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Professor of Medicine, Director, Center for Innovative Medicine
The research program we have undertaken for the past two decades is centered on the genetic basis for premature coronary artery disease, focusing on lipoprotein disorders, especially high-density lipoproteins (HDL). My training is that of a cardiologist, with a post-doctoral fellowship in lipoprotein metabolism and molecular genetics. Through extensive family studies, we have identified several genes associated with HDL, including the ATP binding cassette AI (ABCA1) the cause of Tangier disease and the rate-limiting step in HDL formation. For the past 10 years, we have focused on the mechanisms of HDL biogenesis and the environment created on the cell membrane through the ABCA1 transporter. The second major focus of our laboratory has been the study of the genetics of HDL. We have used the combined approaches of carefully phenotyped family studies, with bioinformatics data from genome-wide association studies. A third area of interest is the study of autosomal dominant hypercholesterolemia and premature vascular calcifications.
|2000 - 2010||Chief, Division of Cardiology, McGill University Health Center|
|2000 - 2010||Head of Cardiology, McGill University|
|2000 -||Professor, Department of Medicine, McGill University|
|2001 -||Associate Member, Department of Human Genetics McGill University|
|2006 -||Associate Member, Department of Biochemistry, McGill University|
|2010 -||Director, Center for Innovative Medicine, McGill University Health Center|
|2000||Chercheurs Nationaux, Fonds de la recherche en santé du Québec (FRSQ)|
|2000||McGill-Novartis Chair in Medicine, Department of Medicine, McGill University|
|2001||Fellow, American Heart Association Council on Atherosclerosis, Thrombosis and Vascular Biology|
|2006||McGill-Novartis Chair in Medicine, Department of Medicine, McGill University; renewed|
|2008||Member, American Society for Biochemistry and Molecular Biology (ASBMB)|
|2011||Margolese National Brain and Heart Disorders Prize (Inaugural). U British Columbia|
|2011 -||Elected Fellow in the Canadian Academy of Health Sciences (CAHS)|
|Selected peer-reviewed publications|