{"id":252768,"date":"2025-01-23T23:31:23","date_gmt":"2025-01-23T22:31:23","guid":{"rendered":"https:\/\/r3i.org\/hito-noticias-de-reduce-it-el-icosapent-etilico-reduce-el-riesgo-de-ictus-isquemico\/"},"modified":"2025-02-15T22:51:24","modified_gmt":"2025-02-15T21:51:24","slug":"hito-noticias-de-reduce-it-el-icosapent-etilico-reduce-el-riesgo-de-ictus-isquemico","status":"publish","type":"page","link":"https:\/\/r3i.org\/es\/hito-noticias-de-reduce-it-el-icosapent-etilico-reduce-el-riesgo-de-ictus-isquemico\/","title":{"rendered":"Hito – Noticias de REDUCE-IT: El icosapent et\u00edlico reduce el riesgo de ictus isqu\u00e9mico"},"content":{"rendered":"

[et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb1px|||||\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_row _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb header_2_text_color=\u00bbgcid-primary-color\u00bb header_5_text_color=\u00bbgcid-secondary-color\u00bb text_orientation=\u00bbcenter\u00bb width=\u00bb99%\u00bb custom_margin=\u00bb|-147px||||\u00bb custom_padding=\u00bb|0px||||\u00bb global_colors_info=\u00bb{%22gcid-primary-color%22:%91%22quote_text_color%22,%22quote_text_color%22,%22quote_text_color%22,%22header_2_text_color%22%93,%22gcid-secondary-color%22:%91%22header_5_text_color%22%93}\u00bb]<\/p>\n

Noticias de REDUCE-IT: el etilo de icosapento reduce el riesgo de accidente cerebrovascular isqu\u00e9mico<\/h2>\n

9 de agosto de 2021<\/span><\/h5>\n
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En un nuevo an\u00e1lisis de REDUCE-IT, se demuestra que el tratamiento con etilo de icosapento reduce el riesgo de desarrollar un primer accidente cerebrovascular isqu\u00e9mico en un 36 %.
Bhatt DL, Steg PG, Miller M, et al. Reduction in Ischemic Stroke With Icosapent Ethyl – Insights From REDUCE-IT. Stroke 2021; 52 (Suppl_1). CONFERENCIA INTERNACIONAL SOBRE ACCIDENTES CEREBROVASCULARES DE 2021 RES\u00daMENES ORALES<\/em><\/div>\n
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RESUMEN DEL ESTUDIO<\/strong><\/p>\n\n\n\n\n\n\n\n
Objetivo:<\/strong><\/td>\nInvestigar el efecto del tratamiento con etilo de icosapento en dosis altas en el riesgo de cualquier accidente cerebrovascular y el accidente cerebrovascular isqu\u00e9mico en pacientes tratados con estatinas, de 45 a\u00f1os o m\u00e1s, con enfermedad cardiovascular establecida o diabetes y otros factores de riesgo cardiovascular, como niveles elevados de triglic\u00e9ridos (TG).<\/td>\n<\/tr>\n
Dise\u00f1o del estudio:<\/strong><\/td>\nREDUCE-IT fue un ensayo multinacional, aleatorizado y doble ciego. Los pacientes fueron aleatorizados para recibir tratamiento con etilo de icosapento, un \u00e9ster et\u00edlico estable y purificado de \u00e1cido eicosapentaenoico (4 gramos\/d\u00eda), o placebo. Se realiz\u00f3 un seguimiento de los pacientes durante una mediana de 4,9 a\u00f1os.<\/td>\n<\/tr>\n
Poblaci\u00f3n del estudio:<\/strong><\/td>\nEn REDUCE-IT, se aleatorizaron a 8179 pacientes con colesterol de lipoprote\u00ednas de baja densidad controlado (mediana de 75 mg\/dl o 1,94 mmol\/l) y TG elevados (mediana de 216 mg\/dl o 2,44 mmol\/l). En conjunto, 71 % de los pacientes se encontraban en prevenci\u00f3n secundaria y 29 % ten\u00edan diabetes mellitus y al menos un factor de riesgo adicional.<\/td>\n<\/tr>\n
Resultado del estudio:<\/strong><\/td>\nPrimer accidente cerebrovascular, primer accidente cerebrovascular isqu\u00e9mico y primer accidente cerebrovascular hemorr\u00e1gico.<\/td>\n<\/tr>\n
M\u00e9todos:<\/strong><\/td>\nAn\u00e1lisis predise\u00f1ado y a posteriori.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

RESULTADOS<\/strong><\/p>\n

El tratamiento con etilo de icosapento se asoci\u00f3 con una reducci\u00f3n significativa del riesgo de un primer accidente cerebrovascular y un primer accidente cerebrovascular isqu\u00e9mico. Por cada 1000\u00a0pacientes tratados con etilo de icosapento durante 5\u00a0a\u00f1os, se evitaron aproximadamente 14\u00a0accidentes cerebrovasculares (mortales o no mortales) (p\u00a0=\u00a00,008). No hubo exceso de riesgo de accidente cerebrovascular hemorr\u00e1gico con etilo de icosapento (0,3\u00a0% frente a 0,2\u00a0%; p\u00a0=\u00a00,55).<\/p>\n

<\/strong><\/p>\n

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<\/strong><\/p>\n\n\n\n\n\n\n
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 <\/p>\n<\/td>\n

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Etilo de icosapento (N = 4089)<\/p>\n<\/td>\n

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Placebo (N = 4090)<\/p>\n<\/td>\n

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Cociente de riesgo (IC 95 %)<\/p>\n<\/td>\n

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Valor de p<\/p>\n<\/td>\n<\/tr>\n

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 <\/p>\n<\/td>\n

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Tasas de episodios<\/p>\n<\/td>\n<\/tr>\n

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Accidente cerebrovascular<\/p>\n<\/td>\n

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2.4%<\/p>\n<\/td>\n

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3.3%<\/p>\n<\/td>\n

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0.72 (0.55-0.93)<\/p>\n<\/td>\n

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0.01<\/p>\n<\/td>\n<\/tr>\n

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Accidente cerebrovascular isqu\u00e9mico<\/p>\n<\/td>\n

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2.0%<\/p>\n<\/td>\n

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3.0%<\/p>\n<\/td>\n

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0.64 (0.49-0.85)<\/p>\n<\/td>\n

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0.002<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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<\/div>\n
Conclusi\u00f3n:<\/strong><\/div>\n
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En REDUCE-IT, el etilo de icosapento redujo significativamente el riesgo de accidente cerebrovascular isqu\u00e9mico, sin exceso de accidente cerebrovascular hemorr\u00e1gico, en pacientes tratados con estatinas con TG elevados y aterosclerosis o diabetes.<\/p>\n

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COMENTARIO<\/strong><\/p>\n

En REDUCE-IT (Reducci\u00f3n de episodios cardiovasculares con etilo de icosapento – Ensayo de intervenci\u00f3n), se demostr\u00f3 que el tratamiento con dosis altas de etilo de icosapento (4 g\/d\u00eda) redujo significativamente los episodios cardiovasculares en pacientes de alto riesgo en prevenci\u00f3n primaria y secundaria, con niveles elevados de TG a pesar del uso de estatinas (1). Si bien se reconoci\u00f3 que probablemente hay otros efectos implicados adem\u00e1s de la reducci\u00f3n de los TG (2), el estudio representa un hito para el concepto de que los TG elevados (un sustituto de las lipoprote\u00ednas ricas en TG y sus remanentes) probablemente contribuyen al riesgo cardiovascular residual. Estos hallazgos tambi\u00e9n fueron fundamentales para cambiar las recomendaciones de los lineamientos para el manejo de los TG elevados en pacientes de alto riesgo (3).<\/p>\n

Este \u00faltimo an\u00e1lisis de REDUCE-IT se suma a los datos que confirman que el etilo de icosapento en dosis altas tambi\u00e9n redujo el riesgo de accidente cerebrovascular en pacientes tratados con estatinas. En particular, el riesgo de un primer accidente cerebrovascular isqu\u00e9mico se redujo en un 36 %. Estos hallazgos son importantes dada la carga del accidente cerebrovascular para la sociedad, los sistemas de salud y las personas y sus cuidadores (4). A nivel mundial, aunque la carga de accidentes cerebrovasculares estandarizada por edad ha disminuido, el creciente n\u00famero de casos (casi se duplic\u00f3 entre 1990 y 2017) debido principalmente al crecimiento y al envejecimiento poblacional, subrayan la necesidad de identificar factores de riesgo reversibles (5). Estos \u00faltimos hallazgos de REDUCE-IT sugieren se\u00f1alar los TG elevados como objetivo para reducir el riesgo residual de accidente cerebrovascular.<\/p>\n

Se espera el informe completo de este an\u00e1lisis.<\/p>\n<\/div>\n\n\n\n\n
Referencias<\/strong><\/td>\n\n

1. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular risk reduction with icosapent ethyl for hypertriglyceridemia. N Engl J Med 2019;380:11-22.<\/p>\n

2. Sharma G, Martin SS, Blumenthal RS. Effects of omega-3 fatty acids on major adverse cardiovascular events: what matters most: the drug, the dose, or the placebo? JAMA 2020;324:2262-4.<\/p>\n

3. Mach F, Baigent C, Catapano AL, et al. 2019 ESC\/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020;41:111-88.<\/p>\n

4. Khan SU, Khan MZ, Khan MU, et al. Clinical and economic burden of stroke among young, midlife, and older adults in the United States, 2002-2017. Mayo Clin Proc Innov Qual Outcomes. 2021;5:431-41.<\/p>\n

5. Morovatdar N, Avan A, Azarpazhooh MR, et al. Secular trends of ischaemic heart disease, stroke, and dementia in high-income countries from 1990 to 2017: the Global Burden of Disease Study 2017. Neurol Sci 2021; doi: 10.1007\/s10072-021-05259-2.<\/p>\n<\/td>\n<\/tr>\n

Palabras claves<\/strong><\/td>\nresidual cardiovascular risk; stroke; icosapent ethyl; REDUCE-IT<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

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Noticias de REDUCE-IT: el etilo de icosapento reduce el riesgo de accidente cerebrovascular isqu\u00e9mico 9 de agosto de 2021 En un nuevo an\u00e1lisis de REDUCE-IT, se demuestra que el tratamiento con etilo de icosapento reduce el riesgo de desarrollar un primer accidente cerebrovascular isqu\u00e9mico en un 36 %.Bhatt DL, Steg PG, Miller M, et al. 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