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HDL-cholesterol and triglycerides linked with insulin secretion in non-diabetic individuals

Although experimental studies suggest that lipoproteins directly affect beta cell function, evidence from clinical studies is less consistent. This question was investigated in a cross sectional, observational prospective multicentre study including 1,016 non-diabetic subjects (aged 30-60 years and with body mass index 20.0-39.9 kg/m2). The study measured fasting lipids, fasting insulin and Oral Glucose Tolerance Test (OGTT)-induced insulin secretion and clearance, and peripheral insulin sensitivity (by the euglycemic clamp) at baseline and after 3.5 years. There was no association between low-density lipoprotein cholesterol levels and fasting or stimulated insulin secretion or clearance. However, low levels of high-density lipoprotein (HDL) cholesterol and elevated triglycerides were associated with abnormalities in insulin secretion characteristic of the pre-diabetic state, independent of changes in body weight or plasma glucose.
Plasma HDL-cholesterol and triglycerides, but not LDL-cholesterol, are associated with insulin secretion in non-diabetic subjects

Natali A, Baldi S, Bonnet F et al.