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Gender disparity in lipid targets for men and women in the Arabian Gulf

Women living in the Arabian Gulf, especially those at very high cardiovascular risk, were much less likely to attain recommended lipid goals according to this analysis of the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS). The analysis included 4,384 high and very high risk patients (mean age 57±11 years and 40% women) on lipid lowering therapy in six Arabian Gulf countries. Compared with male patients, females in this study were at higher cardiometabolic risk, as shown by a higher prevalence of diabetes (84% vs 71%; p<0.001) and metabolic syndrome (49% vs 35%; p<0.001), but were less likely to achieve their recommended lipid goals, for low-density lipoprotein cholesterol (LDL-C) (28% vs 32%; p = 0.002), high-density lipoprotein cholesterol (HDL-C) (42% vs 50%; p<0.001), and apolipoprotein B (38% vs 42%; p = 0.015). Among the very high risk cohort, only 1 in five women attained LDL-C goal and about 1 in three attained non-HDL-C goals, significantly lower than in men. These data, from a large prospective study, highlight an unmet clinical need to improve lipid management in high risk patients of both sexes, but especially very high risk women, in this region.
Gender disparity in lipid target achievements in high and very high atherosclerotic cardiovascular disease risk patients in the Arabian Gulf.

Al-Zakwani I, Shehab A, Al-Hinai AT et al.