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The initiative

Prof. Paula Fioretto

Prof. Paula Fioretto  
University of Padova,
Padova, Italy
 
Current position
 
  Associate Professor of Endocrinology, Dep. of Medical and Surgical Sciences,  University of Padova, Italy
 
Scientific training
 
1984 M.D. - University of Padova, gaining 110/110 cum Laude
1984 Licensed to practice Medicine in Italy (by National Board Examination),
1983 - 1984 Residency, Dep. of Internal Medicine, University of Padova
1985 - 1987 Fellowship, Dep. of Endocrinology, Metabolism, Diabetes, University of Padova
1987 Specialized in Endocrinology, gaining 70/70, University of Padova
1996 Specialized in Internal Medicine, gaining 70/70, University of Padova
1994 Ph.D. in Clinical Pathophysiology, University of Milan
1989 - 1992 Post-doctoral Research Fellow, Dep.t of Pediatrics, University of Minnesota, Minneapolis, MN, USA
 
 
Professional Associations
 
2005 - President of European Diabetic Nephropathy Study Group (EASD)
2006 - Chair, Scientific Committee of Società Italiana di Dabetologia
 
Awards
 
1989 - 1990 Italian National Council for Reaserch Fellowship
1990 - 1992 Juvenile Diabetes Foundation Fellowship Award
1992 Award of the Societa' Italiana di Diabetologia for research performed on chronic diabetic complications          
1994   Young investigator Award of the Societa' Italiana di Diabetologia based on original publications
1995 Albert Renold Award of the European Association for the Study of Diabetes
1996 - 2000 Juvenile Diabetes Foundation Career Development Award
1998 Morgagni Joung Investigator Award     
2003 Award of the Societa' Italiana di Diabetologia based on original publications,
2004 Novartis Diabetes Young Investigator Award
2007 Castelli-Pedroli prize (Glogi lecture) of the European Association for the Study of Diabetes      
 
Publications (selection)
  • Fioretto P, Mauer SM, Bilous RW, Goetz FC, Sutherland  DER, Steffes MW. Effects of pancreas transplantation on renal structure in insulin-dependent diabetic patients with their own kidneys. The Lancet, 342: 1193-96, 1993.
  • Fioretto P, Steffes MW, Mauer SM. Glomerular structure in non-proteinuric insulin-dipendent diabetic patients with various levels of albuminuria. Diabetes, 43: 1358-1364, 1994.
  • Fioretto P, Steffes MW, Sutherland DER, Mauer M. Sequential renal biopsies in insulin-dependent diabetic patients: structural factors associated with clinical progression. Kidney International, 48: 1929-1935, 1995.
  • Fioretto P, Mauer M, Brocco E, Velussi M, Frigato F, Muollo B, Sambatero M, Abaterusso A, Baggio B, Crepaldi G, Nosadini R. Patterns of renal injury in type 2 diabetic patients with microalbuminuria.
  • Diabetologia, 39: 1569-1576, 1996.
  • Lurbe A, Fiorettto P, Mauer M, Lapointe MS, Battle D. Growth phenotype of cultured skin fibroblasts from insulin-dependent diabetic patients with and without nephropathy and its association to overactivity of the Na+/H+ antiporter. Kidney International, 50: 1684-1693, 1996.
  • Brocco E, Fioretto P, Mauer M, Saller A, Carraro A, Frigato F, Chiesura-Corona M, Bianchi L, Baggio B, Maioli M, Abaterusso C, Velussi M, Sambataro M, Virgili F, Ossi E, Nosadini R. Renal structure and function in non-insulin dependent diabetic patients with microalbuminuria.   Kidney International, 63: S40-44, 1997.
  • Fioretto P, Stehouwer CDA, Mauer M, Chiesura-Corona M, Carraro A, Brocco E, Van Hishberg VWM, Crepaldi G, Nosadini R.Heterogeneous nature of microalbuminuria in NIDDM: studies of endothelial function and renal structure. Diabetologia, 41: 233-236, 1998.
  • Brito PL, Fioretto P, Drummond K, KIim Y, Steffes MW, Basgen JM, Mauer M. Proximal tubular basement membrane width in insulin dependent diabetes mellitus. Kidney International, 53: 754-761, 1998.
  • Nosadini R, Brocco E, Saller A, Cernigoi AM, Abaterusso C, Bortoloso E, Dalla Vestra M, Maioli M, Piarulli F, Fioretto P. Renal function in non insulin-dependent diabetes mellitus patients treated with angiotensin-converting enzyme inhibitors and calcium channel blockers. Journal of Hypertension,16, S4: 27-32, 1998.
  • Fioretto P, Steffes MW, Sutherland DER, Goetz FC, Mauer M. Reversal of lesions of diabetic nephropathy after pancreas transplantation. New England Journal of Medicine, 339: 69-75, 1998.
  • Stehower CD, Yudkin JS, Fioretto P, Nosadini R. How heterogeneous is microalbuminuria in diabetes mellitus? The case for 'benign' and 'malignant microalbuminuria. Nephrology Dialysis Transplantation, 13: 2751-2754, 1998.
  • Fioretto P, Steffes MW, Rich SS, Miller M, Barbosa J, Mauer M. Is diabetic nephropathy inherited? Studies of glomerular structure in type 1 diabetic sibling pairs.  Diabetes, 48: 865-869, 1999.
  • Trevisan R, Fioretto P, Barbosa J, Mauer M. Insulin-dependent diabetic sibling pairs are concordant for sodium-hydrogen antiport activity. Kidney International, 55: 2383-2389, 1999.
  • Nosadini R, Velussi M, Brocco E, Bruseghin M, Abaterusso C, Saller A, Dalla Vestra M, Carraro A, Bortoloso E, Sambatero M, Barzon I, Frigato F, Muollo F, Chiesura-Corona M, Pacini G, Baggio B, Piarulli F, Sfriso A, Fioretto P. Course of renal function in type 2 diabetic patients with abnormalities of albumin excretion rate. Diabetes, 49: 476-484, 2000.
  • Caramori ML, Fioretto P, Mauer M. The need for early predictors of diabetic nephropathy risk: is albumin excretion rate sufficient? Diabetes, 49: 1399-1408, 2000.
  • Solini A, Dalla Vestra M, Saller A, Nosadini R, Crepaldi G, Fioretto P. The angiotensin convertine enzyme DD genotype is associated with glomerulopathy lesions in type 2 diabetes. Diabetes, 51: 251-255, 2002.
  • Mussap M, Dalla Vestra M, Saller A, Nosadini R, Fioretto P, Plebani M. Cystatin C is a more sensitive marker than creatinine for estimation of GFR in type 2 diabetic patients. Kidney International, 61: 1453-1461, 2002.
  • Baggio B, Budakovic A, Dalla Vestra M, Saller A, Fioretto P. Effects of cigarette smoking on glomerular structure and function in type 2 diabetic patients. J  Am Society of Nephrology, 13: 2730-2736, 2002.
  • Dalla Vestra M, Masiero A, Roiter AM, Saller A, Crepaldi G, Fioretto P. Are podocytes relevant in diabetic nephropathy? Studies in type 2 diabetic patients. Diabetes, 52: 1031-1035, 2003
  • Caramori ML, Fioretto P, Mauer M. Low GFR in normoalbuminuric type 1 diabetic patients: an indicator of more advanced glomerular lesions. Diabetes, 52: 1036-1040, 2003.
  • De Cosmo S, Trevisan R, Dalla Vestra M, Argiolas A, Vedovato M, Solini A, Saller A, Trischitta V, Fioretto P. The PC-1 aminoacid variant Q121 associates with lower GFR in type 2 diabetic patients with abnormal albumin excretion rate. Diabetes Care, 26: 2898-2902, 2003.
  • Bortoloso E, Del  Prete D, Gambaro G, Dalla Vestra M, Gambaro G , Saller A, Antonucci F, Baggio B, Anglani F, Fioretto P. Quantitative and qualitative changes in VEGF gene expression in glomeruli of patients with type 2 diabetes. European Journal of Endocrinology, 150: 799-807, 2004
  • Mauer M, Fioretto P. Preventing microalbuminuria in type 2 diabetes. New Engl J Med, 352: 833-834 (letter), 2005.
  • Dalla Vestra M, Mussap M, Gallina P, Bruseghin M, Cernigoi AM, Saller A, Plebani M, Fioretto P. Acute phase markers of inflammation and glomerular structure in type 2 diabetic patients J Am Soc Nephrol, 16: S78-S82, 2005.
  • Solini A, Fioretto P.  Antihypertensive therapy and multifactorial approach for nephroprotection in patients with type 2 diabetes. J Am Soc Nephrol, 16: S18-S21, 2005.
  • De Cosmo S, Trevisan R, Minenna A, Vedovato M, Viti R, Santini S, Fioretto P, Trischitta V. Insulin resistance and cluster of abnormalities related to the metabolic sindrome are associated with reduced GFR in patients with type 2 diabetes. Diabetes Care, 29: 432-434, 2006.
  • Fioretto P, Sutherland  DER, Najafian B, Mauer M. Remodeling of renal interstitial and tubular lesions in pancreas transplantat recipients. Kidney International, 69: 907-912, 2006, 2006
  • Caramori ML, Kim Y, Fioretto P, Huang C, Rich SS, Miller ME, Russell GB, Mauer M.  Cellular basis of diabetic nephropathy: IV Antioxidant enzyme mRNA expression levels in skin fibroblasts of type 1 diabetic sibling pairs. Nephrology Dialysis Transplantation, 21:3122-3126, 2006.
  • Caramori ML, Fioretto P, Mauer M. Enhancing the predictive value of urinary albumin for diabetic nephropathy. J Am Soc Nephrol, 17: 339-352, 2006.
  • Fioretto P, Bruseghin M, Berto I, Gallina P, Mussap M. Renal protection in diabetes: role of glycemic control. J Am Soc Nephrol, 17: S86-S89, 2006
  • Fioretto P, Mauer M. Histopathology of diabetic Nephropathy. Seminars of Nephrology, 27: 195-207, 2007
 
Research
 

Prof. Paola Fioretto spent 4 years as Research Fellow at the University of Minnesota, Minneapolis, where she became an expert in renal structure in diabetes. In USA and in Italy she has studied renal structure in both type1 and type 2 diabetes.
Among her contributions, the description of heterogeneity in renal structural changes underlying renal dysfunction in type 2 diabetes, and the demonstration that the lesions of diabetic nephropathy can reverse in humans.