Obesity, genetic risk and triglycerides
The current study corroborates previous findings that obesity accentuates the effects of common genetic susceptibility variants that regulate levels of triglycerides. Using data from the Women's Genome Health Study, investigators evaluated the impact of changes in body mass index (BMI) and waist circumference on a weighted genetic risk score (based on 40 published triglyceride-associated variants). They showed differential association of body mass index (BMI) with the genetic risk score and effects on triglycerides; in overweight (BMI ? 25 kg/m2) women, each unit increase of the risk score was associated with 1.013% increase in triglycerides (compared with 1.011% triglyceride increase in normal weight women, p for interaction = 0.014). These findings were confirmed in meta-analyses combining results for this study with four Scandinavian cohorts, thus reaffirming the link between obesity and genetic risk for elevated triglycerides.
Adiposity and genetic factors in relation to triglycerides and triglyceride-rich lipoproteins in the Women's Genome Health Study.
Ahmad S, Mora S, Franks PW et al.