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PROMINENT\u8a66\u9a13\u306e\u7d50\u679c\u304c\u4e2d\u7acb\u3067\u3042\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u5c06\u6765\u306b\u3064\u3044\u3066\u7591\u554f\u304c\u5448\u3055\u308c\u3066\u3044\u308b\u3002\u672c\u89e3\u8aac\u3067\u306f\u3001\u3053\u306e\u8a66\u9a13\u3067\u89b3\u5bdf\u3055\u308c\u305f\u6709\u52b9\u6027\u306e\u6b20\u5982\u306b\u3064\u3044\u3066\u3001\u8003\u3048\u3089\u308c\u308b\u7406\u7531\u3092\u8003\u5bdf\u3059\u308b\u3002\u3057\u304b\u3057\u3001\u672b\u68a2\u52d5\u8108\u75be\u60a3\u306b\u4f34\u3046\u5fae\u5c0f\u8840\u7ba1\u306e\u865a\u8840\u6027\u5408\u4f75\u75c7\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u6307\u6a19\u306f\u3042\u308a\u3001\u305d\u306e\u5f8c\u306e\u89e3\u6790\u3067\u4e0b\u80a2\u865a\u8840\u6027\u6f70\u760d\u307e\u305f\u306f\u58ca\u75bd\u306e\u767a\u751f\u7387\u306e\u6e1b\u5c11\u304c\u793a\u3055\u308c\u305f\u3002\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u5b89\u5168\u6027\u306b\u95a2\u3059\u308b\u5b89\u5fc3\u611f\u306f\u3001PROMINENT\u8a66\u9a13\u3084\u5b9f\u9a13\u7684\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u65b0\u305f\u306a\u30c7\u30fc\u30bf\u3068\u3068\u3082\u306b\u3001\u975e\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u6027\u809d\u75be\u60a3\uff08\u4ee3\u8b1d\u6a5f\u80fd\u969c\u5bb3\u306b\u4f34\u3046\u8102\u80aa\u6027\u809d\u75be\u60a3\u3068\u3082\u547c\u3070\u308c\u308b\uff09\u3084\u7cd6\u5c3f\u75c5\u306b\u4f34\u3046\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u306b\u304a\u3051\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u6709\u7528\u6027\u3092\u793a\u5506\u3057\u3066\u304a\u308a\u3001\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3067\u3042\u308b\u3002 <\/p>\n

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\u4ed6\u306e\u51fa\u7248\u7269<\/spanhelvetica><\/h2>\n

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2020 <\/span><\/h2>\n

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\u9078\u629e\u7684\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u5897\u6b96\u56e0\u5b50\u6d3b\u6027\u5316\u53d7\u5bb9\u4f53\u03b1\u30e2\u30b8\u30e5\u30ec\u30fc\u30bf\u30fc\uff08SPPARM\u03b1\uff09\uff1a\u6162\u6027\u814e\u81d3\u75c5\u306b\u304a\u3051\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u65b0\u305f\u306a\u624b\u6bb5\u304b\uff1f<\/span><\/h3>\n
Jean-Charles Fruchart, Michel P. Hermans, Jamila Fruchart-Najib<\/span><\/h6>\n

\u672c\u30ec\u30d3\u30e5\u30fc\u306e\u76ee\u7684<\/b>
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2019 <\/span><\/h2>\n

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\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\uff1aSPPARM\u03b1\u306e\u30b3\u30f3\u30bb\u30d7\u30c8\u304c\u9375\u3092\u63e1\u308b\u304b\uff1f<\/span><\/h3>\n
Jean-Charles Fruchart , Raul D. Santos, Shizuya Yamashita,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n

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\u00a0<\/span>
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\u00a0<\/span>
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Jean\u2010Charles Fruchart, Raul D. Santos, Carlos Aguilar\u2010Salinas,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n

50\u540d\u4ee5\u4e0a\u306e\u56fd\u969b\u7684\u306b\u6709\u540d\u306a\u81e8\u5e8a\u304a\u3088\u3073\u79d1\u5b66\u306e\u5c02\u9580\u5bb6\u304c\u96c6\u307e\u308a\u3001SPPARM\u03b1\u30b3\u30f3\u30bb\u30d7\u30c8\u3068\u6b8b\u5b58\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u8a71\u3057\u5408\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u753b\u671f\u7684\u306a\u8ad6\u6587\u306f\u3001\u81e8\u5e8a\u533b\u306b\u3068\u3063\u3066\u4e0d\u53ef\u6b20\u306a\u3082\u306e\u304c\u8a18\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/em>
\u00a0<\/span>
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\u00a0<\/span>
R3i \u3068\u56fd\u969b\u52d5\u8108\u786c\u5316\u5b66\u4f1a\u306e\u5171\u540c\u30b3\u30f3\u30bb\u30f3\u30b5\u30b9\u306f\u3001\u4e16\u754c\u3092\u30ea\u30fc\u30c9\u3059\u308b 50 \u540d\u4ee5\u4e0a\u306e\u5c02\u9580\u5bb6\u3067\u69cb\u6210\u3055\u308c\u3001\u6700\u521d\u306e SPPARM\u03b1\u30a2\u30b4\u30cb\u30b9\u30c8\u3067\u3042\u308b\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u3092\u30ec\u30d3\u30e5\u30fc\u3057\u307e\u3057\u305f\u3002\u5c02\u9580\u5bb6\u306e\u5408\u610f\u3068\u3057\u3066\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u85ac\u7406\u6d3b\u6027\u3084\u3001\u305d\u3057\u3066\u91cd\u8981\u306a\u3053\u3068\u306b\u3001\u5b89\u5168\u306a\u809d\u81d3\u3068\u814e\u81d3\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u57fa\u3065\u304d\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u306f\u7570\u306a\u308b\u65b0\u3057\u3044\u6cbb\u7642\u30af\u30e9\u30b9\u3067\u3042\u308b\u3068\u7d50\u8ad6\u4ed8\u3051\u307e\u3057\u305f\u3002\u6700\u7d42\u7684\u306a\u7b54\u3048\u306f\u3001 2\u578b\u7cd6\u5c3f\u75c5\u304a\u3088\u3073\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6709\u3059\u308b\u8d85\u9ad8\u30ea\u30b9\u30af\u60a3\u80051\u4e07\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u8a66\u9a13\u3001PROMINENT\u306b\u3042\u308a\u307e\u3059\u3002<\/span><\/p>\n

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SPPARM\u03b1\uff1a\u30e9\u30b6\u30ed\u52b9\u679c<\/span><\/h3>\n
Jean-Charles Fruchart , Raul D. Santos<\/span><\/h6>\n

SPPARM\u03b1\u2013\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u5fa9\u6d3b\u304b\u65b0\u85ac\u3078\u306e\u5206\u985e\u304b\uff1f<\/em>
\u00a0<\/span>
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\u00a0<\/span>
\u672c\u30ec\u30d3\u30e5\u30fc\u3067\u306f\u3001SPPARM\u03b1\u30b3\u30f3\u30bb\u30d7\u30c8\u306e\u6839\u62e0\u3068\u3001\u30da\u30de\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u7528\u3044\u305f\u6cbb\u7642\u5fdc\u7528\u306b\u3064\u3044\u3066\u8b70\u8ad6\u3057\u307e\u3059\u3002\u7279\u306b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3067\u793a\u3055\u308c\u305f\u8840\u6e05\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u306e\u8457\u660e\u306a\u4e0a\u6607\u3092\u8a8d\u3081\u305a\u3001\u307e\u305f\u814e\u81d3\u3068\u809d\u81d3\u306e\u5b89\u5168\u6027\u304c\u5411\u4e0a\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u826f\u597d\u306a\u30ea\u30b9\u30af\uff0d\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u3053\u308c\u307e\u3067\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5fc3\u8840\u7ba1\u30a2\u30a6\u30c8\u30ab\u30e0\u7814\u7a76\u306ePROMINENT\u306f\u3001\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u306eSPPARM\u03b1\u30b3\u30f3\u30bb\u30d7\u30c8\u3092\u691c\u8a3c\u3059\u308b\u91cd\u8981\u306a\u8a66\u9a13\u3067\u3059\u3002<\/span><\/p>\n

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2014 <\/span><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” background_color=”gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd” custom_margin=”19px||||false|false” custom_padding=”||0px|||” border_radii=”on|20px|20px|20px|20px” global_colors_info=”{%22gcid-b673dc17-1b2a-464e-affa-1bf1ab41c0fd%22:%91%22background_color%22%93}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_3_text_color=”gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf” header_6_text_color=”gcid-secondary-color” custom_margin=”||-12px|||” custom_padding=”|28px||28px|false|false” global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22%93,%22gcid-4907c8d4-9eff-49de-91ce-43a2d3a729cf%22:%91%22header_3_text_color%22%93,%22gcid-secondary-color%22:%91%22header_6_text_color%22%93}”]<\/p>\n

2014\u5e74\u5f53\u6642\u306e2\u578b\u7cd6\u5c3f\u75c5\u306b\u6b8b\u5b58\u3059\u308b\u5fae\u5c0f\u8840\u7ba1\u306e\u30ea\u30b9\u30af\u3001\u518d\u8003\u306e\u6642\u671f\u304b\uff1fResidual Risk Reduction Initiative\uff08R3i\uff09\u306e\u8996\u70b9<\/span><\/h3>\n
Michel P Hermans, Jean-Charles Fruchart, Jean Davignon,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n

\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u3001\u814e\u75c7\u3001\u795e\u7d4c\u969c\u5bb3\u306a\u3069\u306e2\u578b\u7cd6\u5c3f\u75c5\u306b\u4f34\u3046\u5fae\u5c0f\u8840\u7ba1\u5408\u4f75\u75c7\u306f\u3001\u7cd6\u5c3f\u75c5\u306b\u3088\u308b\u793e\u4f1a\u7684\u8ca0\u62c5\u306e\u4e3b\u8981\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u751f\u6d3b\u7fd2\u6163\u3078\u306e\u4ecb\u5165\u306b\u52a0\u3048\u3001\u8840\u7cd6\u5024\u3001\u8840\u5727\u3001\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6a19\u7684\u3068\u3057\u3066\u52b9\u679c\u306e\u3042\u308b\u8907\u5408\u7684\u306a\u4ecb\u5165\u3092\u884c\u3063\u3066\u3082\u3001\u5fae\u5c0f\u8840\u7ba1\u3078\u306e\u30ea\u30b9\u30af\u306f\u4f9d\u7136\u3068\u3057\u3066\u9ad8\u3044\u307e\u307e\u6b8b\u5b58\u3057\u3066\u3044\u308b\u3002Residual Risk Reduction Initiative\uff08R3i\uff09\u306f\u3001\u3053\u308c\u3089\u306e\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u30812\u3064\u306e\u91cd\u8981\u306a\u512a\u5148\u4e8b\u9805\u3092\u91cd\u8996\u3057\u3066\u3044\u308b\u3002\u7b2c\u4e00\u306b\u3001\u8102\u8cea\u76ee\u6a19\u9054\u6210\u7387\u3092\u4e0a\u3052\u308b\u306b\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4e0a\u6607\u3001\u8840\u6f3f\u4e2d\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4f4e\u4e0b\u3068\u3044\u3063\u305f\u5fc3\u4ee3\u8b1d\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u6700\u9069\u306b\u7ba1\u7406\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u3002\u7b2c\u4e8c\u306b\u30012\u672c\u306e\u4e3b\u8981\u306a\u8a66\u9a13\u3067\u5831\u544a\u3055\u308c\u305f\u4e00\u8cab\u6027\u306e\u3042\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304d\u3001\u4f75\u5b58\u75be\u60a3\u3092\u6709\u3059\u308b2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u3067\u7cd6\u5c3f\u75c5\u6027\u7db2\u819c\u75c7\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u305f\u3081\u306b\u306f\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u7642\u6cd5\u306e\u8ffd\u52a0\u3092\u691c\u8a0e\u3059\u308b\u4fa1\u5024\u304c\u3042\u308b\u3053\u3068\u3001\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u30c7\u30fc\u30bf\u306f\u524d\u5411\u304d\u8a66\u9a13\u3067\u691c\u8a3c\u3092\u884c\u3046\u305f\u3081\u306e\u5f37\u529b\u306a\u6839\u62e0\u3068\u306a\u308b\u30022\u578b\u7cd6\u5c3f\u75c5\u306e\u5fae\u5c0f\u8840\u7ba1\u5408\u4f75\u75c7\u306b\u6f5c\u3080\u5927\u304d\u306a\u6b8b\u5b58\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u306b\u306f\u3001\u3053\u306e2\u3064\u306e\u512a\u5148\u4e8b\u9805\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3068R3i\u306f\u5f37\u304f\u78ba\u4fe1\u3057\u3066\u3044\u308b\u3002<\/span><\/p>\n

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2013\u5e74\u5f53\u6642\u306e\u5927\u8840\u7ba1\u6b8b\u5b58\u30ea\u30b9\u30af\u304b\u3089\u79c1\u305f\u3061\u306f\u4f55\u3092\u5b66\u3093\u3060\u306e\u304b\uff1f<\/span><\/h3>\n
Jean-Charles Fruchart, Jean Davignon, Michel P. Hermans,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n

\u5317\u7c73\u304a\u3088\u3073\u5357\u7c73\u3001\u6b27\u5dde\u3001\u4e2d\u6771\u3001\u30a2\u30b8\u30a2\u304a\u3088\u3073\u65e5\u672c\u306e\u512a\u308c\u305f\u5c02\u9580\u5bb640\u540d\u3067\u69cb\u6210\u3055\u308c\u305fResidual Risk Reduction Initiative\uff08R3i\uff09\u56fd\u969b\u904b\u55b6\u59d4\u54e1\u4f1a\u306f\u73fe\u5728\u3001\u8102\u8cea\u306b\u95a2\u9023\u3059\u308b\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u91cd\u8981\u306a\u5bc4\u4e0e\u56e0\u5b50\u3067\u3042\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306b\u5bfe\u3057\u3066\u512a\u5148\u7684\u306b\u53d6\u308b\u3079\u304d\u5bfe\u7b56\u306b\u30cf\u30a4\u30e9\u30a4\u30c8\u3092\u5f53\u3066\u3066\u3044\u308b\u3002R3i\u306f\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304c\u30de\u30fc\u30ab\u30fc\u3068\u306a\u308bTG-rich\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB\u542b\u6709\u30ea\u30dd\u86cb\u767d\u3068\u3001\uff08\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767dHDL\u306b\u307f\u3089\u308c\u308b\uff09\u30a2\u30dd\u30ea\u30dd\u86cb\u767dA-I\u30ea\u30dd\u86cb\u767d\u304c\u4e0d\u5747\u8861\u306a\u72b6\u614b\u3092\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3068\u5b9a\u7fa9\u3057\u3066\u3044\u308b\u3002 R3i\u306f\u3001\u4ee5\u4e0b\u30923\u3064\u306e\u91cd\u8981\u306a\u512a\u5148\u4e8b\u9805\u306b\u4f4d\u7f6e\u3065\u3051\u305f\u3002 \u2022 \u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u542b\u3080\u9ad8\u30ea\u30b9\u30af\u60a3\u8005\u306b\u304a\u3051\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306e\u8a8d\u8b58\u3092\u6539\u5584\u3059\u308b \u2022 \u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u6a19\u7684\u306b\u3059\u308b\u306b\u3042\u305f\u3063\u3066\u3001non-HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff0dHDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff09\u3092\u6cbb\u7642\u6c7a\u5b9a\u306e\u5224\u65ad\u6750\u6599\u3068\u3059\u308b \u2022 \u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306e\u7ba1\u7406\u304a\u3088\u3073\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u63a8\u5968\u3055\u308c\u3066\u3044\u308b\u6cbb\u7642\u3078\u306e\u30a2\u30c9\u30d2\u30a2\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3059\u308b\u3002\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3001\u30ca\u30a4\u30a2\u30b7\u30f3\uff08\u5317\u7c73\u304a\u3088\u3073\u5357\u7c73\uff09\u3001\u30aa\u30e1\u30ac3\u8102\u80aa\u9178\u307e\u305f\u306f\u30a8\u30bc\u30c1\u30df\u30d6\u306e\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u8ffd\u52a0\u306f\u5168\u3066non-HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u6e1b\u5c11\u3055\u305b\u308b\u65b9\u6cd5\u3067\u3042\u308b\u3002 R3i\u306f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u3092\u3088\u308a\u52b9\u679c\u7684\u306b\u72d9\u3063\u305f\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u306e\u5fc5\u8981\u6027\u3092\u8a8d\u8b58\u3057\u3066\u304a\u308a\u3001\u672c\u8ad6\u3067\u5c06\u6765\u306e\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u691c\u8a0e\u3059\u308b\u3002\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\uff08LDL\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u5341\u5206\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u60a3\u8005\u306e\u65e5\u5e38\u7684\u7ba1\u7406\u306b\u95a2\u3057\u3066\u3001\u91cd\u8981\u306a\u610f\u7fa9\u3092\u6301\u3064\u5185\u5bb9\u3067\u3042\u308b\u3002<\/span><\/p>\n

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2013 <\/span><\/h2>\n

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2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u304a\u3088\u3073HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u5fae\u5c0f\u8840\u7ba1\u6027\u814e\u75c7\u304a\u3088\u3073\u7db2\u819c\u75c7\u306e\u95a2\u9023\uff1a13\u30f5\u56fd\u306b\u304a\u3051\u308b\u30b0\u30ed\u30fc\u30d0\u30eb\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76<\/span><\/h3>\n
\n
Frank M. Sacks, Michel P. Hermans, Paola Fioretto,\u00a0<\/span>\u8a73\u7d30…<\/a><\/div>\n<\/section>\n

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2012 <\/span><\/h2>\n

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ACCORD Lipid\u8a66\u9a13\u306b\u304a\u3051\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff0b\u30b7\u30f3\u30d0\u30b9\u30bf\u30c1\u30f3\u4f75\u7528\u7642\u6cd5\u306e\u98df\u5f8c\u9ad8\u8102\u8840\u75c7\u306b\u5bfe\u3059\u308b\u52b9\u679c<\/span><\/h3>\n
G. Reyes-Soffer, C Ngai, L Lovato,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n
\n
ACCORD Lipid\u8a66\u9a13\u306e\u60a3\u8005\u30b5\u30d6\u30b0\u30eb\u30fc\u30d7\u3092\u5bfe\u8c61\u306b\u5b9f\u65bd\u3055\u308c\u305f\u3053\u306e\u88dc\u52a9\u8a66\u9a13\u3067\u306f\u3001\u7d4c\u53e3\u8102\u80aa\u8ca0\u8377\u8a66\u9a13\u5f8c\u306e\u98df\u5f8c\u9ad8\u8102\u8840\u75c7\u304c\u8a55\u4fa1\u3055\u308c\u305f\u3002\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u306e\u6295\u4e0e\u306b\u3088\u308a\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u30a2\u30dd\u30ea\u30dd\u86cb\u767dB48\u3078\u306e\u98df\u5f8c\u66dd\u9732\u91cf\u304c\u4f4e\u4e0b\u3057\u305f\u306e\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306e\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u9ad8\u304b\u3063\u305f\u60a3\u8005\u306e\u307f\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304c\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u7a7a\u8179\u6642\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u304c\u9855\u8457\u306b\u4e0a\u6607\u3057\u3066\u3044\u308b\u5834\u5408\u306b\u306e\u307f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027TG-rich\u30ec\u30e0\u30ca\u30f3\u30c8\u30ea\u30dd\u86cb\u767d\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3092\u6539\u5584\u3057\u30012\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u5927\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3055\u305b\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/span><\/div>\n<\/section>\n

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2011 <\/span><\/h2>\n

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PCSK9\uff1a\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b\u306b\u304a\u3051\u308b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff0b\u30b9\u30bf\u30c1\u30f3\u4f75\u7528\u7642\u6cd5\u306e\u6a5f\u80fd\u7684\u95a2\u9023\u6027<\/span><\/h3>\n
JC Fruchart International Journal of Diabetes Mellitus<\/span><\/h6>\n
\n
\u8457\u8005\u306f\u3001PCSK9\u306e\u751f\u7406\u5b66\u7684\u4f5c\u7528\u3001\u3059\u306a\u308f\u3061LDL-C\u53d7\u5bb9\u4f53\u3092\u6a19\u7684\u3068\u3059\u308b\u6a5f\u80fd\u3092\u4ecb\u3057\u3066LDL-C\u5024\u3092\u8abf\u7bc0\u3059\u308b\u6a5f\u80fd\u306b\u3064\u3044\u3066\u6982\u8aac\u3057\u305f\u3002\u6b21\u306b\u30b9\u30bf\u30c1\u30f3\u3068\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3001\u7279\u306b\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u304cPCSK9\u306b\u3069\u306e\u3088\u3046\u306b\u4f5c\u7528\u3059\u308b\u304b\u3092\u8aac\u660e\u3057\u305f\u3002\u6700\u5f8c\u306b\u3001\u3053\u306e\u30c7\u30fc\u30bf\u304c\uff081\uff09\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3068\u30b9\u30bf\u30c1\u30f3\u306e\u4f75\u7528\u306b\u3088\u308aLDL-C\u4f4e\u4e0b\u52b9\u679c\u304c\u6700\u9069\u5316\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u3059\u6a5f\u80fd\u7684\u6839\u62e0\u3067\u3042\u308b\u3053\u3068\u3001\uff082\uff092\u578b\u7cd6\u5c3f\u75c5\u3084\u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b7\u30f3\u30c9\u30ed\u30fc\u30e0\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001PSCK9\u304c\u6cbb\u7642\u6a19\u7684\u306b\u306a\u308a\u3046\u308b\u3053\u3068\u3092\u793a\u3059\u308b\u3082\u306e\u3067\u3042\u308a\u3001\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u3067\u306a\u304a\u6b8b\u5b58\u3059\u308b\u9ad8\u3044\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6291\u3048\u308b\u65b0\u305f\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u958b\u3044\u305f\u3001\u3068\u7d50\u8ad6\u3057\u305f\u3002<\/span><\/div>\n<\/section>\n

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\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u306f2\u578b\u7cd6\u5c3f\u75c5\u306e\u5927\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u4e88\u6e2c\u3059\u308b\u304b\uff1f<\/span><\/h3>\n
RS Rosenson, P Fioretto, PM Dodson Atherosclerosis<\/span><\/h6>\n
\n
\u60a3\u800554,117\u4f8b\u3092\u5bfe\u8c61\u3068\u3057\u305f25\u306e\u7814\u7a76\u306b\u57fa\u3065\u304f\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u3068\u5927\u8840\u7ba1\u969c\u5bb3\u306e\u95a2\u9023\u6027\u306b\u6ce8\u76ee\u3057\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u8840\u7ba1\u30ea\u30b9\u30af\u8a55\u4fa1\u306b\u304a\u3044\u3066\u5fae\u5c0f\u8840\u7ba1\u969c\u5bb3\u3092\u65e9\u671f\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u5f37\u8abf\u3057\u305f\u3002<\/span><\/div>\n<\/section>\n

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2010 <\/span><\/h2>\n

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ACCORD Lipid\u8a66\u9a13\u306e\u610f\u7fa9\uff1aResidual Risk Reduction initiative\uff08R3i\uff09\u306e\u6700\u65b0\u533b\u5b66\u7814\u7a76\u304b\u3089\u306e\u5c55\u671b\u3068\u898b\u89e3<\/span><\/h3>\n
Fruchart JC, Sacks FM, Hermans MP<\/span><\/h6>\n
\n
ACCORD Lipid\u8a66\u9a13\u306e\u7d50\u679c\u306b\u3064\u3044\u3066\u8ad6\u3058\u305f\u3053\u306e\u89e3\u8aac\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u8102\u8cea\u7570\u5e38\u75c7\u30de\u30cd\u30b8\u30e1\u30f3\u30c8\u306b\u306f\u500b\u3005\u306e\u60a3\u8005\u306e\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u57fa\u3065\u304f\u6a19\u7684\u3092\u7d5e\u3063\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u6307\u6458\u3059\u308b\u7d50\u679c\u3067\u3042\u3063\u305f\u3001\u3068\u7d50\u8ad6\u3057\u3066\u3044\u308b\u3002\u7279\u306b\u30b9\u30bf\u30c1\u30f3\u3092\u6295\u4e0e\u3057\u305f\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u3067\u306f\u3001\u30d5\u30a7\u30ce\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u3092\u8ffd\u52a0\u6295\u4e0e\u3059\u308b\u3053\u3068\u3067\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u3055\u3089\u306a\u308b\u4f4e\u6e1b\u304c\u671f\u5f85\u3067\u304d\u308b\u3002<\/span><\/div>\n<\/section>\n

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Non-LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u95a2\u9023\u8102\u8cea\u7570\u5e38\u75c7\uff08Non-LDL-related dyslipidaemia\uff09\u3068\u51a0\u52d5\u8108\u30ea\u30b9\u30af\uff1a\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76<\/span><\/h3>\n
Assmann G, Cullen P, Schulte H. Diabetes and Vascular Disease Research<\/span><\/h6>\n
\n
\u5fc3\u7b4b\u6897\u585e\u306b\u4f34\u3046non-LDL-C\u95a2\u9023\u8102\u8cea\u7570\u5e38\u75c7\u306e\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u305f\u3081\u3001\u521d\u56de\u5fc3\u7b4b\u6897\u585e\u3092\u767a\u75c7\u3057\u305f23\uff5e65\u6b73\u306e\u7537\u6027823\u540d\u3068\u3001\u6027\u5225\u3001\u5e74\u9f62\u3001\u55ab\u7159\u72b6\u6cc1\u3001DM\u3001BP\u3001LDL-C\u3092\u30de\u30c3\u30c1\u3055\u305b\u305f\u5fc3\u7b4b\u6897\u585e\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044823\u540d\u306ePROCAM\u5bfe\u7167\u3092\u6bd4\u8f03\u3057\u305f\u3002\u3053\u306e\u75c7\u4f8b\u5bfe\u7167\u7814\u7a76\u3067\u4e3b\u306b2\u3064\u306e\u77e5\u898b\u304c\u5f97\u3089\u308c\u305f\u3002\u7b2c1\u306b\u3001\u8102\u8cea\u7570\u5e38\u75c7\u306b\u4f34\u3046\u5fc3\u7b4b\u6897\u585e\u306e\u76f8\u5bfe\u30ea\u30b9\u30af\u4e0a\u6607\u306f\u3001LDL-C\u5024\u304c\u4f4e\u3044\u60a3\u8005\u3067\u6700\u3082\u5927\u304d\u3044\u3053\u3068\u3002\u7b2c2\u306b\u3001\u5f93\u6765\u304b\u3089\u3042\u308b\u4ed6\u306e\u5fc3\u7b4b\u6897\u585e\u30ea\u30b9\u30af\u56e0\u5b50\u3092\u8003\u616e\u306b\u5165\u308c\u305f\u5834\u5408\u3001HDL-C\u4f4e\u5024\u306e\u307b\u3046\u304cTG\u9ad8\u5024\u3088\u308a\u3082\u5fc3\u7b4b\u6897\u585e\u30ea\u30b9\u30af\u306b\u5927\u304d\u304f\u5f71\u97ff\u3059\u308b\u3053\u3068\u3067\u3042\u308b\u3002<\/span><\/div>\n<\/section>\n

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2\u578b\u7cd6\u5c3f\u75c5\u306b\u304a\u3051\u308b\u8102\u8cea\u6539\u5584\u85ac\u4f75\u7528\u7642\u6cd5\uff08\u901a\u4fe1\uff09<\/span><\/h3>\n
Sacks FM, Carey VJ, Fruchart JC New England Journal of Medicine<\/span><\/h6>\n
\n
“5\u3064\u306e\u81e8\u5e8a\u8a66\u9a13\uff08FIELD\u3001BIP\u3001HHS\u3001VA-HIT\u3001ACCORD\uff09\u306e\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306b\u57fa\u3065\u304d\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\u6cbb\u7642\u304c\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306e\u51a0\u52d5\u8108\u75be\u60a3\u30a4\u30d9\u30f3\u30c8\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u8457\u8005\u3089\u306f\u7d50\u8ad6\u3057\u3066\u3044\u308b\u3002 “<\/span><\/div>\n<\/section>\n

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2009 <\/span><\/h2>\n

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\u7cd6\u5c3f\u75c5\u306e\u6b8b\u5b58\u5fae\u5c0f\u8840\u7ba1\u30ea\u30b9\u30af\uff1a\u30a2\u30f3\u30e1\u30c3\u30c8\u30cb\u30fc\u30ba\u3068\u4eca\u5f8c\u306e\u65b9\u5411\u6027<\/span><\/h3>\n
Fioretto P, Dodson PM, Ziegler D,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n
\n
2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u306f\u6700\u65b0\u306e\u6a19\u6e96\u6cbb\u7642\u306b\u57fa\u3065\u3044\u3066\u6700\u9069\u306a\u7ba1\u7406\u3092\u53d7\u3051\u3066\u3044\u3066\u3082\u306a\u304a\u6b8b\u5b58\u3059\u308b\u9ad8\u3044\u5fae\u5c0f\u8840\u7ba1\u30ea\u30b9\u30af\u306b\u66dd\u3055\u308c\u3066\u304a\u308a\u3001\u65e9\u6025\u306b\u5bfe\u51e6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u3001\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306e\u8457\u8005\u3089\u306f\u5f37\u8abf\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u8102\u8cea\u7570\u5e38\u75c7\u306e\u662f\u6b63\u304c\u3055\u3089\u306a\u308b\u30d9\u30cd\u30d5\u30a3\u30c3\u30c8\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u7d50\u8ad6\u3065\u3051\u3066\u3044\u308b\u3002<\/span><\/div>\n<\/section>\n

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2008 <\/span><\/h2>\n

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R3i\u306e\u516c\u5f0f\u898b\u89e3<\/span><\/h3>\n
Jean-Charles Fruchart PhD, Frank Sacks MD, Michel P. Hermans MD PhD,\u00a0<\/span>\u8a73\u7d30…<\/a><\/h6>\n
\n
Residual Risk Reduction Initiative\uff1a\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u6b8b\u5b58\u3059\u308b\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u4f4e\u6e1b\u3059\u308b\u305f\u3081\u306e\u884c\u52d5\u8981\u8acb<\/span><\/div>\n<\/section>\n

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