u306bTG\u5024\u3092\u4f4e\u4e0b\u3055\u305b\u305f\u3068\u7d50\u8ad6\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u30d7\u30e9\u30bb\u30dc\u306b\u5bfe\u3059\u308b\u521d\u56deMACE\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u306fTG\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u306b\u95a2\u4fc2\u306a\u304f\u751f\u3058\u305f\u3002 <\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u3092\u8d85\u3048\u3066\u4e00\u8cab\u3057\u3066\u4e3b\u8981\u306a\u6709\u5bb3\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u305f\uff1aSUSTAIN 6\u8a66\u9a13\u3068PIONEER 6\u8a66\u9a13\u306epost hoc\u89e3\u6790\u3002<\/div>\n
Verma S, David J-P, Leiter LA, et al.<\/div>\n

Diabetes Obes Metab 2023;25:2388-92\u3002<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/37374110\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\uff1a\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306e\u6a19\u7684\u6cbb\u7642\u958b\u767a\u30c4\u30fc\u30eb\uff1f<\/h5>\n
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\u8840\u6f3f\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u306f\u3001\u6a19\u7684\u6cbb\u7642\u85ac\u306e\u63a2\u7d22\u306b\u304a\u3044\u3066\u6ce8\u76ee\u3055\u308c\u3066\u304a\u308a\u3001\u500b\u5225\u5316\u533b\u7642\u306e\u91cd\u8981\u306a\u8981\u70b9\u3067\u3042\u308b\u60a3\u8005\u306e\u5c64\u5225\u5316\u3068\u6cbb\u7642\u53cd\u5fdc\u306e\u4e88\u6e2c\u3092\u3088\u308a\u826f\u304f\u884c\u3046\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u3001\u7279\u7570\u7684\u306a\u4ecb\u5165\u3092\u5c0e\u304f\u30c4\u30fc\u30eb\u3068\u3057\u3066\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u7528\u3044\u308b\u3053\u3068\u306e\u81e8\u5e8a\u7684\u5229\u70b9\u306f\u3001\u307e\u3060\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u3002
\u6700\u8fd1\u306e\u89e3\u6790\u3067\u306f\u3001**PCSK9\uff08\u30d7\u30ed\u30d7\u30ed\u30c6\u30a4\u30f3\u30b3\u30f3\u30d9\u30eb\u30bf\u30fc\u30bc\u30fb\u30b5\u30d6\u30c1\u30ea\u30b7\u30f3\uff0f\u30b1\u30ad\u30b7\u30f39\u578b\uff09\u963b\u5bb3**\u306b\u3088\u308b**\u4f4e\u6bd4\u91cd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u4f4e\u4e0b\u53cd\u5fdc**\u304c\u3001**\u9ad8\u611f\u5ea6C\u53cd\u5fdc\u6027\u30bf\u30f3\u30d1\u30af\uff08hsCRP\uff09\u5024\u306b\u5909\u5316\u304c\u306a\u3044\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u7d30\u80de\u30ec\u30d9\u30eb\u304a\u3088\u3073\u52d5\u8108\u30d7\u30e9\u30fc\u30af\u306e\u708e\u75c7\u306e\u6e1b\u5c11\u3068\u3082\u95a2\u9023\u3057\u3066\u3044\u308b**\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002 \u672c\u7814\u7a76\u3067\u306f\u3001PCSK9\u963b\u5bb3\u306b\u3088\u308b\u6297\u708e\u75c7\u4f5c\u7528\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3001SPIRE\uff08Studies of PCSK9 Inhibition and the Reduction of Vascular Events\uff09-1\u8a66\u9a13\u304a\u3088\u3073\u30dc\u30b3\u30b7\u30ba\u30de\u30d6\uff08bococizumab\uff09\u3092\u7528\u3044\u305f2\u8a66\u9a13\u306b\u7d44\u307f\u5165\u308c\u3089\u308c\u305f\u60a3\u8005173\u4f8b\u306e\u30d7\u30ed\u30c6\u30aa\u30df\u30af\u30b9\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u691c\u8a0e\u3057\u305f\u300212\u30f5\u6708\u5f8c\u306eLDL-C\u6e1b\u5c11\u7387\u304c<15\uff05\u3067\u3042\u3063\u305f\u60a3\u8005\u3001\u3042\u308b\u3044\u306f\u8ffd\u8de1\u30c7\u30fc\u30bf\u304c\u6b20\u843d\u3057\u3066\u3044\u305f\u60a3\u8005\u306f\u9664\u5916\u3055\u308c\u305f\u3002
bococizumab\u3092\u6295\u4e0e\u3055\u308c\u305f\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u306f30\u7a2e\u306e\u708e\u75c7\u6027\u86cb\u767d\u306b\u5909\u5316\u3092\u4e0e\u3048\u308b\u3053\u3068\u306a\u304fPCSK9\u8840\u6f3f\u30ec\u30d9\u30eb\u306e\u9078\u629e\u7684\u4f4e\u4e0b\u3092\u793a\u3057\u3001PCSK9\u963b\u5bb3\u306e\u81e8\u5e8a\u7684\u5229\u76ca\u306f\u3082\u3063\u3071\u3089\u8102\u8cea\u4f4e\u4e0b\u7d4c\u8def\u306b\u95a2\u9023\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u9650\u3089\u308c\u305f\u30b5\u30f3\u30d7\u30eb\u6570\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u672c\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u6b8b\u5b58\u708e\u75c7\u6027\u30ea\u30b9\u30af\u306b\u5bfe\u51e6\u3059\u308b\u305f\u3081\u306b\u3001LDL-C\u4f4e\u4e0b\u7642\u6cd5\u306b\u52a0\u3048\u3066\u6a19\u7684\u6297\u708e\u75c7\u7642\u6cd5\u3092\u4f75\u7528\u3059\u308b\u3053\u3068\u3092\u3055\u3089\u306b\u6b63\u5f53\u5316\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/div>\n
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[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931″ text_font_size=”12px” text_line_height=”1.5em” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-7ac71fca-d8d0-448d-9b31-949fbf26d931%22:%91%22text_text_color%22%93}”]<\/p>\n

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\u8840\u6f3f\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u306b\u5bfe\u3059\u308bPCSK9\u963b\u5bb3\u306e\u52b9\u679c\uff1aSPIRE\u30b5\u30d6\u30b9\u30bf\u30c7\u30a3\u3002<\/div>\n
Kraaijenhof JM\u3001Opstal TSJ\u3001Cornel JH\u3001\u4ed6<\/div>\n

Arterioscler Thromb Vasc Biol 2023; DOI: 10.1161\/ATVBAHA.123.319272<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/37317854\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5168\u6b7b\u4ea1<\/h5>\n
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\u5fc3\u4e0d\u5168\u306f\u3001\u4e16\u754c\u7684\u306a\u9ad8\u9f62\u5316\u306e\u9032\u5c55\u306b\u3088\u308a\u3001\u307e\u3059\u307e\u3059\u5927\u304d\u306a\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u78ba\u7acb\u3055\u308c\u305f\u8102\u8cea\u5371\u967a\u56e0\u5b50\u306e\u307b\u304b\u306b\u3001\u84c4\u7a4d\u3055\u308c\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u304b\u3089\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304c\u865a\u8840\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\u304c\u3001\u5fc3\u4e0d\u5168\u60a3\u8005\u306b\u304a\u3051\u308b\u5168\u6b7b\u4ea1\u306e\u6307\u6a19\u3068\u306a\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002 <\/span>
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\u3053\u306e\u4e2d\u56fd\u306e\u7814\u7a76\u3067\u306f\u3001\u5fc3\u4e0d\u5168\u3067\u5165\u9662\u3057\u305f2,823\u4eba\u306e\u60a3\u8005\uff08\u5e73\u5747\u5e74\u9f6256.8\u6b73\u300171\uff05\u304c\u7537\u6027\u300128\uff05\u304c\u99c6\u51fa\u7387\u304c\u7dad\u6301\u3055\u308c\u305f\u5fc3\u4e0d\u5168\uff09\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u7591\u554f\u306b\u53d6\u308a\u7d44\u3093\u3060\u3002\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mmol\/L\uff09-\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mmol\/L\uff09-\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08mmol\/L\uff09\u3068\u3057\u3066\u8a08\u7b97\u3055\u308c\u305f\u3002\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u5168\u6b7b\u4ea1\u7387\u3067\u3042\u3063\u305f\u3002.<\/span>
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\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u9ad8\u3044\u3053\u3068\u306f\u3001\u5168\u6b7b\u4ea1\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u72ec\u7acb\u3057\u3066\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3053\u306e\u95a2\u9023\u306f\u3001\u5e74\u9f62\u3001\u6027\u5225\u3001\u80a5\u6e80\u5ea6\u3001\u9ad8\u8840\u5727\u3001\u7cd6\u5c3f\u75c5\u3001NYHA\u6a5f\u80fd\u5206\u985e\u3001NT-proBNP\u3092\u542b\u3080\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u89e3\u6790\u306b\u304a\u3044\u3066\u3082\u6301\u7d9a\u3057\u3001\u3053\u306e\u3053\u3068\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u4e88\u6e2c\u80fd\u3092\u6709\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u304b\u3089\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u4e88\u5f8c\u4e0d\u826f\u306e\u5fc3\u4e0d\u5168\u60a3\u8005\u306e\u9451\u5225\u306b\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u3057\u304b\u3057\u3001\u8457\u8005\u3089\u306f\u7814\u7a76\u30c7\u30b6\u30a4\u30f3\uff08\u5f8c\u65b9\u8996\u7684\u89b3\u5bdf\u7814\u7a76\uff09\u3084\u5165\u9662\u5f8c\u306e\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306b\u95a2\u3059\u308b\u60c5\u5831\u4e0d\u8db3\u306a\u3069\u3001\u3044\u304f\u3064\u304b\u306e\u9650\u754c\u3092\u8a8d\u3081\u3066\u3044\u308b\u3002\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/span><\/div>\n
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Zhao L, Zhao X, Tian P, et al.<\/div>\n

Front Cardiovasc Med 2023;10:1063562.<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9975541\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u306f\u30b9\u30c6\u30f3\u30c8\u5185\u65b0\u751f\u7ca5\u816b\u306e\u65e9\u671f\u5f62\u6210\u306b\u95a2\u9023\u3059\u308b<\/h5>\n
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\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u542b\u3080\u73fe\u4ee3\u7684\u306a\u4e88\u9632\u7642\u6cd5\u3092\u53d7\u3051\u3066\u3044\u308b\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u4ee3\u8b1d\u7570\u5e38\u304c\u30b9\u30c6\u30f3\u30c8\u5185\u65b0\u751f\u5185\u819c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\uff08neoatherosclerosis\uff09\u306e\u65e9\u671f\u5f62\u6210\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3001\u3053\u306e\u65e5\u672c\u4eba\u7814\u7a76\u8005\u306e\u7d50\u679c\u304b\u3089\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002<\/p>\n

\u73fe\u4e16\u4ee3\u306e\u85ac\u5264\u6eb6\u51fa\u30b9\u30c6\u30f3\u30c8\u3092\u7528\u3044\u305f\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\uff08PCI\uff09\u3092\u53d7\u3051\u305f\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u3092\u53d7\u3051\u305f\u51a0\u52d5\u8108\u75be\u60a3\u60a3\u8005114\u4f8b\u3092\u5bfe\u8c61\u306b\u3001\u5149\u5e72\u6e09\u65ad\u5c64\u8a08\u3092\u7528\u3044\u3066\u8a55\u4fa1\u3092\u884c\u3063\u305f\u3002\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08TRL-C\uff09\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08non-HDL-C\uff09\u3001\u30de\u30ed\u30f3\u30b8\u30a2\u30eb\u30c7\u30d2\u30c9\u4fee\u98feLDL\uff08MDA-LDL\uff09\u3092\u542b\u3080\u8102\u8cea\u304c\u6e2c\u5b9a\u3055\u308c\u305f\u3002 <\/p>\n

12\u30f5\u6708\u76ee\u306b\u306f17\u4f8b\uff0814.9\uff05\uff09\u304c\u30b9\u30c6\u30f3\u30c8\u5185\u65b0\u751f\u52d5\u8108\u786c\u5316\u75c7\u3092\u767a\u75c7\u3057\u3066\u3044\u305f\u3002LDL-C\u5024\u306f\u30b9\u30c6\u30f3\u30c8\u5185\u65b0\u751f\u52d5\u8108\u786c\u5316\u306e\u3042\u308b\u60a3\u8005\u3068\u306a\u3044\u60a3\u8005\u3067\u5dee\u304c\u306a\u304b\u3063\u305f\u304c\uff0877.2 vs 69.8 mg\/dL\uff1bp=0.15\uff09\u3001\u65b0\u751f\u52d5\u8108\u786c\u5316\u3092\u767a\u75c7\u3057\u305f\u60a3\u8005\u3067\u306fTG\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dCIII\u3001TRL-C\u3001\u975eHDL-C\u3001MDA-LDL\u3092\u542b\u3080\u4ed6\u306e\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u3084\u30ea\u30dd\u86cb\u767d\u306e\u5024\u304c\u6709\u610f\u306b\u9ad8\u304b\u3063\u305f\u3002\u591a\u5909\u91cf\u30ed\u30b8\u30b9\u30c6\u30a3\u30c3\u30af\u56de\u5e30\u5206\u6790\u3067\u306f\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dCIII\u3001TRL-C\u3001\u975eHDL-C\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u3001MDA-LDL\u30ec\u30d9\u30eb\u304c\u30b9\u30c6\u30f3\u30c8\u5185\u65b0\u751f\u52d5\u8108\u786c\u5316\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305f\u3002\u3053\u308c\u3089\u306e\u6240\u898b\u306f\u3001\u7d4c\u76ae\u7684\u51a0\u52d5\u8108\u30a4\u30f3\u30bf\u30fc\u30d9\u30f3\u30b7\u30e7\u30f3\u3092\u53d7\u3051\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306b\u304a\u3051\u308b\u65e9\u671f\u306e\u65b0\u52d5\u8108\u786c\u5316\u5f62\u6210\u306b\u304a\u3051\u308bTG\u30ea\u30c3\u30c1\u30ea\u30dd\u86cb\u767d\u306e\u4e0a\u6607\u306e\u5f79\u5272\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002 <\/p><\/div>\n<\/div>\n

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\u9152\u4e95\u4eae\u3001\u95a2\u672c\u54f2\u4e5f\u3001\u6728\u5834\u8061\u3001\u4ed6\u3002<\/div>\n

J Clin Lipidol 2023;S1933-2874(23)00021-1.<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36828767\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u3044\u3068\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b<\/h5>\n
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\u30c7\u30f3\u30de\u30fc\u30af\u306e\u4e00\u822c\u4f4f\u6c11\u3092\u5bfe\u8c61\u3068\u3057\u305f\u524d\u5411\u304d\u7814\u7a76\u306e\u7d50\u679c\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u5fc3\u8840\u7ba1\u7cfb\u304a\u3088\u3073\u5168\u6b7b\u56e0\u6b7b\u4ea1\u306e\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u3057\u304b\u3057\u3001\u764c\u95a2\u9023\u6b7b\u3068\u306e\u95a2\u9023\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002 <\/span>
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\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304c\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4e0a\u6607\u3068\u56e0\u679c\u95a2\u4fc2\u304c\u3042\u308b\u3053\u3068\u306f\u5e83\u7bc4\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308b\u304c\u3001\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u4ee5\u5916\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u3082\u4e0a\u6607\u3055\u305b\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3042\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\uff082003\uff5e2015\u5e74\uff09\u306b20\uff5e69\u6b73\u3067\u3042\u3063\u305fCopenhagen General Population Study\u306e87,192\u4eba\u304b\u3089\u306a\u308b\u73fe\u4ee3\u306e\u96c6\u56e3\u30d9\u30fc\u30b9\u30b3\u30db\u30fc\u30c8\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u7591\u554f\u306b\u53d6\u308a\u7d44\u3093\u3060\u3002 <\/span>
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13\u5e74\u9593\u306e\u8ffd\u8de1\u306e\u7d50\u679c\u3001687\u4eba\u304c\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u3067\u30011594\u4eba\u304c\u764c\u3067\u3001856\u4eba\u304c\u305d\u306e\u4ed6\u306e\u539f\u56e0\u3067\u6b7b\u4ea1\u3057\u305f\u3002<\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c0.5mmol\/L\uff08<19mg\/dL\uff09\u306e\u4eba\u3068\u6bd4\u8f03\u3057\u3066\u30011.0mmol\/L\uff0839mg\/dL\uff09\u4ee5\u4e0a\u306e\u4eba\u306f\u3001\u3053\u306e\u96c6\u56e3\u306e22\uff05\u3092\u5360\u3081\u3001\u5fc3\u8840\u7ba1\u7cfb\u75be\u60a3\u307e\u305f\u306f\u305d\u306e\u4ed6\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c2\u500d\u9ad8\u304b\u3063\u305f\uff08\u305d\u308c\u305e\u308c\u30cf\u30b6\u30fc\u30c9\u6bd42.2\u300195\uff05\u4fe1\u983c\u533a\u95931.3-3.5\uff1b\u304a\u3088\u30732.1\u30011.4-3.3\uff09\u3002\u3057\u304b\u3057\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306f\u764c\u306b\u3088\u308b\u6b7b\u4ea1\u306b\u306f\u5f71\u97ff\u3092\u53ca\u307c\u3055\u306a\u304b\u3063\u305f\uff081.0\u30010.7-1.3\uff09\u3002 <\/span>
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\u8457\u8005\u3089\u306f\u3001\u3053\u308c\u3089\u306e\u7d50\u679c\u3092\u4ed6\u306e\u7814\u7a76\u3067\u88cf\u3065\u3051\u308b\u3053\u3068\u3092\u52e7\u3081\u3066\u3044\u308b\u304c\u3001\u3053\u306e\u6240\u898b\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304c\u3001\u764c\u4ee5\u5916\u306e\u5fc3\u8840\u7ba1\u7cfb\u304a\u3088\u3073\u975e\u5fc3\u8840\u7ba1\u7cfb\u306e\u539f\u56e0\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Wadstr\u00f6m BN\u3001Pedersen KM\u3001Wulff AB\u3001Nordestgaard BG<\/div>\n

Eur Heart J 2023;ehac822. doi: 10.1093\/eurheartj\/ehac822.<\/p><\/div>\n<\/div>\n

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[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36631967\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”18px||||false|false” border_radii=”off|13px|13px|13px|13px” border_width_all=”4px” border_color_all=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_width_all_tablet=”4px” border_width_all_phone=”0px” border_width_all_last_edited=”on|phone” border_color_all_tablet=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_phone=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” border_color_all_last_edited=”on|phone” box_shadow_style=”preset2″ global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22border_color_all%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” header_5_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_5_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

\u6b8b\u7559\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fc3\u8840\u7ba1\u75be\u60a3<\/h5>\n
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\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u3059\u306a\u308f\u3061\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306b\u5bcc\u3080\u30ea\u30dd\u86cb\u767d\u3084\u305d\u306e\u6b8b\u5b58\u7269\u306b\u542b\u307e\u308c\u308b\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u52d5\u8108\u786c\u5316\u306e\u91cd\u8981\u306a\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u6d6e\u4e0a\u3057\u3066\u3044\u308b\u3002\u672c\u7814\u7a76\u3067\u306f\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u304c\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u306e\u4e0a\u6607\u306b\u4f34\u3046\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304b\u3069\u3046\u304b\u3092\u691c\u8a0e\u3057\u305f\u3002\u97d3\u56fd\u306e\u5168\u56fd\u96c6\u56e3\u7814\u7a76\u306e\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u3001\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u3068LDL-C\u306e\u4e0a\u6607\u306e\u76f8\u4e57\u52b9\u679c\u3092\u793a\u3057\u305f\u3002 <\/p>\n

\u672c\u7814\u7a76\u306f\u3001\u97d3\u56fd\u306e\u56fd\u6c11\u5065\u5eb7\u4fdd\u967a\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304b\u3089\u5165\u624b\u3057\u305f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u65e2\u5f80\u6b74\u306e\u306a\u304440\uff5e70\u6b73\u306e\u6210\u4eba3,686,034\u4eba\uff08\u5973\u602746\uff05\uff09\u306e\u30c7\u30fc\u30bf\u3092\u5206\u6790\u3057\u305f\u30022014\u5e74\u304b\u30892017\u5e74\u306e\u9593\u306b\u3001144,004\u4ef6\u306e\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08\u4e3b\u8981\u30a2\u30a6\u30c8\u30ab\u30e0\uff09\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u3068LDL-C\u5024\uff08\u9ad8\u3044\u304b\u3069\u3046\u304b\uff09\u3067\u5206\u985e\u3059\u308b\u3068\u3001LDL-C\u5024\u3068\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u306e\u4e21\u65b9\u304c\u9ad8\u3044\u6210\u4eba\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c27\uff05\u9ad8\u304b\u3063\u305f\uff08\u30cf\u30b6\u30fc\u30c9\u6bd41.266\u300195\uff05\u4fe1\u983c\u533a\u9593\uff08CI\uff091.243-1.289\uff1b7.9\uff05\uff09\u3067\u3001LDL-C\u5358\u72ec\u9ad8\u5024\u7fa4\uff081.098\u300195\uff05CI 1.083-1.113\uff09\u304a\u3088\u3073\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5358\u72ec\u9ad8\u5024\u7fa4\uff081.102\u300195\uff05CI 1.087-1.118\uff09\u3088\u308a\u3082\u9ad8\u304b\u3063\u305f\u3002\u3055\u3089\u306b\u3001LDL-C\u3092\u542b\u3080\u8907\u6570\u306e\u5909\u6570\u3067\u8abf\u6574\u3057\u305f\u5f8c\u3082\u3001\u6b8b\u5b58\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u306b\u6bd4\u4f8b\u3057\u3066\u3044\u305f\u3002\u8457\u8005\u3089\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u306b\u306f\u3001LDL-C\u306e\u4e0a\u6607\u3068\u30ec\u30e0\u30ca\u30f3\u30c8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e0a\u6607\u306e\u4e21\u65b9\u3092\u8003\u616e\u3059\u3079\u304d\u3067\u3042\u308b\u3068\u7d50\u8ad6\u3057\u3066\u3044\u308b\u3002 <\/p><\/div>\n

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Lee SJ, Kim S-E, Go T=H, et al.<\/div>\n

Eur J Prev Cardiol 2023;zwad036. doi: 10.1093\/eurjpc\/zwad036<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Pettinelli P, Fern\u00e1ndez T, Aguirre C, et al.<\/div>\n

Br J Nutr 2023;1-30. doi: 10.1017\/S0007114523000028.<\/p><\/div>\n<\/div>\n

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\u3053\u306e\u7814\u7a76\u3067\u306f\u3001Cholesterol Treatment Trialists Collaboration\u306b\u3088\u3063\u3066\u5b9f\u65bd\u3055\u308c\u305f\u8102\u8cea\u4f4e\u4e0b\u7642\u6cd5\u306b\u95a2\u3059\u308b\u5927\u898f\u6a21\uff081000\u4eba\u4ee5\u4e0a\uff09\u8a66\u9a13\u3092\u7cfb\u7d71\u7684\u306b\u691c\u7d22\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u8a66\u9a13\u3067\u691c\u8a0e\u3055\u308c\u305f\u8102\u8cea\u4f4e\u4e0b\u6cbb\u7642\u306f\u30b9\u30bf\u30c1\u30f3\u3001\u30a8\u30bc\u30c1\u30df\u30d6\u3001PCSK9\u963b\u5bb3\u85ac\u3067\u3042\u3063\u305f\u3002\u7279\u306b\u3001\u9ad8\u9f62\u8005\uff08>70\u307e\u305f\u306f>75years\uff09\u3001\u5973\u6027\u3001\u767d\u4eba\u4ee5\u5916\u306e\u4eba\u7a2e\u3001\u6162\u6027\u814e\u4e0d\u5168\u3001\u5fc3\u4e0d\u5168\u3001\u514d\u75ab\u6291\u5236\u3001\u764c\u3001\u8a8d\u77e5\u75c7\u3001\u6cbb\u7642\u4e2d\u306e\u7532\u72b6\u817a\u75be\u60a3\u3001\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\u3001\u7cbe\u795e\u75be\u60a3\u3001\u5fc3\u623f\u7d30\u52d5\u3001\u6162\u6027\u75be\u60a3\u306e\u5408\u4f75\u3001\u30dd\u30ea\u30d5\u30a1\u30fc\u30de\u30b7\u30fc\u306b\u95a2\u3059\u308b\u7d44\u307f\u5165\u308c\u57fa\u6e96\u3092\u8abf\u67fb\u3057\u305f\u3002 <\/span>
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Aeschbacher-Germann M, Kaiser N, Speierer A, et al.<\/div>\n

J Am Heart Assoc 2023;12:e026551.<\/p><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36620945\/&#8221<\/a>; url_new_window=”on” button_text=”\u51fa\u7248\u7269\u3092\u898b\u308b” _builder_version=”4.27.4″ _module_preset=”default” button_bg_color=”gcid-secondary-color” custom_margin=”0px||||false|false” global_colors_info=”{%22gcid-secondary-color%22:%91%22button_bg_color%22%93}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”15px” header_2_text_color=”#FFFFFF” header_2_font_size=”32px” custom_margin=”||-13px|||” custom_padding=”9px|||27px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22%93}”]<\/p>\n

2015 <\/span><\/h2>\n

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