{"id":253692,"date":"2025-01-25T15:36:43","date_gmt":"2025-01-25T14:36:43","guid":{"rendered":"https:\/\/r3i.org\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bangptl3%e3%83%a2%e3%83%8e\/"},"modified":"2025-02-15T20:35:26","modified_gmt":"2025-02-15T19:35:26","slug":"%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bangptl3%e3%83%a2%e3%83%8e","status":"publish","type":"page","link":"https:\/\/r3i.org\/ja\/%e3%83%95%e3%82%a9%e3%83%bc%e3%82%ab%e3%82%b9-%e9%ab%98%e3%83%88%e3%83%aa%e3%82%b0%e3%83%aa%e3%82%bb%e3%83%aa%e3%83%89%e8%a1%80%e7%97%87%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bangptl3%e3%83%a2%e3%83%8e\/","title":{"rendered":"\u30d5\u30a9\u30fc\u30ab\u30b9 – \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3051\u308bANGPTL3\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”1px|||||” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_2_text_color=”gcid-primary-color” header_5_text_color=”gcid-secondary-color” text_orientation=”center” width=”99%” custom_margin=”|-147px||||” custom_padding=”|0px||||” hover_enabled=”0″ global_colors_info=”{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}” sticky_enabled=”0″]

\u30d5\u30a9\u30fc\u30ab\u30b9 –\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3051\u308bANGPTL3\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53<\/span><\/h2>\n
17 2020\u5e742\u6708<\/span><\/h5>\n

ANGPTL3\uff08\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u86cb\u767d\u8cea3\uff09\u306b\u5bfe\u3059\u308b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u3067\u3042\u308bEvinacumab\u306f\u3001\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2cI\u76f8\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u5b9f\u8cea\u7684\u304b\u3064\u6301\u7d9a\u7684\u306b\u6e1b\u5c11\u3055\u305b\u305f\u3002<\/span><\/p>\n

Ahmad Z\u3001Baneljee P\u3001Hamon S\u3089\uff1a\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u306b\u3088\u308b\u30a2\u30f3\u30b8\u30aa\u30dd\u30a8\u30c1\u30f3\u69d8\u30bf\u30f3\u30d1\u30af\u8cea3\u306e\u963b\u5bb3\u306f\u3001\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306b\u304a\u3051\u308b\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3002Circulation 2019; DOI: 10.1161\/CIRCULATIONAHA.118.039107 <\/span><\/p>\n

\u7814\u7a76\u6982\u8981<\/b><\/p>\n\n\n\n\n\n\n\n
\u76ee\u7684<\/strong><\/td>\n\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\uff08TG\uff09\u304a\u3088\u3073\/\u307e\u305f\u306f\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08LDL-C\uff09\u4e0a\u6607\u3092\u6709\u3059\u308b\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001evinacumab\u306e\u5358\u56de\u304a\u3088\u3073\u8907\u6570\u56de\u4e0a\u884c\u6295\u4e0e\u306e\u5b89\u5168\u6027\u304a\u3088\u3073\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3002<\/td>\n<\/tr>\n
\u8a66\u9a13\u30c7\u30b6\u30a4\u30f3\uff1a<\/strong><\/td>\n2\u3064\u306e\u7b2cI\u76f8\u8a66\u9a13\uff1a1) \u30d2\u30c8\u521d\u56de\u7121\u4f5c\u70ba\u5316\u3001\u5358\u56de\u4e0a\u884c\u7528\u91cf\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\uff08\u30a8\u30d3\u30ca\u30af\u30de\u30d6 75\u3001150\u3001250 mg \u76ae\u4e0b\u6295\u4e0e[SC] \u307e\u305f\u306f 5\u300110\u300120 mg\/kg \u9759\u6ce8[IV] \uff09\u3001\u8a66\u9a13ID\u3001NCT01749878\u3001\u304a\u3088\u3073 2) \u7121\u4f5c\u70ba\u5316\u3001\u5358\u56de\u4e0a\u884c\u7528\u91cf\u3001\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u3001\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\uff08\u30a8\u30d3\u30ca\u30af\u30de\u30d6 150\u3001300\u3001450 mg SC \u90311\u56de\u6295\u4e0e\u3001300\u3001450 mg 2\u9031\u9593\u6bce\u6295\u4e0e\u3001\u307e\u305f\u306f 20 mg\/kg \u9759\u6ce8\uff09\u3001\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8907\u6570\u56de\u6f38\u5897\u6295\u4e0e\u8a66\u9a13\uff08\u30a8\u30d3\u30ca\u30af\u30de\u30d6150\u3001300\u3001450mg\u3092\u90311\u56de\u76ae\u4e0b\u6295\u4e0e\u3001300\u307e\u305f\u306f450mg\u30922\u9031\u3054\u3068\u3001\u307e\u305f\u306f20mg\/kg\u30924\u9031\u3054\u3068\u306b56\u65e5\u76ee\u307e\u3067\u9759\u8108\u5185\u6295\u4e0e\uff09\u3001\u8a66\u9a13ID\u306fNCT02107872\u3067\u3042\u308b\u3002<\/td>\n<\/tr>\n
\u7814\u7a76\u5bfe\u8c61\u8005\uff1a<\/strong><\/td>\n\u5358\u56de\u6295\u4e0e\u8a66\u9a13\u306f\u3001\u6df7\u5408\u578b\u8102\u8cea\u7570\u5e38\u75c7\uff08TG\u4e0a\u6607\uff08[150 to 450 mg\/dL] \uff09\u307e\u305f\u306fLDL-C\u4e0a\u6607\uff08\u2267100mg\/dL\uff09\u3068\u5b9a\u7fa9\uff09\u306e\u5065\u5eb7\u306a\u7537\u5973\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002\u8907\u6570\u56de\u6295\u4e0e\u8a66\u9a13\u3067\u306f\u3001TG\u4e0a\u6607\uff08150\uff5e500mg\/dL\u3092\u542b\u3080\uff09\u304a\u3088\u3073LDL-C\u4e0a\u6607\uff08100mg\/dL\u4ee5\u4e0a\uff09\u306e\u5065\u5eb7\u306a\u7537\u5973\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3002 <\/td>\n<\/tr>\n
\u6709\u52b9\u6027\u306e\u5909\u6570\uff1a<\/strong><\/td>\n\n

– \u5b89\u5168\u6027\u304a\u3088\u3073\u5fcd\u5bb9\u6027\u306f\u3001\u81ea\u767a\u7684\u306b\u5831\u544a\u3055\u308c\u305f\u6709\u5bb3\u4e8b\u8c61\uff08AE\uff09\u3001\u8eab\u4f53\u8a3a\u5bdf\u3001\u30d0\u30a4\u30bf\u30eb\u30b5\u30a4\u30f3\u3001\u5fc3\u96fb\u56f3\u30c7\u30fc\u30bf\u304a\u3088\u3073\u81e8\u5e8a\u8a55\u4fa1\u306b\u3088\u308a\u8a55\u4fa1\u3057\u305f\u3002\u6025\u6027\u6295\u4e0e\u53cd\u5fdc\u306f\u3001\u8a66\u9a13\u85ac\u6295\u4e0e\u4e2d\u307e\u305f\u306f\u6295\u4e0e\u5f8c2\u6642\u9593\u4ee5\u5185\u306b\u767a\u73fe\u3057\u305f\u3059\u3079\u3066\u306eAE\u3068\u5b9a\u7fa9\u3057\u305f\u3002 <\/p>\n

– \u8102\u8cea\u30ec\u30d9\u30eb\u306e\u7d4c\u6642\u7684\u5909\u5316\uff1aTG\u3001\u8d85\u4f4e\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08VLDL-C\uff09\u3001\u975e\u9ad8\u6bd4\u91cd\u30ea\u30dd\u86cb\u767d\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u975eHDL-C\uff09\u3001\u30a2\u30dd\u30ea\u30dd\u86cb\u767d\uff08\u30a2\u30dd\uff09B\u3001LDL-C\u3001\u30ea\u30dd\u86cb\u767d\uff08a\uff09\u3001HDL-C\u3001\u30a2\u30ddA1\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3002<\/p>\n<\/td>\n<\/tr>\n

\u65b9\u6cd5\uff1a<\/strong><\/td>\n\n

\u5358\u56de\u6295\u4e0e\u8a66\u9a13\uff1a<\/strong> <\/span>\u672c\u8a66\u9a13\u306f\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u671f\u9593\uff0821\u65e5\u76ee\u304b\u30892\u65e5\u76ee\uff09\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u8a3a\u5bdf\u3001\u6cbb\u7642\u671f\u9593\u304a\u3088\u3073\u89b3\u5bdf\u671f\u9593\u3067\u69cb\u6210\u3055\u308c\u305f\u3002\u60a3\u8005\u306f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u306b3\uff1a1\uff08\u30a8\u30d3\u30ca\u30af\u30de\u30d6\uff1a\u30d7\u30e9\u30bb\u30dc\uff09\u306e\u5272\u5408\u3067\u30016\u3064\u306e\u6f38\u5897\u6295\u4e0e\u30ec\u30d9\u30eb\u306e\u3046\u30611\u3064\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\uff1a3\u3064\u306eSC\u6295\u4e0e\uff0875\u3001150\u3001250mg\uff09\u30683\u3064\u306e\u9759\u8108\u5185\u6295\u4e0e\uff085\u300110\u300120mg\/kg\uff09\u3002SC\u6295\u4e0e\u3068\u9759\u6ce8\u6295\u4e0e\u306f\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u6642\u306e\u8102\u8cea\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u57fa\u3065\u3044\u30662\u3064\u306e\u30b3\u30db\u30fc\u30c8\u306b\u5206\u3051\u3089\u308c\u305f\u3002\u6700\u592712\u4eba\u306e\u88ab\u9a13\u8005\u306bevinacumab\u304c\u6295\u4e0e\u3055\u308c\u30014\u4eba\u306b\u30d7\u30e9\u30bb\u30dc\u304c\u6295\u4e0e\u3055\u308c\u305f\u3002\u88ab\u9a13\u8005\u306f4\u65e5\u76ee\u306e\u8a55\u4fa1\u304c\u7d42\u4e86\u3059\u308b\u307e\u3067\u30af\u30ea\u30cb\u30c3\u30af\u306b\u3068\u3069\u307e\u308a\u3001\u6700\u521d\u306e4\u56de\u306e\u6295\u4e0e\u306b\u3064\u3044\u3066\u306f8\u300111\u300115\u300122\u300129\u300143\u300164\u300185\u3001106\u65e5\u76ee\uff08\u8a66\u9a13\u7d42\u4e86\u6642\uff09\u306b\u3001\u6700\u5f8c\u306e2\u56de\u306e\u6295\u4e0e\u306b\u3064\u3044\u3066\u306f8\u300111\u300115\u300122\u300129\u300143\u300164\u300185\u3001126\u65e5\u76ee\u306b\u5916\u6765\u53d7\u8a3a\u306e\u305f\u3081\u306b\u30af\u30ea\u30cb\u30c3\u30af\u306b\u623b\u3063\u305f\u3002 <\/p>\n

\u8907\u6570\u56de\u6295\u4e0e\u8a66\u9a13\uff1a<\/strong> <\/span>\u672c\u8a66\u9a13\u306f\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\uff0821\u65e5\u76ee\u304b\u30892\u65e5\u76ee\uff09\u3001\u4e8c\u91cd\u76f2\u691c\u6cbb\u7642\u3001\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u306e3\u3064\u306e\u671f\u9593\u304b\u3089\u69cb\u6210\u3055\u308c\u305f\u3002\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u6642\u3001\u88ab\u9a13\u8005\u306fevinacumab\u306e\u7528\u91cf\u30ec\u30d9\u30eb\u304a\u3088\u3073\u30ec\u30b8\u30e1\u30f3\u3054\u3068\u306b6\u3064\u306e\u30b3\u30db\u30fc\u30c8\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u5404\u30b3\u30db\u30fc\u30c8\u5185\u3067\u306f\u30018\u4eba\u306e\u88ab\u9a13\u8005\u304cevinacumab\uff1a\u30d7\u30e9\u30bb\u30dc\uff1d3\uff1a1\u306e\u5272\u5408\u3067\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002\u88ab\u9a13\u8005\u306f3\u65e5\u76ee\u306e\u8a55\u4fa1\u304c\u7d42\u4e86\u3059\u308b\u307e\u3067\u901a\u9662\u3057\u30018\u65e5\u76ee\u300115\u65e5\u76ee\u300122\u65e5\u76ee\u300129\u65e5\u76ee\u300136\u65e5\u76ee\u300143\u65e5\u76ee\u300150\u65e5\u76ee\u300157\u65e5\u76ee\u300178\u65e5\u76ee\u300199\u65e5\u76ee\u3001120\u65e5\u76ee\u3001141\u65e5\u76ee\u3001162\u65e5\u76ee\u3001183\u65e5\u76ee\uff08\u8a66\u9a13\u7d42\u4e86\u6642\uff09\u306b\u5916\u6765\u53d7\u8a3a\u306e\u305f\u3081\u518d\u6765\u9662\u3057\u305f\u3002\u30b3\u30db\u30fc\u30c81\u30013\u30015\u3067\u306f50\u65e5\u76ee\u3001\u30b3\u30db\u30fc\u30c82\u30684\u3067\u306f43\u65e5\u76ee\u3001\u30b3\u30db\u30fc\u30c86\u3067\u306f29\u65e5\u76ee\u306b\u8a66\u9a13\u6cbb\u7642\u306f\u7d42\u4e86\u3057\u305f\u3002 <\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u7d50\u679c<\/strong><\/p>\n

\n

\u5358\u56de\u6295\u4e0e\u8a66\u9a13\uff1a<\/strong><\/p>\n

83\u4eba\u306e\u88ab\u9a13\u8005\u304c\u767b\u9332\u3055\u308c\u300162\u4eba\u304cevinacumab\u7fa4\u306b\u300121\u4eba\u304c\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u3089\u308c\u305f\u3002<\/p>\n

– \u7528\u91cf\u5236\u9650\u6bd2\u6027\u306f\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n

– \u6cbb\u7642\u7dca\u6025\u6027\u306e\u3042\u308bAE\u306f\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u7fa4\u306732\u4f8b\uff0851.6\uff05\uff09\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u30679\u4f8b\uff0842.9\uff05\uff09\u5831\u544a\u3055\u308c\u305f\u304c\u3001\u91cd\u7be4\u306a\u3082\u306e\u3001\u6cbb\u7642\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u3082\u306e\u306f\u306a\u304b\u3063\u305f\u3002<\/p>\n

– \u30a2\u30e9\u30cb\u30f3\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08ALT\uff09\u306e\u5358\u56de\u4e0a\u6607\u304c7\u540d\uff0811.3\uff05\uff09\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u30a2\u30df\u30ce\u30c8\u30e9\u30f3\u30b9\u30d5\u30a7\u30e9\u30fc\u30bc\uff08AST\uff09\u306e\u5358\u56de\u4e0a\u6607\u304c4\u540d\uff086.5\uff05\uff09\u3001\u30af\u30ec\u30a2\u30c1\u30cb\u30f3\u30db\u30b9\u30db\u30ad\u30ca\u30fc\u30bc\uff08CPK\uff09\u306e\u5358\u56de\u4e0a\u6607\u304c2\u540d\uff083.2\uff05\uff09\u306b\u8a8d\u3081\u3089\u308c\u305f\u3002\u3053\u308c\u3089\u306f\u7528\u91cf\u306b\u95a2\u9023\u3057\u306a\u304b\u3063\u305f\u3002\u30d7\u30e9\u30bb\u30dc\u3067\u306fALT\u3001AST\u3001CPK\u306e\u4e0a\u6607\u306f\u5831\u544a\u3055\u308c\u306a\u304b\u3063\u305f\u3002 <\/p>\n

– TG\u306e\u6e1b\u5c11\u306f\u7528\u91cf\u4f9d\u5b58\u7684\u306b\u89b3\u5bdf\u3055\u308c\u3001\u6700\u5927\u6e1b\u5c11\u306f10mg\/kg\u3092\u9759\u8108\u5185\u6295\u4e0e\u3057\u305f3\u65e5\u76ee\u306e76.9\uff05\u3067\u3042\u3063\u305f\u3002<\/p>\n

\u8907\u6570\u56de\u6295\u4e0e\u8a66\u9a13\uff1a<\/strong><\/p>\n

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– \u5168\u4f53\u3068\u3057\u3066\u3001\u30a8\u30d3\u30ca\u30af\u30de\u30d6SC\u7fa421\u4f8b\uff0867.7%\uff09\u306b\u5bfe\u3057\u3066\u30d7\u30e9\u30bb\u30dc\u7fa49\u4f8b\uff0875.0%\uff09\u3001\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u9759\u6ce8\u7fa46\u4f8b\uff0885.7%\uff09\u306b\u5bfe\u3057\u3066\u30d7\u30e9\u30bb\u30dc\u7fa41\u4f8b\uff0850.0%\uff09\u3067\u6cbb\u7642\u7dca\u6025\u6027\u306e\u3042\u308bAE\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u91cd\u7be4\u306a\u3082\u306e\u3001\u6cbb\u7642\u4e2d\u6b62\u306b\u81f3\u3063\u305f\u3082\u306e\u306f\u306a\u304b\u3063\u305f\u3002 <\/p>\n

– CPK\u306e\u5358\u56de\u4e0a\u6607\u304c1\u4eba\u306e\u60a3\u8005\u306b\u5831\u544a\u3055\u308c\u305f\u3002<\/p>\n

– 57\u65e5\u76ee\u306eTG\u6e1b\u5c11\u306e\u4e2d\u592e\u5024\u306f\u3001\u30a8\u30d3\u30ca\u30af\u30de\u30d6300mg\u6bce\u9031SC\u3001450mg\u6bce\u9031SC\u3001\u304a\u3088\u307320mg\/kg\u9759\u6ce8\u3067\u7d0470\uff05\u3067\u3042\u3063\u305f\u3002TG\u306e\u6700\u5927\u6e1b\u5c11\u306f20mg\/kg\u30924\u9031\u306b1\u56de\u9759\u8108\u5185\u6295\u4e0e\u3057\u305f\u5834\u5408\u306e2\u65e5\u76ee\u306783.1\uff05\u3067\u3042\u3063\u305f\u3002 <\/p>\n

 <\/p>\n\n\n\n
\u7d50\u8ad6<\/strong><\/td>\nEvinacumab\u306f2\u3064\u306e\u7b2c1\u76f8\u8a66\u9a13\u3067\u826f\u597d\u306a\u5fcd\u5bb9\u6027\u3092\u793a\u3057\u305f\u3002\u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u8840\u75c7\u306e\u88ab\u9a13\u8005\u306b\u304a\u3051\u308b\u8102\u8cea\u306e\u5909\u5316\u306f\u3001ANGPTL3\u6b20\u640d\u6a5f\u80fd\u5909\u7570\u3067\u89b3\u5bdf\u3055\u308c\u305f\u3082\u306e\u3068\u540c\u69d8\u3067\u3042\u3063\u305f\u3002\u5f8c\u8005\u306f\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u306e\u3067\u3001ANGPTL3\u306e\u963b\u5bb3\u306f\u81e8\u5e8a\u8ee2\u5e30\u3092\u6539\u5584\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
\n

\u30b3\u30e1\u30f3\u30c8<\/strong><\/p>\n

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ANGPTL3\u306f\u4e3b\u306b\u3001\u5faa\u74b0\u4e2d\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u591a\u304f\u542b\u3080\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u4e2d\u306e\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3092\u52a0\u6c34\u5206\u89e3\u3059\u308b\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u30ea\u30d1\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u3001\u307e\u305f\u5185\u76ae\u30ea\u30d1\u30fc\u30bc\u3092\u963b\u5bb3\u3057\u3066HDL-C\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001ANGPTL3\u907a\u4f1d\u5b50\u306e\u6a5f\u80fd\u55aa\u5931\u578b\u907a\u4f1d\u5b50\u5909\u7570\u3068\u3001\u8840\u6f3f\u4e2d\u306eLDL-C\u3001HDL-C\u3001\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306e\u4f4e\u50245-7\u3001\u304a\u3088\u3073\u30d2\u30c8\u306b\u304a\u3051\u308b\u51a0\u52d5\u8108\u6027\u5fc3\u75be\u60a3\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u3002 <\/p>\n

\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u306f\u3001ANGPTL3\u306b\u5bfe\u3059\u308b\u5b8c\u5168\u30d2\u30c8\u578b\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\u6cbb\u7642\u85ac\u3067\u3042\u308b\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u306f\u3001\u5065\u5eb7\u306a\u30d2\u30c8\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u304a\u3088\u3073\u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u3001TG\u3001\u975eHDL-C\u304a\u3088\u3073LDL-C\u3092\u4f4e\u4e0b\u3055\u305b\u305f9,10\u3002\u672c\u7814\u7a76\u3067\u5f97\u3089\u308c\u305f\u77e5\u898b\u306f\u3001\u8efd\u5ea6\u304b\u3089\u4e2d\u7b49\u5ea6\u306eTG\u4e0a\u6607\u60a3\u8005\u306b\u304a\u3051\u308b\u30a8\u30d3\u30ca\u30af\u30de\u30d6\u306e\u5b89\u5168\u6027\u3001\u5fcd\u5bb9\u6027\u304a\u3088\u3073TG\u4f4e\u4e0b\u52b9\u679c\u3092\u793a\u3059\u3082\u306e\u3067\u3042\u308a\u3001\u3053\u306e\u3088\u3046\u306a\u81e8\u5e8a\u74b0\u5883\u306b\u304a\u3051\u308b\u3088\u308a\u5927\u898f\u6a21\u306a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u3053\u306e\u65b0\u898f\u85ac\u5264\u306e\u3055\u3089\u306a\u308b\u958b\u767a\u3092\u652f\u6301\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u3002 <\/p>\n<\/div>\n\n\n\n\n
\u53c2\u8003\u6587\u732e<\/strong><\/td>\n\n

1.Florentin M, Kostapanos MS, Anagnostis P, Liamis G. Recent developments in pharmacotherapy for hypertriglyceridemia: What’s the current state of the art?Expert Opin Pharmacother 2019:1-14. <\/p>\n

2.Toth PP, Granowitz C, Hull M, et al. \u9ad8\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u306f\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3001\u533b\u7642\u8cbb\u3001\u8cc7\u6e90\u4f7f\u7528\u306e\u5897\u52a0\u3068\u95a2\u9023\u3059\u308b\uff1a\u9ad8\u6b8b\u5b58\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u3092\u6709\u3059\u308b\u30b9\u30bf\u30c1\u30f3\u6cbb\u7642\u60a3\u8005\u306e\u5b9f\u4e16\u754c\u884c\u653f\u8acb\u6c42\u5206\u6790\u3002J Am Heart Assoc. 2018;7:e008740. <\/p>\n

3.Nordestgaard BG, Varbo A. \u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002Lancet 2014;384:626-35 <\/p>\n

4.Kersten S. Angiopoietin-like 3 in lipoprotein metabolism.Nat Rev Endocrinol 2017;13:731-9. <\/p>\n

5.\u8102\u8cea\u6fc3\u5ea6\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3059\u308b\u907a\u4f1d\u5b50\u5ea7\u3092\u65b0\u305f\u306b\u540c\u5b9a\u3002Nat Genet.2008;40:161-9. <\/p>\n

6.\u30a8\u30af\u30bd\u30fc\u30e0\u914d\u5217\u6c7a\u5b9a\u3001ANGPTL3\u5909\u7570\u3001\u5bb6\u65cf\u6027\u8907\u5408\u578b\u4f4e\u8102\u8840\u75c7\u3002N Engl J Med 2010;363:2220-7. <\/p>\n

7.ANGPTL\u30d5\u30a1\u30df\u30ea\u30fc\u30e1\u30f3\u30d0\u30fc\u306e\u7a00\u306a\u6a5f\u80fd\u55aa\u5931\u5909\u7570\u304c\u30d2\u30c8\u306e\u8840\u6f3f\u30c8\u30ea\u30b0\u30ea\u30bb\u30ea\u30c9\u5024\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3002J Clin Invest.2009;119:70-79 <\/p>\n

8.Stitziel NO, Khera AV, Wang X. ANGPTL3\u306e\u6b20\u640d\u3068\u51a0\u52d5\u8108\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4e88\u9632\u3002J Am Coll Cardiol 2017;69:2054-2063 <\/p>\n

9.Dewey FE, Gusarova V, Dunbar RL, et al. ANGPTL3\u306e\u907a\u4f1d\u7684\u304a\u3088\u3073\u85ac\u7406\u5b66\u7684\u4e0d\u6d3b\u6027\u5316\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u3002N Engl J Med 2017;377:211-221. <\/p>\n

10.Gaudet D, Gipe DA, Pordy R, et al. \u30db\u30e2\u63a5\u5408\u6027\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u306b\u304a\u3051\u308bANGPTL3\u963b\u5bb3\u3002N Engl J Med 2017;377:296-297. <\/p>\n<\/td>\n<\/tr>\n

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